P61826 (CAPSD_PAVC) Reviewed, UniProtKB/Swiss-Prot
Last modified March 6, 2013. Version 39. History...
Names and origin
|Protein names||Recommended name:|
Capsid protein VP2
Coat protein VP2
|Organism||Canine parvovirus type 2 (CPV-2)|
|Taxonomic identifier||10788 [NCBI]|
|Taxonomic lineage||Viruses › ssDNA viruses › Parvoviridae › Parvovirinae › Parvovirus ›|
|Virus host||Canis familiaris (Dog) (Canis lupus familiaris) [TaxID: 9615]|
Felis catus (Cat) (Felis silvestris catus) [TaxID: 9685]
|Sequence length||584 AA.|
|Protein existence||Inferred from homology|
General annotation (Comments)
Capsid protein self-assembles to form an icosahedral capsid with a T=1 symmetry, about 22 nm in diameter, and consisting of 60 copies of two size variants of the capsid proteins, VP1 and VP2, which differ by the presence of an N-terminal extension in the minor protein VP1. The capsid encapsulates the genomic ssDNA. Capsid proteins are responsible for the attachment to host cell receptor TFRC. This attachment induces virion internalization predominantly through clathrin-endocytosis. Binding to the host receptors also induces capsid rearrangements leading to surface exposure of VP1 N-terminus, specifically its phospholipase A2-like region and nuclear localization signal(s). VP1 N-terminus might serve as a lipolytic enzyme to breach the endosomal membrane during entry into host cell. Intracytoplasmic transport involves microtubules and interaction between capsid proteins and host dynein. Exposure of nuclear localization signal probably allows nuclear import of capsids By similarity.
Interacts with host TFRC By similarity.
The N-terminus of VP1 is sequestered within the mature capsid. It contains a phospholipase A2-like region and nuclear localization signals that might be exposed by capsid modifications during virus entry By similarity.
The capsids of autonomous parvoviruses expose a proportion of VP2 N-terminus and part of that sequence can be cleaved of to form VP3 By similarity.
Belongs to the parvoviridae capsid protein family.
|This entry describes 2 isoforms produced by alternative splicing. [Select]|
|Isoform VP2 (identifier: P61826-1) |
This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
|Note: Major splicing isoform produced by deletion of the initiating AUG for VP1 and downstream translation of VP2.|
|Isoform VP1 (identifier: P61826-2) |
The sequence of this isoform is not available.
|Note: Minor splicing isoform.|
Sequence annotation (Features)
|AJ698134 Genomic DNA. Translation: CAG27358.1.|
3D structure databases
|SMR||P61826. Positions 37-584. |
Protocols and materials databases
Family and domain databases
|Gene3D||22.214.171.124. 1 hit. |
|InterPro||IPR016184. Capsid/spike_ssDNA_virus. |
|Pfam||PF00740. Parvo_coat. 1 hit. |
|SUPFAM||SSF88645. Capsid/spike_ssDNA_virus. 1 hit. |
|Accession||Primary (citable) accession number: P61826|
|Entry status||Reviewed (UniProtKB/Swiss-Prot)|
|Annotation program||Viral Protein Annotation Program|
Index of protein domains and families