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Protein

Metallothionein-1

Gene

MtnA

Organism
Drosophila ananassae (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

This protein binds cations of several transition elements. It is thought to be involved in detoxification processes.

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Cadmium, Copper, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Metallothionein-1
Short name:
MT-1
Gene namesi
Name:MtnA
OrganismiDrosophila ananassae (Fruit fly)
Taxonomic identifieri7217 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Organism-specific databases

FlyBaseiFBgn0013782. Dana\MtnA.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 4040Metallothionein-1PRO_0000197352Add
BLAST

Expressioni

Developmental stagei

Late embryogenesis, larva and adult.

Inductioni

Strongly induced by cadmium, copper and mercury.

Interactioni

Protein-protein interaction databases

STRINGi7217.FBpp0120344.

Family & Domainsi

Domaini

All cysteine residues are arranged in C-X-C groups. These are thought to be the metal-binding sites in other metallothioneins.

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG4738. Eukaryota.
ENOG410Z9YK. LUCA.
OrthoDBiEOG789CFK.

Family and domain databases

InterProiIPR000966. Metalthion_5.
[Graphical view]
PfamiPF02067. Metallothio_5. 1 hit.
[Graphical view]
PRINTSiPR00872. MTDIPTERA.

Sequencei

Sequence statusi: Complete.

P61873-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40
MPCPCGSGCK CASQATKGSC NCGSDCKCGG DKKSACGCSK
Length:40
Mass (Da):3,852
Last modified:June 7, 2004 - v1
Checksum:i9182A53CCCAE634A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S75822 Genomic DNA. Translation: AAB32801.2.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S75822 Genomic DNA. Translation: AAB32801.2.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7217.FBpp0120344.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

FlyBaseiFBgn0013782. Dana\MtnA.

Phylogenomic databases

eggNOGiKOG4738. Eukaryota.
ENOG410Z9YK. LUCA.
OrthoDBiEOG789CFK.

Family and domain databases

InterProiIPR000966. Metalthion_5.
[Graphical view]
PfamiPF02067. Metallothio_5. 1 hit.
[Graphical view]
PRINTSiPR00872. MTDIPTERA.
ProtoNetiSearch...

Publicationsi

  1. "Molecular evolution of the metallothionein gene Mtn in the melanogaster species group: results from Drosophila ananassae."
    Stephan W., Rodriguez V.S., Zhou B., Parsch J.
    Genetics 138:135-143(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiMT1_DROAN
AccessioniPrimary (citable) accession number: P61873
Secondary accession number(s): P22254
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: June 7, 2004
Last modified: November 11, 2015
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. Metallothioneins
    Classification of metallothioneins and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.