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P61794

- LPAR1_RAT

UniProt

P61794 - LPAR1_RAT

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Protein

Lysophosphatidic acid receptor 1

Gene

Lpar1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Seems to be coupled to the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Stimulates phospholipase C (PLC) activity in a manner that is dependent on RALA activation (By similarity).By similarity

GO - Molecular functioni

  1. G-protein alpha-subunit binding Source: RGD
  2. G-protein coupled receptor activity Source: RGD
  3. lysophosphatidic acid receptor activity Source: InterPro
  4. phospholipid binding Source: RGD

GO - Biological processi

  1. activation of MAPK activity Source: Ensembl
  2. bleb assembly Source: Ensembl
  3. cellular response to oxygen levels Source: RGD
  4. G-protein coupled receptor signaling pathway Source: RGD
  5. myelination Source: RGD
  6. negative regulation of neuron projection development Source: RGD
  7. neurogenesis Source: RGD
  8. positive regulation of apoptotic process Source: RGD
  9. positive regulation of cell death Source: RGD
  10. positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway Source: RGD
  11. positive regulation of dendritic spine development Source: RGD
  12. positive regulation of I-kappaB kinase/NF-kappaB signaling Source: Ensembl
  13. positive regulation of Rho protein signal transduction Source: Ensembl
  14. positive regulation of smooth muscle cell chemotaxis Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_233455. G alpha (i) signalling events.
REACT_239650. Lysosphingolipid and LPA receptors.
REACT_263374. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Lysophosphatidic acid receptor 1
Short name:
LPA receptor 1
Short name:
LPA-1
Alternative name(s):
Lysophosphatidic acid receptor Edg-2
Gene namesi
Name:Lpar1
Synonyms:Edg2, Gpcr91, Lpa1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 5

Organism-specific databases

RGDi620563. Lpar1.

Subcellular locationi

Cell surface By similarity. Cell membrane; Multi-pass membrane protein
Note: Prior to LPA treatment found predominantly at the cell surface but in the presence of LPA co-localizes with RALA in the endocytic vesicles.By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5050ExtracellularSequence AnalysisAdd
BLAST
Transmembranei51 – 7525Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini76 – 827CytoplasmicSequence Analysis
Transmembranei83 – 11129Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini112 – 12514ExtracellularSequence AnalysisAdd
BLAST
Transmembranei126 – 14419Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini145 – 16319CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei164 – 18926Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini190 – 20516ExtracellularSequence AnalysisAdd
BLAST
Transmembranei206 – 22621Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini227 – 25832CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei259 – 28022Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini281 – 29414ExtracellularSequence AnalysisAdd
BLAST
Transmembranei295 – 31521Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini316 – 36449CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. cell surface Source: UniProtKB
  2. cytoplasm Source: RGD
  3. dendritic shaft Source: RGD
  4. dendritic spine Source: RGD
  5. endocytic vesicle Source: Ensembl
  6. integral component of membrane Source: UniProtKB-KW
  7. plasma membrane Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 364364Lysophosphatidic acid receptor 1PRO_0000069419Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi27 – 271N-linked (GlcNAc...)Sequence Analysis
Glycosylationi35 – 351N-linked (GlcNAc...)Sequence Analysis
Lipidationi327 – 3271S-palmitoyl cysteineBy similarity

Keywords - PTMi

Glycoprotein, Lipoprotein, Palmitate

PTM databases

PhosphoSiteiP61794.

Expressioni

Gene expression databases

GenevestigatoriP61794.

Interactioni

Subunit structurei

Interacts with RALA and ADRBK1.By similarity

Structurei

3D structure databases

ProteinModelPortaliP61794.
SMRiP61794. Positions 34-326.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG274798.
GeneTreeiENSGT00760000118804.
HOGENOMiHOG000233501.
HOVERGENiHBG103071.
InParanoidiP61794.
KOiK04289.
OMAiPQCFYNE.
OrthoDBiEOG7HTHH1.
PhylomeDBiP61794.
TreeFamiTF330052.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR004065. LPA_rcpt.
IPR002277. LPA_rcpt_EDG2.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01148. EDG2RECEPTOR.
PR00237. GPCRRHODOPSN.
PR01527. LPARECEPTOR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P61794-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAAASTSSPV ISQPQFTAMN EQQCFYNESI AFFYNRSGKY LATEWNTVSK
60 70 80 90 100
LVMGLGITVC VFIMLANLLV MVAIYVNRRF HFPIYYLMAN LAAADFFAGL
110 120 130 140 150
AYFYLMFNTG PNTRRLTVST WLLRQGLIDT SLTASVANLL AIAIERHITV
160 170 180 190 200
FRMQLHTRMS NRRVVVVIVV IWTMAIVMGA IPSVGWNCIC DIDHCSNMAP
210 220 230 240 250
LYSDSYLVFW AIFNLVTFVV MVVLYAHIFG YVRQRTMRMS RHSSGPRRNR
260 270 280 290 300
DTMMSLLKTV VIVLGAFIVC WTPGLVLLLL DVCCPQCDVL AYEKFFLLLA
310 320 330 340 350
EFNSAMNPII YSYRDKEMSA TFRQILCCQR NENPNGPTEG SDRSASSLNH
360
TILAGVHSND HSVV
Length:364
Mass (Da):41,119
Last modified:June 7, 2004 - v1
Checksum:iB0FA6265AA6688B7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF014418 mRNA. Translation: AAB86381.1.
AF090347 mRNA. Translation: AAG24469.1.
BC089227 mRNA. Translation: AAH89227.1.
RefSeqiNP_446388.1. NM_053936.3.
XP_006238257.1. XM_006238195.2.
XP_006238259.1. XM_006238197.2.
XP_006238262.1. XM_006238200.2.
XP_006238263.1. XM_006238201.2.
XP_008761954.1. XM_008763732.1.
UniGeneiRn.11200.

Genome annotation databases

EnsembliENSRNOT00000044348; ENSRNOP00000043652; ENSRNOG00000013656.
GeneIDi116744.
KEGGirno:116744.
UCSCiRGD:620563. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF014418 mRNA. Translation: AAB86381.1 .
AF090347 mRNA. Translation: AAG24469.1 .
BC089227 mRNA. Translation: AAH89227.1 .
RefSeqi NP_446388.1. NM_053936.3.
XP_006238257.1. XM_006238195.2.
XP_006238259.1. XM_006238197.2.
XP_006238262.1. XM_006238200.2.
XP_006238263.1. XM_006238201.2.
XP_008761954.1. XM_008763732.1.
UniGenei Rn.11200.

3D structure databases

ProteinModelPortali P61794.
SMRi P61794. Positions 34-326.
ModBasei Search...
MobiDBi Search...

Chemistry

BindingDBi P61794.
ChEMBLi CHEMBL4595.
GuidetoPHARMACOLOGYi 272.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei P61794.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000044348 ; ENSRNOP00000043652 ; ENSRNOG00000013656 .
GeneIDi 116744.
KEGGi rno:116744.
UCSCi RGD:620563. rat.

Organism-specific databases

CTDi 1902.
RGDi 620563. Lpar1.

Phylogenomic databases

eggNOGi NOG274798.
GeneTreei ENSGT00760000118804.
HOGENOMi HOG000233501.
HOVERGENi HBG103071.
InParanoidi P61794.
KOi K04289.
OMAi PQCFYNE.
OrthoDBi EOG7HTHH1.
PhylomeDBi P61794.
TreeFami TF330052.

Enzyme and pathway databases

Reactomei REACT_233455. G alpha (i) signalling events.
REACT_239650. Lysosphingolipid and LPA receptors.
REACT_263374. G alpha (q) signalling events.

Miscellaneous databases

NextBioi 286803.
PROi P61794.

Gene expression databases

Genevestigatori P61794.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR004065. LPA_rcpt.
IPR002277. LPA_rcpt_EDG2.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR01148. EDG2RECEPTOR.
PR00237. GPCRRHODOPSN.
PR01527. LPARECEPTOR.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A rat G protein-coupled receptor selectively expressed in myelin-forming cells."
    Allard J., Barron S., Diaz J., Lubetzki C., Zalc B., Schwartz J.-C., Sokoloff P.
    Eur. J. Neurosci. 10:1045-1053(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Olfactory bulb.
  2. "Identification and characterization of novel G-protein coupled receptors expressed in regenerating peripheral nerve."
    Carroll S.L., Miller M.L., Benedict-Hamilton H.M.
    Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiLPAR1_RAT
AccessioniPrimary (citable) accession number: P61794
Secondary accession number(s): O88584
, P56487, P70420, Q5FWS2, Q61130
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: June 7, 2004
Last modified: November 26, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3