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Protein

Aquaporin PIP1-1

Gene

PIP1-1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Water channel required to facilitate the transport of water across cell membrane. Its function is impaired by Hg2+.1 Publication

GO - Molecular functioni

  • glycerol channel activity Source: GO_Central
  • water channel activity Source: TAIR

GO - Biological processi

  • cellular water homeostasis Source: GO_Central
  • ion transmembrane transport Source: GO_Central
  • response to water deprivation Source: TAIR
  • water transport Source: TAIR
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

ReactomeiR-ATH-432047. Passive transport by Aquaporins.

Protein family/group databases

TCDBi1.A.8.11.3. the major intrinsic protein (mip) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Aquaporin PIP1-1
Short name:
AtPIP1;1
Alternative name(s):
Plasma membrane aquaporin-1
Plasma membrane intrinsic protein 1a
Short name:
PIP1a
Gene namesi
Name:PIP1-1
Synonyms:PIP1A
Ordered Locus Names:At3g61430
ORF Names:F2A19.30
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

TAIRiAT3G61430.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 54CytoplasmicSequence analysisAdd BLAST54
Transmembranei55 – 75Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini76 – 91ExtracellularSequence analysisAdd BLAST16
Transmembranei92 – 112Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini113 – 132CytoplasmicSequence analysisAdd BLAST20
Transmembranei133 – 153Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini154 – 174ExtracellularSequence analysisAdd BLAST21
Transmembranei175 – 195Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini196 – 208CytoplasmicSequence analysisAdd BLAST13
Transmembranei209 – 229Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini230 – 256ExtracellularSequence analysisAdd BLAST27
Transmembranei257 – 277Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini278 – 286CytoplasmicSequence analysis9

GO - Cellular componenti

  • chloroplast envelope Source: TAIR
  • integral component of plasma membrane Source: GO_Central
  • membrane Source: TAIR
  • mitochondrion Source: TAIR
  • plasma membrane Source: TAIR
  • plasmodesma Source: TAIR
  • vacuole Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000640451 – 286Aquaporin PIP1-1Add BLAST286

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionine1 Publication1
Modified residuei284PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP61837.
PRIDEiP61837.

Expressioni

Tissue specificityi

Widely expressed. Expressed in roots, above ground and in flower buds.2 Publications

Gene expression databases

GenevisibleiP61837. AT.

Interactioni

Protein-protein interaction databases

BioGridi10630. 6 interactors.
IntActiP61837. 5 interactors.
STRINGi3702.AT3G61430.1.

Structurei

3D structure databases

ProteinModelPortaliP61837.
SMRiP61837.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi114 – 116NPA 13
Motifi235 – 237NPA 23

Domaini

Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0223. Eukaryota.
COG0580. LUCA.
HOGENOMiHOG000288286.
InParanoidiP61837.
KOiK09872.
OMAiMEHREED.
OrthoDBiEOG09360H22.
PhylomeDBiP61837.

Family and domain databases

CDDicd00333. MIP. 1 hit.
Gene3Di1.20.1080.10. 1 hit.
InterProiIPR023271. Aquaporin-like.
IPR000425. MIP.
IPR022357. MIP_CS.
[Graphical view]
PANTHERiPTHR19139. PTHR19139. 1 hit.
PfamiPF00230. MIP. 1 hit.
[Graphical view]
PRINTSiPR00783. MINTRINSICP.
SUPFAMiSSF81338. SSF81338. 1 hit.
TIGRFAMsiTIGR00861. MIP. 1 hit.
PROSITEiPS00221. MIP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P61837-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGKEEDVRV GANKFPERQP IGTSAQSDKD YKEPPPAPFF EPGELSSWSF
60 70 80 90 100
WRAGIAEFIA TFLFLYITVL TVMGVKRSPN MCASVGIQGI AWAFGGMIFA
110 120 130 140 150
LVYCTAGISG GHINPAVTFG LFLARKLSLT RALYYIVMQC LGAICGAGVV
160 170 180 190 200
KGFQPKQYQA LGGGANTVAH GYTKGSGLGA EIIGTFVLVY TVFSATDAKR
210 220 230 240 250
NARDSHVPIL APLPIGFAVF LVHLATIPIT GTGINPARSL GAAIIYNKDH
260 270 280
SWDDHWVFWV GPFIGAALAA LYHVVVIRAI PFKSRS
Length:286
Mass (Da):30,689
Last modified:June 7, 2004 - v1
Checksum:i5C0284F6BB5EA7B7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti15F → L in AAM65975 (Ref. 5) Curated1
Sequence conflicti231G → A in CAA53475 (PubMed:7920711).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X75881 mRNA. Translation: CAA53475.1.
AL132962 Genomic DNA. Translation: CAB71073.1.
CP002686 Genomic DNA. Translation: AEE80201.1.
CP002686 Genomic DNA. Translation: AEE80202.1.
AY097398 mRNA. Translation: AAM19914.1.
AY058113 mRNA. Translation: AAL25530.1.
AK229222 mRNA. Translation: BAF01089.1.
AY088439 mRNA. Translation: AAM65975.1.
PIRiT47935.
RefSeqiNP_001078323.1. NM_001084854.2.
NP_191702.1. NM_116008.4.
UniGeneiAt.23835.

Genome annotation databases

EnsemblPlantsiAT3G61430.1; AT3G61430.1; AT3G61430.
AT3G61430.2; AT3G61430.2; AT3G61430.
GeneIDi825316.
GrameneiAT3G61430.1; AT3G61430.1; AT3G61430.
AT3G61430.2; AT3G61430.2; AT3G61430.
KEGGiath:AT3G61430.

Cross-referencesi

Web resourcesi

Protein Spotlight

Liquid states - Issue 36 of July 2003

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X75881 mRNA. Translation: CAA53475.1.
AL132962 Genomic DNA. Translation: CAB71073.1.
CP002686 Genomic DNA. Translation: AEE80201.1.
CP002686 Genomic DNA. Translation: AEE80202.1.
AY097398 mRNA. Translation: AAM19914.1.
AY058113 mRNA. Translation: AAL25530.1.
AK229222 mRNA. Translation: BAF01089.1.
AY088439 mRNA. Translation: AAM65975.1.
PIRiT47935.
RefSeqiNP_001078323.1. NM_001084854.2.
NP_191702.1. NM_116008.4.
UniGeneiAt.23835.

3D structure databases

ProteinModelPortaliP61837.
SMRiP61837.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi10630. 6 interactors.
IntActiP61837. 5 interactors.
STRINGi3702.AT3G61430.1.

Protein family/group databases

TCDBi1.A.8.11.3. the major intrinsic protein (mip) family.

Proteomic databases

PaxDbiP61837.
PRIDEiP61837.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT3G61430.1; AT3G61430.1; AT3G61430.
AT3G61430.2; AT3G61430.2; AT3G61430.
GeneIDi825316.
GrameneiAT3G61430.1; AT3G61430.1; AT3G61430.
AT3G61430.2; AT3G61430.2; AT3G61430.
KEGGiath:AT3G61430.

Organism-specific databases

TAIRiAT3G61430.

Phylogenomic databases

eggNOGiKOG0223. Eukaryota.
COG0580. LUCA.
HOGENOMiHOG000288286.
InParanoidiP61837.
KOiK09872.
OMAiMEHREED.
OrthoDBiEOG09360H22.
PhylomeDBiP61837.

Enzyme and pathway databases

ReactomeiR-ATH-432047. Passive transport by Aquaporins.

Miscellaneous databases

PROiP61837.

Gene expression databases

GenevisibleiP61837. AT.

Family and domain databases

CDDicd00333. MIP. 1 hit.
Gene3Di1.20.1080.10. 1 hit.
InterProiIPR023271. Aquaporin-like.
IPR000425. MIP.
IPR022357. MIP_CS.
[Graphical view]
PANTHERiPTHR19139. PTHR19139. 1 hit.
PfamiPF00230. MIP. 1 hit.
[Graphical view]
PRINTSiPR00783. MINTRINSICP.
SUPFAMiSSF81338. SSF81338. 1 hit.
TIGRFAMsiTIGR00861. MIP. 1 hit.
PROSITEiPS00221. MIP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPIP11_ARATH
AccessioniPrimary (citable) accession number: P61837
Secondary accession number(s): P43285
, Q0WP60, Q8L9H0, Q9LDT6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: June 7, 2004
Last modified: November 30, 2016
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.