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Protein

Stannin

Gene

Snn

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in the toxic effects of organotins (By similarity). Plays a role in endosomal maturation (PubMed:27015288).By similarity1 Publication

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Recommended name:
Stannin
Gene namesi
Name:Snn
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:1276549 Snn

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 10Mitochondrial intermembraneBy similarity10
Transmembranei11 – 31HelicalSequence analysisAdd BLAST21
Topological domaini32 – 88CytoplasmicBy similarityAdd BLAST57

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000720151 – 88StanninAdd BLAST88

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei49PhosphoserineCombined sources1
Modified residuei83PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP61807
PRIDEiP61807

PTM databases

iPTMnetiP61807
PhosphoSitePlusiP61807
SwissPalmiP61807

Expressioni

Gene expression databases

BgeeiENSMUSG00000037972
CleanExiMM_SNN
ExpressionAtlasiP61807 baseline and differential
GenevisibleiP61807 MM

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

IntActiP61807, 1 interactor
MINTiP61807

Structurei

3D structure databases

ProteinModelPortaliP61807
SMRiP61807
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the stannin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IYFC Eukaryota
ENOG4111TD3 LUCA
GeneTreeiENSGT00390000009447
HOGENOMiHOG000261688
HOVERGENiHBG017824
InParanoidiP61807
OMAiYSARGPC
OrthoDBiEOG091G16Q5
PhylomeDBiP61807
TreeFamiTF336244

Family and domain databases

Gene3Di4.10.280.20, 1 hit
InterProiView protein in InterPro
IPR015137 SNN_cytoplasm
IPR015136 SNN_linker
IPR015135 SNN_transmemb
IPR027435 Stannin_sf
PfamiView protein in Pfam
PF09051 SNN_cytoplasm, 1 hit
PF09050 SNN_linker, 1 hit
PF09049 SNN_transmemb, 1 hit

Sequencei

Sequence statusi: Complete.

P61807-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSIMDHSPTT GVVTVIVILI AIAALGALIL GCWCYLRLQR ISQSEDEESI
60 70 80
VGDGETKEPF LLVQYSAKGP CVERKAKLMT ANSPEVHG
Length:88
Mass (Da):9,501
Last modified:June 7, 2004 - v1
Checksum:iEB8DA73323D816C5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF030522 Genomic DNA Translation: AAC28428.1
BC017685 mRNA Translation: AAH17685.1
BC063027 mRNA Translation: AAH63027.1
CCDSiCCDS37255.1
RefSeqiNP_033249.1, NM_009223.3
XP_006521943.1, XM_006521880.1
UniGeneiMm.325800

Genome annotation databases

EnsembliENSMUST00000089011; ENSMUSP00000086405; ENSMUSG00000037972
GeneIDi20621
KEGGimmu:20621
UCSCiuc007yeq.3 mouse

Similar proteinsi

Entry informationi

Entry nameiSNN_MOUSE
AccessioniPrimary (citable) accession number: P61807
Secondary accession number(s): O88369
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: June 7, 2004
Last modified: April 25, 2018
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health