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P61829

- ATP9_YEAST

UniProt

P61829 - ATP9_YEAST

Protein

ATP synthase subunit 9, mitochondrial

Gene

OLI1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F0 domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei59 – 591Reversibly protonated during proton transportBy similarity

    GO - Molecular functioni

    1. hydrogen ion transmembrane transporter activity Source: InterPro
    2. lipid binding Source: UniProtKB-KW

    GO - Biological processi

    1. ATP catabolic process Source: GOC
    2. ATP hydrolysis coupled proton transport Source: InterPro
    3. ATP synthesis coupled proton transport Source: SGD

    Keywords - Biological processi

    Hydrogen ion transport, Ion transport, Transport

    Keywords - Ligandi

    Lipid-binding

    Enzyme and pathway databases

    BioCyciYEAST:G3O-34383-MONOMER.
    ReactomeiREACT_189012. Mitochondrial protein import.

    Protein family/group databases

    TCDBi3.A.2.1.3. the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ATP synthase subunit 9, mitochondrial
    Alternative name(s):
    Lipid-binding protein
    Oligomycin resistance protein 1
    Gene namesi
    Name:OLI1
    Synonyms:ATP9, OLI3, PHO2
    Ordered Locus Names:Q0130
    Encoded oniMitochondrion
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Mitochondrion

    Organism-specific databases

    CYGDiQ0130.
    SGDiS000007274. OLI1.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: Reactome
    2. integral component of membrane Source: UniProtKB-KW
    3. mitochondrial inner membrane Source: Reactome
    4. mitochondrial intermembrane space Source: Reactome
    5. mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) Source: SGD

    Keywords - Cellular componenti

    CF(0), Membrane, Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 7676ATP synthase subunit 9, mitochondrialPRO_0000112240Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-formylmethionine1 Publication

    Keywords - PTMi

    Formylation

    Expressioni

    Gene expression databases

    GenevestigatoriP61829.

    Interactioni

    Subunit structurei

    F-type ATPases have 2 components, CF1 - the catalytic core - and CF0 - the membrane proton channel. In yeast, the dimeric form of ATP synthase consists of 17 polypeptides: alpha, beta, gamma, delta, epsilon, 4 (B), 5 (OSCP), 6 (A), 8, 9 (C), d, E (Tim11), f, g, h, i/j and k.

    Protein-protein interaction databases

    BioGridi34780. 10 interactions.
    DIPiDIP-3041N.
    MINTiMINT-4981559.

    Structurei

    Secondary structure

    1
    76
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi2 – 1413
    Helixi15 – 184
    Helixi19 – 3921
    Helixi41 – 433
    Helixi44 – 7330

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2WPDX-ray3.43J/K/L/M/N/O/P/Q/R/S1-76[»]
    2XOKX-ray3.01K/L/M/N/O/P/Q/R/S/T1-76[»]
    3U2FX-ray2.00K/L/M/N/O1-76[»]
    3U2YX-ray2.50K/L/M/N/O1-76[»]
    3U32X-ray2.00K/L/M/N/O1-76[»]
    3UD0X-ray2.00K/L/M/N/O1-76[»]
    3ZRYX-ray6.50J/K/L/M/N/O/P/Q/R/S1-76[»]
    4B2Qelectron microscopy37.00J/K/L/M/N/O/P/Q/R/S/j/k/l/m/n/o/p/q/r/s1-76[»]
    4F4SX-ray1.90A/B/C/D/E/K/L/M/N/O1-76[»]
    ProteinModelPortaliP61829.
    SMRiP61829. Positions 2-75.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP61829.

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei14 – 3421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei52 – 7221HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ATPase C chain family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0636.
    GeneTreeiENSGT00390000006210.
    HOGENOMiHOG000235245.
    KOiK02128.
    OMAiNPETEEK.
    OrthoDBiEOG72NS3W.

    Family and domain databases

    Gene3Di1.20.20.10. 1 hit.
    HAMAPiMF_01396. ATP_synth_c_bact.
    InterProiIPR000454. ATPase_F0-cplx_csu.
    IPR020537. ATPase_F0-cplx_csu_DDCD_BS.
    IPR002379. ATPase_proteolipid_c_like_dom.
    [Graphical view]
    PfamiPF00137. ATP-synt_C. 1 hit.
    [Graphical view]
    PRINTSiPR00124. ATPASEC.
    SUPFAMiSSF81333. SSF81333. 1 hit.
    PROSITEiPS00605. ATPASE_C. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P61829-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQLVLAAKYI GAGISTIGLL GAGIGIAIVF AALINGVSRN PSIKDTVFPM   50
    AILGFALSEA TGLFCLMVSF LLLFGV 76
    Length:76
    Mass (Da):7,759
    Last modified:July 21, 1986 - v1
    Checksum:i82B4477D6F75D758
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti46 – 461T → L in strain: DS400/A3 and KL14-4A.
    Natural varianti53 – 531L → F in strain: DS400/A3, DS401 and oligomycin-resistant mutant.
    Natural varianti57 – 571L → V in oligomycin-resistant mutant and cross-resistance to venturicidin.
    Natural varianti65 – 651C → S in oligomycin-resistant mutant.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L00007 Genomic DNA. Translation: AAA32146.1.
    J01462 Genomic DNA. Translation: AAA32169.1.
    V00707 Genomic DNA. Translation: CAA24079.1.
    L36899 Genomic DNA. Translation: AAA67535.1.
    X03968 Genomic DNA. Translation: CAA27605.1.
    AJ011856 Genomic DNA. Translation: CAA09838.1.
    PIRiA23024. LWBYA.
    RefSeqiNP_009319.1. NM_001184366.1.

    Genome annotation databases

    EnsemblFungiiQ0130; Q0130; Q0130.
    GeneIDi854584.
    KEGGisce:Q0130.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L00007 Genomic DNA. Translation: AAA32146.1 .
    J01462 Genomic DNA. Translation: AAA32169.1 .
    V00707 Genomic DNA. Translation: CAA24079.1 .
    L36899 Genomic DNA. Translation: AAA67535.1 .
    X03968 Genomic DNA. Translation: CAA27605.1 .
    AJ011856 Genomic DNA. Translation: CAA09838.1 .
    PIRi A23024. LWBYA.
    RefSeqi NP_009319.1. NM_001184366.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2WPD X-ray 3.43 J/K/L/M/N/O/P/Q/R/S 1-76 [» ]
    2XOK X-ray 3.01 K/L/M/N/O/P/Q/R/S/T 1-76 [» ]
    3U2F X-ray 2.00 K/L/M/N/O 1-76 [» ]
    3U2Y X-ray 2.50 K/L/M/N/O 1-76 [» ]
    3U32 X-ray 2.00 K/L/M/N/O 1-76 [» ]
    3UD0 X-ray 2.00 K/L/M/N/O 1-76 [» ]
    3ZRY X-ray 6.50 J/K/L/M/N/O/P/Q/R/S 1-76 [» ]
    4B2Q electron microscopy 37.00 J/K/L/M/N/O/P/Q/R/S/j/k/l/m/n/o/p/q/r/s 1-76 [» ]
    4F4S X-ray 1.90 A/B/C/D/E/K/L/M/N/O 1-76 [» ]
    ProteinModelPortali P61829.
    SMRi P61829. Positions 2-75.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 34780. 10 interactions.
    DIPi DIP-3041N.
    MINTi MINT-4981559.

    Protein family/group databases

    TCDBi 3.A.2.1.3. the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii Q0130 ; Q0130 ; Q0130 .
    GeneIDi 854584.
    KEGGi sce:Q0130.

    Organism-specific databases

    CYGDi Q0130.
    SGDi S000007274. OLI1.

    Phylogenomic databases

    eggNOGi COG0636.
    GeneTreei ENSGT00390000006210.
    HOGENOMi HOG000235245.
    KOi K02128.
    OMAi NPETEEK.
    OrthoDBi EOG72NS3W.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-34383-MONOMER.
    Reactomei REACT_189012. Mitochondrial protein import.

    Miscellaneous databases

    EvolutionaryTracei P61829.
    NextBioi 977052.

    Gene expression databases

    Genevestigatori P61829.

    Family and domain databases

    Gene3Di 1.20.20.10. 1 hit.
    HAMAPi MF_01396. ATP_synth_c_bact.
    InterProi IPR000454. ATPase_F0-cplx_csu.
    IPR020537. ATPase_F0-cplx_csu_DDCD_BS.
    IPR002379. ATPase_proteolipid_c_like_dom.
    [Graphical view ]
    Pfami PF00137. ATP-synt_C. 1 hit.
    [Graphical view ]
    PRINTSi PR00124. ATPASEC.
    SUPFAMi SSF81333. SSF81333. 1 hit.
    PROSITEi PS00605. ATPASE_C. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Amino acid sequence of the ATPase proteolipid from mitochondria, chloroplasts and bacteria (wild type and mutants)."
      Sebald W., Hoppe J., Wachter E.
      (In) Quagliariello E., Palmieri F., Papa S., Klingenberg M. (eds.); Function and molecular aspects of biomembrane transport, pp.63-74, Elsevier, Amsterdam (1979)
      Cited for: PROTEIN SEQUENCE.
    2. "Nucleotide sequence of the mitochondrial structural gene for subunit 9 of yeast ATPase complex."
      Hensgens L.A.M., Grivell L.A., Borst P., Bos J.L.
      Proc. Natl. Acad. Sci. U.S.A. 76:1663-1667(1979) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: KL14-4A.
    3. "Organization of mitochondrial DNA in yeast."
      Tzagoloff A., Macino G., Nobrega M.P., Li M.
      (In) Cummings D.J., Brost P., Dawid I.B., Weissman S.M., Fox C.F. (eds.); Extrachromosomal DNA, pp.339-355, Academic Press, New York (1979)
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: DS401.
    4. "Assembly of the mitochondrial membrane system. The DNA sequence of a mitochondrial ATPase gene in Saccharomyces cerevisiae."
      Macino G., Tzagoloff A.
      J. Biol. Chem. 254:4617-4623(1979) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: DS400/A3.
    5. "Biogenesis of mitochondria: DNA sequence analysis of mit- mutations in the mitochondrial oli1 gene coding for mitochondrial ATPase subunit 9 in Saccharomyces cerevisiae."
      Ooi B.G., McMullen G.L., Linnane A.W., Nagley P., Novitski C.E.
      Nucleic Acids Res. 13:1327-1339(1985) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    6. "The complete sequence of the mitochondrial genome of Saccharomyces cerevisiae."
      Foury F., Roganti T., Lecrenier N., Purnelle B.
      FEBS Lett. 440:325-331(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 96604 / S288c / FY1679.
    7. "NH2-terminal sequence of the isolated yeast ATP synthase subunit 6 reveals post-translational cleavage."
      Michon T., Galante M., Velours J.
      Eur. J. Biochem. 172:621-625(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 1-8, FORMYLATION AT MET-1.
    8. "Molecular architecture of the rotary motor in ATP synthase."
      Stock D., Leslie A.G., Walker J.E.
      Science 286:1700-1705(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: 3D-STRUCTURE MODELING.

    Entry informationi

    Entry nameiATP9_YEAST
    AccessioniPrimary (citable) accession number: P61829
    Secondary accession number(s): P00841, Q37750
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: July 21, 1986
    Last modified: October 1, 2014
    This is version 97 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families
    3. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

    External Data

    Dasty 3