P61822 (RNAS1_MIOTA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ribonuclease pancreatic
EC=3.1.27.5

Alternative name(s):
RNase 1
RNase A

Gene names

Name:	RNASE1
Synonyms:	RNS1

Organism

Miopithecus talapoin (Angolan talapoin) (Cercopithecus talapoin)

Taxonomic identifier

36231 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Cercopithecoidea › Cercopithecidae › Cercopithecinae › Miopithecus

Protein attributes

Sequence length	152 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Endonuclease that catalyzes the cleavage of RNA on the 3' side of pyrimidine nucleotides. Acts on single stranded and double stranded RNA By similarity.
Catalytic activity	Endonucleolytic cleavage to nucleoside 3'-phosphates and 3'-phosphooligonucleotides ending in Cp or Up with 2',3'-cyclic phosphate intermediates.
Subunit structure	Monomer. Interacts with and forms tight 1:1 complexes with RNH1. Dimerization of two such complexes may occur. Interaction with RNH1 inhibits this protein By similarity.
Subcellular location	Secreted By similarity.
Sequence similarities	Belongs to the pancreatic ribonuclease family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Endonuclease Hydrolase Nuclease
PTM	Disulfide bond Glycoprotein
Gene Ontology (GO)
Biological_process	nucleic acid phosphodiester bond hydrolysis Inferred from electronic annotation. Source: GOC
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	nucleic acid binding Inferred from electronic annotation. Source: InterPro pancreatic ribonuclease activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 24	24	By similarity
	Chain	25 – 152	128	Ribonuclease pancreatic		PRO_0000030928
Regions
	Region	65 – 69	5	Substrate binding By similarity
Sites
	Active site	36	1	Proton acceptor By similarity
	Active site	143	1	Proton donor By similarity
	Binding site	31	1	Substrate By similarity
	Binding site	34	1	Substrate By similarity
	Binding site	90	1	Substrate By similarity
	Binding site	109	1	Substrate By similarity
Amino acid modifications
	Glycosylation	46	1	N-linked (GlcNAc...) Potential
	Glycosylation	112	1	N-linked (GlcNAc...) Potential
	Disulfide bond	50 ↔ 108		By similarity
	Disulfide bond	64 ↔ 119		By similarity
	Disulfide bond	82 ↔ 134		By similarity
	Disulfide bond	89 ↔ 96		By similarity

Sequences

	Sequence		Length	Mass (Da)
	P61822 [UniParc]. Last modified June 7, 2004. Version 1. Checksum: BC946B77BC4DCB7D	FASTA	152	17,066
	10 20 30 40 50 60 MALDKSVILL PLLVLVLLVL GCLGRESRAK KFQRQHMDSG SSPSSNSTYC NQMMKRRSMT 70 80 90 100 110 120 QGRCKPVNTF VHEPLVDVQN VCFQEKVTCK NGQTNCFKSK SSMHITDCRL TNGSRYPNCA 130 140 150 YRTSPKERRI IVACEGSPYV PVHFDASVED ST

References

[1]	"Adaptive evolution of a duplicated pancreatic ribonuclease gene in a leaf-eating monkey." Zhang J., Zhang Y.-P., Rosenberg H.F. Nat. Genet. 30:411-415(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF449636 Genomic DNA. Translation: AAL87057.1.
3D structure databases
ProteinModelPortal	P61822.
SMR	P61822. Positions 25-151.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOVERGEN	HBG008396.
Family and domain databases
Gene3D	3.10.130.10. 1 hit.
InterPro	IPR001427. RNaseA. IPR023411. RNaseA_AS. IPR023412. RNaseA_domain. [Graphical view]
PANTHER	PTHR11437. PTHR11437. 1 hit.
Pfam	PF00074. RnaseA. 1 hit. [Graphical view]
PRINTS	PR00794. RIBONUCLEASE.
ProDom	PD000535. RNaseA. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00092. RNAse_Pc. 1 hit. [Graphical view]
SUPFAM	SSF54076. RNaseA. 1 hit.
PROSITE	PS00127. RNASE_PANCREATIC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

RNAS1_MIOTA

Accession

Primary (citable) accession number: P61822
Secondary accession number(s): Q8SPF2

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 7, 2004
Last sequence update:	June 7, 2004
Last modified:	April 3, 2013
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program