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P61873 (MT1_DROAN) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 26. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Metallothionein-1

Short name=MT-1
Gene names
Name:MtnA
OrganismDrosophila ananassae (Fruit fly)
Taxonomic identifier7217 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Protein attributes

Sequence length40 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

This protein binds cations of several transition elements. It is thought to be involved in detoxification processes.

Developmental stage

Late embryogenesis, larva and adult.

Induction

Strongly induced by cadmium, copper and mercury.

Domain

All cysteine residues are arranged in C-X-C groups. These are thought to be the metal-binding sites in other metallothioneins.

Sequence similarities

Belongs to the metallothionein superfamily. Type 5 family.

Ontologies

Keywords
   LigandCadmium
Copper
Metal-binding
Zinc
Gene Ontology (GO)
   Molecular_functionmetal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 4040Metallothionein-1
PRO_0000197352

Sequences

Sequence LengthMass (Da)Tools
P61873 [UniParc].

Last modified June 7, 2004. Version 1.
Checksum: 9182A53CCCAE634A

FASTA403,852
        10         20         30         40 
MPCPCGSGCK CASQATKGSC NCGSDCKCGG DKKSACGCSK 

« Hide

References

[1]"Molecular evolution of the metallothionein gene Mtn in the melanogaster species group: results from Drosophila ananassae."
Stephan W., Rodriguez V.S., Zhou B., Parsch J.
Genetics 138:135-143(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
S75822 Genomic DNA. Translation: AAB32801.2.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

FlyBaseFBgn0013782. Dana\MtnA.

Phylogenomic databases

eggNOGNOG262036.
InParanoidP61873.
OrthoDBEOG789CFK.

Family and domain databases

InterProIPR000966. Metalthion_5.
[Graphical view]
PfamPF02067. Metallothio_5. 1 hit.
[Graphical view]
PRINTSPR00872. MTDIPTERA.
ProtoNetSearch...

Entry information

Entry nameMT1_DROAN
AccessionPrimary (citable) accession number: P61873
Secondary accession number(s): P22254
Entry history
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: June 7, 2004
Last modified: November 13, 2013
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Metallothioneins

Classification of metallothioneins and list of entries

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase