P61873 (MT1_DROAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Metallothionein-1
Short name=MT-1

Gene names

Name:

MtnA

Organism

Drosophila ananassae (Fruit fly)

Taxonomic identifier

7217 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Panarthropoda › Arthropoda › Mandibulata › Pancrustacea › Hexapoda › Insecta › Dicondylia › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Eremoneura › Cyclorrhapha › Schizophora › Acalyptratae › Ephydroidea › Drosophilidae › Drosophilinae › Drosophilini › Drosophilina › Drosophiliti › Drosophila › Sophophora › melanogaster group › ananassae subgroup › ananassae species complex

Protein attributes

Sequence length	40 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	This protein binds cations of several transition elements. It is thought to be involved in detoxification processes.
Developmental stage	Late embryogenesis, larva and adult.
Induction	Strongly induced by cadmium, copper and mercury.
Domain	All cysteine residues are arranged in C-X-C groups. These are thought to be the metal-binding sites in other metallothioneins.
Sequence similarities	Belongs to the metallothionein superfamily. Type 5 family.

Ontologies

Keywords
Ligand	Cadmium Copper Metal-binding Zinc
Gene Ontology (GO)
Molecular_function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 40	40	Metallothionein-1		PRO_0000197352

Sequences

	Sequence		Length	Mass (Da)
	P61873 [UniParc]. Last modified June 7, 2004. Version 1. Checksum: 9182A53CCCAE634A	FASTA	40	3,852
	10 20 30 40 MPCPCGSGCK CASQATKGSC NCGSDCKCGG DKKSACGCSK

References

[1]	"Molecular evolution of the metallothionein gene Mtn in the melanogaster species group: results from Drosophila ananassae." Stephan W., Rodriguez V.S., Zhou B., Parsch J. Genetics 138:135-143(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	S75822 Genomic DNA. Translation: AAB32801.2.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
FlyBase	FBgn0013782. Dana\MtnA.
Phylogenomic databases
eggNOG	NOG262036.
InParanoid	P61873.
OrthoDB	EOG45TB50.
Family and domain databases
InterPro	IPR000966. Metalthion_5. [Graphical view]
Pfam	PF02067. Metallothio_5. 1 hit. [Graphical view]
PRINTS	PR00872. MTDIPTERA.
ProtoNet	Search...

Entry information

Entry name

MT1_DROAN

Accession

Primary (citable) accession number: P61873
Secondary accession number(s): P22254

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 7, 2004
Last sequence update:	June 7, 2004
Last modified:	April 3, 2013
This is version 25 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Drosophila annotation project