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Protein

C-C chemokine receptor type 5

Gene

CCR5

Organism
Macaca mulatta (Rhesus macaque)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
C-C chemokine receptor type 5
Short name:
C-C CKR-5
Short name:
CC-CKR-5
Short name:
CCR-5
Short name:
CCR5
Alternative name(s):
CD_antigen: CD195
Gene namesi
Name:CCR5
Synonyms:CMKBR5
OrganismiMacaca mulatta (Rhesus macaque)
Taxonomic identifieri9544 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
Proteomesi
  • UP000006718 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 30ExtracellularSequence analysisAdd BLAST30
Transmembranei31 – 58Helical; Name=1Sequence analysisAdd BLAST28
Topological domaini59 – 68CytoplasmicSequence analysis10
Transmembranei69 – 89Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini90 – 102ExtracellularSequence analysisAdd BLAST13
Transmembranei103 – 124Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini125 – 141CytoplasmicSequence analysisAdd BLAST17
Transmembranei142 – 166Helical; Name=4Sequence analysisAdd BLAST25
Topological domaini167 – 198ExtracellularSequence analysisAdd BLAST32
Transmembranei199 – 218Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini219 – 235CytoplasmicSequence analysisAdd BLAST17
Transmembranei236 – 260Helical; Name=6Sequence analysisAdd BLAST25
Topological domaini261 – 277ExtracellularSequence analysisAdd BLAST17
Transmembranei278 – 301Helical; Name=7Sequence analysisAdd BLAST24
Topological domaini302 – 352CytoplasmicSequence analysisAdd BLAST51

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3217397.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000692641 – 352C-C chemokine receptor type 5Add BLAST352

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei3SulfotyrosineBy similarity1
Glycosylationi6O-linked (GalNAc...)By similarity1
Glycosylationi7O-linked (GalNAc...)Curated1
Modified residuei10SulfotyrosineSequence analysis1
Modified residuei14SulfotyrosineSequence analysis1
Modified residuei15SulfotyrosineSequence analysis1
Glycosylationi16O-linked (GalNAc...)Sequence analysis1
Glycosylationi17O-linked (GalNAc...)Sequence analysis1
Disulfide bondi101 ↔ 178PROSITE-ProRule annotation
Lipidationi321S-palmitoyl cysteineBy similarity1
Lipidationi323S-palmitoyl cysteineBy similarity1
Lipidationi324S-palmitoyl cysteineBy similarity1
Modified residuei336Phosphoserine; by BARK1By similarity1
Modified residuei337Phosphoserine; by BARK1By similarity1
Modified residuei342Phosphoserine; by BARK1By similarity1
Modified residuei349Phosphoserine; by BARK1By similarity1

Post-translational modificationi

Sulfated on at least 2 of the N-terminal tyrosines. Sulfation is required for efficient binding of the chemokines, CCL3 and CCL4 (By similarity).By similarity
O-glycosylated, but not N-glycosylated. Ser-6 appears to be the major site. Also sialylated glycans present which contribute to chemokine binding. Thr-16 and Ser-17 may also be glycosylated and, if so, with small moieties such as a T-antigen (By similarity).By similarity
Palmitoylation in the C-terminal is important for cell surface expression.By similarity
Phosphorylation on serine residues in the C-terminal is stimulated by binding CC chemokines especially by APO-RANTES.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein, Sulfation

Interactioni

Subunit structurei

Interacts with PRAF2. Efficient ligand binding to CCL3/MIP-1alpha and CCL4/MIP-1beta requires sulfation, O-glycosylation and sialic acid modifications. Glycosylation on Ser-6 is required for efficient binding of CCL4. Interacts with GRK2. Interacts with ARRB1 and ARRB2. Interacts with CNIH4.By similarity

Structurei

3D structure databases

ProteinModelPortaliP61813.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG106917.
InParanoidiP61813.
KOiK04180.

Family and domain databases

InterProiIPR002240. Chemokine_CCR5.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00657. CCCHEMOKINER.
PR01110. CHEMOKINER5.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P61813-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDYQVSSPTY DIDYYTSEPC QKINVKQIAA RLLPPLYSLV FIFGFVGNIL
60 70 80 90 100
VVLILINCKR LKSMTDIYLL NLAISDLLFL LTVPFWAHYA AAQWDFGNTM
110 120 130 140 150
CQLLTGLYFI GFFSGIFFII LLTIDRYLAI VHAVFALKAR TVTFGVVTSV
160 170 180 190 200
ITWVVAVFAS LPGIIFTRSQ REGLHYTCSS HFPYSQYQFW KNFQTLKMVI
210 220 230 240 250
LGLVLPLLVM VICYSGILKT LLRCRNEKKR HRAVRLIFTI MIVYFLFWAP
260 270 280 290 300
YNIVLLLNTF QEFFGLNNCS SSNRLDQAMQ VTETLGMTHC CINPIIYAFV
310 320 330 340 350
GEKFRNYLLV FFQKHIAKRF CKCCSIFQQE APERASSVYT RSTGEQEISV

GL
Length:352
Mass (Da):40,507
Last modified:June 7, 2004 - v1
Checksum:i58B96C85909FACB2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti241M → I in AAC34132 (PubMed:11461684).Curated1
Sequence conflicti292I → M in AAC34132 (PubMed:11461684).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U77672 Genomic DNA. Translation: AAC51109.1.
U73739 mRNA. Translation: AAC51158.1.
U96762 mRNA. Translation: AAC34132.1.
AF005662 Genomic DNA. Translation: AAB62556.1.
RefSeqiNP_001036238.2. NM_001042773.3.
NP_001296331.1. NM_001309402.1.
UniGeneiMmu.3440.
Mmu.36443.

Genome annotation databases

GeneIDi735311.
KEGGimcc:735311.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U77672 Genomic DNA. Translation: AAC51109.1.
U73739 mRNA. Translation: AAC51158.1.
U96762 mRNA. Translation: AAC34132.1.
AF005662 Genomic DNA. Translation: AAB62556.1.
RefSeqiNP_001036238.2. NM_001042773.3.
NP_001296331.1. NM_001309402.1.
UniGeneiMmu.3440.
Mmu.36443.

3D structure databases

ProteinModelPortaliP61813.
ModBaseiSearch...
MobiDBiSearch...

Chemistry databases

ChEMBLiCHEMBL3217397.

Protein family/group databases

GPCRDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi735311.
KEGGimcc:735311.

Organism-specific databases

CTDi1234.

Phylogenomic databases

HOVERGENiHBG106917.
InParanoidiP61813.
KOiK04180.

Family and domain databases

InterProiIPR002240. Chemokine_CCR5.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00657. CCCHEMOKINER.
PR01110. CHEMOKINER5.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCCR5_MACMU
AccessioniPrimary (citable) accession number: P61813
Secondary accession number(s): O02746, P79436
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: June 7, 2004
Last modified: November 2, 2016
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.