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P61837

- PIP11_ARATH

UniProt

P61837 - PIP11_ARATH

Protein

Aquaporin PIP1-1

Gene

PIP1-1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 1 (07 Jun 2004)
      Previous versions | rss
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    Functioni

    Water channel required to facilitate the transport of water across cell membrane. Its function is impaired by Hg2+.1 Publication

    GO - Molecular functioni

    1. water channel activity Source: TAIR

    GO - Biological processi

    1. response to water deprivation Source: TAIR
    2. water transport Source: TAIR

    Keywords - Biological processi

    Transport

    Enzyme and pathway databases

    ReactomeiREACT_187715. Erythrocytes take up carbon dioxide and release oxygen.
    REACT_187717. Erythrocytes take up oxygen and release carbon dioxide.
    REACT_206372. Regulation of water balance by renal Aquaporins.

    Protein family/group databases

    TCDBi1.A.8.11.3. the major intrinsic protein (mip) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Aquaporin PIP1-1
    Short name:
    AtPIP1;1
    Alternative name(s):
    Plasma membrane aquaporin-1
    Plasma membrane intrinsic protein 1a
    Short name:
    PIP1a
    Gene namesi
    Name:PIP1-1
    Synonyms:PIP1A
    Ordered Locus Names:At3g61430
    ORF Names:F2A19.30
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 3

    Organism-specific databases

    TAIRiAT3G61430.

    Subcellular locationi

    Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication

    GO - Cellular componenti

    1. chloroplast envelope Source: TAIR
    2. integral component of membrane Source: UniProtKB-KW
    3. membrane Source: TAIR
    4. mitochondrion Source: TAIR
    5. plasma membrane Source: TAIR
    6. plasmodesma Source: TAIR
    7. vacuole Source: TAIR

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 286286Aquaporin PIP1-1PRO_0000064045Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionine1 Publication
    Modified residuei284 – 2841PhosphoserineBy similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    PaxDbiP61837.
    PRIDEiP61837.

    Expressioni

    Tissue specificityi

    Widely expressed. Expressed in roots, above ground and in flower buds.2 Publications

    Gene expression databases

    ArrayExpressiP61837.
    GenevestigatoriP61837.

    Interactioni

    Protein-protein interaction databases

    BioGridi10630. 5 interactions.
    IntActiP61837. 5 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliP61837.
    SMRiP61837. Positions 34-278.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 5454CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini76 – 9116ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini113 – 13220CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini154 – 17421ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini196 – 20813CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini230 – 25627ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini278 – 2869CytoplasmicSequence Analysis

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei55 – 7521Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei92 – 11221Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei133 – 15321Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei175 – 19521Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei209 – 22921Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei257 – 27721Helical; Name=6Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi114 – 1163NPA 1
    Motifi235 – 2373NPA 2

    Domaini

    Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).

    Sequence similaritiesi

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0580.
    HOGENOMiHOG000288286.
    InParanoidiP61837.
    KOiK09872.
    OMAiMNRFSPS.
    PhylomeDBiP61837.

    Family and domain databases

    Gene3Di1.20.1080.10. 1 hit.
    InterProiIPR023271. Aquaporin-like.
    IPR000425. MIP.
    IPR022357. MIP_CS.
    [Graphical view]
    PANTHERiPTHR19139. PTHR19139. 1 hit.
    PfamiPF00230. MIP. 1 hit.
    [Graphical view]
    PRINTSiPR00783. MINTRINSICP.
    SUPFAMiSSF81338. SSF81338. 1 hit.
    TIGRFAMsiTIGR00861. MIP. 1 hit.
    PROSITEiPS00221. MIP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P61837-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEGKEEDVRV GANKFPERQP IGTSAQSDKD YKEPPPAPFF EPGELSSWSF    50
    WRAGIAEFIA TFLFLYITVL TVMGVKRSPN MCASVGIQGI AWAFGGMIFA 100
    LVYCTAGISG GHINPAVTFG LFLARKLSLT RALYYIVMQC LGAICGAGVV 150
    KGFQPKQYQA LGGGANTVAH GYTKGSGLGA EIIGTFVLVY TVFSATDAKR 200
    NARDSHVPIL APLPIGFAVF LVHLATIPIT GTGINPARSL GAAIIYNKDH 250
    SWDDHWVFWV GPFIGAALAA LYHVVVIRAI PFKSRS 286
    Length:286
    Mass (Da):30,689
    Last modified:June 7, 2004 - v1
    Checksum:i5C0284F6BB5EA7B7
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti15 – 151F → L in AAM65975. 1 PublicationCurated
    Sequence conflicti231 – 2311G → A in CAA53475. (PubMed:7920711)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X75881 mRNA. Translation: CAA53475.1.
    AL132962 Genomic DNA. Translation: CAB71073.1.
    CP002686 Genomic DNA. Translation: AEE80201.1.
    CP002686 Genomic DNA. Translation: AEE80202.1.
    AY097398 mRNA. Translation: AAM19914.1.
    AY058113 mRNA. Translation: AAL25530.1.
    AK229222 mRNA. Translation: BAF01089.1.
    AY088439 mRNA. Translation: AAM65975.1.
    PIRiT47935.
    RefSeqiNP_001078323.1. NM_001084854.1.
    NP_191702.1. NM_116008.3.
    UniGeneiAt.23835.

    Genome annotation databases

    EnsemblPlantsiAT3G61430.1; AT3G61430.1; AT3G61430.
    AT3G61430.2; AT3G61430.2; AT3G61430.
    GeneIDi825316.
    KEGGiath:AT3G61430.

    Cross-referencesi

    Web resourcesi

    Protein Spotlight

    Liquid states - Issue 36 of July 2003

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X75881 mRNA. Translation: CAA53475.1 .
    AL132962 Genomic DNA. Translation: CAB71073.1 .
    CP002686 Genomic DNA. Translation: AEE80201.1 .
    CP002686 Genomic DNA. Translation: AEE80202.1 .
    AY097398 mRNA. Translation: AAM19914.1 .
    AY058113 mRNA. Translation: AAL25530.1 .
    AK229222 mRNA. Translation: BAF01089.1 .
    AY088439 mRNA. Translation: AAM65975.1 .
    PIRi T47935.
    RefSeqi NP_001078323.1. NM_001084854.1.
    NP_191702.1. NM_116008.3.
    UniGenei At.23835.

    3D structure databases

    ProteinModelPortali P61837.
    SMRi P61837. Positions 34-278.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 10630. 5 interactions.
    IntActi P61837. 5 interactions.

    Protein family/group databases

    TCDBi 1.A.8.11.3. the major intrinsic protein (mip) family.

    Proteomic databases

    PaxDbi P61837.
    PRIDEi P61837.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT3G61430.1 ; AT3G61430.1 ; AT3G61430 .
    AT3G61430.2 ; AT3G61430.2 ; AT3G61430 .
    GeneIDi 825316.
    KEGGi ath:AT3G61430.

    Organism-specific databases

    GeneFarmi 4862. 182.
    TAIRi AT3G61430.

    Phylogenomic databases

    eggNOGi COG0580.
    HOGENOMi HOG000288286.
    InParanoidi P61837.
    KOi K09872.
    OMAi MNRFSPS.
    PhylomeDBi P61837.

    Enzyme and pathway databases

    Reactomei REACT_187715. Erythrocytes take up carbon dioxide and release oxygen.
    REACT_187717. Erythrocytes take up oxygen and release carbon dioxide.
    REACT_206372. Regulation of water balance by renal Aquaporins.

    Gene expression databases

    ArrayExpressi P61837.
    Genevestigatori P61837.

    Family and domain databases

    Gene3Di 1.20.1080.10. 1 hit.
    InterProi IPR023271. Aquaporin-like.
    IPR000425. MIP.
    IPR022357. MIP_CS.
    [Graphical view ]
    PANTHERi PTHR19139. PTHR19139. 1 hit.
    Pfami PF00230. MIP. 1 hit.
    [Graphical view ]
    PRINTSi PR00783. MINTRINSICP.
    SUPFAMi SSF81338. SSF81338. 1 hit.
    TIGRFAMsi TIGR00861. MIP. 1 hit.
    PROSITEi PS00221. MIP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Water channels in the plant plasma membrane cloned by immunoselection from a mammalian expression system."
      Kammerloher W., Fischer U., Piechottka G.P., Schaeffner A.R.
      Plant J. 6:187-199(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
      Strain: cv. Landsberg erecta.
      Tissue: Root.
    2. "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana."
      Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B., Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M., Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V., Choisne N., Artiguenave F.
      , Robert C., Brottier P., Wincker P., Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H., Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H., Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A., Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H., Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J., Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B., Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D., de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E., Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G., Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X., Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M., Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B., Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J., Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C., Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y., Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K., Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
      Nature 408:820-822(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    3. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    4. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
      Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
      , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
      Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Columbia.
    5. "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs."
      Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A., Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y., Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.
      , Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y., Shinozaki K.
      Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Columbia.
    6. "Full-length cDNA from Arabidopsis thaliana."
      Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B., Feldmann K.A.
      Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    7. "From genome to function: the Arabidopsis aquaporins."
      Quigley F., Rosenberg J.M., Shachar-Hill Y., Bohnert H.J.
      Genome Biol. 3:RESEARCH0001.1-RESEARCH0001.17(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NOMENCLATURE, TISSUE SPECIFICITY.
    8. Cited for: ACETYLATION AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY.

    Entry informationi

    Entry nameiPIP11_ARATH
    AccessioniPrimary (citable) accession number: P61837
    Secondary accession number(s): P43285
    , Q0WP60, Q8L9H0, Q9LDT6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 7, 2004
    Last sequence update: June 7, 2004
    Last modified: October 1, 2014
    This is version 96 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. Protein Spotlight
      Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3