Lysophosphatidic acid receptor 1 - Rattus norvegicus (Rat)

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P61794 (LPAR1_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 82. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Lysophosphatidic acid receptor 1
Short name=LPA receptor 1
Short name=LPA-1

Alternative name(s):
Lysophosphatidic acid receptor Edg-2

Gene names

Name:	Lpar1
Synonyms:	Edg2, Gpcr91, Lpa1

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	364 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Seems to be coupled to the G(i)/G(o), G₁₂/G₁₃, and G(q) families of heteromeric G proteins. Stimulates phospholipase C (PLC) activity in a manner that is dependent on RALA activation By similarity.
Subunit structure	Interacts with RALA and ADRBK1 By similarity.
Subcellular location	Cell surface By similarity. Cell membrane; Multi-pass membrane protein. Note: Prior to LPA treatment found predominantly at the cell surface but in the presence of LPA co-localizes with RALA in the endocytic vesicles By similarity.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Glycoprotein Lipoprotein Palmitate
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	activation of MAPK activity Inferred from electronic annotation. Source: Compara bleb assembly Inferred from electronic annotation. Source: Compara cellular response to oxygen levels Inferred from expression pattern PubMed 18978343. Source: RGD elevation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway Inferred from direct assay PubMed 16242672. Source: RGD myelination Inferred from expression pattern PubMed 10384882. Source: RGD negative regulation of neuron projection development Inferred from mutant phenotype PubMed 18978343. Source: RGD positive regulation of I-kappaB kinase/NF-kappaB cascade Inferred from electronic annotation. Source: Compara positive regulation of Rho protein signal transduction Inferred from electronic annotation. Source: Compara positive regulation of apoptotic process Inferred from mutant phenotype PubMed 16890224. Source: RGD positive regulation of dendritic spine development Inferred from direct assay PubMed 16638019. Source: RGD positive regulation of smooth muscle cell chemotaxis Inferred from mutant phenotype PubMed 19742132. Source: RGD
Cellular_component	cell surface Inferred from sequence or structural similarity. Source: UniProtKB cytoplasm Inferred from direct assay PubMed 18978343. Source: RGD dendritic shaft Inferred from direct assay PubMed 16638019. Source: RGD dendritic spine Inferred from direct assay PubMed 16638019. Source: RGD endocytic vesicle Inferred from electronic annotation. Source: Compara integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from direct assay PubMed 18978343. Source: RGD
Molecular_function	G-protein alpha-subunit binding Inferred from mutant phenotype PubMed 16504475. Source: RGD G-protein coupled receptor activity Traceable author statement PubMed 12123830. Source: RGD lysophosphatidic acid receptor activity Inferred from electronic annotation. Source: InterPro phospholipid binding Inferred from direct assay PubMed 16242672. Source: RGD
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 364

364

Lysophosphatidic acid receptor 1

PRO_0000069419

Regions

Topological domain

1 – 50

Extracellular Potential

Transmembrane

51 – 75

Helical; Name=1; Potential

Topological domain

76 – 82

Cytoplasmic Potential

Transmembrane

83 – 111

Helical; Name=2; Potential

Topological domain

112 – 125

Extracellular Potential

Transmembrane

126 – 144

Helical; Name=3; Potential

Topological domain

145 – 163

Cytoplasmic Potential

Transmembrane

164 – 189

Helical; Name=4; Potential

Topological domain

190 – 205

Extracellular Potential

Transmembrane

206 – 226

Helical; Name=5; Potential

Topological domain

227 – 258

Cytoplasmic Potential

Transmembrane

259 – 280

Helical; Name=6; Potential

Topological domain

281 – 294

Extracellular Potential

Transmembrane

295 – 315

Helical; Name=7; Potential

Topological domain

316 – 364

Cytoplasmic Potential

Amino acid modifications

Lipidation

327

S-palmitoyl cysteine By similarity

Glycosylation

N-linked (GlcNAc...) Potential

Glycosylation

N-linked (GlcNAc...) Potential

Sequences

Sequence

Length

Mass (Da)

Tools

P61794 [UniParc].

Last modified June 7, 2004. Version 1.
Checksum: B0FA6265AA6688B7
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FASTA

364

41,119

        10         20         30         40         50         60 
MAAASTSSPV ISQPQFTAMN EQQCFYNESI AFFYNRSGKY LATEWNTVSK LVMGLGITVC 

        70         80         90        100        110        120 
VFIMLANLLV MVAIYVNRRF HFPIYYLMAN LAAADFFAGL AYFYLMFNTG PNTRRLTVST 

       130        140        150        160        170        180 
WLLRQGLIDT SLTASVANLL AIAIERHITV FRMQLHTRMS NRRVVVVIVV IWTMAIVMGA 

       190        200        210        220        230        240 
IPSVGWNCIC DIDHCSNMAP LYSDSYLVFW AIFNLVTFVV MVVLYAHIFG YVRQRTMRMS 

       250        260        270        280        290        300 
RHSSGPRRNR DTMMSLLKTV VIVLGAFIVC WTPGLVLLLL DVCCPQCDVL AYEKFFLLLA 

       310        320        330        340        350        360 
EFNSAMNPII YSYRDKEMSA TFRQILCCQR NENPNGPTEG SDRSASSLNH TILAGVHSND 


HSVV

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A rat G protein-coupled receptor selectively expressed in myelin-forming cells." Allard J., Barron S., Diaz J., Lubetzki C., Zalc B., Schwartz J.-C., Sokoloff P. Eur. J. Neurosci. 10:1045-1053(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Sprague-Dawley. Tissue: Olfactory bulb.
[2]	"Identification and characterization of novel G-protein coupled receptors expressed in regenerating peripheral nerve." Carroll S.L., Miller M.L., Benedict-Hamilton H.M. Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Sprague-Dawley.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF014418 mRNA. Translation: AAB86381.1. AF090347 mRNA. Translation: AAG24469.1. BC089227 mRNA. Translation: AAH89227.1.
IPI	IPI00231300.
RefSeq	NP_446388.1. NM_053936.3.
UniGene	Rn.11200.
3D structure databases
ProteinModelPortal	P61794.
SMR	P61794. Positions 34-326.
ModBase	Search...
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	P61794.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000044348; ENSRNOP00000043652; ENSRNOG00000013656.
GeneID	116744.
KEGG	rno:116744.
UCSC	RGD:620563. rat.
Organism-specific databases
CTD	1902.
RGD	620563. Lpar1.
Phylogenomic databases
eggNOG	NOG274798.
GeneTree	ENSGT00700000104435.
HOGENOM	HOG000233501.
HOVERGEN	HBG103071.
InParanoid	P61794.
KO	K04289.
OMA	PQCFYNE.
OrthoDB	EOG4P2Q2J.
Gene expression databases
Genevestigator	P61794.
GermOnline	ENSRNOG00000013656. Rattus norvegicus.
Family and domain databases
InterPro	IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR004065. LPA_rcpt. IPR002277. LPA_rcpt_EDG2. [Graphical view]
PANTHER	PTHR22750:SF12. PTHR22750:SF12. 1 hit.
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR01148. EDG2RECEPTOR. PR00237. GPCRRHODOPSN. PR01527. LPARECEPTOR.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
BindingDB	P61794.
ChEMBL	CHEMBL4595.
NextBio	286803.

Entry information

Entry name

LPAR1_RAT

Accession

Primary (citable) accession number: P61794
Secondary accession number(s): O88584

Q61130

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 7, 2004
Last sequence update:	June 7, 2004
Last modified:	May 1, 2013
This is version 82 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein family/group databases

PTM databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents