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Protein

60S ribosomal protein L12

Gene

rpl-12

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Binds directly to 26S ribosomal RNA.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein, RNA-binding

Enzyme and pathway databases

ReactomeiR-CEL-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-CEL-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-CEL-72689. Formation of a pool of free 40S subunits.
R-CEL-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-CEL-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L12
Gene namesi
Name:rpl-12
ORF Names:JC8.3
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome IV

Organism-specific databases

WormBaseiJC8.3a; CE17986; WBGene00004424; rpl-12.
JC8.3c; CE39743; WBGene00004424; rpl-12.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001044601 – 16560S ribosomal protein L12Add BLAST165

Proteomic databases

EPDiP61866.
PaxDbiP61866.
PRIDEiP61866.

PTM databases

iPTMnetiP61866.

Expressioni

Gene expression databases

BgeeiWBGene00004424.

Interactioni

Protein-protein interaction databases

BioGridi43368. 2 interactors.
DIPiDIP-26259N.
IntActiP61866. 1 interactor.
MINTiMINT-1060363.
STRINGi6239.JC8.3a.

Structurei

3D structure databases

ProteinModelPortaliP61866.
SMRiP61866.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0886. Eukaryota.
COG0080. LUCA.
GeneTreeiENSGT00390000006922.
HOGENOMiHOG000082125.
InParanoidiP61866.
KOiK02870.
OMAiGCTIDGR.
OrthoDBiEOG091G0PW6.
PhylomeDBiP61866.

Family and domain databases

CDDicd00349. Ribosomal_L11. 1 hit.
Gene3Di1.10.10.250. 1 hit.
3.30.1550.10. 1 hit.
HAMAPiMF_00736. Ribosomal_L11. 1 hit.
InterProiView protein in InterPro
IPR000911. Ribosomal_L11/L12.
IPR036796. Ribosomal_L11/L12_N_sf.
IPR020783. Ribosomal_L11_C.
IPR036769. Ribosomal_L11_C_sf.
IPR020785. Ribosomal_L11_CS.
IPR020784. Ribosomal_L11_N.
PANTHERiPTHR11661. PTHR11661. 1 hit.
PfamiView protein in Pfam
PF00298. Ribosomal_L11. 1 hit.
PF03946. Ribosomal_L11_N. 1 hit.
SMARTiView protein in SMART
SM00649. RL11. 1 hit.
SUPFAMiSSF46906. SSF46906. 1 hit.
SSF54747. SSF54747. 1 hit.
PROSITEiView protein in PROSITE
PS00359. RIBOSOMAL_L11. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform a (identifier: P61866-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPPKFDPTEI KIVYLRCVGG EVGATSALAP KVGPLGLSPK KIGEDIAKAT
60 70 80 90 100
QDWKGLKVTC KLTIQNRVAK IDVVPSAASL IVKELKEPPR DRKKVKNVKH
110 120 130 140 150
NGDLTVDTII KIARIMRPRS MAKKLEGTVK EILGTAQSVG CTIDGQHPHD
160
IIESIANGEI EIPAQ
Note: No experimental confirmation available.
Length:165
Mass (Da):17,831
Last modified:June 7, 2004 - v1
Checksum:i0ECCD325C5347CBF
GO
Isoform c (identifier: P61866-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-115: Missing.

Note: No experimental confirmation available.
Show »
Length:50
Mass (Da):5,371
Checksum:iFDE4B433520291A5
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0207251 – 115Missing in isoform c. CuratedAdd BLAST115

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z82274 Genomic DNA. Translation: CAB05226.1.
Z82274 Genomic DNA. Translation: CAJ76933.1.
PIRiT23150.
RefSeqiNP_001040960.1. NM_001047495.4. [P61866-2]
NP_502542.1. NM_070141.6. [P61866-1]
UniGeneiCel.22878.

Genome annotation databases

EnsemblMetazoaiJC8.3a; JC8.3a; WBGene00004424. [P61866-1]
GeneIDi178279.
KEGGicel:CELE_JC8.3.
UCSCiJC8.3a.2. c. elegans. [P61866-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiRL12_CAEEL
AccessioniPrimary (citable) accession number: P61866
Secondary accession number(s): O62290, Q2EEM7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: June 7, 2004
Last modified: November 22, 2017
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families