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Protein

Calmodulin

Gene

cmd-1

Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca2+. Among the enzymes to be stimulated by the calmodulin-Ca2+ complex are a number of protein kinases and phosphatases.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi21 – 32121PROSITE-ProRule annotationAdd
BLAST
Calcium bindingi57 – 68122PROSITE-ProRule annotationAdd
BLAST
Calcium bindingi94 – 105123PROSITE-ProRule annotationAdd
BLAST
Calcium bindingi130 – 141124PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Calmodulin
Short name:
CaM
Gene namesi
Name:cmd-1
Synonyms:cmd1
ORF Names:94C8.160, NCU04120
OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Taxonomic identifieri367110 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
Proteomesi
  • UP000001805 Componenti: Chromosome 2, Linkage Group V

Organism-specific databases

EuPathDBiFungiDB:NCU04120.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 149148CalmodulinPRO_0000198321Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity

Post-translational modificationi

Trimethylation of Lys-116 observed in other calmodulins is absent here.

Keywords - PTMi

Acetylation

Structurei

3D structure databases

ProteinModelPortaliP61859.
SMRiP61859. Positions 3-146.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini8 – 4336EF-hand 1PROSITE-ProRule annotationAdd
BLAST
Domaini44 – 7936EF-hand 2PROSITE-ProRule annotationAdd
BLAST
Domaini81 – 11636EF-hand 3PROSITE-ProRule annotationAdd
BLAST
Domaini117 – 14933EF-hand 4PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the calmodulin family.Curated
Contains 4 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

HOGENOMiHOG000233018.
InParanoidiP61859.
KOiK02183.
OMAiHRISGKA.
OrthoDBiEOG092C4XFN.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF13499. EF-hand_7. 2 hits.
[Graphical view]
SMARTiSM00054. EFh. 4 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 4 hits.
PS50222. EF_HAND_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P61859-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADSLTEEQV SEFKEAFSLF DKDGDGQITT KELGTVMRSL GQNPSESELQ
60 70 80 90 100
DMINEVDADN NGTIDFPEFL TMMARKMKDT DSEEEIREAF KVFDRDNNGF
110 120 130 140
ISAAELRHVM TSIGEKLTDD EVDEMIREAD QDGDGRIDYN EFVQLMMQK
Length:149
Mass (Da):16,997
Last modified:January 23, 2007 - v2
Checksum:i391C14BA2C533A89
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti38 – 381R → L in AAA33569 (PubMed:7916628).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L02964 Genomic DNA. Translation: AAA33564.1.
L02963 mRNA. Translation: AAA33569.1.
X70923 mRNA. Translation: CAA50271.1.
AL807366 Genomic DNA. Translation: CAD36980.1.
CM002240 Genomic DNA. Translation: EAA32040.2.
PIRiS58709.
RefSeqiXP_961276.2. XM_956183.3.

Genome annotation databases

EnsemblFungiiEFNCRT00000003921; EFNCRP00000003921; EFNCRG00000003916.
GeneIDi3877440.
KEGGincr:NCU04120.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L02964 Genomic DNA. Translation: AAA33564.1.
L02963 mRNA. Translation: AAA33569.1.
X70923 mRNA. Translation: CAA50271.1.
AL807366 Genomic DNA. Translation: CAD36980.1.
CM002240 Genomic DNA. Translation: EAA32040.2.
PIRiS58709.
RefSeqiXP_961276.2. XM_956183.3.

3D structure databases

ProteinModelPortaliP61859.
SMRiP61859. Positions 3-146.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiEFNCRT00000003921; EFNCRP00000003921; EFNCRG00000003916.
GeneIDi3877440.
KEGGincr:NCU04120.

Organism-specific databases

EuPathDBiFungiDB:NCU04120.

Phylogenomic databases

HOGENOMiHOG000233018.
InParanoidiP61859.
KOiK02183.
OMAiHRISGKA.
OrthoDBiEOG092C4XFN.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF13499. EF-hand_7. 2 hits.
[Graphical view]
SMARTiSM00054. EFh. 4 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 4 hits.
PS50222. EF_HAND_2. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCALM_NEUCR
AccessioniPrimary (citable) accession number: P61859
Secondary accession number(s): P40907, Q02052, Q7RVV3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 83 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

This protein has four functional calcium-binding sites.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.