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Protein

Aquaporin PIP1-1

Gene

PIP1-1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Water channel required to facilitate the transport of water across cell membrane. Its function is impaired by Hg2+.1 Publication

GO - Molecular functioni

  • water channel activity Source: TAIR

GO - Biological processi

  • ion transmembrane transport Source: GO_Central
  • response to water deprivation Source: TAIR
  • water transport Source: TAIR

Keywordsi

Biological processTransport

Protein family/group databases

TCDBi1.A.8.11.3 the major intrinsic protein (mip) family

Names & Taxonomyi

Protein namesi
Recommended name:
Aquaporin PIP1-1
Short name:
AtPIP1;1
Alternative name(s):
Plasma membrane aquaporin-1
Plasma membrane intrinsic protein 1a
Short name:
PIP1a
Gene namesi
Name:PIP1-1
Synonyms:PIP1A
Ordered Locus Names:At3g61430
ORF Names:F2A19.30
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

AraportiAT3G61430
TAIRilocus:2082822 AT3G61430

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 54CytoplasmicSequence analysisAdd BLAST54
Transmembranei55 – 75Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini76 – 91ExtracellularSequence analysisAdd BLAST16
Transmembranei92 – 112Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini113 – 132CytoplasmicSequence analysisAdd BLAST20
Transmembranei133 – 153Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini154 – 174ExtracellularSequence analysisAdd BLAST21
Transmembranei175 – 195Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini196 – 208CytoplasmicSequence analysisAdd BLAST13
Transmembranei209 – 229Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini230 – 256ExtracellularSequence analysisAdd BLAST27
Transmembranei257 – 277Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini278 – 286CytoplasmicSequence analysis9

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000640451 – 286Aquaporin PIP1-1Add BLAST286

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionine1 Publication1
Modified residuei284PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP61837
PRIDEiP61837

PTM databases

iPTMnetiP61837

Expressioni

Tissue specificityi

Widely expressed. Expressed in roots, above ground and in flower buds.2 Publications

Gene expression databases

ExpressionAtlasiP61837 baseline and differential
GenevisibleiP61837 AT

Interactioni

Protein-protein interaction databases

BioGridi106307 interactors.
IntActiP61837 5 interactors.
STRINGi3702.AT3G61430.1

Structurei

3D structure databases

ProteinModelPortaliP61837
SMRiP61837
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi114 – 116NPA 13
Motifi235 – 237NPA 23

Domaini

Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0223 Eukaryota
COG0580 LUCA
HOGENOMiHOG000288286
InParanoidiP61837
KOiK09872
OMAiASCHEFE
OrthoDBiEOG09360H22
PhylomeDBiP61837

Family and domain databases

CDDicd00333 MIP, 1 hit
Gene3Di1.20.1080.101 hit
InterProiView protein in InterPro
IPR023271 Aquaporin-like
IPR034294 Aquaporin_transptr
IPR000425 MIP
IPR022357 MIP_CS
PANTHERiPTHR19139 PTHR19139, 1 hit
PfamiView protein in Pfam
PF00230 MIP, 1 hit
PRINTSiPR00783 MINTRINSICP
SUPFAMiSSF81338 SSF81338, 1 hit
TIGRFAMsiTIGR00861 MIP, 1 hit
PROSITEiView protein in PROSITE
PS00221 MIP, 1 hit

Sequencei

Sequence statusi: Complete.

P61837-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGKEEDVRV GANKFPERQP IGTSAQSDKD YKEPPPAPFF EPGELSSWSF
60 70 80 90 100
WRAGIAEFIA TFLFLYITVL TVMGVKRSPN MCASVGIQGI AWAFGGMIFA
110 120 130 140 150
LVYCTAGISG GHINPAVTFG LFLARKLSLT RALYYIVMQC LGAICGAGVV
160 170 180 190 200
KGFQPKQYQA LGGGANTVAH GYTKGSGLGA EIIGTFVLVY TVFSATDAKR
210 220 230 240 250
NARDSHVPIL APLPIGFAVF LVHLATIPIT GTGINPARSL GAAIIYNKDH
260 270 280
SWDDHWVFWV GPFIGAALAA LYHVVVIRAI PFKSRS
Length:286
Mass (Da):30,689
Last modified:June 7, 2004 - v1
Checksum:i5C0284F6BB5EA7B7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti15F → L in AAM65975 (Ref. 5) Curated1
Sequence conflicti231G → A in CAA53475 (PubMed:7920711).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X75881 mRNA Translation: CAA53475.1
AL132962 Genomic DNA Translation: CAB71073.1
CP002686 Genomic DNA Translation: AEE80201.1
CP002686 Genomic DNA Translation: AEE80202.1
AY097398 mRNA Translation: AAM19914.1
AY058113 mRNA Translation: AAL25530.1
AK229222 mRNA Translation: BAF01089.1
AY088439 mRNA Translation: AAM65975.1
PIRiT47935
RefSeqiNP_001078323.1, NM_001084854.2
NP_191702.1, NM_116008.4
UniGeneiAt.23835

Genome annotation databases

EnsemblPlantsiAT3G61430.1; AT3G61430.1; AT3G61430
AT3G61430.2; AT3G61430.2; AT3G61430
GeneIDi825316
GrameneiAT3G61430.1; AT3G61430.1; AT3G61430
AT3G61430.2; AT3G61430.2; AT3G61430
KEGGiath:AT3G61430

Similar proteinsi

Entry informationi

Entry nameiPIP11_ARATH
AccessioniPrimary (citable) accession number: P61837
Secondary accession number(s): P43285
, Q0WP60, Q8L9H0, Q9LDT6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: June 7, 2004
Last modified: April 25, 2018
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome