ID RNAS1_BOVIN Reviewed; 150 AA. AC P61823; A6QPW8; P00656; Q9TSF2; DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot. DT 07-JUN-2004, sequence version 1. DT 27-MAR-2024, entry version 173. DE RecName: Full=Ribonuclease pancreatic; DE EC=4.6.1.18; DE AltName: Full=RNase 1; DE AltName: Full=RNase A; DE Flags: Precursor; GN Name=RNASE1; Synonyms=RNS1; OS Bos taurus (Bovine). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; OC Bovinae; Bos. OX NCBI_TaxID=9913; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX PubMed=2838818; DOI=10.1093/nar/16.12.5491; RA Carsana A., Confalone E., Palmieri M., Libonati M., Furia A.; RT "Structure of the bovine pancreatic ribonuclease gene: the unique RT intervening sequence in the 5' untranslated region contains a promoter-like RT element."; RL Nucleic Acids Res. 16:5491-5502(1988). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=Hereford; TISSUE=Fetal pancreas; RG NIH - Mammalian Gene Collection (MGC) project; RL Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases. RN [3] RP NUCLEOTIDE SEQUENCE [MRNA] OF 23-150, AND FUNCTION. RX PubMed=7479688; DOI=10.1093/protein/8.3.261; RA Delcardayre S.B., Ribo M., Yokel E.M., Quirk D.J., Rutter W.J., RA Raines R.T.; RT "Engineering ribonuclease A: production, purification and characterization RT of wild-type enzyme and mutants at Gln11."; RL Protein Eng. 8:261-273(1995). RN [4] RP PROTEIN SEQUENCE OF 27-150, AND DISULFIDE BONDS. RC TISSUE=Pancreas; RX PubMed=13989651; RA Smyth D.G., Stein W.H., Moore S.; RT "The sequence of amino acid residues in bovine pancreatic ribonuclease: RT revisions and confirmations."; RL J. Biol. Chem. 238:227-234(1963). RN [5] RP PROTEIN SEQUENCE OF 27-150. RC TISSUE=Pancreas; RX PubMed=14235531; RA Plummer T.H. Jr., Hirs C.H.W.; RT "On the structure of bovine pancreatic ribonuclease B. Isolation of a RT glycopeptide."; RL J. Biol. Chem. 239:2530-2538(1964). RN [6] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 27-150. RX PubMed=8587129; DOI=10.1007/bf00173164; RA Confalone E., Beintema J.J., Sasso M.P., Carsana A., Palmieri M., RA Vento M.T., Furia A.; RT "Molecular evolution of genes encoding ribonucleases in ruminant species."; RL J. Mol. Evol. 41:850-858(1995). RN [7] RP ACTIVE SITE. RX PubMed=14342316; RA Heinrikson R.L., Stein W.H., Crestfield A.M., Moore S.; RT "The reactivities of the histidine residues at the active site of RT ribonuclease toward halo acids of different structures."; RL J. Biol. Chem. 240:2921-2934(1965). RN [8] RP ACTIVE SITE. RX PubMed=5801478; DOI=10.1016/0022-2836(69)90389-1; RA Shall S., Barnard E.A.; RT "Heavy atom-labelled derivatives of bovine pancreatic ribonuclease. I. RT Specific reactions of ribonuclease with N-acetylhomocysteine thiolactone RT and silver ion."; RL J. Mol. Biol. 41:237-251(1969). RN [9] RP GLYCATION AT LYS-27; LYS-33; LYS-63 AND LYS-67. RX PubMed=4030761; DOI=10.1016/s0021-9258(19)85131-1; RA Watkins N.G., Thorpe S.R., Baynes J.W.; RT "Glycation of amino groups in protein. Studies on the specificity of RT modification of RNase by glucose."; RL J. Biol. Chem. 260:10629-10636(1985). RN [10] RP DNA-BINDING. RX PubMed=3961503; DOI=10.1126/science.3961503; RA McPherson A., Brayer G., Cascio D., Williams R.; RT "The mechanism of binding of a polynucleotide chain to pancreatic RT ribonuclease."; RL Science 232:765-768(1986). RN [11] RP GLYCOSYLATION AT ASN-60. RX PubMed=19358553; DOI=10.1021/ac900231w; RA Thaysen-Andersen M., Mysling S., Hojrup P.; RT "Site-specific glycoprofiling of N-linked glycopeptides using MALDI-TOF MS: RT strong correlation between signal strength and glycoform quantities."; RL Anal. Chem. 81:3933-3943(2009). RN [12] RP X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS). RX PubMed=5460889; DOI=10.1016/s0021-9258(18)63395-2; RA Wyckoff H.W., Tsernoglou D., Hanson A.W., Knox J.R., Lee B., Richards F.M.; RT "The three-dimensional structure of ribonuclease-S. Interpretation of an RT electron density map at a nominal resolution of 2 A."; RL J. Biol. Chem. 245:305-328(1970). RN [13] RP X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS). RX PubMed=4835726; DOI=10.1016/0022-2836(74)90125-9; RA Carlisle C.H., Palmer R.A., Mazumdar S.K., Gorinsky B.A., Yeates D.G.R.; RT "The structure of ribonuclease at 2.5-A resolution."; RL J. Mol. Biol. 85:1-18(1974). RN [14] RP X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS). RX PubMed=6276380; DOI=10.1016/s0021-9258(19)68195-0; RA Wlodawer A., Bott R., Sjoelin L.; RT "The refined crystal structure of ribonuclease A at 2.0-A resolution."; RL J. Biol. Chem. 257:1325-1332(1982). RN [15] RP X-RAY CRYSTALLOGRAPHY (1.26 ANGSTROMS). RX PubMed=3401445; DOI=10.1021/bi00408a010; RA Wlodawer A., Svensson L.A., Sjoelin L., Gilliland G.L.; RT "Structure of phosphate-free ribonuclease A refined at 1.26 A."; RL Biochemistry 27:2705-2717(1988). RN [16] RP X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS). RX PubMed=9154942; DOI=10.1021/bi9700330; RA Leonidas D.D., Shapiro R., Irons L.I., Russo N., Acharya K.R.; RT "Crystal structures of ribonuclease A complexes with 5'-diphosphoadenosine RT 3'-phosphate and 5'-diphosphoadenosine 2'-phosphate at 1.7-A resolution."; RL Biochemistry 36:5578-5588(1997). RN [17] RP X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 2-125 OF MUTANT GLY-67. RX PubMed=11087402; DOI=10.1021/bi001862f; RA Kelemen B.R., Schultz L.W., Sweeney R.Y., Raines R.T.; RT "Excavating an active site: the nucleobase specificity of ribonuclease A."; RL Biochemistry 39:14487-14494(2000). RN [18] RP X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) OF MUTANTS ALA-38 AND ALA-145. RX PubMed=11305910; DOI=10.1021/bi0100182; RA Park C., Schultz L.W., Raines R.T.; RT "Contribution of the active site histidine residues of ribonuclease A to RT nucleic acid binding."; RL Biochemistry 40:4949-4956(2001). RN [19] RP X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) IN COMPLEX WITH SUBSTRATE ANALOG. RX PubMed=11513604; DOI=10.1021/bi010888j; RA Jardine A.M., Leonidas D.D., Jenkins J.L., Park C., Raines R.T., RA Acharya K.R., Shapiro R.; RT "Cleavage of 3',5'-pyrophosphate-linked dinucleotides by ribonuclease A and RT angiogenin."; RL Biochemistry 40:10262-10272(2001). RN [20] RP X-RAY CRYSTALLOGRAPHY (1.4 ANGSTROMS) OF MUTANTS ALA-120; PHE-120 AND RP TRP-120. RX PubMed=11742124; DOI=10.1110/ps.31102; RA Chatani E., Hayashi R., Moriyama H., Ueki T.; RT "Conformational strictness required for maximum activity and stability of RT bovine pancreatic ribonuclease A as revealed by crystallographic study of RT three Phe120 mutants at 1.4 A resolution."; RL Protein Sci. 11:72-81(2002). RN [21] RP STRUCTURE BY NMR. RX PubMed=2775743; DOI=10.1021/bi00440a033; RA Robertson A.D., Purisima E.O., Eastman M.A., Scheraga H.A.; RT "Proton NMR assignments and regular backbone structure of bovine pancreatic RT ribonuclease A in aqueous solution."; RL Biochemistry 28:5930-5938(1989). RN [22] RP STRUCTURE BY NMR. RX PubMed=2776756; DOI=10.1111/j.1432-1033.1989.tb21092.x; RA Rico M., Bruix M., Santoro J., Gonzalez C., Neira J.L., Nieto J.L., RA Herranz J.; RT "Sequential 1H-NMR assignment and solution structure of bovine pancreatic RT ribonuclease A."; RL Eur. J. Biochem. 183:623-638(1989). RN [23] RP STRUCTURE BY NMR. RX PubMed=1841699; DOI=10.1007/bf01875521; RA Rico M., Santoro J., Gonzalez C., Bruix M., Neira J.L., Nieto J.L., RA Herranz J.; RT "3D structure of bovine pancreatic ribonuclease A in aqueous solution: an RT approach to tertiary structure determination from a small basis of 1H NMR RT NOE correlations."; RL J. Biomol. NMR 1:283-298(1991). CC -!- FUNCTION: Endonuclease that catalyzes the cleavage of RNA on the 3' CC side of pyrimidine nucleotides. Acts on single-stranded and double- CC stranded RNA. {ECO:0000269|PubMed:7479688}. CC -!- CATALYTIC ACTIVITY: CC Reaction=an [RNA] containing cytidine + H2O = an [RNA]-3'-cytidine-3'- CC phosphate + a 5'-hydroxy-ribonucleotide-3'-[RNA].; EC=4.6.1.18; CC -!- CATALYTIC ACTIVITY: CC Reaction=an [RNA] containing uridine + H2O = an [RNA]-3'-uridine-3'- CC phosphate + a 5'-hydroxy-ribonucleotide-3'-[RNA].; EC=4.6.1.18; CC -!- SUBUNIT: Interacts with and forms tight 1:1 complexes with RNH1. CC Dimerization of two such complexes may occur. Interaction with RNH1 CC inhibits this protein (By similarity). Monomer. {ECO:0000250, CC ECO:0000269|PubMed:11513604}. CC -!- INTERACTION: CC P61823; Q80UW2: Fbxo2; Xeno; NbExp=2; IntAct=EBI-908364, EBI-2314714; CC P61823; P17967: PDI1; Xeno; NbExp=2; IntAct=EBI-908364, EBI-13012; CC P61823; P13489: RNH1; Xeno; NbExp=3; IntAct=EBI-908364, EBI-1237106; CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- TISSUE SPECIFICITY: Pancreas. CC -!- MISCELLANEOUS: Ribonuclease can destabilize or unwind the DNA helix by CC complexing with single-stranded DNA; this complex arises by an extended CC multisite cation-anion interaction between the lysine and arginine CC residues of the enzyme and the phosphate groups of the nucleotides. CC -!- SIMILARITY: Belongs to the pancreatic ribonuclease family. CC {ECO:0000305}. CC -!- WEB RESOURCE: Name=Worthington enzyme manual; CC URL="https://www.worthington-biochem.com/RNASE/"; CC -!- WEB RESOURCE: Name=Functional Glycomics Gateway - Glycan Binding; CC Note=RNase A; CC URL="http://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_oth_other_805"; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; X07283; CAA30263.1; -; Genomic_DNA. DR EMBL; BC149529; AAI49530.1; -; mRNA. DR EMBL; BC149636; AAI49637.1; -; mRNA. DR EMBL; S80747; AAB35594.1; -; mRNA. DR EMBL; S81740; AAB36134.1; -; Genomic_DNA. DR PIR; S00897; NRBO. DR RefSeq; NP_001014408.2; NM_001014386.4. DR RefSeq; XP_005211519.1; XM_005211462.2. DR PDB; 1A2W; X-ray; 2.10 A; A/B=27-150. DR PDB; 1A5P; X-ray; 1.60 A; A=27-150. DR PDB; 1A5Q; X-ray; 2.30 A; A=27-150. DR PDB; 1AFK; X-ray; 1.70 A; A/B=27-150. DR PDB; 1AFL; X-ray; 1.70 A; A/B=27-150. DR PDB; 1AFU; X-ray; 2.00 A; A/B=27-150. DR PDB; 1AQP; X-ray; 2.00 A; A=27-150. DR PDB; 1B6V; X-ray; 2.00 A; A/B=27-150. DR PDB; 1BEL; X-ray; 1.60 A; A=27-150. DR PDB; 1BZQ; X-ray; 2.80 A; A/B/C/D=27-150. DR PDB; 1C0B; X-ray; 1.90 A; A=23-150. DR PDB; 1C0C; X-ray; 2.00 A; A=23-150. DR PDB; 1C8W; X-ray; 1.80 A; A=27-150. DR PDB; 1C9V; X-ray; 1.70 A; A=27-150. DR PDB; 1C9X; X-ray; 1.80 A; A=27-150. DR PDB; 1CJQ; X-ray; 3.00 A; A=27-41, B=50-150. DR PDB; 1CJR; X-ray; 2.30 A; A=27-41, B=50-150. DR PDB; 1D5D; X-ray; 2.25 A; A=27-41, B=50-150. DR PDB; 1D5E; X-ray; 2.25 A; A=27-41, B=50-150. DR PDB; 1D5H; X-ray; 2.25 A; A=27-41, B=50-150. DR PDB; 1DFJ; X-ray; 2.50 A; E=27-150. DR PDB; 1DY5; X-ray; 0.87 A; A/B=27-150. DR PDB; 1EIC; X-ray; 1.40 A; A=27-150. DR PDB; 1EID; X-ray; 1.40 A; A=27-150. DR PDB; 1EIE; X-ray; 1.40 A; A=27-150. DR PDB; 1EOS; X-ray; 2.00 A; A/B=27-150. DR PDB; 1EOW; X-ray; 2.00 A; A=27-150. DR PDB; 1F0V; X-ray; 1.70 A; A/B/C/D=27-150. DR PDB; 1FEV; X-ray; 2.25 A; A=27-41, B=50-150. DR PDB; 1FS3; X-ray; 1.40 A; A=27-150. DR PDB; 1GV7; X-ray; 2.10 A; A=84-99. DR PDB; 1IZP; X-ray; 1.50 A; A=27-150. DR PDB; 1IZQ; X-ray; 1.80 A; A=27-150. DR PDB; 1IZR; X-ray; 1.50 A; A=27-150. DR PDB; 1J7Z; X-ray; 2.25 A; A=27-41, B=47-150. DR PDB; 1J80; X-ray; 2.10 A; A=27-41, B=47-150. DR PDB; 1J81; X-ray; 2.20 A; A=27-41, B=47-150. DR PDB; 1J82; X-ray; 2.30 A; A=27-41, B=47-150. DR PDB; 1JN4; X-ray; 1.80 A; A/B=27-150. DR PDB; 1JS0; X-ray; 2.20 A; A/B/C=27-150. DR PDB; 1JVT; X-ray; 2.05 A; A/B=27-150. DR PDB; 1JVU; X-ray; 1.78 A; A/B=27-150. DR PDB; 1JVV; X-ray; 2.20 A; A/B=27-150. DR PDB; 1KF2; X-ray; 1.10 A; A=27-150. DR PDB; 1KF3; X-ray; 1.05 A; A=27-150. DR PDB; 1KF4; X-ray; 1.10 A; A=27-150. DR PDB; 1KF5; X-ray; 1.15 A; A=27-150. DR PDB; 1KF7; X-ray; 1.15 A; A=27-150. DR PDB; 1KF8; X-ray; 1.15 A; A=27-150. DR PDB; 1KH8; X-ray; 2.00 A; A=27-150. DR PDB; 1LSQ; X-ray; 1.90 A; A/B=27-150. DR PDB; 1O0F; X-ray; 1.50 A; A/B=27-150. DR PDB; 1O0H; X-ray; 1.20 A; A/B=27-150. DR PDB; 1O0M; X-ray; 1.50 A; A/B=27-150. DR PDB; 1O0N; X-ray; 1.50 A; A/B=27-150. DR PDB; 1O0O; X-ray; 1.20 A; A/B=27-150. DR PDB; 1QHC; X-ray; 1.70 A; A/B=27-150. DR PDB; 1RAR; X-ray; 1.90 A; A=28-150. DR PDB; 1RAS; X-ray; 1.70 A; A=28-150. DR PDB; 1RAT; X-ray; 1.50 A; A=27-150. DR PDB; 1RBB; X-ray; 2.50 A; A/B=27-150. DR PDB; 1RBC; X-ray; 2.00 A; A=47-150, S=27-41. DR PDB; 1RBD; X-ray; 1.70 A; A=47-150, S=27-41. DR PDB; 1RBE; X-ray; 1.75 A; A=47-150, S=27-41. DR PDB; 1RBF; X-ray; 1.80 A; A=47-150, S=27-41. DR PDB; 1RBG; X-ray; 1.80 A; A=47-150, S=27-41. DR PDB; 1RBH; X-ray; 1.70 A; A=47-150, S=27-41. DR PDB; 1RBI; X-ray; 1.80 A; A=47-150, S=27-41. DR PDB; 1RBJ; X-ray; 2.70 A; A=27-150. DR PDB; 1RBN; X-ray; 2.10 A; A=27-150. DR PDB; 1RBW; X-ray; 1.69 A; A=27-150. DR PDB; 1RBX; X-ray; 1.69 A; A=27-150. DR PDB; 1RCA; X-ray; 1.90 A; A=27-150. DR PDB; 1RCN; X-ray; 2.32 A; E=27-150. DR PDB; 1RHA; X-ray; 1.80 A; A=27-150. DR PDB; 1RHB; X-ray; 1.50 A; A=27-150. DR PDB; 1RNC; X-ray; 1.50 A; A=27-150. DR PDB; 1RND; X-ray; 1.50 A; A=27-150. DR PDB; 1RNM; X-ray; 2.00 A; E=27-150. DR PDB; 1RNN; X-ray; 1.80 A; E=27-150. DR PDB; 1RNO; X-ray; 1.90 A; A=27-150. DR PDB; 1RNQ; X-ray; 2.00 A; A=27-150. DR PDB; 1RNU; X-ray; 1.60 A; A=27-150. DR PDB; 1RNV; X-ray; 1.60 A; A=27-150. DR PDB; 1RNW; X-ray; 1.80 A; A=27-150. DR PDB; 1RNX; X-ray; 1.90 A; A=27-150. DR PDB; 1RNY; X-ray; 2.00 A; A=27-150. DR PDB; 1RNZ; X-ray; 1.90 A; A=27-150. DR PDB; 1ROB; X-ray; 1.60 A; A=27-150. DR PDB; 1RPF; X-ray; 2.20 A; A=27-150. DR PDB; 1RPG; X-ray; 1.40 A; A=27-150. DR PDB; 1RPH; X-ray; 2.20 A; A=27-150. DR PDB; 1RSM; X-ray; 2.00 A; A=27-150. DR PDB; 1RTA; X-ray; 2.50 A; E=27-150. DR PDB; 1RTB; X-ray; 2.50 A; A=27-150. DR PDB; 1RUV; X-ray; 1.25 A; A=27-150. DR PDB; 1SRN; X-ray; 1.80 A; A=27-144, B=137-150. DR PDB; 1SSA; X-ray; 2.00 A; A=27-144, B=137-150. DR PDB; 1SSB; X-ray; 2.00 A; A=27-144, B=137-150. DR PDB; 1SSC; X-ray; 2.00 A; A=27-138, B=140-150. DR PDB; 1U1B; X-ray; 2.00 A; A/B=27-150. DR PDB; 1UN5; X-ray; 2.60 A; A=64-74. DR PDB; 1W4O; X-ray; 1.60 A; A/B=27-150. DR PDB; 1W4P; X-ray; 1.69 A; A/B=27-150. DR PDB; 1W4Q; X-ray; 1.68 A; A/B=27-150. DR PDB; 1WBU; X-ray; 1.90 A; A/B=27-150. DR PDB; 1XPS; X-ray; 1.80 A; A/B=27-150. DR PDB; 1XPT; X-ray; 1.90 A; A/B=27-150. DR PDB; 1YMN; X-ray; 1.45 A; A=27-150. DR PDB; 1YMR; X-ray; 1.50 A; A=27-150. DR PDB; 1YMW; X-ray; 1.50 A; A=27-150. DR PDB; 1Z3L; X-ray; 1.80 A; E=47-150, S=27-41. DR PDB; 1Z3M; X-ray; 2.00 A; E=47-150, S=27-41. DR PDB; 1Z3P; X-ray; 2.00 A; E=47-150, S=27-41. DR PDB; 1Z6D; X-ray; 1.54 A; A/B=27-150. DR PDB; 1Z6S; X-ray; 1.50 A; A/B=27-150. DR PDB; 2AAS; NMR; -; A=27-150. DR PDB; 2APQ; X-ray; 1.80 A; A=27-150. DR PDB; 2BLP; X-ray; 1.40 A; A=27-150. DR PDB; 2BLZ; X-ray; 1.40 A; A=27-150. DR PDB; 2E33; X-ray; 2.70 A; B=27-150. DR PDB; 2E3W; X-ray; 1.05 A; A=27-150. DR PDB; 2G4W; X-ray; 1.84 A; A/B=27-150. DR PDB; 2G4X; X-ray; 1.95 A; A=27-150. DR PDB; 2G8Q; X-ray; 1.50 A; A/B=27-150. DR PDB; 2G8R; X-ray; 1.70 A; A/B=27-150. DR PDB; 2NUI; X-ray; 1.10 A; A=27-150. DR PDB; 2OP2; X-ray; 1.60 A; A=27-150. DR PDB; 2OQF; X-ray; 2.30 A; A/B/C/D=27-150. DR PDB; 2P42; X-ray; 1.80 A; A/C=27-150. DR PDB; 2P43; X-ray; 1.65 A; A=27-150. DR PDB; 2P44; X-ray; 1.80 A; A=27-150. DR PDB; 2P45; X-ray; 1.10 A; A=27-150. DR PDB; 2P46; X-ray; 2.50 A; A/C=27-150. DR PDB; 2P47; X-ray; 2.50 A; A=27-150. DR PDB; 2P48; X-ray; 2.30 A; A=27-150. DR PDB; 2P49; X-ray; 1.38 A; A=27-150. DR PDB; 2P4A; X-ray; 1.90 A; A/C=27-150. DR PDB; 2QCA; X-ray; 1.33 A; A=27-150. DR PDB; 2RAT; X-ray; 1.50 A; A=27-150. DR PDB; 2RLN; X-ray; 1.85 A; E=42-150, S=27-41. DR PDB; 2RNS; X-ray; 1.60 A; A=27-150. DR PDB; 2W5G; X-ray; 1.70 A; A/B=27-150. DR PDB; 2W5I; X-ray; 2.40 A; A/B=27-150. DR PDB; 2W5K; X-ray; 1.70 A; A/B=27-150. DR PDB; 2W5L; X-ray; 1.70 A; A/B=27-150. DR PDB; 2W5M; X-ray; 1.80 A; A/B=27-150. DR PDB; 2XOG; X-ray; 1.72 A; A/B=27-150. DR PDB; 2XOI; X-ray; 1.72 A; A/B=27-150. DR PDB; 3A1R; Neutron; 1.70 A; A=27-150. DR PDB; 3D6O; X-ray; 1.58 A; A/B=27-150. DR PDB; 3D6P; X-ray; 1.60 A; A/B=27-150. DR PDB; 3D6Q; X-ray; 1.60 A; A/B=27-150. DR PDB; 3D7B; X-ray; 1.60 A; A/B=27-150. DR PDB; 3D8Y; X-ray; 1.72 A; A/B=27-150. DR PDB; 3D8Z; X-ray; 1.98 A; A/B=27-150. DR PDB; 3DH5; X-ray; 1.60 A; A=27-150. DR PDB; 3DH6; X-ray; 1.60 A; A=27-150. DR PDB; 3DI7; X-ray; 1.60 A; A=27-150. DR PDB; 3DI8; X-ray; 1.60 A; A=27-150. DR PDB; 3DI9; X-ray; 2.00 A; A=27-150. DR PDB; 3DIB; X-ray; 1.40 A; A=27-150. DR PDB; 3DIC; X-ray; 1.60 A; A=27-150. DR PDB; 3DXG; X-ray; 1.39 A; A/B=27-150. DR PDB; 3DXH; X-ray; 1.40 A; A/B=27-150. DR PDB; 3EUX; X-ray; 1.65 A; A/B=27-150. DR PDB; 3EUY; X-ray; 1.95 A; A/B=27-150. DR PDB; 3EUZ; X-ray; 1.84 A; A/B=27-150. DR PDB; 3EV0; X-ray; 1.76 A; A/B=27-150. DR PDB; 3EV1; X-ray; 2.00 A; A/B=27-150. DR PDB; 3EV2; X-ray; 2.02 A; A/B=27-150. DR PDB; 3EV3; X-ray; 1.68 A; A/B=27-150. DR PDB; 3EV4; X-ray; 1.93 A; A/B=27-150. DR PDB; 3EV5; X-ray; 1.68 A; A/B=27-150. DR PDB; 3EV6; X-ray; 1.76 A; A/B=27-150. DR PDB; 3FKZ; X-ray; 1.99 A; A/B=27-150. DR PDB; 3FL0; X-ray; 1.94 A; A/B=27-150. DR PDB; 3FL1; X-ray; 1.90 A; A/B=27-150. DR PDB; 3FL3; X-ray; 1.60 A; A/B=27-150. DR PDB; 3I67; X-ray; 1.30 A; A=27-150. DR PDB; 3I6F; X-ray; 1.30 A; A=27-150. DR PDB; 3I6H; X-ray; 1.30 A; A=27-150. DR PDB; 3I6J; X-ray; 1.30 A; A=27-150. DR PDB; 3I7W; X-ray; 2.35 A; A=27-150. DR PDB; 3I7X; X-ray; 2.60 A; A=27-150. DR PDB; 3I7Y; X-ray; 2.40 A; A=27-150. DR PDB; 3JW1; X-ray; 1.60 A; A/B=27-150. DR PDB; 3LXO; X-ray; 1.55 A; A=27-150. DR PDB; 3MWQ; X-ray; 1.68 A; A=26-150. DR PDB; 3MWR; X-ray; 1.85 A; A=27-150. DR PDB; 3MX8; X-ray; 2.10 A; A=26-150. DR PDB; 3MZQ; X-ray; 1.50 A; A=23-150. DR PDB; 3MZR; X-ray; 1.50 A; A=23-150. DR PDB; 3OQY; X-ray; 1.49 A; A/B=47-150, a/b=27-41. DR PDB; 3OQZ; X-ray; 2.50 A; A/B=47-150, a/b=27-41. DR PDB; 3OR0; X-ray; 2.30 A; A/B=47-150, a/b=27-41. DR PDB; 3QL1; X-ray; 1.29 A; A=27-150. DR PDB; 3QL2; X-ray; 1.49 A; A/B=27-150. DR PDB; 3QSK; X-ray; 1.75 A; A=27-150. DR PDB; 3RAT; X-ray; 1.50 A; A=27-150. DR PDB; 3RH1; X-ray; 2.10 A; A=27-150. DR PDB; 3RID; X-ray; 2.18 A; A/B/C/D=27-150. DR PDB; 3RN3; X-ray; 1.45 A; A=27-150. DR PDB; 3RSD; X-ray; 1.60 A; A=27-150. DR PDB; 3RSK; X-ray; 2.00 A; A=27-150. DR PDB; 3RSP; X-ray; 1.70 A; A=27-150. DR PDB; 3SRN; X-ray; 2.00 A; A=27-139, B=140-146. DR PDB; 4AO1; X-ray; 1.58 A; A=27-150. DR PDB; 4G8V; X-ray; 1.70 A; A/B=27-150. DR PDB; 4G8Y; X-ray; 1.80 A; A/B=27-150. DR PDB; 4G90; X-ray; 1.90 A; A/B=27-150. DR PDB; 4J5Z; X-ray; 1.80 A; A=27-150. DR PDB; 4J60; X-ray; 1.69 A; A=27-150. DR PDB; 4J61; X-ray; 1.69 A; A=27-150. DR PDB; 4J62; X-ray; 2.04 A; A=27-150. DR PDB; 4J63; X-ray; 2.04 A; A=27-150. DR PDB; 4J64; X-ray; 1.78 A; A=27-150. DR PDB; 4J65; X-ray; 1.96 A; A=27-150. DR PDB; 4J66; X-ray; 2.04 A; A=27-150. DR PDB; 4J67; X-ray; 1.86 A; A=27-150. DR PDB; 4J68; X-ray; 1.78 A; A=27-150. DR PDB; 4J69; X-ray; 1.89 A; A=27-150. DR PDB; 4J6A; X-ray; 2.04 A; A=27-150. DR PDB; 4K7L; X-ray; 1.38 A; A=27-41, B=47-150. DR PDB; 4K7M; X-ray; 1.80 A; A=27-150. DR PDB; 4L55; X-ray; 1.65 A; A/B=27-150. DR PDB; 4MXF; X-ray; 2.25 A; A/B=27-150. DR PDB; 4O36; X-ray; 1.22 A; A=27-41, B=47-150. DR PDB; 4O37; X-ray; 1.40 A; A=27-41, B=47-150. DR PDB; 4OKF; X-ray; 1.54 A; A=27-41, B=47-150. DR PDB; 4OOH; X-ray; 1.89 A; A=27-150. DR PDB; 4OT4; X-ray; 1.85 A; A/B=27-150. DR PDB; 4PEQ; X-ray; 2.21 A; A/C=27-150. DR PDB; 4POU; X-ray; 1.75 A; A=27-150. DR PDB; 4QH3; X-ray; 2.00 A; A/B=27-150. DR PDB; 4RAT; X-ray; 1.50 A; A=27-150. DR PDB; 4RSD; X-ray; 1.60 A; A=27-150. DR PDB; 4RSK; X-ray; 2.10 A; A=27-150. DR PDB; 4RTE; X-ray; 1.95 A; A=27-150. DR PDB; 4S0Q; X-ray; 2.09 A; A/B=27-150. DR PDB; 4S18; X-ray; 2.27 A; A/B=27-150. DR PDB; 4SRN; X-ray; 2.00 A; A=27-139, B=140-150. DR PDB; 4WYN; X-ray; 1.80 A; A/B=27-150. DR PDB; 4WYP; X-ray; 1.50 A; A/B=27-150. DR PDB; 4WYZ; X-ray; 1.45 A; A/B=27-150. DR PDB; 4YGW; X-ray; 2.18 A; B=48-150, b=27-41. DR PDB; 4ZZ4; Neutron; 1.80 A; A=27-150. DR PDB; 5D6U; X-ray; 1.52 A; A=27-150. DR PDB; 5D97; Neutron; 1.80 A; A=27-150. DR PDB; 5E5E; X-ray; 1.98 A; A/B=27-150. DR PDB; 5E5F; X-ray; 1.68 A; A/B=27-150. DR PDB; 5ET4; X-ray; 2.10 A; A/B/C/D=27-150. DR PDB; 5JLG; X-ray; 1.79 A; A/B=27-150. DR PDB; 5JMG; X-ray; 1.85 A; A/B=27-150. DR PDB; 5JML; X-ray; 2.29 A; A/B=27-150. DR PDB; 5NA9; X-ray; 2.07 A; A=27-150. DR PDB; 5NJ7; X-ray; 2.15 A; A/B=27-150. DR PDB; 5OBC; X-ray; 2.07 A; A/B=27-150. DR PDB; 5OBD; X-ray; 1.98 A; A/B=27-150. DR PDB; 5OBE; X-ray; 1.82 A; A/B=27-150. DR PDB; 5OGH; X-ray; 1.16 A; A=27-150. DR PDB; 5OLD; X-ray; 1.78 A; A/B=27-150. DR PDB; 5RAT; X-ray; 1.50 A; A=27-150. DR PDB; 5RSA; X-ray; 2.00 A; A=27-150. DR PDB; 6ETK; X-ray; 0.85 A; A=27-150. DR PDB; 6ETL; X-ray; 0.85 A; A=27-150. DR PDB; 6ETM; X-ray; 0.92 A; A=27-150. DR PDB; 6ETN; X-ray; 0.92 A; A=27-150. DR PDB; 6ETO; X-ray; 1.02 A; A=27-150. DR PDB; 6ETP; X-ray; 1.02 A; A=27-150. DR PDB; 6ETQ; X-ray; 1.08 A; A=27-150. DR PDB; 6ETR; X-ray; 1.17 A; A=27-150. DR PDB; 6F60; X-ray; 1.14 A; A/B=27-150. DR PDB; 6GOK; X-ray; 2.65 A; A/B=27-150. DR PDB; 6PVU; X-ray; 1.49 A; A/B=27-150. DR PDB; 6PVV; X-ray; 1.65 A; A/B=27-150. DR PDB; 6PVW; X-ray; 1.60 A; A/B=27-150. DR PDB; 6PVX; X-ray; 1.55 A; A/B=27-150. DR PDB; 6QE9; X-ray; 2.03 A; A/B=27-150. DR PDB; 6RAT; X-ray; 1.50 A; A=27-150. DR PDB; 6RSA; X-ray; 2.00 A; A=27-150. DR PDB; 6XHC; X-ray; 1.60 A; A/B=27-150. DR PDB; 6XHD; X-ray; 1.51 A; A/B=27-150. DR PDB; 6XHE; X-ray; 1.88 A; A/B=27-150. DR PDB; 6XHF; X-ray; 1.45 A; A/B=27-150. DR PDB; 6XVX; X-ray; 1.40 A; AAA/BBB=27-150. DR PDB; 6XW0; X-ray; 1.80 A; AAA/BBB=27-150. DR PDB; 6YO1; X-ray; 1.90 A; A/B=27-150. DR PDB; 7P4R; X-ray; 0.85 A; AAA=27-150. DR PDB; 7P8R; X-ray; 1.27 A; A/B=27-150. DR PDB; 7PNI; X-ray; 2.13 A; AAA/BBB=27-150. DR PDB; 7Q75; X-ray; 1.64 A; A=27-150. DR PDB; 7Q76; X-ray; 1.48 A; A=27-150. DR PDB; 7Q77; X-ray; 1.60 A; A=27-150. DR PDB; 7Q78; X-ray; 1.52 A; A=27-150. DR PDB; 7Q79; X-ray; 1.55 A; A=27-150. DR PDB; 7Q7A; X-ray; 1.56 A; A=27-150. DR PDB; 7Q7B; X-ray; 1.78 A; A=27-150. DR PDB; 7QHR; X-ray; 1.40 A; A/B=27-150. DR PDB; 7QPW; X-ray; 1.15 A; AAA/BBB=27-150. DR PDB; 7QPY; X-ray; 1.42 A; A/B=27-150. DR PDB; 7QPZ; X-ray; 1.45 A; A/B=27-150. DR PDB; 7QQ0; X-ray; 1.32 A; AAA/BBB=27-150. DR PDB; 7QWH; X-ray; 1.57 A; AAA/BBB=27-150. DR PDB; 7R1P; X-ray; 1.42 A; AAA/BBB=27-150. DR PDB; 7RAT; X-ray; 1.50 A; A=27-150. DR PDB; 7RSA; X-ray; 1.26 A; A=27-150. DR PDB; 7Z6D; X-ray; 1.45 A; A/B=27-150. DR PDB; 7Z6G; X-ray; 1.71 A; A/B=27-150. DR PDB; 8OQC; X-ray; 1.50 A; A=27-150. DR PDB; 8OQD; X-ray; 1.54 A; A=27-150. DR PDB; 8OQE; X-ray; 1.50 A; A=27-150. DR PDB; 8OQF; X-ray; 1.50 A; A=27-150. DR PDB; 8OQG; X-ray; 1.60 A; A=27-150. DR PDB; 8PX0; X-ray; 1.80 A; A/B=27-150. DR PDB; 8R5V; X-ray; 1.80 A; A/B=1-150. DR PDB; 8RAT; X-ray; 1.50 A; A=27-150. DR PDB; 8RSA; X-ray; 1.80 A; A/B=27-150. DR PDB; 9RAT; X-ray; 1.50 A; A=27-150. DR PDB; 9RSA; X-ray; 1.80 A; A/B=27-150. DR PDBsum; 1A2W; -. DR PDBsum; 1A5P; -. DR PDBsum; 1A5Q; -. DR PDBsum; 1AFK; -. DR PDBsum; 1AFL; -. DR PDBsum; 1AFU; -. DR PDBsum; 1AQP; -. DR PDBsum; 1B6V; -. DR PDBsum; 1BEL; -. DR PDBsum; 1BZQ; -. DR PDBsum; 1C0B; -. DR PDBsum; 1C0C; -. DR PDBsum; 1C8W; -. DR PDBsum; 1C9V; -. DR PDBsum; 1C9X; -. DR PDBsum; 1CJQ; -. DR PDBsum; 1CJR; -. DR PDBsum; 1D5D; -. DR PDBsum; 1D5E; -. DR PDBsum; 1D5H; -. DR PDBsum; 1DFJ; -. DR PDBsum; 1DY5; -. DR PDBsum; 1EIC; -. DR PDBsum; 1EID; -. DR PDBsum; 1EIE; -. DR PDBsum; 1EOS; -. DR PDBsum; 1EOW; -. DR PDBsum; 1F0V; -. DR PDBsum; 1FEV; -. DR PDBsum; 1FS3; -. DR PDBsum; 1GV7; -. DR PDBsum; 1IZP; -. DR PDBsum; 1IZQ; -. DR PDBsum; 1IZR; -. DR PDBsum; 1J7Z; -. DR PDBsum; 1J80; -. DR PDBsum; 1J81; -. DR PDBsum; 1J82; -. DR PDBsum; 1JN4; -. DR PDBsum; 1JS0; -. DR PDBsum; 1JVT; -. DR PDBsum; 1JVU; -. DR PDBsum; 1JVV; -. DR PDBsum; 1KF2; -. DR PDBsum; 1KF3; -. DR PDBsum; 1KF4; -. DR PDBsum; 1KF5; -. DR PDBsum; 1KF7; -. DR PDBsum; 1KF8; -. DR PDBsum; 1KH8; -. DR PDBsum; 1LSQ; -. DR PDBsum; 1O0F; -. DR PDBsum; 1O0H; -. DR PDBsum; 1O0M; -. DR PDBsum; 1O0N; -. DR PDBsum; 1O0O; -. DR PDBsum; 1QHC; -. DR PDBsum; 1RAR; -. DR PDBsum; 1RAS; -. DR PDBsum; 1RAT; -. DR PDBsum; 1RBB; -. DR PDBsum; 1RBC; -. DR PDBsum; 1RBD; -. DR PDBsum; 1RBE; -. DR PDBsum; 1RBF; -. DR PDBsum; 1RBG; -. DR PDBsum; 1RBH; -. DR PDBsum; 1RBI; -. DR PDBsum; 1RBJ; -. DR PDBsum; 1RBN; -. DR PDBsum; 1RBW; -. DR PDBsum; 1RBX; -. DR PDBsum; 1RCA; -. DR PDBsum; 1RCN; -. DR PDBsum; 1RHA; -. DR PDBsum; 1RHB; -. DR PDBsum; 1RNC; -. DR PDBsum; 1RND; -. DR PDBsum; 1RNM; -. DR PDBsum; 1RNN; -. DR PDBsum; 1RNO; -. DR PDBsum; 1RNQ; -. DR PDBsum; 1RNU; -. DR PDBsum; 1RNV; -. DR PDBsum; 1RNW; -. DR PDBsum; 1RNX; -. DR PDBsum; 1RNY; -. DR PDBsum; 1RNZ; -. DR PDBsum; 1ROB; -. DR PDBsum; 1RPF; -. DR PDBsum; 1RPG; -. DR PDBsum; 1RPH; -. DR PDBsum; 1RSM; -. DR PDBsum; 1RTA; -. DR PDBsum; 1RTB; -. DR PDBsum; 1RUV; -. DR PDBsum; 1SRN; -. DR PDBsum; 1SSA; -. DR PDBsum; 1SSB; -. DR PDBsum; 1SSC; -. DR PDBsum; 1U1B; -. DR PDBsum; 1UN5; -. DR PDBsum; 1W4O; -. DR PDBsum; 1W4P; -. DR PDBsum; 1W4Q; -. DR PDBsum; 1WBU; -. DR PDBsum; 1XPS; -. DR PDBsum; 1XPT; -. DR PDBsum; 1YMN; -. DR PDBsum; 1YMR; -. DR PDBsum; 1YMW; -. DR PDBsum; 1Z3L; -. DR PDBsum; 1Z3M; -. DR PDBsum; 1Z3P; -. DR PDBsum; 1Z6D; -. DR PDBsum; 1Z6S; -. DR PDBsum; 2AAS; -. DR PDBsum; 2APQ; -. DR PDBsum; 2BLP; -. DR PDBsum; 2BLZ; -. DR PDBsum; 2E33; -. DR PDBsum; 2E3W; -. DR PDBsum; 2G4W; -. DR PDBsum; 2G4X; -. DR PDBsum; 2G8Q; -. DR PDBsum; 2G8R; -. DR PDBsum; 2NUI; -. DR PDBsum; 2OP2; -. DR PDBsum; 2OQF; -. DR PDBsum; 2P42; -. DR PDBsum; 2P43; -. DR PDBsum; 2P44; -. DR PDBsum; 2P45; -. DR PDBsum; 2P46; -. DR PDBsum; 2P47; -. DR PDBsum; 2P48; -. DR PDBsum; 2P49; -. DR PDBsum; 2P4A; -. DR PDBsum; 2QCA; -. DR PDBsum; 2RAT; -. DR PDBsum; 2RLN; -. DR PDBsum; 2RNS; -. DR PDBsum; 2W5G; -. DR PDBsum; 2W5I; -. DR PDBsum; 2W5K; -. DR PDBsum; 2W5L; -. DR PDBsum; 2W5M; -. DR PDBsum; 2XOG; -. DR PDBsum; 2XOI; -. DR PDBsum; 3A1R; -. DR PDBsum; 3D6O; -. DR PDBsum; 3D6P; -. DR PDBsum; 3D6Q; -. DR PDBsum; 3D7B; -. DR PDBsum; 3D8Y; -. DR PDBsum; 3D8Z; -. DR PDBsum; 3DH5; -. DR PDBsum; 3DH6; -. DR PDBsum; 3DI7; -. DR PDBsum; 3DI8; -. DR PDBsum; 3DI9; -. DR PDBsum; 3DIB; -. DR PDBsum; 3DIC; -. DR PDBsum; 3DXG; -. DR PDBsum; 3DXH; -. DR PDBsum; 3EUX; -. DR PDBsum; 3EUY; -. DR PDBsum; 3EUZ; -. DR PDBsum; 3EV0; -. DR PDBsum; 3EV1; -. DR PDBsum; 3EV2; -. DR PDBsum; 3EV3; -. DR PDBsum; 3EV4; -. DR PDBsum; 3EV5; -. DR PDBsum; 3EV6; -. DR PDBsum; 3FKZ; -. DR PDBsum; 3FL0; -. DR PDBsum; 3FL1; -. DR PDBsum; 3FL3; -. DR PDBsum; 3I67; -. DR PDBsum; 3I6F; -. DR PDBsum; 3I6H; -. DR PDBsum; 3I6J; -. DR PDBsum; 3I7W; -. DR PDBsum; 3I7X; -. DR PDBsum; 3I7Y; -. DR PDBsum; 3JW1; -. DR PDBsum; 3LXO; -. DR PDBsum; 3MWQ; -. DR PDBsum; 3MWR; -. DR PDBsum; 3MX8; -. DR PDBsum; 3MZQ; -. DR PDBsum; 3MZR; -. DR PDBsum; 3OQY; -. DR PDBsum; 3OQZ; -. DR PDBsum; 3OR0; -. DR PDBsum; 3QL1; -. DR PDBsum; 3QL2; -. DR PDBsum; 3QSK; -. DR PDBsum; 3RAT; -. DR PDBsum; 3RH1; -. DR PDBsum; 3RID; -. DR PDBsum; 3RN3; -. DR PDBsum; 3RSD; -. DR PDBsum; 3RSK; -. DR PDBsum; 3RSP; -. DR PDBsum; 3SRN; -. DR PDBsum; 4AO1; -. DR PDBsum; 4G8V; -. DR PDBsum; 4G8Y; -. DR PDBsum; 4G90; -. DR PDBsum; 4J5Z; -. DR PDBsum; 4J60; -. DR PDBsum; 4J61; -. DR PDBsum; 4J62; -. DR PDBsum; 4J63; -. DR PDBsum; 4J64; -. DR PDBsum; 4J65; -. DR PDBsum; 4J66; -. DR PDBsum; 4J67; -. DR PDBsum; 4J68; -. DR PDBsum; 4J69; -. DR PDBsum; 4J6A; -. DR PDBsum; 4K7L; -. DR PDBsum; 4K7M; -. DR PDBsum; 4L55; -. DR PDBsum; 4MXF; -. DR PDBsum; 4O36; -. DR PDBsum; 4O37; -. DR PDBsum; 4OKF; -. DR PDBsum; 4OOH; -. DR PDBsum; 4OT4; -. DR PDBsum; 4PEQ; -. DR PDBsum; 4POU; -. DR PDBsum; 4QH3; -. DR PDBsum; 4RAT; -. DR PDBsum; 4RSD; -. DR PDBsum; 4RSK; -. DR PDBsum; 4RTE; -. DR PDBsum; 4S0Q; -. DR PDBsum; 4S18; -. DR PDBsum; 4SRN; -. DR PDBsum; 4WYN; -. DR PDBsum; 4WYP; -. DR PDBsum; 4WYZ; -. DR PDBsum; 4YGW; -. DR PDBsum; 4ZZ4; -. DR PDBsum; 5D6U; -. DR PDBsum; 5D97; -. DR PDBsum; 5E5E; -. DR PDBsum; 5E5F; -. DR PDBsum; 5ET4; -. DR PDBsum; 5JLG; -. DR PDBsum; 5JMG; -. DR PDBsum; 5JML; -. DR PDBsum; 5NA9; -. DR PDBsum; 5NJ7; -. DR PDBsum; 5OBC; -. DR PDBsum; 5OBD; -. DR PDBsum; 5OBE; -. DR PDBsum; 5OGH; -. DR PDBsum; 5OLD; -. DR PDBsum; 5RAT; -. DR PDBsum; 5RSA; -. DR PDBsum; 6ETK; -. DR PDBsum; 6ETL; -. DR PDBsum; 6ETM; -. DR PDBsum; 6ETN; -. DR PDBsum; 6ETO; -. DR PDBsum; 6ETP; -. DR PDBsum; 6ETQ; -. DR PDBsum; 6ETR; -. DR PDBsum; 6F60; -. DR PDBsum; 6GOK; -. DR PDBsum; 6PVU; -. DR PDBsum; 6PVV; -. DR PDBsum; 6PVW; -. DR PDBsum; 6PVX; -. DR PDBsum; 6QE9; -. DR PDBsum; 6RAT; -. DR PDBsum; 6RSA; -. DR PDBsum; 6XHC; -. DR PDBsum; 6XHD; -. DR PDBsum; 6XHE; -. DR PDBsum; 6XHF; -. DR PDBsum; 6XVX; -. DR PDBsum; 6XW0; -. DR PDBsum; 6YO1; -. DR PDBsum; 7P4R; -. DR PDBsum; 7P8R; -. DR PDBsum; 7PNI; -. DR PDBsum; 7Q75; -. DR PDBsum; 7Q76; -. DR PDBsum; 7Q77; -. DR PDBsum; 7Q78; -. DR PDBsum; 7Q79; -. DR PDBsum; 7Q7A; -. DR PDBsum; 7Q7B; -. DR PDBsum; 7QHR; -. DR PDBsum; 7QPW; -. DR PDBsum; 7QPY; -. DR PDBsum; 7QPZ; -. DR PDBsum; 7QQ0; -. DR PDBsum; 7QWH; -. DR PDBsum; 7R1P; -. DR PDBsum; 7RAT; -. DR PDBsum; 7RSA; -. DR PDBsum; 7Z6D; -. DR PDBsum; 7Z6G; -. DR PDBsum; 8OQC; -. DR PDBsum; 8OQD; -. DR PDBsum; 8OQE; -. DR PDBsum; 8OQF; -. DR PDBsum; 8OQG; -. DR PDBsum; 8PX0; -. DR PDBsum; 8R5V; -. DR PDBsum; 8RAT; -. DR PDBsum; 8RSA; -. DR PDBsum; 9RAT; -. DR PDBsum; 9RSA; -. DR AlphaFoldDB; P61823; -. DR BMRB; P61823; -. DR PCDDB; P61823; -. DR SASBDB; P61823; -. DR SMR; P61823; -. DR BioGRID; 159601; 1. DR DIP; DIP-36384N; -. DR IntAct; P61823; 7. DR MINT; P61823; -. DR STRING; 9913.ENSBTAP00000011586; -. DR BindingDB; P61823; -. DR ChEMBL; CHEMBL6091; -. DR DrugCentral; P61823; -. DR CarbonylDB; P61823; -. DR GlyConnect; 529; 26 N-Linked glycans (1 site). DR GlyCosmos; P61823; 5 sites, 22 glycans. DR PaxDb; 9913-ENSBTAP00000011586; -. DR PeptideAtlas; P61823; -. DR ABCD; P61823; 5 sequenced antibodies. DR Ensembl; ENSBTAT00000011586.5; ENSBTAP00000011586.4; ENSBTAG00000008793.5. DR GeneID; 282340; -. DR KEGG; bta:282340; -. DR VEuPathDB; HostDB:ENSBTAG00000008793; -. DR eggNOG; ENOG502SQ4K; Eukaryota. DR GeneTree; ENSGT00940000160869; -. DR HOGENOM; CLU_117006_0_0_1; -. DR InParanoid; P61823; -. DR OMA; ICHEAST; -. DR OrthoDB; 4596772at2759; -. DR TreeFam; TF333393; -. DR BRENDA; 4.6.1.18; 908. DR SABIO-RK; P61823; -. DR EvolutionaryTrace; P61823; -. DR PRO; PR:P61823; -. DR Proteomes; UP000009136; Chromosome 10. DR Bgee; ENSBTAG00000008793; Expressed in corpus epididymis and 92 other cell types or tissues. DR ExpressionAtlas; P61823; baseline and differential. DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. DR GO; GO:0016829; F:lyase activity; IEA:UniProtKB-KW. DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro. DR GO; GO:0004522; F:ribonuclease A activity; IEA:UniProtKB-EC. DR GO; GO:0004540; F:RNA nuclease activity; IBA:GO_Central. DR GO; GO:0050830; P:defense response to Gram-positive bacterium; IBA:GO_Central. DR CDD; cd06265; RNase_A_canonical; 1. DR Gene3D; 3.10.130.10; Ribonuclease A-like domain; 1. DR InterPro; IPR001427; RNaseA. DR InterPro; IPR036816; RNaseA-like_dom_sf. DR InterPro; IPR023411; RNaseA_AS. DR InterPro; IPR023412; RNaseA_domain. DR PANTHER; PTHR11437; RIBONUCLEASE; 1. DR PANTHER; PTHR11437:SF24; RIBONUCLEASE PANCREATIC; 1. DR Pfam; PF00074; RnaseA; 1. DR PRINTS; PR00794; RIBONUCLEASE. DR SMART; SM00092; RNAse_Pc; 1. DR SUPFAM; SSF54076; RNase A-like; 1. DR PROSITE; PS00127; RNASE_PANCREATIC; 1. PE 1: Evidence at protein level; KW 3D-structure; Direct protein sequencing; Disulfide bond; Endonuclease; KW Glycation; Glycoprotein; Hydrolase; Lyase; Nuclease; Reference proteome; KW Secreted; Signal. FT SIGNAL 1..26 FT /evidence="ECO:0000269|PubMed:13989651, FT ECO:0000269|PubMed:14235531" FT CHAIN 27..150 FT /note="Ribonuclease pancreatic" FT /id="PRO_0000030915" FT ACT_SITE 38 FT /note="Proton acceptor" FT ACT_SITE 145 FT /note="Proton donor" FT BINDING 33 FT /ligand="substrate" FT BINDING 36 FT /ligand="substrate" FT BINDING 67..71 FT /ligand="substrate" FT BINDING 92 FT /ligand="substrate" FT BINDING 111 FT /ligand="substrate" FT CARBOHYD 27 FT /note="N-linked (Glc) (glycation) lysine; in vitro" FT /evidence="ECO:0000269|PubMed:4030761" FT CARBOHYD 33 FT /note="N-linked (Glc) (glycation) lysine; in vitro" FT /evidence="ECO:0000269|PubMed:4030761" FT CARBOHYD 60 FT /note="N-linked (GlcNAc...) asparagine; partial" FT /evidence="ECO:0000269|PubMed:19358553" FT /id="CAR_000006" FT CARBOHYD 63 FT /note="N-linked (Glc) (glycation) lysine; in vitro" FT /evidence="ECO:0000269|PubMed:4030761" FT CARBOHYD 67 FT /note="N-linked (Glc) (glycation) lysine; in vitro" FT /evidence="ECO:0000269|PubMed:4030761" FT DISULFID 52..110 FT /evidence="ECO:0000269|PubMed:13989651" FT DISULFID 66..121 FT /evidence="ECO:0000269|PubMed:13989651" FT DISULFID 84..136 FT /evidence="ECO:0000269|PubMed:13989651" FT DISULFID 91..98 FT /evidence="ECO:0000269|PubMed:13989651" FT MUTAGEN 38 FT /note="H->A: Loss of activity." FT MUTAGEN 145 FT /note="H->A: Loss of activity." FT HELIX 30..38 FT /evidence="ECO:0007829|PDB:6ETK" FT STRAND 43..45 FT /evidence="ECO:0007829|PDB:1DY5" FT HELIX 48..50 FT /evidence="ECO:0007829|PDB:3FL0" FT HELIX 51..58 FT /evidence="ECO:0007829|PDB:6ETK" FT TURN 59..62 FT /evidence="ECO:0007829|PDB:6ETK" FT STRAND 63..65 FT /evidence="ECO:0007829|PDB:6ETK" FT STRAND 68..73 FT /evidence="ECO:0007829|PDB:6ETK" FT HELIX 77..81 FT /evidence="ECO:0007829|PDB:6ETK" FT HELIX 82..85 FT /evidence="ECO:0007829|PDB:6ETK" FT STRAND 86..89 FT /evidence="ECO:0007829|PDB:6ETK" FT STRAND 92..94 FT /evidence="ECO:0007829|PDB:3DH6" FT STRAND 98..100 FT /evidence="ECO:0007829|PDB:6ETK" FT STRAND 105..112 FT /evidence="ECO:0007829|PDB:6ETK" FT STRAND 118..120 FT /evidence="ECO:0007829|PDB:1YMN" FT STRAND 123..130 FT /evidence="ECO:0007829|PDB:6ETK" FT STRAND 132..137 FT /evidence="ECO:0007829|PDB:6ETK" FT TURN 138..141 FT /evidence="ECO:0007829|PDB:6ETK" FT STRAND 142..149 FT /evidence="ECO:0007829|PDB:6ETK" SQ SEQUENCE 150 AA; 16461 MW; 74E5DC61E679187D CRC64; MALKSLVLLS LLVLVLLLVR VQPSLGKETA AAKFERQHMD SSTSAASSSN YCNQMMKSRN LTKDRCKPVN TFVHESLADV QAVCSQKNVA CKNGQTNCYQ SYSTMSITDC RETGSSKYPN CAYKTTQANK HIIVACEGNP YVPVHFDASV //