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Protein

Metallothionein-1

Gene

MtnA

Organism
Drosophila ananassae (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

This protein binds cations of several transition elements. It is thought to be involved in detoxification processes.

GO - Molecular functioni

Keywordsi

LigandCadmium, Copper, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Metallothionein-1
Short name:
MT-1
Gene namesi
Name:MtnA
OrganismiDrosophila ananassae (Fruit fly)
Taxonomic identifieri7217 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Organism-specific databases

FlyBaseiFBgn0013782. Dana\MtnA.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001973521 – 40Metallothionein-1Add BLAST40

Expressioni

Developmental stagei

Late embryogenesis, larva and adult.

Inductioni

Strongly induced by cadmium, copper and mercury.

Structurei

3D structure databases

SMRiP61873.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

All cysteine residues are arranged in C-X-C groups. These are thought to be the metal-binding sites in other metallothioneins.

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG4738. Eukaryota.
ENOG410Z9YK. LUCA.
OrthoDBiEOG091G1A2R.

Family and domain databases

InterProiView protein in InterPro
IPR000966. Metalthion_5.
PfamiView protein in Pfam
PF02067. Metallothio_5. 1 hit.
PRINTSiPR00872. MTDIPTERA.

Sequencei

Sequence statusi: Complete.

P61873-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40
MPCPCGSGCK CASQATKGSC NCGSDCKCGG DKKSACGCSK
Length:40
Mass (Da):3,852
Last modified:June 7, 2004 - v1
Checksum:i9182A53CCCAE634A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S75822 Genomic DNA. Translation: AAB32801.2.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiMT1_DROAN
AccessioniPrimary (citable) accession number: P61873
Secondary accession number(s): P22254
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: June 7, 2004
Last modified: July 5, 2017
This is version 36 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. Metallothioneins
    Classification of metallothioneins and list of entries
  3. SIMILARITY comments
    Index of protein domains and families