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P61794 (LPAR1_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Lysophosphatidic acid receptor 1

Short name=LPA receptor 1
Short name=LPA-1
Alternative name(s):
Lysophosphatidic acid receptor Edg-2
Gene names
Name:Lpar1
Synonyms:Edg2, Gpcr91, Lpa1
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length364 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Seems to be coupled to the G(i)/G(o), G12/G13, and G(q) families of heteromeric G proteins. Stimulates phospholipase C (PLC) activity in a manner that is dependent on RALA activation By similarity.

Subunit structure

Interacts with RALA and ADRBK1 By similarity.

Subcellular location

Cell surface By similarity. Cell membrane; Multi-pass membrane protein. Note: Prior to LPA treatment found predominantly at the cell surface but in the presence of LPA co-localizes with RALA in the endocytic vesicles By similarity.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
   Cellular componentCell membrane
Membrane
   DomainTransmembrane
Transmembrane helix
   Molecular functionG-protein coupled receptor
Receptor
Transducer
   PTMGlycoprotein
Lipoprotein
Palmitate
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processG-protein coupled receptor signaling pathway

Inferred from mutant phenotype PubMed 16504475. Source: RGD

activation of MAPK activity

Inferred from electronic annotation. Source: Ensembl

bleb assembly

Inferred from electronic annotation. Source: Ensembl

cellular response to oxygen levels

Inferred from expression pattern PubMed 18978343. Source: RGD

myelination

Inferred from expression pattern PubMed 10384882. Source: RGD

negative regulation of neuron projection development

Inferred from mutant phenotype PubMed 18978343. Source: RGD

neurogenesis

Inferred from expression pattern Ref.1. Source: RGD

positive regulation of I-kappaB kinase/NF-kappaB signaling

Inferred from electronic annotation. Source: Ensembl

positive regulation of Rho protein signal transduction

Inferred from electronic annotation. Source: Ensembl

positive regulation of apoptotic process

Inferred from mutant phenotype PubMed 16890224. Source: RGD

positive regulation of cell death

Inferred from mutant phenotype PubMed 18978343. Source: RGD

positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway

Inferred from direct assay PubMed 16242672. Source: RGD

positive regulation of dendritic spine development

Inferred from direct assay PubMed 16638019. Source: RGD

positive regulation of smooth muscle cell chemotaxis

Inferred from mutant phenotype PubMed 19742132. Source: RGD

   Cellular_componentcell surface

Inferred from sequence or structural similarity. Source: UniProtKB

cytoplasm

Inferred from direct assay PubMed 18978343. Source: RGD

dendritic shaft

Inferred from direct assay PubMed 16638019. Source: RGD

dendritic spine

Inferred from direct assay PubMed 16638019. Source: RGD

endocytic vesicle

Inferred from electronic annotation. Source: Ensembl

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from direct assay PubMed 18978343. Source: RGD

   Molecular_functionG-protein alpha-subunit binding

Inferred from mutant phenotype PubMed 16504475. Source: RGD

G-protein coupled receptor activity

Traceable author statement PubMed 12123830. Source: RGD

lysophosphatidic acid receptor activity

Inferred from electronic annotation. Source: InterPro

phospholipid binding

Inferred from direct assay PubMed 16242672. Source: RGD

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 364364Lysophosphatidic acid receptor 1
PRO_0000069419

Regions

Topological domain1 – 5050Extracellular Potential
Transmembrane51 – 7525Helical; Name=1; Potential
Topological domain76 – 827Cytoplasmic Potential
Transmembrane83 – 11129Helical; Name=2; Potential
Topological domain112 – 12514Extracellular Potential
Transmembrane126 – 14419Helical; Name=3; Potential
Topological domain145 – 16319Cytoplasmic Potential
Transmembrane164 – 18926Helical; Name=4; Potential
Topological domain190 – 20516Extracellular Potential
Transmembrane206 – 22621Helical; Name=5; Potential
Topological domain227 – 25832Cytoplasmic Potential
Transmembrane259 – 28022Helical; Name=6; Potential
Topological domain281 – 29414Extracellular Potential
Transmembrane295 – 31521Helical; Name=7; Potential
Topological domain316 – 36449Cytoplasmic Potential

Amino acid modifications

Lipidation3271S-palmitoyl cysteine By similarity
Glycosylation271N-linked (GlcNAc...) Potential
Glycosylation351N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
P61794 [UniParc].

Last modified June 7, 2004. Version 1.
Checksum: B0FA6265AA6688B7

FASTA36441,119
        10         20         30         40         50         60 
MAAASTSSPV ISQPQFTAMN EQQCFYNESI AFFYNRSGKY LATEWNTVSK LVMGLGITVC 

        70         80         90        100        110        120 
VFIMLANLLV MVAIYVNRRF HFPIYYLMAN LAAADFFAGL AYFYLMFNTG PNTRRLTVST 

       130        140        150        160        170        180 
WLLRQGLIDT SLTASVANLL AIAIERHITV FRMQLHTRMS NRRVVVVIVV IWTMAIVMGA 

       190        200        210        220        230        240 
IPSVGWNCIC DIDHCSNMAP LYSDSYLVFW AIFNLVTFVV MVVLYAHIFG YVRQRTMRMS 

       250        260        270        280        290        300 
RHSSGPRRNR DTMMSLLKTV VIVLGAFIVC WTPGLVLLLL DVCCPQCDVL AYEKFFLLLA 

       310        320        330        340        350        360 
EFNSAMNPII YSYRDKEMSA TFRQILCCQR NENPNGPTEG SDRSASSLNH TILAGVHSND 


HSVV 

« Hide

References

« Hide 'large scale' references
[1]"A rat G protein-coupled receptor selectively expressed in myelin-forming cells."
Allard J., Barron S., Diaz J., Lubetzki C., Zalc B., Schwartz J.-C., Sokoloff P.
Eur. J. Neurosci. 10:1045-1053(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Sprague-Dawley.
Tissue: Olfactory bulb.
[2]"Identification and characterization of novel G-protein coupled receptors expressed in regenerating peripheral nerve."
Carroll S.L., Miller M.L., Benedict-Hamilton H.M.
Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Sprague-Dawley.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF014418 mRNA. Translation: AAB86381.1.
AF090347 mRNA. Translation: AAG24469.1.
BC089227 mRNA. Translation: AAH89227.1.
RefSeqNP_446388.1. NM_053936.3.
XP_006238257.1. XM_006238195.1.
XP_006238258.1. XM_006238196.1.
XP_006238259.1. XM_006238197.1.
XP_006238260.1. XM_006238198.1.
XP_006238261.1. XM_006238199.1.
XP_006238262.1. XM_006238200.1.
XP_006238263.1. XM_006238201.1.
UniGeneRn.11200.

3D structure databases

ProteinModelPortalP61794.
SMRP61794. Positions 34-326.
ModBaseSearch...
MobiDBSearch...

Chemistry

BindingDBP61794.
ChEMBLCHEMBL4595.
GuidetoPHARMACOLOGY272.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteP61794.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000044348; ENSRNOP00000043652; ENSRNOG00000013656.
GeneID116744.
KEGGrno:116744.
UCSCRGD:620563. rat.

Organism-specific databases

CTD1902.
RGD620563. Lpar1.

Phylogenomic databases

eggNOGNOG274798.
GeneTreeENSGT00740000115422.
HOGENOMHOG000233501.
HOVERGENHBG103071.
InParanoidP61794.
KOK04289.
OMAPQCFYNE.
OrthoDBEOG7HTHH1.
PhylomeDBP61794.
TreeFamTF330052.

Gene expression databases

ArrayExpressP61794.
GenevestigatorP61794.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR004065. LPA_rcpt.
IPR002277. LPA_rcpt_EDG2.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR01148. EDG2RECEPTOR.
PR00237. GPCRRHODOPSN.
PR01527. LPARECEPTOR.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio286803.
PROP61794.

Entry information

Entry nameLPAR1_RAT
AccessionPrimary (citable) accession number: P61794
Secondary accession number(s): O88584 expand/collapse secondary AC list , P56487, P70420, Q5FWS2, Q61130
Entry history
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: June 7, 2004
Last modified: April 16, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries