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P61794

- LPAR1_RAT

UniProt

P61794 - LPAR1_RAT

Protein

Lysophosphatidic acid receptor 1

Gene

Lpar1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 1 (07 Jun 2004)
      Previous versions | rss
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    Functioni

    Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Seems to be coupled to the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Stimulates phospholipase C (PLC) activity in a manner that is dependent on RALA activation By similarity.By similarity

    GO - Molecular functioni

    1. G-protein alpha-subunit binding Source: RGD
    2. G-protein coupled receptor activity Source: RGD
    3. lysophosphatidic acid receptor activity Source: InterPro
    4. phospholipid binding Source: RGD

    GO - Biological processi

    1. activation of MAPK activity Source: Ensembl
    2. bleb assembly Source: Ensembl
    3. cellular response to oxygen levels Source: RGD
    4. G-protein coupled receptor signaling pathway Source: RGD
    5. myelination Source: RGD
    6. negative regulation of neuron projection development Source: RGD
    7. neurogenesis Source: RGD
    8. positive regulation of apoptotic process Source: RGD
    9. positive regulation of cell death Source: RGD
    10. positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway Source: RGD
    11. positive regulation of dendritic spine development Source: RGD
    12. positive regulation of I-kappaB kinase/NF-kappaB signaling Source: Ensembl
    13. positive regulation of Rho protein signal transduction Source: Ensembl
    14. positive regulation of smooth muscle cell chemotaxis Source: RGD

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lysophosphatidic acid receptor 1
    Short name:
    LPA receptor 1
    Short name:
    LPA-1
    Alternative name(s):
    Lysophosphatidic acid receptor Edg-2
    Gene namesi
    Name:Lpar1
    Synonyms:Edg2, Gpcr91, Lpa1
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 5

    Organism-specific databases

    RGDi620563. Lpar1.

    Subcellular locationi

    Cell surface By similarity. Cell membrane; Multi-pass membrane protein
    Note: Prior to LPA treatment found predominantly at the cell surface but in the presence of LPA co-localizes with RALA in the endocytic vesicles.By similarity

    GO - Cellular componenti

    1. cell surface Source: UniProtKB
    2. cytoplasm Source: RGD
    3. dendritic shaft Source: RGD
    4. dendritic spine Source: RGD
    5. endocytic vesicle Source: Ensembl
    6. integral component of membrane Source: UniProtKB-KW
    7. plasma membrane Source: RGD

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 364364Lysophosphatidic acid receptor 1PRO_0000069419Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi27 – 271N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi35 – 351N-linked (GlcNAc...)Sequence Analysis
    Lipidationi327 – 3271S-palmitoyl cysteineBy similarity

    Keywords - PTMi

    Glycoprotein, Lipoprotein, Palmitate

    PTM databases

    PhosphoSiteiP61794.

    Expressioni

    Gene expression databases

    ArrayExpressiP61794.
    GenevestigatoriP61794.

    Interactioni

    Subunit structurei

    Interacts with RALA and ADRBK1.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP61794.
    SMRiP61794. Positions 34-326.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 5050ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini76 – 827CytoplasmicSequence Analysis
    Topological domaini112 – 12514ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini145 – 16319CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini190 – 20516ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini227 – 25832CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini281 – 29414ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini316 – 36449CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei51 – 7525Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei83 – 11129Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei126 – 14419Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei164 – 18926Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei206 – 22621Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei259 – 28022Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei295 – 31521Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG274798.
    GeneTreeiENSGT00740000115422.
    HOGENOMiHOG000233501.
    HOVERGENiHBG103071.
    InParanoidiP61794.
    KOiK04289.
    OMAiPQCFYNE.
    OrthoDBiEOG7HTHH1.
    PhylomeDBiP61794.
    TreeFamiTF330052.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR004065. LPA_rcpt.
    IPR002277. LPA_rcpt_EDG2.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR01148. EDG2RECEPTOR.
    PR00237. GPCRRHODOPSN.
    PR01527. LPARECEPTOR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P61794-1 [UniParc]FASTAAdd to Basket

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    MAAASTSSPV ISQPQFTAMN EQQCFYNESI AFFYNRSGKY LATEWNTVSK    50
    LVMGLGITVC VFIMLANLLV MVAIYVNRRF HFPIYYLMAN LAAADFFAGL 100
    AYFYLMFNTG PNTRRLTVST WLLRQGLIDT SLTASVANLL AIAIERHITV 150
    FRMQLHTRMS NRRVVVVIVV IWTMAIVMGA IPSVGWNCIC DIDHCSNMAP 200
    LYSDSYLVFW AIFNLVTFVV MVVLYAHIFG YVRQRTMRMS RHSSGPRRNR 250
    DTMMSLLKTV VIVLGAFIVC WTPGLVLLLL DVCCPQCDVL AYEKFFLLLA 300
    EFNSAMNPII YSYRDKEMSA TFRQILCCQR NENPNGPTEG SDRSASSLNH 350
    TILAGVHSND HSVV 364
    Length:364
    Mass (Da):41,119
    Last modified:June 7, 2004 - v1
    Checksum:iB0FA6265AA6688B7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF014418 mRNA. Translation: AAB86381.1.
    AF090347 mRNA. Translation: AAG24469.1.
    BC089227 mRNA. Translation: AAH89227.1.
    RefSeqiNP_446388.1. NM_053936.3.
    XP_006238257.1. XM_006238195.1.
    XP_006238258.1. XM_006238196.1.
    XP_006238259.1. XM_006238197.1.
    XP_006238260.1. XM_006238198.1.
    XP_006238261.1. XM_006238199.1.
    XP_006238262.1. XM_006238200.1.
    XP_006238263.1. XM_006238201.1.
    UniGeneiRn.11200.

    Genome annotation databases

    EnsembliENSRNOT00000044348; ENSRNOP00000043652; ENSRNOG00000013656.
    GeneIDi116744.
    KEGGirno:116744.
    UCSCiRGD:620563. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF014418 mRNA. Translation: AAB86381.1 .
    AF090347 mRNA. Translation: AAG24469.1 .
    BC089227 mRNA. Translation: AAH89227.1 .
    RefSeqi NP_446388.1. NM_053936.3.
    XP_006238257.1. XM_006238195.1.
    XP_006238258.1. XM_006238196.1.
    XP_006238259.1. XM_006238197.1.
    XP_006238260.1. XM_006238198.1.
    XP_006238261.1. XM_006238199.1.
    XP_006238262.1. XM_006238200.1.
    XP_006238263.1. XM_006238201.1.
    UniGenei Rn.11200.

    3D structure databases

    ProteinModelPortali P61794.
    SMRi P61794. Positions 34-326.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    BindingDBi P61794.
    ChEMBLi CHEMBL4595.
    GuidetoPHARMACOLOGYi 272.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei P61794.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000044348 ; ENSRNOP00000043652 ; ENSRNOG00000013656 .
    GeneIDi 116744.
    KEGGi rno:116744.
    UCSCi RGD:620563. rat.

    Organism-specific databases

    CTDi 1902.
    RGDi 620563. Lpar1.

    Phylogenomic databases

    eggNOGi NOG274798.
    GeneTreei ENSGT00740000115422.
    HOGENOMi HOG000233501.
    HOVERGENi HBG103071.
    InParanoidi P61794.
    KOi K04289.
    OMAi PQCFYNE.
    OrthoDBi EOG7HTHH1.
    PhylomeDBi P61794.
    TreeFami TF330052.

    Miscellaneous databases

    NextBioi 286803.
    PROi P61794.

    Gene expression databases

    ArrayExpressi P61794.
    Genevestigatori P61794.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR004065. LPA_rcpt.
    IPR002277. LPA_rcpt_EDG2.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR01148. EDG2RECEPTOR.
    PR00237. GPCRRHODOPSN.
    PR01527. LPARECEPTOR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A rat G protein-coupled receptor selectively expressed in myelin-forming cells."
      Allard J., Barron S., Diaz J., Lubetzki C., Zalc B., Schwartz J.-C., Sokoloff P.
      Eur. J. Neurosci. 10:1045-1053(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Sprague-Dawley.
      Tissue: Olfactory bulb.
    2. "Identification and characterization of novel G-protein coupled receptors expressed in regenerating peripheral nerve."
      Carroll S.L., Miller M.L., Benedict-Hamilton H.M.
      Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Sprague-Dawley.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiLPAR1_RAT
    AccessioniPrimary (citable) accession number: P61794
    Secondary accession number(s): O88584
    , P56487, P70420, Q5FWS2, Q61130
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 7, 2004
    Last sequence update: June 7, 2004
    Last modified: October 1, 2014
    This is version 92 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3