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P61873

- MT1_DROAN

UniProt

P61873 - MT1_DROAN

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Protein
Metallothionein-1
Gene
MtnA
Organism
Drosophila ananassae (Fruit fly)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

This protein binds cations of several transition elements. It is thought to be involved in detoxification processes.

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Ligandi

Cadmium, Copper, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Metallothionein-1
Short name:
MT-1
Gene namesi
Name:MtnA
OrganismiDrosophila ananassae (Fruit fly)
Taxonomic identifieri7217 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Organism-specific databases

FlyBaseiFBgn0013782. Dana\MtnA.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 4040Metallothionein-1
PRO_0000197352Add
BLAST

Expressioni

Developmental stagei

Late embryogenesis, larva and adult.

Inductioni

Strongly induced by cadmium, copper and mercury.

Family & Domainsi

Domaini

All cysteine residues are arranged in C-X-C groups. These are thought to be the metal-binding sites in other metallothioneins.

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG262036.
InParanoidiP61873.
OrthoDBiEOG789CFK.

Family and domain databases

InterProiIPR000966. Metalthion_5.
[Graphical view]
PfamiPF02067. Metallothio_5. 1 hit.
[Graphical view]
PRINTSiPR00872. MTDIPTERA.

Sequencei

Sequence statusi: Complete.

P61873-1 [UniParc]FASTAAdd to Basket

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MPCPCGSGCK CASQATKGSC NCGSDCKCGG DKKSACGCSK              40
Length:40
Mass (Da):3,852
Last modified:June 7, 2004 - v1
Checksum:i9182A53CCCAE634A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S75822 Genomic DNA. Translation: AAB32801.2.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S75822 Genomic DNA. Translation: AAB32801.2 .

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

FlyBasei FBgn0013782. Dana\MtnA.

Phylogenomic databases

eggNOGi NOG262036.
InParanoidi P61873.
OrthoDBi EOG789CFK.

Family and domain databases

InterProi IPR000966. Metalthion_5.
[Graphical view ]
Pfami PF02067. Metallothio_5. 1 hit.
[Graphical view ]
PRINTSi PR00872. MTDIPTERA.
ProtoNeti Search...

Publicationsi

  1. "Molecular evolution of the metallothionein gene Mtn in the melanogaster species group: results from Drosophila ananassae."
    Stephan W., Rodriguez V.S., Zhou B., Parsch J.
    Genetics 138:135-143(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiMT1_DROAN
AccessioniPrimary (citable) accession number: P61873
Secondary accession number(s): P22254
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: June 7, 2004
Last modified: November 13, 2013
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. Metallothioneins
    Classification of metallothioneins and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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