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P61837

- PIP11_ARATH

UniProt

P61837 - PIP11_ARATH

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Protein

Aquaporin PIP1-1

Gene

PIP1-1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Water channel required to facilitate the transport of water across cell membrane. Its function is impaired by Hg2+.1 Publication

GO - Molecular functioni

  1. water channel activity Source: TAIR

GO - Biological processi

  1. response to water deprivation Source: TAIR
  2. water transport Source: TAIR
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

ReactomeiREACT_187715. Erythrocytes take up carbon dioxide and release oxygen.
REACT_187717. Erythrocytes take up oxygen and release carbon dioxide.
REACT_206372. Regulation of water balance by renal Aquaporins.

Protein family/group databases

TCDBi1.A.8.11.3. the major intrinsic protein (mip) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Aquaporin PIP1-1
Short name:
AtPIP1;1
Alternative name(s):
Plasma membrane aquaporin-1
Plasma membrane intrinsic protein 1a
Short name:
PIP1a
Gene namesi
Name:PIP1-1
Synonyms:PIP1A
Ordered Locus Names:At3g61430
ORF Names:F2A19.30
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 3

Organism-specific databases

TAIRiAT3G61430.

Subcellular locationi

Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication

GO - Cellular componenti

  1. chloroplast envelope Source: TAIR
  2. integral component of membrane Source: UniProtKB-KW
  3. membrane Source: TAIR
  4. mitochondrion Source: TAIR
  5. plasma membrane Source: TAIR
  6. plasmodesma Source: TAIR
  7. vacuole Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 286286Aquaporin PIP1-1PRO_0000064045Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine1 Publication
Modified residuei284 – 2841PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP61837.
PRIDEiP61837.

Expressioni

Tissue specificityi

Widely expressed. Expressed in roots, above ground and in flower buds.2 Publications

Gene expression databases

ExpressionAtlasiP61837. baseline and differential.
GenevestigatoriP61837.

Interactioni

Protein-protein interaction databases

BioGridi10630. 5 interactions.
IntActiP61837. 5 interactions.

Structurei

3D structure databases

ProteinModelPortaliP61837.
SMRiP61837. Positions 34-278.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5454CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini76 – 9116ExtracellularSequence AnalysisAdd
BLAST
Topological domaini113 – 13220CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini154 – 17421ExtracellularSequence AnalysisAdd
BLAST
Topological domaini196 – 20813CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini230 – 25627ExtracellularSequence AnalysisAdd
BLAST
Topological domaini278 – 2869CytoplasmicSequence Analysis

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei55 – 7521Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei92 – 11221Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei133 – 15321Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei175 – 19521Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei209 – 22921Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei257 – 27721Helical; Name=6Sequence AnalysisAdd
BLAST

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi114 – 1163NPA 1
Motifi235 – 2373NPA 2

Domaini

Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0580.
HOGENOMiHOG000288286.
InParanoidiP61837.
KOiK09872.
OMAiMNRFSPS.
PhylomeDBiP61837.

Family and domain databases

Gene3Di1.20.1080.10. 1 hit.
InterProiIPR023271. Aquaporin-like.
IPR000425. MIP.
IPR022357. MIP_CS.
[Graphical view]
PANTHERiPTHR19139. PTHR19139. 1 hit.
PfamiPF00230. MIP. 1 hit.
[Graphical view]
PRINTSiPR00783. MINTRINSICP.
SUPFAMiSSF81338. SSF81338. 1 hit.
TIGRFAMsiTIGR00861. MIP. 1 hit.
PROSITEiPS00221. MIP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P61837-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEGKEEDVRV GANKFPERQP IGTSAQSDKD YKEPPPAPFF EPGELSSWSF
60 70 80 90 100
WRAGIAEFIA TFLFLYITVL TVMGVKRSPN MCASVGIQGI AWAFGGMIFA
110 120 130 140 150
LVYCTAGISG GHINPAVTFG LFLARKLSLT RALYYIVMQC LGAICGAGVV
160 170 180 190 200
KGFQPKQYQA LGGGANTVAH GYTKGSGLGA EIIGTFVLVY TVFSATDAKR
210 220 230 240 250
NARDSHVPIL APLPIGFAVF LVHLATIPIT GTGINPARSL GAAIIYNKDH
260 270 280
SWDDHWVFWV GPFIGAALAA LYHVVVIRAI PFKSRS
Length:286
Mass (Da):30,689
Last modified:June 7, 2004 - v1
Checksum:i5C0284F6BB5EA7B7
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti15 – 151F → L in AAM65975. 1 PublicationCurated
Sequence conflicti231 – 2311G → A in CAA53475. (PubMed:7920711)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X75881 mRNA. Translation: CAA53475.1.
AL132962 Genomic DNA. Translation: CAB71073.1.
CP002686 Genomic DNA. Translation: AEE80201.1.
CP002686 Genomic DNA. Translation: AEE80202.1.
AY097398 mRNA. Translation: AAM19914.1.
AY058113 mRNA. Translation: AAL25530.1.
AK229222 mRNA. Translation: BAF01089.1.
AY088439 mRNA. Translation: AAM65975.1.
PIRiT47935.
RefSeqiNP_001078323.1. NM_001084854.1.
NP_191702.1. NM_116008.3.
UniGeneiAt.23835.

Genome annotation databases

EnsemblPlantsiAT3G61430.1; AT3G61430.1; AT3G61430.
AT3G61430.2; AT3G61430.2; AT3G61430.
GeneIDi825316.
KEGGiath:AT3G61430.

Cross-referencesi

Web resourcesi

Protein Spotlight

Liquid states - Issue 36 of July 2003

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X75881 mRNA. Translation: CAA53475.1 .
AL132962 Genomic DNA. Translation: CAB71073.1 .
CP002686 Genomic DNA. Translation: AEE80201.1 .
CP002686 Genomic DNA. Translation: AEE80202.1 .
AY097398 mRNA. Translation: AAM19914.1 .
AY058113 mRNA. Translation: AAL25530.1 .
AK229222 mRNA. Translation: BAF01089.1 .
AY088439 mRNA. Translation: AAM65975.1 .
PIRi T47935.
RefSeqi NP_001078323.1. NM_001084854.1.
NP_191702.1. NM_116008.3.
UniGenei At.23835.

3D structure databases

ProteinModelPortali P61837.
SMRi P61837. Positions 34-278.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 10630. 5 interactions.
IntActi P61837. 5 interactions.

Protein family/group databases

TCDBi 1.A.8.11.3. the major intrinsic protein (mip) family.

Proteomic databases

PaxDbi P61837.
PRIDEi P61837.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT3G61430.1 ; AT3G61430.1 ; AT3G61430 .
AT3G61430.2 ; AT3G61430.2 ; AT3G61430 .
GeneIDi 825316.
KEGGi ath:AT3G61430.

Organism-specific databases

GeneFarmi 4862. 182.
TAIRi AT3G61430.

Phylogenomic databases

eggNOGi COG0580.
HOGENOMi HOG000288286.
InParanoidi P61837.
KOi K09872.
OMAi MNRFSPS.
PhylomeDBi P61837.

Enzyme and pathway databases

Reactomei REACT_187715. Erythrocytes take up carbon dioxide and release oxygen.
REACT_187717. Erythrocytes take up oxygen and release carbon dioxide.
REACT_206372. Regulation of water balance by renal Aquaporins.

Gene expression databases

ExpressionAtlasi P61837. baseline and differential.
Genevestigatori P61837.

Family and domain databases

Gene3Di 1.20.1080.10. 1 hit.
InterProi IPR023271. Aquaporin-like.
IPR000425. MIP.
IPR022357. MIP_CS.
[Graphical view ]
PANTHERi PTHR19139. PTHR19139. 1 hit.
Pfami PF00230. MIP. 1 hit.
[Graphical view ]
PRINTSi PR00783. MINTRINSICP.
SUPFAMi SSF81338. SSF81338. 1 hit.
TIGRFAMsi TIGR00861. MIP. 1 hit.
PROSITEi PS00221. MIP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Water channels in the plant plasma membrane cloned by immunoselection from a mammalian expression system."
    Kammerloher W., Fischer U., Piechottka G.P., Schaeffner A.R.
    Plant J. 6:187-199(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Strain: cv. Landsberg erecta.
    Tissue: Root.
  2. "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana."
    Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B., Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M., Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V., Choisne N., Artiguenave F.
    , Robert C., Brottier P., Wincker P., Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H., Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H., Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A., Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H., Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J., Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B., Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D., de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E., Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G., Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X., Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M., Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B., Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J., Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C., Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y., Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K., Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
    Nature 408:820-822(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  3. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  4. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  5. "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs."
    Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A., Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y., Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.
    , Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y., Shinozaki K.
    Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  6. "Full-length cDNA from Arabidopsis thaliana."
    Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B., Feldmann K.A.
    Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  7. "From genome to function: the Arabidopsis aquaporins."
    Quigley F., Rosenberg J.M., Shachar-Hill Y., Bohnert H.J.
    Genome Biol. 3:RESEARCH0001.1-RESEARCH0001.17(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NOMENCLATURE, TISSUE SPECIFICITY.
  8. Cited for: ACETYLATION AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY.

Entry informationi

Entry nameiPIP11_ARATH
AccessioniPrimary (citable) accession number: P61837
Secondary accession number(s): P43285
, Q0WP60, Q8L9H0, Q9LDT6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: June 7, 2004
Last modified: October 29, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3