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Protein

Stannin

Gene

Snn

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in the toxic effects of organotins.

Names & Taxonomyi

Protein namesi
Recommended name:
Stannin
Gene namesi
Name:Snn
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 16

Organism-specific databases

MGIiMGI:1276549. Snn.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1010Mitochondrial intermembraneBy similarity
Transmembranei11 – 3121HelicalSequence AnalysisAdd
BLAST
Topological domaini32 – 8857CytoplasmicBy similarityAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial outer membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 8888StanninPRO_0000072015Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei49 – 491Phosphoserine1 Publication
Modified residuei83 – 831Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP61807.
PRIDEiP61807.

PTM databases

PhosphoSiteiP61807.

Expressioni

Gene expression databases

BgeeiP61807.
CleanExiMM_SNN.
ExpressionAtlasiP61807. baseline and differential.
GenevestigatoriP61807.

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

IntActiP61807. 1 interaction.
MINTiMINT-7997209.

Structurei

3D structure databases

ProteinModelPortaliP61807.
SMRiP61807. Positions 1-88.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the stannin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG47301.
HOGENOMiHOG000261688.
HOVERGENiHBG017824.
InParanoidiP61807.
OMAiYSARGPC.
OrthoDBiEOG7N8ZZJ.
PhylomeDBiP61807.
TreeFamiTF336244.

Family and domain databases

Gene3Di4.10.280.20. 1 hit.
InterProiIPR015137. SNN_cytoplasm.
IPR015136. SNN_linker.
IPR015135. SNN_transmemb.
IPR027435. Stannin.
[Graphical view]
PfamiPF09051. SNN_cytoplasm. 1 hit.
PF09050. SNN_linker. 1 hit.
PF09049. SNN_transmemb. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P61807-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSIMDHSPTT GVVTVIVILI AIAALGALIL GCWCYLRLQR ISQSEDEESI
60 70 80
VGDGETKEPF LLVQYSAKGP CVERKAKLMT ANSPEVHG
Length:88
Mass (Da):9,501
Last modified:June 7, 2004 - v1
Checksum:iEB8DA73323D816C5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF030522 Genomic DNA. Translation: AAC28428.1.
BC017685 mRNA. Translation: AAH17685.1.
BC063027 mRNA. Translation: AAH63027.1.
CCDSiCCDS37255.1.
RefSeqiNP_033249.1. NM_009223.3.
XP_006521943.1. XM_006521880.1.
UniGeneiMm.325800.

Genome annotation databases

EnsembliENSMUST00000089011; ENSMUSP00000086405; ENSMUSG00000037972.
GeneIDi20621.
KEGGimmu:20621.
UCSCiuc007yeq.3. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF030522 Genomic DNA. Translation: AAC28428.1.
BC017685 mRNA. Translation: AAH17685.1.
BC063027 mRNA. Translation: AAH63027.1.
CCDSiCCDS37255.1.
RefSeqiNP_033249.1. NM_009223.3.
XP_006521943.1. XM_006521880.1.
UniGeneiMm.325800.

3D structure databases

ProteinModelPortaliP61807.
SMRiP61807. Positions 1-88.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP61807. 1 interaction.
MINTiMINT-7997209.

PTM databases

PhosphoSiteiP61807.

Proteomic databases

MaxQBiP61807.
PRIDEiP61807.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000089011; ENSMUSP00000086405; ENSMUSG00000037972.
GeneIDi20621.
KEGGimmu:20621.
UCSCiuc007yeq.3. mouse.

Organism-specific databases

CTDi8303.
MGIiMGI:1276549. Snn.

Phylogenomic databases

eggNOGiNOG47301.
HOGENOMiHOG000261688.
HOVERGENiHBG017824.
InParanoidiP61807.
OMAiYSARGPC.
OrthoDBiEOG7N8ZZJ.
PhylomeDBiP61807.
TreeFamiTF336244.

Miscellaneous databases

ChiTaRSiSnn. mouse.
NextBioi299013.
PROiP61807.
SOURCEiSearch...

Gene expression databases

BgeeiP61807.
CleanExiMM_SNN.
ExpressionAtlasiP61807. baseline and differential.
GenevestigatoriP61807.

Family and domain databases

Gene3Di4.10.280.20. 1 hit.
InterProiIPR015137. SNN_cytoplasm.
IPR015136. SNN_linker.
IPR015135. SNN_transmemb.
IPR027435. Stannin.
[Graphical view]
PfamiPF09051. SNN_cytoplasm. 1 hit.
PF09050. SNN_linker. 1 hit.
PF09049. SNN_transmemb. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Chromosomal localization and characterization of the stannin (Snn) gene."
    Dejneka N.S., Polavarapu R., Deng X., Martin-Deleon P.A., Billingsley M.L.
    Mamm. Genome 9:556-564(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Kidney and Mammary tumor.
  3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-49 AND SER-83, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic brain.

Entry informationi

Entry nameiSNN_MOUSE
AccessioniPrimary (citable) accession number: P61807
Secondary accession number(s): O88369
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: June 7, 2004
Last modified: January 7, 2015
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.