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Protein

Superoxide dismutase [Cu-Zn]

Gene

Sod

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

Catalytic activityi

2 superoxide + 2 H+ = O2 + H2O2.

Cofactori

Protein has several cofactor binding sites:
  • Cu cationNote: Binds 1 copper ion per subunit.
  • Zn2+Note: Binds 1 zinc ion per subunit.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi45Copper; catalytic1
Metal bindingi47Copper; catalytic1
Metal bindingi62Copper; catalytic1
Metal bindingi62Zinc; structural1
Metal bindingi70Zinc; structural1
Metal bindingi79Zinc; structural1
Metal bindingi82Zinc; structural1
Metal bindingi119Copper; catalytic1

GO - Molecular functioni

  • antioxidant activity Source: FlyBase
  • copper ion binding Source: GO_Central
  • protein homodimerization activity Source: FlyBase
  • superoxide dismutase activity Source: FlyBase
  • zinc ion binding Source: GO_Central

GO - Biological processi

  • age-dependent response to oxidative stress Source: FlyBase
  • aging Source: FlyBase
  • determination of adult lifespan Source: FlyBase
  • regulation of autophagy of mitochondrion Source: FlyBase
  • regulation of terminal button organization Source: FlyBase
  • response to oxidative stress Source: FlyBase

Keywordsi

Molecular functionAntioxidant, Oxidoreductase
LigandCopper, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-DME-114608. Platelet degranulation.
R-DME-3299685. Detoxification of Reactive Oxygen Species.

Names & Taxonomyi

Protein namesi
Recommended name:
Superoxide dismutase [Cu-Zn] (EC:1.15.1.1)
Gene namesi
Name:Sod
ORF Names:CG11793
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0003462. Sod.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved2 Publications
ChainiPRO_00001640852 – 153Superoxide dismutase [Cu-Zn]Add BLAST152

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei53Phosphothreonine1 Publication1
Disulfide bondi56 ↔ 145
Modified residuei59Phosphoserine1 Publication1

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

PRIDEiP61851.

PTM databases

iPTMnetiP61851.

Expressioni

Gene expression databases

BgeeiFBgn0003462.
ExpressionAtlasiP61851. differential.
GenevisibleiP61851. DM.

Interactioni

Subunit structurei

Homodimer.

GO - Molecular functioni

  • protein homodimerization activity Source: FlyBase

Protein-protein interaction databases

BioGridi64623. 62 interactors.
IntActiP61851. 3 interactors.
MINTiMINT-280564.

Structurei

3D structure databases

ProteinModelPortaliP61851.
SMRiP61851.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Cu-Zn superoxide dismutase family.Curated

Phylogenomic databases

GeneTreeiENSGT00530000063226.
InParanoidiP61851.
KOiK04565.
OrthoDBiEOG091G0OG2.
PhylomeDBiP61851.

Family and domain databases

CDDicd00305. Cu-Zn_Superoxide_Dismutase. 1 hit.
Gene3Di2.60.40.200. 1 hit.
InterProiView protein in InterPro
IPR036423. SOD-like_Cu/Zn_dom_sf.
IPR024134. SOD_Cu/Zn_/chaperone.
IPR018152. SOD_Cu/Zn_BS.
IPR001424. SOD_Cu_Zn_dom.
PANTHERiPTHR10003. PTHR10003. 1 hit.
PfamiView protein in Pfam
PF00080. Sod_Cu. 1 hit.
PRINTSiPR00068. CUZNDISMTASE.
SUPFAMiSSF49329. SSF49329. 1 hit.
PROSITEiView protein in PROSITE
PS00087. SOD_CU_ZN_1. 1 hit.
PS00332. SOD_CU_ZN_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P61851-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVVKAVCVIN GDAKGTVFFE QESSGTPVKV SGEVCGLAKG LHGFHVHEFG
60 70 80 90 100
DNTNGCMSSG PHFNPYGKEH GAPVDENRHL GDLGNIEATG DCPTKVNITD
110 120 130 140 150
SKITLFGADS IIGRTVVVHA DADDLGQGGH ELSKSTGNAG ARIGCGVIGI

AKV
Length:153
Mass (Da):15,699
Last modified:January 23, 2007 - v2
Checksum:i4A6AAAA1EB545E70
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti97N → K in CAA35210 (PubMed:2493630).Curated1
Sequence conflicti97N → K in AAD14963 (PubMed:8013910).Curated1
Sequence conflicti97N → K in AAA28905 (PubMed:3128462).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00367 mRNA. Translation: CAA68443.1.
Z19591 Genomic DNA. Translation: CAA79639.1.
M24421 Genomic DNA. Translation: AAA28906.1.
X13780 Genomic DNA. Translation: CAA32028.1.
X17332 Genomic DNA. Translation: CAA35210.1.
AE014296 Genomic DNA. Translation: AAF50095.1.
AY071435 mRNA. Translation: AAL49057.1.
S72589 Genomic DNA. Translation: AAD14963.2.
M18823 Genomic DNA. Translation: AAA28905.1.
PIRiS02725. DSFFCZ.
RefSeqiNP_476735.1. NM_057387.5.
UniGeneiDm.926.

Genome annotation databases

EnsemblMetazoaiFBtr0076229; FBpp0075958; FBgn0003462.
GeneIDi39251.
KEGGidme:Dmel_CG11793.

Similar proteinsi

Entry informationi

Entry nameiSODC_DROME
AccessioniPrimary (citable) accession number: P61851
Secondary accession number(s): P00444, Q27770, Q9VTF6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: October 25, 2017
This is version 125 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families