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P61807

- SNN_MOUSE

UniProt

P61807 - SNN_MOUSE

Protein

Stannin

Gene

Snn

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Plays a role in the toxic effects of organotins.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Stannin
    Gene namesi
    Name:Snn
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 16

    Organism-specific databases

    MGIiMGI:1276549. Snn.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial outer membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion outer membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 8888StanninPRO_0000072015Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei49 – 491Phosphoserine1 Publication
    Modified residuei83 – 831Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiP61807.

    PTM databases

    PhosphoSiteiP61807.

    Expressioni

    Gene expression databases

    ArrayExpressiP61807.
    BgeeiP61807.
    CleanExiMM_SNN.
    GenevestigatoriP61807.

    Interactioni

    Subunit structurei

    Monomer.By similarity

    Protein-protein interaction databases

    IntActiP61807. 1 interaction.
    MINTiMINT-7997209.

    Structurei

    3D structure databases

    ProteinModelPortaliP61807.
    SMRiP61807. Positions 1-88.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1010Mitochondrial intermembraneBy similarity
    Topological domaini32 – 8857CytoplasmicBy similarityAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei11 – 3121HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the stannin family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG47301.
    HOGENOMiHOG000261688.
    HOVERGENiHBG017824.
    InParanoidiP61807.
    OMAiYSARGPC.
    OrthoDBiEOG7N8ZZJ.
    PhylomeDBiP61807.
    TreeFamiTF336244.

    Family and domain databases

    Gene3Di4.10.280.20. 1 hit.
    InterProiIPR015137. SNN_cytoplasm.
    IPR015136. SNN_linker.
    IPR015135. SNN_transmemb.
    IPR027435. Stannin.
    [Graphical view]
    PfamiPF09051. SNN_cytoplasm. 1 hit.
    PF09050. SNN_linker. 1 hit.
    PF09049. SNN_transmemb. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P61807-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSIMDHSPTT GVVTVIVILI AIAALGALIL GCWCYLRLQR ISQSEDEESI   50
    VGDGETKEPF LLVQYSAKGP CVERKAKLMT ANSPEVHG 88
    Length:88
    Mass (Da):9,501
    Last modified:June 7, 2004 - v1
    Checksum:iEB8DA73323D816C5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF030522 Genomic DNA. Translation: AAC28428.1.
    BC017685 mRNA. Translation: AAH17685.1.
    BC063027 mRNA. Translation: AAH63027.1.
    CCDSiCCDS37255.1.
    RefSeqiNP_033249.1. NM_009223.3.
    XP_006521943.1. XM_006521880.1.
    UniGeneiMm.325800.

    Genome annotation databases

    EnsembliENSMUST00000089011; ENSMUSP00000086405; ENSMUSG00000037972.
    GeneIDi20621.
    KEGGimmu:20621.
    UCSCiuc007yeq.3. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF030522 Genomic DNA. Translation: AAC28428.1 .
    BC017685 mRNA. Translation: AAH17685.1 .
    BC063027 mRNA. Translation: AAH63027.1 .
    CCDSi CCDS37255.1.
    RefSeqi NP_033249.1. NM_009223.3.
    XP_006521943.1. XM_006521880.1.
    UniGenei Mm.325800.

    3D structure databases

    ProteinModelPortali P61807.
    SMRi P61807. Positions 1-88.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P61807. 1 interaction.
    MINTi MINT-7997209.

    PTM databases

    PhosphoSitei P61807.

    Proteomic databases

    PRIDEi P61807.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000089011 ; ENSMUSP00000086405 ; ENSMUSG00000037972 .
    GeneIDi 20621.
    KEGGi mmu:20621.
    UCSCi uc007yeq.3. mouse.

    Organism-specific databases

    CTDi 8303.
    MGIi MGI:1276549. Snn.

    Phylogenomic databases

    eggNOGi NOG47301.
    HOGENOMi HOG000261688.
    HOVERGENi HBG017824.
    InParanoidi P61807.
    OMAi YSARGPC.
    OrthoDBi EOG7N8ZZJ.
    PhylomeDBi P61807.
    TreeFami TF336244.

    Miscellaneous databases

    ChiTaRSi SNN. mouse.
    NextBioi 299013.
    PROi P61807.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P61807.
    Bgeei P61807.
    CleanExi MM_SNN.
    Genevestigatori P61807.

    Family and domain databases

    Gene3Di 4.10.280.20. 1 hit.
    InterProi IPR015137. SNN_cytoplasm.
    IPR015136. SNN_linker.
    IPR015135. SNN_transmemb.
    IPR027435. Stannin.
    [Graphical view ]
    Pfami PF09051. SNN_cytoplasm. 1 hit.
    PF09050. SNN_linker. 1 hit.
    PF09049. SNN_transmemb. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Chromosomal localization and characterization of the stannin (Snn) gene."
      Dejneka N.S., Polavarapu R., Deng X., Martin-Deleon P.A., Billingsley M.L.
      Mamm. Genome 9:556-564(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Kidney and Mammary tumor.
    3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-49 AND SER-83, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic brain.

    Entry informationi

    Entry nameiSNN_MOUSE
    AccessioniPrimary (citable) accession number: P61807
    Secondary accession number(s): O88369
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 7, 2004
    Last sequence update: June 7, 2004
    Last modified: October 1, 2014
    This is version 77 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3