Lysophosphatidic acid receptor 1 - Mus musculus (Mouse)

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Alternative products

Sequence annotation (Features)

Sequences

References

Cross-references

Entry information

Relevant documents

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Alternative products

Sequence annotation (Features)

Sequences

References

Cross-references

Entry information

Relevant documents

Molecule processing

Regions

Amino acid modifications

Natural variations

Experimental info

Molecule processing

Regions

Amino acid modifications

Natural variations

Experimental info

Sequence databases

3D structure databases

Protein family/group databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

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Reviewed, UniProtKB/Swiss-Prot P61793 (LPAR1_MOUSE)

Last modified June 16, 2009. Version 53. History...

Clusters with 100%, 90%, 50% identity |

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Protein names

Recommended name:
    Lysophosphatidic acid receptor 1
      Short name=LPA receptor 1
      Short name=LPA-1
Alternative name(s):
    Lysophosphatidic acid receptor Edg-2
    Rec1.3
    VZG-1

Gene names

Name:	Lpar1
Synonyms:	Edg2, Gpcr26, Lpa1, Vzg1

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

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Sequence length	364 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

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Function	Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Seems to be coupled to the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Tissue specificity	Expressed within the embryonic cerebral cortex, where it is enriched in the ventricular zone. In the adult brain, also expressed in oligodendrocytes, as well as Schwann cells of the peripheral nervous system. Expressed in many other tissues, including testes, lung, heart, intestine, spleen, kidney, thymus, and stomach. No expression in liver.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

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Keywords
Cellular component	Cell membrane Membrane
Coding sequence diversity	Alternative splicing
Domain	Transmembrane
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Glycoprotein Lipoprotein Palmitate
Gene Ontology (GO)
Biological process	G-protein coupled receptor protein signaling pathway Inferred from direct assay. Source: MGI activation of MAPK activity Inferred from direct assay. Source: MGI bleb formation Inferred from genetic interaction. Source: MGI positive regulation of MAPKKK cascade Inferred from direct assay. Source: MGI positive regulation of Rho protein signal transduction Inferred from direct assay. Source: MGI
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	PDZ domain binding Inferred from physical interaction. Source: MGI lysosphingolipid and lysophosphatidic acid receptor activity Inferred from direct assay. Source: MGI
Complete GO annotation...

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Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Chain

1 – 364

364

Lysophosphatidic acid receptor 1

PRO_0000069418

Topological domain

1 – 50

Extracellular Potential

Transmembrane

51 – 75

1 Potential

Topological domain

76 – 82

Cytoplasmic Potential

Transmembrane

83 – 111

2 Potential

Topological domain

112 – 125

Extracellular Potential

Transmembrane

126 – 144

3 Potential

Topological domain

145 – 163

Cytoplasmic Potential

Transmembrane

164 – 189

4 Potential

Topological domain

190 – 205

Extracellular Potential

Transmembrane

206 – 226

5 Potential

Topological domain

227 – 258

Cytoplasmic Potential

Transmembrane

259 – 280

6 Potential

Topological domain

281 – 294

Extracellular Potential

Transmembrane

295 – 315

7 Potential

Topological domain

316 – 364

Cytoplasmic Potential

Lipidation

327

S-palmitoyl cysteine By similarity

Glycosylation

N-linked (GlcNAc...) Potential

Glycosylation

N-linked (GlcNAc...) Potential

Alternative sequence

1 – 18

Missing in isoform 2.

VSP_001986

Sequence conflict

119

S → N in AAC34301. Ref.3

Sequence conflict

119

S → N in AAC34302. Ref.3

Sequence conflict

181 – 183

IPS → MPT in AAC34301. Ref.3

Sequence conflict

181 – 183

IPS → MPT in AAC34302. Ref.3

Sequence conflict

225

Y → S in AAC53035. Ref.2

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Sequence		Length	Mass (Da)
Isoform 1 [UniParc]. Last modified June 7, 2004. Version 1. Checksum: B0FA6265AA6688B7 Show »	FASTA	364	41,119
10 20 30 40 50 60 MAAASTSSPV ISQPQFTAMN EQQCFYNESI AFFYNRSGKY LATEWNTVSK LVMGLGITVC 70 80 90 100 110 120 VFIMLANLLV MVAIYVNRRF HFPIYYLMAN LAAADFFAGL AYFYLMFNTG PNTRRLTVST 130 140 150 160 170 180 WLLRQGLIDT SLTASVANLL AIAIERHITV FRMQLHTRMS NRRVVVVIVV IWTMAIVMGA 190 200 210 220 230 240 IPSVGWNCIC DIDHCSNMAP LYSDSYLVFW AIFNLVTFVV MVVLYAHIFG YVRQRTMRMS 250 260 270 280 290 300 RHSSGPRRNR DTMMSLLKTV VIVLGAFIVC WTPGLVLLLL DVCCPQCDVL AYEKFFLLLA 310 320 330 340 350 360 EFNSAMNPII YSYRDKEMSA TFRQILCCQR NENPNGPTEG SDRSASSLNH TILAGVHSND HSVV « Hide
Isoform 2 [UniParc] [UniParc]. Checksum: 7634E3976257933D Show »	FASTA	346	39,343
10 20 30 40 50 60 MNEQQCFYNE SIAFFYNRSG KYLATEWNTV SKLVMGLGIT VCVFIMLANL LVMVAIYVNR 70 80 90 100 110 120 RFHFPIYYLM ANLAAADFFA GLAYFYLMFN TGPNTRRLTV STWLLRQGLI DTSLTASVAN 130 140 150 160 170 180 LLAIAIERHI TVFRMQLHTR MSNRRVVVVI VVIWTMAIVM GAIPSVGWNC ICDIDHCSNM 190 200 210 220 230 240 APLYSDSYLV FWAIFNLVTF VVMVVLYAHI FGYVRQRTMR MSRHSSGPRR NRDTMMSLLK 250 260 270 280 290 300 TVVIVLGAFI VCWTPGLVLL LLDVCCPQCD VLAYEKFFLL LAEFNSAMNP IIYSYRDKEM 310 320 330 340 SATFRQILCC QRNENPNGPT EGSDRSASSL NHTILAGVHS NDHSVV « Hide

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	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Ventricular zone gene-1 (vzg-1) encodes a lysophosphatidic acid receptor expressed in neurogenic regions of the developing cerebral cortex." Hecht J.H., Weiner J.A., Post S.R., Chun J. J. Cell Biol. 135:1071-1083(1996) [PubMed: 8922387] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Strain: BALB/c.
[2]	"Cloning, characterization, and chromosomal localization of rec1.3, a member of the G-protein-coupled receptor family highly expressed in brain." Macrae A.D., Premont R.T., Jaber M., Petersen A.S., Lefkowitz R.J. Brain Res. Mol. Brain Res. 42:245-254(1996) [PubMed: 9013780] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2). Strain: C57BL/6. Tissue: Brain.
[3]	"Complete cDNA sequence, genomic structure, and chromosomal localization of the LPA receptor gene, lpA1/vzg-1/Gpcr26." Contos J.J.A., Chun J. Genomics 51:364-378(1998) [PubMed: 9721207] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS 1 AND 2). Strain: 129/SvJ.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Strain: FVB/N-3.
[5]	"Lysophosphatidic acid receptors." Contos J.J.A., Ishii I., Chun J. Mol. Pharmacol. 58:1188-1196(2000) [PubMed: 11093753] [Abstract] Cited for: REVIEW.
+	Additional computationally mapped references.

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Sequence databases
	U70622 mRNA. Translation: AAC52923.1. U48235 mRNA. Translation: AAC53035.1. AF075456, AF075453, AF075455 Genomic DNA. Translation: AAC34301.1. AF075456, AF075455 Genomic DNA. Translation: AAC34302.1. BC025425 mRNA. Translation: AAH25425.1.
IPI	IPI00380474. IPI00406388.
RefSeq	NP_034466.2. NP_766577.1.
UniGene	Mm.4772
3D structure databases
ModBase	Search...
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	P61793.
Proteomic databases
PRIDE	P61793.
Genome annotation databases
Ensembl	ENSMUSG00000038668. Mus musculus. [Contig view]
GeneID	14745.
KEGG	mmu:14745.
Organism-specific databases
MGI	MGI:108429. Lpar1.
Phylogenomic databases
HOGENOM	P61793.
HOVERGEN	P61793.
OMA	P61793. QRSENTS.
Gene expression databases
ArrayExpress	P61793.
Bgee	P61793.
GermOnline	ENSMUSG00000038668. Mus musculus.
Family and domain databases
InterPro	IPR000276. 7TM_GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_supfam. IPR004065. LPA_rcpt. IPR002277. LPA_rcpt_EDG2. [Graphical view]
PANTHER	PTHR22750:SF12. LPA_rcpt. 1 hit.
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR01148. EDG2RECEPTOR. PR00237. GPCRRHODOPSN. PR01527. LPARECEPTOR.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	286803.
SOURCE	Search...

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Entry name

LPAR1_MOUSE

Accession

Primary (citable) accession number: P61793
Secondary accession number(s): O88584

Q61130

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 7, 2004
Last sequence update:	June 7, 2004
Last modified:	June 16, 2009
This is version 53 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

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7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: P61793-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: P61793-2)

The sequence of this isoform differs from the canonical sequence as follows:
1-18: Missing.