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Protein

Calmodulin

Gene

cmd-1

Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca2+. Among the enzymes to be stimulated by the calmodulin-Ca2+ complex are a number of protein kinases and phosphatases.

Miscellaneous

This protein has four functional calcium-binding sites.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi21 – 321PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi57 – 682PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi94 – 1053PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi130 – 1414PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

Keywordsi

LigandCalcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Calmodulin
Short name:
CaM
Gene namesi
Name:cmd-1
Synonyms:cmd1
ORF Names:94C8.160, NCU04120
OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Taxonomic identifieri367110 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
Proteomesi
  • UP000001805 Componenti: Chromosome 2, Linkage Group V

Organism-specific databases

EuPathDBiFungiDB:NCU04120

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001983212 – 149CalmodulinAdd BLAST148

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1

Post-translational modificationi

Trimethylation of Lys-116 observed in other calmodulins is absent here.

Keywords - PTMi

Acetylation

Proteomic databases

PRIDEiP61859

Structurei

3D structure databases

ProteinModelPortaliP61859
SMRiP61859
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 43EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini44 – 79EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini81 – 116EF-hand 3PROSITE-ProRule annotationAdd BLAST36
Domaini117 – 149EF-hand 4PROSITE-ProRule annotationAdd BLAST33

Sequence similaritiesi

Belongs to the calmodulin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

HOGENOMiHOG000233018
InParanoidiP61859
KOiK02183
OMAiESELTDM
OrthoDBiEOG092C4XFN

Family and domain databases

CDDicd00051 EFh, 2 hits
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
PfamiView protein in Pfam
PF13499 EF-hand_7, 2 hits
SMARTiView protein in SMART
SM00054 EFh, 4 hits
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 4 hits
PS50222 EF_HAND_2, 4 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P61859-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADSLTEEQV SEFKEAFSLF DKDGDGQITT KELGTVMRSL GQNPSESELQ
60 70 80 90 100
DMINEVDADN NGTIDFPEFL TMMARKMKDT DSEEEIREAF KVFDRDNNGF
110 120 130 140
ISAAELRHVM TSIGEKLTDD EVDEMIREAD QDGDGRIDYN EFVQLMMQK
Length:149
Mass (Da):16,997
Last modified:January 23, 2007 - v2
Checksum:i391C14BA2C533A89
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti38R → L in AAA33569 (PubMed:7916628).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L02964 Genomic DNA Translation: AAA33564.1
L02963 mRNA Translation: AAA33569.1
X70923 mRNA Translation: CAA50271.1
AL807366 Genomic DNA Translation: CAD36980.1
CM002240 Genomic DNA Translation: EAA32040.2
PIRiS58709
RefSeqiXP_961276.2, XM_956183.3

Genome annotation databases

EnsemblFungiiEAA32040; EAA32040; NCU04120
GeneIDi3877440
KEGGincr:NCU04120

Similar proteinsi

Entry informationi

Entry nameiCALM_NEUCR
AccessioniPrimary (citable) accession number: P61859
Secondary accession number(s): P40907, Q02052, Q7RVV3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 96 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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