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P61769

- B2MG_HUMAN

UniProt

P61769 - B2MG_HUMAN

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Protein

Beta-2-microglobulin

Gene
B2M, CDABP0092, HDCMA22P
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.

GO - Molecular functioni

  1. identical protein binding Source: IntAct
  2. protein binding Source: IntAct

GO - Biological processi

  1. antigen processing and presentation of exogenous peptide antigen via MHC class I Source: Reactome
  2. antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent Source: Reactome
  3. antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent Source: Reactome
  4. antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent Source: Ensembl
  5. antigen processing and presentation of peptide antigen via MHC class I Source: Reactome
  6. cytokine-mediated signaling pathway Source: Reactome
  7. innate immune response Source: Reactome
  8. interferon-gamma-mediated signaling pathway Source: Reactome
  9. positive regulation of T cell mediated cytotoxicity Source: Ensembl
  10. protein refolding Source: Ensembl
  11. regulation of defense response to virus by virus Source: Reactome
  12. regulation of immune response Source: Reactome
  13. response to cadmium ion Source: Ensembl
  14. response to drug Source: Ensembl
  15. response to molecule of bacterial origin Source: Ensembl
  16. retina homeostasis Source: UniProt
  17. T cell differentiation in thymus Source: Ensembl
  18. viral process Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Immunity

Enzyme and pathway databases

ReactomeiREACT_11103. Nef mediated downregulation of MHC class I complex cell surface expression.
REACT_111168. Endosomal/Vacuolar pathway.
REACT_111178. ER-Phagosome pathway.
REACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
REACT_147694. DAP12 interactions.
REACT_147814. DAP12 signaling.
REACT_25078. Interferon gamma signaling.
REACT_75795. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.
REACT_75925. Amyloids.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-2-microglobulin
Cleaved into the following chain:
Gene namesi
Name:B2M
ORF Names:CDABP0092, HDCMA22P
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 15

Organism-specific databases

HGNCiHGNC:914. B2M.

Subcellular locationi

Secreted
Note: Detected in serum and urine.2 Publications

GO - Cellular componenti

  1. cytoplasm Source: HPA
  2. early endosome lumen Source: Reactome
  3. early endosome membrane Source: Reactome
  4. endoplasmic reticulum lumen Source: Reactome
  5. ER to Golgi transport vesicle membrane Source: Reactome
  6. external side of plasma membrane Source: Ensembl
  7. extracellular region Source: Reactome
  8. extracellular space Source: UniProt
  9. extracellular vesicular exosome Source: UniProt
  10. Golgi apparatus Source: HPA
  11. Golgi membrane Source: Reactome
  12. MHC class I protein complex Source: UniProtKB-KW
  13. phagocytic vesicle membrane Source: Reactome
  14. plasma membrane Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Amyloid, MHC I, Secreted

Pathology & Biotechi

Involvement in diseasei

Hypercatabolic hypoproteinemia (HYCATHYP) [MIM:241600]: Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.
Note: The disease is caused by mutations affecting the gene represented in this entry.1 Publication
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti11 – 111A → P in HYCATHYP; lower levels of B2M, MHC class I and FCGRT proteins. 1 Publication
VAR_030660
Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.13 Publications

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi79 – 791D → P: Increases tendency towards amyloid formation. 1 Publication
Mutagenesisi80 – 801W → G: Decreases tendency towards amyloid formation. 2 Publications
Mutagenesisi80 – 801W → V: Increases tendency towards amyloid formation. 2 Publications

Keywords - Diseasei

Amyloidosis, Disease mutation

Organism-specific databases

MIMi241600. phenotype.
Orphaneti314652. Autosomal dominant beta2-microglobulinic amyloidosis.
PharmGKBiPA25207.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 20204 PublicationsAdd
BLAST
Chaini21 – 11999Beta-2-microglobulinPRO_0000018779Add
BLAST
Chaini22 – 11998Beta-2-microglobulin form pI 5.3PRO_0000018780Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi21 – 211N-linked (Glc) (glycation); in hemodialysis-associated amyloidosis1 Publication
Modified residuei22 – 221Pyrrolidone carboxylic acid; in form pI 5.3
Glycosylationi39 – 391N-linked (Glc) (glycation); in vitro1 Publication
Disulfide bondi45 ↔ 1008 Publications
Glycosylationi61 – 611N-linked (Glc) (glycation); in vitro1 Publication
Glycosylationi68 – 681N-linked (Glc) (glycation); in vitro1 Publication
Glycosylationi78 – 781N-linked (Glc) (glycation); in vitro1 Publication
Glycosylationi111 – 1111N-linked (Glc) (glycation); in vitro1 Publication
Glycosylationi114 – 1141N-linked (Glc) (glycation); in vitro1 Publication

Post-translational modificationi

Glycation of Ile-21 is observed in long-term hemodialysis patients.

Keywords - PTMi

Disulfide bond, Glycation, Glycoprotein, Pyrrolidone carboxylic acid

Proteomic databases

MaxQBiP61769.
PaxDbiP61769.
PeptideAtlasiP61769.
PRIDEiP61769.

2D gel databases

DOSAC-COBS-2DPAGEP61769.
OGPiP61769.
SWISS-2DPAGEP61769.

PTM databases

PhosphoSiteiP61769.

Expressioni

Gene expression databases

ArrayExpressiP61769.
BgeeiP61769.
CleanExiHS_B2M.
GenevestigatoriP61769.

Organism-specific databases

HPAiCAB002572.
HPA006361.

Interactioni

Subunit structurei

Heterodimer of an alpha chain and a beta chain. Beta-2-microglobulin is the beta-chain of major histocompatibility complex class I molecules. Polymers of beta 2-microglobulin can be found in tissues from patients on long-term hemodialysis.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
itself9EBI-714718,EBI-714718
CD1AP061262EBI-714718,EBI-1036766
CD1BP290163EBI-714718,EBI-1033762
HFEQ302013EBI-714718,EBI-1028850

Protein-protein interaction databases

BioGridi107044. 15 interactions.
DIPiDIP-6055N.
IntActiP61769. 71 interactions.
MINTiMINT-85778.
STRINGi9606.ENSP00000340858.

Structurei

Secondary structure

1
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi26 – 338
Helixi35 – 373
Beta strandi41 – 5313
Beta strandi56 – 616
Beta strandi64 – 663
Beta strandi71 – 788
Beta strandi79 – 824
Beta strandi86 – 905
Beta strandi98 – 1036
Beta strandi107 – 1093
Beta strandi111 – 1144
Helixi117 – 1193

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1A1MX-ray2.30B21-119[»]
1A1NX-ray2.00B21-119[»]
1A1OX-ray2.30B21-119[»]
1A6ZX-ray2.60B/D21-119[»]
1A9BX-ray3.20B/E21-119[»]
1A9EX-ray2.50B21-119[»]
1AGBX-ray2.20B21-119[»]
1AGCX-ray2.10B21-119[»]
1AGDX-ray2.05B21-119[»]
1AGEX-ray2.30B21-119[»]
1AGFX-ray2.20B21-119[»]
1AKJX-ray2.65B21-119[»]
1AO7X-ray2.60B21-119[»]
1B0GX-ray2.50B/E21-119[»]
1B0RX-ray2.90B21-119[»]
1BD2X-ray2.50B21-119[»]
1C16X-ray3.10B/D/F/H21-119[»]
1CE6X-ray2.90B21-119[»]
1CG9X-ray2.70B21-119[»]
1DE4X-ray2.80B/E/H21-119[»]
1DUYX-ray2.15B/E21-119[»]
1DUZX-ray1.80B/E21-119[»]
1E27X-ray2.20B21-119[»]
1E28X-ray3.00B21-119[»]
1EEYX-ray2.25B/E21-119[»]
1EEZX-ray2.30B/E21-119[»]
1EFXX-ray3.00B21-119[»]
1EXUX-ray2.70B21-119[»]
1GZPX-ray2.80B21-119[»]
1GZQX-ray2.26B21-119[»]
1HHGX-ray2.60B/E21-119[»]
1HHHX-ray3.00B21-119[»]
1HHIX-ray2.50B/E21-119[»]
1HHJX-ray2.50B/E21-119[»]
1HHKX-ray2.50B/E21-119[»]
1HLAX-ray3.50M21-117[»]
1HSAX-ray2.10B/E21-119[»]
1HSBX-ray1.90B21-119[»]
1I1FX-ray2.80B/E21-119[»]
1I1YX-ray2.20B/E21-119[»]
1I4FX-ray1.40B21-119[»]
1I7RX-ray2.20B/E21-119[»]
1I7TX-ray2.80B/E21-119[»]
1I7UX-ray1.80B/E21-119[»]
1IM3X-ray2.20B/F/J/N21-119[»]
1IM9X-ray2.80B/F21-119[»]
1JF1X-ray1.85B21-119[»]
1JGDX-ray1.90B21-119[»]
1JGEX-ray2.10B21-119[»]
1JHTX-ray2.15B21-119[»]
1JNJNMR-A21-119[»]
1K5NX-ray1.09B21-119[»]
1KPRX-ray2.80B/D21-119[»]
1KTLX-ray3.10B/D21-119[»]
1LDSX-ray1.80A21-119[»]
1LP9X-ray2.00B/I21-119[»]
1M05X-ray1.90B/D21-119[»]
1M6OX-ray1.60B21-119[»]
1MHEX-ray2.85B/D21-119[»]
1MI5X-ray2.50B21-119[»]
1N2RX-ray1.70B21-119[»]
1OF2X-ray2.20B21-119[»]
1OGAX-ray1.40B21-119[»]
1OGTX-ray1.47B21-119[»]
1ONQX-ray2.15B/D21-119[»]
1P7QX-ray3.40B21-119[»]
1PY4X-ray2.90A/B/C/D21-119[»]
1Q94X-ray2.40B/E21-119[»]
1QEWX-ray2.20B21-119[»]
1QLFX-ray2.65B21-119[»]
1QQDX-ray2.70B21-118[»]
1QR1X-ray2.40B/E20-119[»]
1QRNX-ray2.80B21-119[»]
1QSEX-ray2.80B20-119[»]
1QSFX-ray2.80B20-119[»]
1QVOX-ray2.22B/E21-119[»]
1R3HX-ray2.50B/D/F/H21-119[»]
1S8DX-ray2.20B21-119[»]
1S9WX-ray2.20B21-119[»]
1S9XX-ray2.50B21-119[»]
1S9YX-ray2.30B21-119[»]
1SYSX-ray2.40B21-119[»]
1SYVX-ray1.70B21-119[»]
1T1WX-ray2.20B21-119[»]
1T1XX-ray2.20B21-119[»]
1T1YX-ray2.00B21-119[»]
1T1ZX-ray1.90B21-119[»]
1T20X-ray2.20B21-119[»]
1T21X-ray2.19B21-119[»]
1T22X-ray2.20B21-119[»]
1TMCX-ray2.30B21-119[»]
1TVBX-ray1.80B/E21-119[»]
1TVHX-ray1.80B/E21-119[»]
1UQSX-ray3.10B21-119[»]
1UR7model-B21-119[»]
1UXSX-ray1.55B21-119[»]
1UXWX-ray1.71B21-119[»]
1VGKX-ray2.06B21-119[»]
1W0VX-ray2.27B21-119[»]
1W0WX-ray2.10B21-119[»]
1W72X-ray2.15B/E21-119[»]
1X7QX-ray1.45B21-119[»]
1XH3X-ray1.48B21-119[»]
1XR8X-ray2.30B21-119[»]
1XR9X-ray1.79B21-119[»]
1XZ0X-ray2.80B/D21-119[»]
1YDPX-ray1.90B21-119[»]
1YPZX-ray3.40B/D21-119[»]
1ZHKX-ray1.60B21-119[»]
1ZHLX-ray1.50B21-119[»]
1ZS8X-ray3.00B/D/F/H/J21-119[»]
1ZSDX-ray1.70B21-119[»]
1ZT4X-ray3.00B/D21-119[»]
1ZVSX-ray2.80B/E21-119[»]
2A83X-ray1.40B21-119[»]
2AK4X-ray2.50B/G/L/R21-119[»]
2AV1X-ray1.95B/E21-119[»]
2AV7X-ray2.05B/E21-119[»]
2AXFX-ray1.80B21-119[»]
2AXGX-ray2.00B21-119[»]
2BCKX-ray2.80B/E21-119[»]
2BNQX-ray1.70B21-119[»]
2BNRX-ray1.90B21-119[»]
2BSRX-ray2.30B21-119[»]
2BSSX-ray2.00B21-119[»]
2BSTX-ray2.10B21-119[»]
2BVOX-ray1.65B21-119[»]
2BVPX-ray1.35B21-119[»]
2BVQX-ray2.00B21-119[»]
2C7UX-ray2.38B/E21-119[»]
2CIIX-ray2.55B21-119[»]
2CIKX-ray1.75B21-119[»]
2CLRX-ray2.00B/E21-119[»]
2D31X-ray3.20B/E21-119[»]
2D4DX-ray2.10A21-119[»]
2D4FX-ray1.70A21-119[»]
2DYPX-ray2.50B21-119[»]
2E8DNMR-A/B/C/D40-61[»]
2ESVX-ray2.60B21-119[»]
2F53X-ray2.10B21-119[»]
2F54X-ray2.70B/G21-119[»]
2F74X-ray2.70B/E21-119[»]
2F8OX-ray1.70A/B21-119[»]
2FYYX-ray1.50B21-119[»]
2FZ3X-ray1.90B21-119[»]
2GITX-ray1.70B/E21-119[»]
2GJ6X-ray2.56B21-119[»]
2GT9X-ray1.75B/E21-119[»]
2GTWX-ray1.55B/E21-119[»]
2GTZX-ray1.70B/E21-119[»]
2GUOX-ray1.90B/E21-119[»]
2H26X-ray1.80B21-119[»]
2H6PX-ray1.90B21-119[»]
2HJKX-ray1.85B21-119[»]
2HJLX-ray1.50B21-119[»]
2HLAX-ray2.60B21-119[»]
2HN7X-ray1.60B21-119[»]
2J8UX-ray2.88B/I21-119[»]
2JCCX-ray2.50B/I21-119[»]
2NW3X-ray1.70B21-119[»]
2NX5X-ray2.70B/G/L/R21-119[»]
2P5EX-ray1.89B21-119[»]
2P5WX-ray2.20B21-119[»]
2PO6X-ray3.20B/F21-119[»]
2PYEX-ray2.30B21-119[»]
2RFXX-ray2.50B21-119[»]
2UWEX-ray2.40B/I21-119[»]
2V2WX-ray1.60B/E21-119[»]
2V2XX-ray1.60B/E21-119[»]
2VB5NMR-A21-119[»]
2VLJX-ray2.40B21-119[»]
2VLKX-ray2.50B21-119[»]
2VLLX-ray1.60B/E21-119[»]
2VLRX-ray2.30B/G21-119[»]
2X4NX-ray2.34B/E21-119[»]
2X4OX-ray2.30B/E21-119[»]
2X4PX-ray2.30B/E21-119[»]
2X4QX-ray1.90B/E21-119[»]
2X4RX-ray2.30B/E21-119[»]
2X4SX-ray2.55B/E21-119[»]
2X4TX-ray2.30B/E21-119[»]
2X4UX-ray2.10B/E21-119[»]
2X70X-ray2.00B/E21-119[»]
2X89X-ray2.16D/E/F/G27-119[»]
2XKSNMR-A21-119[»]
2XKUNMR-A27-119[»]
2XPGX-ray2.60B22-118[»]
2YPKX-ray1.95B21-119[»]
2YPLX-ray2.40B21-119[»]
2YXFX-ray1.13A21-119[»]
2Z9TX-ray1.80A21-119[»]
3AM8X-ray2.80C/D21-119[»]
3B3IX-ray1.86B21-119[»]
3B6SX-ray1.80B21-119[»]
3BGMX-ray1.60B21-119[»]
3BH8X-ray1.65B21-119[»]
3BH9X-ray1.70B21-119[»]
3BHBX-ray2.20B22-119[»]
3BO8X-ray1.80B21-119[»]
3BP4X-ray1.85B21-119[»]
3BP7X-ray1.80B21-119[»]
3BVNX-ray2.55B/E21-119[»]
3BW9X-ray1.75B21-119[»]
3BWAX-ray1.30B21-119[»]
3BXNX-ray1.86B21-119[»]
3BZEX-ray2.50B/D/F/H21-119[»]
3BZFX-ray2.50B/D23-119[»]
3C9NX-ray1.87B21-119[»]
3CDGX-ray3.40B/D21-119[»]
3CIIX-ray4.41B/E21-119[»]
3CIQX-ray2.90A/B/C/D/E/F/G/H/I/J/K/L21-119[»]
3CZFX-ray1.20B21-119[»]
3D18X-ray1.74B21-119[»]
3D25X-ray1.30B22-119[»]
3D2UX-ray2.21B/F21-119[»]
3D39X-ray2.81B21-119[»]
3D3VX-ray2.80B21-119[»]
3DBXX-ray2.00B21-119[»]
3DHJX-ray2.00A21-119[»]
3DHMX-ray1.80A21-119[»]
3DTXX-ray2.10B21-119[»]
3DX6X-ray1.70B21-119[»]
3DX7X-ray1.60B21-119[»]
3DX8X-ray2.10B21-119[»]
3DXAX-ray3.50B/G/L21-119[»]
3EKCX-ray1.80A21-119[»]
3FFCX-ray2.80B/G21-119[»]
3FQNX-ray1.65B22-119[»]
3FQRX-ray1.70B22-119[»]
3FQTX-ray1.80B22-119[»]
3FQUX-ray1.80B22-119[»]
3FQWX-ray1.93B22-119[»]
3FQXX-ray1.70B22-119[»]
3FT2X-ray1.80B21-119[»]
3FT3X-ray1.95B21-119[»]
3FT4X-ray1.90B21-119[»]
3GIVX-ray2.00B/E21-119[»]
3GJFX-ray1.90B/E21-119[»]
3GSNX-ray2.80L21-119[»]
3GSOX-ray1.60B21-119[»]
3GSQX-ray2.12B21-119[»]
3GSRX-ray1.95B21-119[»]
3GSUX-ray1.80B21-119[»]
3GSVX-ray1.90B21-119[»]
3GSWX-ray1.81B21-119[»]
3GSXX-ray2.10B21-119[»]
3H7BX-ray1.88B/E21-119[»]
3H9HX-ray2.00B/E21-119[»]
3H9SX-ray2.70B21-119[»]
3HAEX-ray2.90B/E/K/Q21-119[»]
3HCVX-ray1.95B21-119[»]
3HG1X-ray3.00B21-119[»]
3HLAX-ray2.60B21-119[»]
3HPJX-ray2.00B/E21-119[»]
3HUJX-ray2.50B/D21-119[»]
3I6GX-ray2.20B/E21-119[»]
3I6KX-ray2.80B/F21-119[»]
3I6LX-ray2.40E21-119[»]
3IB4X-ray1.25A21-119[»]
3IXAX-ray2.10B/E21-119[»]
3JTSX-ray2.80B/E/H1-119[»]
3KLAX-ray1.65B/E21-119[»]
3KPLX-ray1.96B21-119[»]
3KPMX-ray1.60B21-119[»]
3KPNX-ray2.00B21-119[»]
3KPOX-ray2.30B21-119[»]
3KPPX-ray1.90B21-119[»]
3KPQX-ray1.84B21-119[»]
3KPRX-ray2.60B/G21-119[»]
3KPSX-ray2.70B21-119[»]
3KWWX-ray2.18B21-119[»]
3KXFX-ray3.10B/F/J/L21-119[»]
3KYNX-ray2.40B21-119[»]
3KYOX-ray1.70B/D21-119[»]
3L3DX-ray1.80B21-119[»]
3L3GX-ray2.10B21-119[»]
3L3IX-ray1.70B21-119[»]
3L3JX-ray2.40B21-119[»]
3L3KX-ray2.60B21-119[»]
3LKNX-ray2.00B21-119[»]
3LKOX-ray1.80B21-119[»]
3LKPX-ray1.80B21-119[»]
3LKQX-ray1.80B21-119[»]
3LKRX-ray2.00B21-119[»]
3LKSX-ray1.90B21-119[»]
3LN4X-ray1.30B21-119[»]
3LN5X-ray1.90B21-119[»]
3LOWX-ray2.30A/B21-119[»]
3LOZX-ray1.80A/B/C/D74-79[»]
3LV3X-ray1.94B21-119[»]
3M17X-ray2.60B/D/F/H21-119[»]
3M1BX-ray3.10B/D/F/H21-119[»]
3MGOX-ray2.30B/E/H/K21-119[»]
3MGTX-ray2.20B/E/H/K21-119[»]
3MR9X-ray1.93B21-119[»]
3MRBX-ray1.40B21-119[»]
3MRCX-ray1.80B21-119[»]
3MRDX-ray1.70B21-119[»]
3MREX-ray1.10B21-119[»]
3MRFX-ray2.30B21-119[»]
3MRGX-ray1.30B21-119[»]
3MRHX-ray2.40B21-119[»]
3MRIX-ray2.10B21-119[»]
3MRJX-ray1.87B21-119[»]
3MRKX-ray1.40B21-119[»]
3MRLX-ray2.41B21-119[»]
3MRMX-ray1.90B21-119[»]
3MRNX-ray2.30B21-119[»]
3MROX-ray2.35B21-119[»]
3MRPX-ray2.10B21-119[»]
3MRQX-ray2.20B21-119[»]
3MRRX-ray1.60B21-119[»]
3MV7X-ray2.00B21-119[»]
3MV8X-ray2.10B21-119[»]
3MV9X-ray2.70B21-119[»]
3MYJX-ray1.89B/E21-119[»]
3MYZX-ray1.60A/B21-119[»]
3MZTX-ray2.70A/B/C/D/E/F21-119[»]
3NA4X-ray1.90A21-119[»]
3NFNX-ray2.39B21-119[»]
3O3AX-ray1.80B/E21-119[»]
3O3BX-ray1.90B/E21-119[»]
3O3DX-ray1.70B/E21-119[»]
3O3EX-ray1.85B/E21-119[»]
3O4LX-ray2.54B21-119[»]
3OV6X-ray2.50A21-119[»]
3OX8X-ray2.16B/E21-119[»]
3OXRX-ray1.70B21-119[»]
3OXSX-ray1.75B21-119[»]
3PWJX-ray1.70B/E21-119[»]
3PWLX-ray1.65B/E21-119[»]
3PWNX-ray1.60B/E21-119[»]
3PWPX-ray2.69B21-119[»]
3QDAX-ray1.57A21-119[»]
3QDGX-ray2.69B21-119[»]
3QDJX-ray2.30B21-119[»]
3QDMX-ray2.80B21-119[»]
3QEQX-ray2.59B21-119[»]
3QFDX-ray1.68B/E21-119[»]
3QFJX-ray2.29B21-119[»]
3QZWX-ray2.80B/E21-119[»]
3REWX-ray1.90B/E21-119[»]
3RL1X-ray2.00B21-119[»]
3RL2X-ray2.39B21-119[»]
3RWJX-ray2.70B21-119[»]
3S6CX-ray2.90A21-119[»]
3SDXX-ray3.12B/D21-119[»]
3SJVX-ray3.10B/G/L/Q21-119[»]
3SKMX-ray1.80B21-119[»]
3SKOX-ray1.60B21-119[»]
3SPVX-ray1.30B21-119[»]
3T8XX-ray1.90B/D21-119[»]
3TIDX-ray1.65B21-119[»]
3TIEX-ray2.25B/E21-119[»]
3TLRX-ray2.45A/B/C/D21-119[»]
3TM6X-ray2.70A/B/C/D/E/F/G/H21-119[»]
3TO2X-ray2.60B21-119[»]
3TZVX-ray3.06D21-119[»]
3U0PX-ray2.80B/D/F21-119[»]
3UPRX-ray2.00B/D21-119[»]
3UTQX-ray1.67B21-119[»]
3UTSX-ray2.71B/G21-119[»]
3UTTX-ray2.60B/G21-119[»]
3V5DX-ray2.00B/E21-119[»]
3V5HX-ray1.63B/E21-119[»]
3V5KX-ray2.31B/E21-119[»]
3VCLX-ray1.70B21-119[»]
3VFMX-ray1.90B21-119[»]
3VFNX-ray1.50B21-119[»]
3VFOX-ray1.70B21-119[»]
3VFPX-ray1.85B21-119[»]
3VFRX-ray1.85B21-119[»]
3VFSX-ray1.85B21-119[»]
3VFTX-ray1.95B21-119[»]
3VFUX-ray1.65B21-119[»]
3VFVX-ray1.55B21-119[»]
3VFWX-ray2.30B21-119[»]
3VH8X-ray1.80B/E21-119[»]
3VRIX-ray1.60B21-119[»]
3VRJX-ray1.90B21-119[»]
3VWJX-ray3.09B21-119[»]
3VWKX-ray2.94B21-119[»]
3VXMX-ray2.50B21-119[»]
3VXNX-ray1.95B21-119[»]
3VXOX-ray2.61B/E21-119[»]
3VXPX-ray2.50B/E21-119[»]
3VXRX-ray2.40B21-119[»]
3VXSX-ray1.80B21-119[»]
3VXUX-ray2.70B/G21-119[»]
3W0WX-ray2.60B21-119[»]
3W39X-ray3.10B/E21-119[»]
3WL9X-ray1.66B21-119[»]
3WLBX-ray2.00B21-119[»]
3WUWX-ray2.00B22-119[»]
4BEOX-ray2.43B/D21-119[»]
4E0KX-ray0.97A/B/C/D78-83[»]
4E0LX-ray1.70A/B/C/D82-89[»]
4E5XX-ray1.95B/E21-119[»]
4EN3X-ray2.57D21-119[»]
4EUPX-ray2.88B/E21-119[»]
4EUQX-ray2.69B/E21-119[»]
4F7MX-ray2.40B/E21-119[»]
4F7PX-ray1.90B21-119[»]
4F7TX-ray1.70B/E21-119[»]
4FTVX-ray2.74B21-119[»]
4FXLX-ray1.40A21-119[»]
4G8GX-ray2.40B21-119[»]
4G8IX-ray1.60B21-119[»]
4G9DX-ray1.60B21-119[»]
4G9FX-ray1.90B21-119[»]
4GKNX-ray2.75B/E21-119[»]
4GKSX-ray2.35B/E21-119[»]
4GUPX-ray3.20B/D21-119[»]
4HKJX-ray3.00B/F/J/N21-119[»]
4HWZX-ray2.40B21-119[»]
4HX1X-ray1.80B21-119[»]
4I48X-ray2.80B21-119[»]
4I4WX-ray1.77B21-119[»]
4JFDX-ray2.46B21-119[»]
4JFEX-ray2.70B21-119[»]
4JFFX-ray2.43B21-119[»]
4JFOX-ray2.11B/E21-119[»]
4JFPX-ray1.91B/E21-119[»]
4JFQX-ray1.90B/E21-119[»]
4JQVX-ray1.50C21-119[»]
4JQXX-ray1.90C21-119[»]
4JRXX-ray2.30B21-119[»]
4JRYX-ray2.80B21-119[»]
4K71X-ray2.40C/F21-119[»]
4K7FX-ray2.00B/E21-119[»]
4KDTX-ray2.60C/D21-119[»]
4L29X-ray3.09B/D/F/H/J/L/N/P/R/T/V/X/Z/b21-119[»]
4L3CX-ray2.64B/D/F/H/J/L/N/P/R/T/V/X/Z/b21-119[»]
4L3EX-ray2.56B21-119[»]
4L4TX-ray2.00B/F21-119[»]
4L4VX-ray1.90B/F21-119[»]
4LCWX-ray2.40B/F21-119[»]
4LHUX-ray2.87B21-119[»]
4MJIX-ray2.99B/G21-119[»]
4MNQX-ray2.74B21-119[»]
4N0FX-ray3.02B/F/I/L21-119[»]
4N0UX-ray3.80B21-119[»]
4N8VX-ray2.50B/E21-119[»]
4NQCX-ray2.50B/F21-119[»]
4NQDX-ray2.20B/F21-119[»]
4NQEX-ray2.10B/F21-119[»]
4NQVX-ray2.39B/D/F/H/J/L21-119[»]
4NQXX-ray2.00B/D/F/H/J/L21-119[»]
4PR5X-ray1.80B21-119[»]
4PRAX-ray1.85B21-119[»]
4PRBX-ray1.75B21-119[»]
4PRDX-ray1.75B21-119[»]
4PREX-ray1.65B21-119[»]
4PRHX-ray2.50B23-119[»]
4PRIX-ray2.40B21-119[»]
4PRNX-ray1.65B21-119[»]
4PRPX-ray2.50B21-119[»]
ProteinModelPortaliP61769.
SMRiP61769. Positions 21-119.

Miscellaneous databases

EvolutionaryTraceiP61769.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini25 – 11389Ig-like C1-typeAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Signal

Phylogenomic databases

eggNOGiNOG40777.
HOVERGENiHBG006197.
KOiK08055.
OrthoDBiEOG7RFTKJ.
PhylomeDBiP61769.
TreeFamiTF334167.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
[Graphical view]
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P61769-1 [UniParc]FASTAAdd to Basket

« Hide

MSRSVALAVL ALLSLSGLEA IQRTPKIQVY SRHPAENGKS NFLNCYVSGF    50
HPSDIEVDLL KNGERIEKVE HSDLSFSKDW SFYLLYYTEF TPTEKDEYAC 100
RVNHVTLSQP KIVKWDRDM 119
Length:119
Mass (Da):13,715
Last modified:July 21, 1986 - v1
Checksum:iAFD2DBEF07DCEF27
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti11 – 111A → P in HYCATHYP; lower levels of B2M, MHC class I and FCGRT proteins. 1 Publication
VAR_030660

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti20 – 201A → G in AAA51811. 1 Publication
Sequence conflicti52 – 521P → Q in AAA51811. 1 Publication
Sequence conflicti119 – 1191M → I in CAG33347. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M17987, M17986 Genomic DNA. Translation: AAA51811.1.
AY187687 mRNA. Translation: AAO20842.1.
AB021288 mRNA. Translation: BAA35182.1.
DQ217933 Genomic DNA. Translation: ABB01003.1.
AF072097 mRNA. Translation: AAD48083.1.
AY007153 mRNA. Translation: AAG02006.1.
CR457066 mRNA. Translation: CAG33347.1.
AK315776 mRNA. Translation: BAG38125.1.
CH471082 Genomic DNA. Translation: EAW77277.1.
BC032589 mRNA. Translation: AAH32589.1.
BC064910 mRNA. Translation: AAH64910.1.
V00567 mRNA. Translation: CAA23830.1.
CCDSiCCDS10113.1.
PIRiA90976. MGHUB2.
RefSeqiNP_004039.1. NM_004048.2.
UniGeneiHs.534255.

Genome annotation databases

EnsembliENST00000558401; ENSP00000452780; ENSG00000166710.
ENST00000559916; ENSP00000453350; ENSG00000166710.
ENST00000561424; ENSP00000453191; ENSG00000166710.
GeneIDi567.
KEGGihsa:567.
UCSCiuc001zuc.3. human.

Polymorphism databases

DMDMi48428791.

Cross-referencesi

Web resourcesi

Wikipedia

Beta-2-microglobulin entry

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M17987 , M17986 Genomic DNA. Translation: AAA51811.1 .
AY187687 mRNA. Translation: AAO20842.1 .
AB021288 mRNA. Translation: BAA35182.1 .
DQ217933 Genomic DNA. Translation: ABB01003.1 .
AF072097 mRNA. Translation: AAD48083.1 .
AY007153 mRNA. Translation: AAG02006.1 .
CR457066 mRNA. Translation: CAG33347.1 .
AK315776 mRNA. Translation: BAG38125.1 .
CH471082 Genomic DNA. Translation: EAW77277.1 .
BC032589 mRNA. Translation: AAH32589.1 .
BC064910 mRNA. Translation: AAH64910.1 .
V00567 mRNA. Translation: CAA23830.1 .
CCDSi CCDS10113.1.
PIRi A90976. MGHUB2.
RefSeqi NP_004039.1. NM_004048.2.
UniGenei Hs.534255.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1A1M X-ray 2.30 B 21-119 [» ]
1A1N X-ray 2.00 B 21-119 [» ]
1A1O X-ray 2.30 B 21-119 [» ]
1A6Z X-ray 2.60 B/D 21-119 [» ]
1A9B X-ray 3.20 B/E 21-119 [» ]
1A9E X-ray 2.50 B 21-119 [» ]
1AGB X-ray 2.20 B 21-119 [» ]
1AGC X-ray 2.10 B 21-119 [» ]
1AGD X-ray 2.05 B 21-119 [» ]
1AGE X-ray 2.30 B 21-119 [» ]
1AGF X-ray 2.20 B 21-119 [» ]
1AKJ X-ray 2.65 B 21-119 [» ]
1AO7 X-ray 2.60 B 21-119 [» ]
1B0G X-ray 2.50 B/E 21-119 [» ]
1B0R X-ray 2.90 B 21-119 [» ]
1BD2 X-ray 2.50 B 21-119 [» ]
1C16 X-ray 3.10 B/D/F/H 21-119 [» ]
1CE6 X-ray 2.90 B 21-119 [» ]
1CG9 X-ray 2.70 B 21-119 [» ]
1DE4 X-ray 2.80 B/E/H 21-119 [» ]
1DUY X-ray 2.15 B/E 21-119 [» ]
1DUZ X-ray 1.80 B/E 21-119 [» ]
1E27 X-ray 2.20 B 21-119 [» ]
1E28 X-ray 3.00 B 21-119 [» ]
1EEY X-ray 2.25 B/E 21-119 [» ]
1EEZ X-ray 2.30 B/E 21-119 [» ]
1EFX X-ray 3.00 B 21-119 [» ]
1EXU X-ray 2.70 B 21-119 [» ]
1GZP X-ray 2.80 B 21-119 [» ]
1GZQ X-ray 2.26 B 21-119 [» ]
1HHG X-ray 2.60 B/E 21-119 [» ]
1HHH X-ray 3.00 B 21-119 [» ]
1HHI X-ray 2.50 B/E 21-119 [» ]
1HHJ X-ray 2.50 B/E 21-119 [» ]
1HHK X-ray 2.50 B/E 21-119 [» ]
1HLA X-ray 3.50 M 21-117 [» ]
1HSA X-ray 2.10 B/E 21-119 [» ]
1HSB X-ray 1.90 B 21-119 [» ]
1I1F X-ray 2.80 B/E 21-119 [» ]
1I1Y X-ray 2.20 B/E 21-119 [» ]
1I4F X-ray 1.40 B 21-119 [» ]
1I7R X-ray 2.20 B/E 21-119 [» ]
1I7T X-ray 2.80 B/E 21-119 [» ]
1I7U X-ray 1.80 B/E 21-119 [» ]
1IM3 X-ray 2.20 B/F/J/N 21-119 [» ]
1IM9 X-ray 2.80 B/F 21-119 [» ]
1JF1 X-ray 1.85 B 21-119 [» ]
1JGD X-ray 1.90 B 21-119 [» ]
1JGE X-ray 2.10 B 21-119 [» ]
1JHT X-ray 2.15 B 21-119 [» ]
1JNJ NMR - A 21-119 [» ]
1K5N X-ray 1.09 B 21-119 [» ]
1KPR X-ray 2.80 B/D 21-119 [» ]
1KTL X-ray 3.10 B/D 21-119 [» ]
1LDS X-ray 1.80 A 21-119 [» ]
1LP9 X-ray 2.00 B/I 21-119 [» ]
1M05 X-ray 1.90 B/D 21-119 [» ]
1M6O X-ray 1.60 B 21-119 [» ]
1MHE X-ray 2.85 B/D 21-119 [» ]
1MI5 X-ray 2.50 B 21-119 [» ]
1N2R X-ray 1.70 B 21-119 [» ]
1OF2 X-ray 2.20 B 21-119 [» ]
1OGA X-ray 1.40 B 21-119 [» ]
1OGT X-ray 1.47 B 21-119 [» ]
1ONQ X-ray 2.15 B/D 21-119 [» ]
1P7Q X-ray 3.40 B 21-119 [» ]
1PY4 X-ray 2.90 A/B/C/D 21-119 [» ]
1Q94 X-ray 2.40 B/E 21-119 [» ]
1QEW X-ray 2.20 B 21-119 [» ]
1QLF X-ray 2.65 B 21-119 [» ]
1QQD X-ray 2.70 B 21-118 [» ]
1QR1 X-ray 2.40 B/E 20-119 [» ]
1QRN X-ray 2.80 B 21-119 [» ]
1QSE X-ray 2.80 B 20-119 [» ]
1QSF X-ray 2.80 B 20-119 [» ]
1QVO X-ray 2.22 B/E 21-119 [» ]
1R3H X-ray 2.50 B/D/F/H 21-119 [» ]
1S8D X-ray 2.20 B 21-119 [» ]
1S9W X-ray 2.20 B 21-119 [» ]
1S9X X-ray 2.50 B 21-119 [» ]
1S9Y X-ray 2.30 B 21-119 [» ]
1SYS X-ray 2.40 B 21-119 [» ]
1SYV X-ray 1.70 B 21-119 [» ]
1T1W X-ray 2.20 B 21-119 [» ]
1T1X X-ray 2.20 B 21-119 [» ]
1T1Y X-ray 2.00 B 21-119 [» ]
1T1Z X-ray 1.90 B 21-119 [» ]
1T20 X-ray 2.20 B 21-119 [» ]
1T21 X-ray 2.19 B 21-119 [» ]
1T22 X-ray 2.20 B 21-119 [» ]
1TMC X-ray 2.30 B 21-119 [» ]
1TVB X-ray 1.80 B/E 21-119 [» ]
1TVH X-ray 1.80 B/E 21-119 [» ]
1UQS X-ray 3.10 B 21-119 [» ]
1UR7 model - B 21-119 [» ]
1UXS X-ray 1.55 B 21-119 [» ]
1UXW X-ray 1.71 B 21-119 [» ]
1VGK X-ray 2.06 B 21-119 [» ]
1W0V X-ray 2.27 B 21-119 [» ]
1W0W X-ray 2.10 B 21-119 [» ]
1W72 X-ray 2.15 B/E 21-119 [» ]
1X7Q X-ray 1.45 B 21-119 [» ]
1XH3 X-ray 1.48 B 21-119 [» ]
1XR8 X-ray 2.30 B 21-119 [» ]
1XR9 X-ray 1.79 B 21-119 [» ]
1XZ0 X-ray 2.80 B/D 21-119 [» ]
1YDP X-ray 1.90 B 21-119 [» ]
1YPZ X-ray 3.40 B/D 21-119 [» ]
1ZHK X-ray 1.60 B 21-119 [» ]
1ZHL X-ray 1.50 B 21-119 [» ]
1ZS8 X-ray 3.00 B/D/F/H/J 21-119 [» ]
1ZSD X-ray 1.70 B 21-119 [» ]
1ZT4 X-ray 3.00 B/D 21-119 [» ]
1ZVS X-ray 2.80 B/E 21-119 [» ]
2A83 X-ray 1.40 B 21-119 [» ]
2AK4 X-ray 2.50 B/G/L/R 21-119 [» ]
2AV1 X-ray 1.95 B/E 21-119 [» ]
2AV7 X-ray 2.05 B/E 21-119 [» ]
2AXF X-ray 1.80 B 21-119 [» ]
2AXG X-ray 2.00 B 21-119 [» ]
2BCK X-ray 2.80 B/E 21-119 [» ]
2BNQ X-ray 1.70 B 21-119 [» ]
2BNR X-ray 1.90 B 21-119 [» ]
2BSR X-ray 2.30 B 21-119 [» ]
2BSS X-ray 2.00 B 21-119 [» ]
2BST X-ray 2.10 B 21-119 [» ]
2BVO X-ray 1.65 B 21-119 [» ]
2BVP X-ray 1.35 B 21-119 [» ]
2BVQ X-ray 2.00 B 21-119 [» ]
2C7U X-ray 2.38 B/E 21-119 [» ]
2CII X-ray 2.55 B 21-119 [» ]
2CIK X-ray 1.75 B 21-119 [» ]
2CLR X-ray 2.00 B/E 21-119 [» ]
2D31 X-ray 3.20 B/E 21-119 [» ]
2D4D X-ray 2.10 A 21-119 [» ]
2D4F X-ray 1.70 A 21-119 [» ]
2DYP X-ray 2.50 B 21-119 [» ]
2E8D NMR - A/B/C/D 40-61 [» ]
2ESV X-ray 2.60 B 21-119 [» ]
2F53 X-ray 2.10 B 21-119 [» ]
2F54 X-ray 2.70 B/G 21-119 [» ]
2F74 X-ray 2.70 B/E 21-119 [» ]
2F8O X-ray 1.70 A/B 21-119 [» ]
2FYY X-ray 1.50 B 21-119 [» ]
2FZ3 X-ray 1.90 B 21-119 [» ]
2GIT X-ray 1.70 B/E 21-119 [» ]
2GJ6 X-ray 2.56 B 21-119 [» ]
2GT9 X-ray 1.75 B/E 21-119 [» ]
2GTW X-ray 1.55 B/E 21-119 [» ]
2GTZ X-ray 1.70 B/E 21-119 [» ]
2GUO X-ray 1.90 B/E 21-119 [» ]
2H26 X-ray 1.80 B 21-119 [» ]
2H6P X-ray 1.90 B 21-119 [» ]
2HJK X-ray 1.85 B 21-119 [» ]
2HJL X-ray 1.50 B 21-119 [» ]
2HLA X-ray 2.60 B 21-119 [» ]
2HN7 X-ray 1.60 B 21-119 [» ]
2J8U X-ray 2.88 B/I 21-119 [» ]
2JCC X-ray 2.50 B/I 21-119 [» ]
2NW3 X-ray 1.70 B 21-119 [» ]
2NX5 X-ray 2.70 B/G/L/R 21-119 [» ]
2P5E X-ray 1.89 B 21-119 [» ]
2P5W X-ray 2.20 B 21-119 [» ]
2PO6 X-ray 3.20 B/F 21-119 [» ]
2PYE X-ray 2.30 B 21-119 [» ]
2RFX X-ray 2.50 B 21-119 [» ]
2UWE X-ray 2.40 B/I 21-119 [» ]
2V2W X-ray 1.60 B/E 21-119 [» ]
2V2X X-ray 1.60 B/E 21-119 [» ]
2VB5 NMR - A 21-119 [» ]
2VLJ X-ray 2.40 B 21-119 [» ]
2VLK X-ray 2.50 B 21-119 [» ]
2VLL X-ray 1.60 B/E 21-119 [» ]
2VLR X-ray 2.30 B/G 21-119 [» ]
2X4N X-ray 2.34 B/E 21-119 [» ]
2X4O X-ray 2.30 B/E 21-119 [» ]
2X4P X-ray 2.30 B/E 21-119 [» ]
2X4Q X-ray 1.90 B/E 21-119 [» ]
2X4R X-ray 2.30 B/E 21-119 [» ]
2X4S X-ray 2.55 B/E 21-119 [» ]
2X4T X-ray 2.30 B/E 21-119 [» ]
2X4U X-ray 2.10 B/E 21-119 [» ]
2X70 X-ray 2.00 B/E 21-119 [» ]
2X89 X-ray 2.16 D/E/F/G 27-119 [» ]
2XKS NMR - A 21-119 [» ]
2XKU NMR - A 27-119 [» ]
2XPG X-ray 2.60 B 22-118 [» ]
2YPK X-ray 1.95 B 21-119 [» ]
2YPL X-ray 2.40 B 21-119 [» ]
2YXF X-ray 1.13 A 21-119 [» ]
2Z9T X-ray 1.80 A 21-119 [» ]
3AM8 X-ray 2.80 C/D 21-119 [» ]
3B3I X-ray 1.86 B 21-119 [» ]
3B6S X-ray 1.80 B 21-119 [» ]
3BGM X-ray 1.60 B 21-119 [» ]
3BH8 X-ray 1.65 B 21-119 [» ]
3BH9 X-ray 1.70 B 21-119 [» ]
3BHB X-ray 2.20 B 22-119 [» ]
3BO8 X-ray 1.80 B 21-119 [» ]
3BP4 X-ray 1.85 B 21-119 [» ]
3BP7 X-ray 1.80 B 21-119 [» ]
3BVN X-ray 2.55 B/E 21-119 [» ]
3BW9 X-ray 1.75 B 21-119 [» ]
3BWA X-ray 1.30 B 21-119 [» ]
3BXN X-ray 1.86 B 21-119 [» ]
3BZE X-ray 2.50 B/D/F/H 21-119 [» ]
3BZF X-ray 2.50 B/D 23-119 [» ]
3C9N X-ray 1.87 B 21-119 [» ]
3CDG X-ray 3.40 B/D 21-119 [» ]
3CII X-ray 4.41 B/E 21-119 [» ]
3CIQ X-ray 2.90 A/B/C/D/E/F/G/H/I/J/K/L 21-119 [» ]
3CZF X-ray 1.20 B 21-119 [» ]
3D18 X-ray 1.74 B 21-119 [» ]
3D25 X-ray 1.30 B 22-119 [» ]
3D2U X-ray 2.21 B/F 21-119 [» ]
3D39 X-ray 2.81 B 21-119 [» ]
3D3V X-ray 2.80 B 21-119 [» ]
3DBX X-ray 2.00 B 21-119 [» ]
3DHJ X-ray 2.00 A 21-119 [» ]
3DHM X-ray 1.80 A 21-119 [» ]
3DTX X-ray 2.10 B 21-119 [» ]
3DX6 X-ray 1.70 B 21-119 [» ]
3DX7 X-ray 1.60 B 21-119 [» ]
3DX8 X-ray 2.10 B 21-119 [» ]
3DXA X-ray 3.50 B/G/L 21-119 [» ]
3EKC X-ray 1.80 A 21-119 [» ]
3FFC X-ray 2.80 B/G 21-119 [» ]
3FQN X-ray 1.65 B 22-119 [» ]
3FQR X-ray 1.70 B 22-119 [» ]
3FQT X-ray 1.80 B 22-119 [» ]
3FQU X-ray 1.80 B 22-119 [» ]
3FQW X-ray 1.93 B 22-119 [» ]
3FQX X-ray 1.70 B 22-119 [» ]
3FT2 X-ray 1.80 B 21-119 [» ]
3FT3 X-ray 1.95 B 21-119 [» ]
3FT4 X-ray 1.90 B 21-119 [» ]
3GIV X-ray 2.00 B/E 21-119 [» ]
3GJF X-ray 1.90 B/E 21-119 [» ]
3GSN X-ray 2.80 L 21-119 [» ]
3GSO X-ray 1.60 B 21-119 [» ]
3GSQ X-ray 2.12 B 21-119 [» ]
3GSR X-ray 1.95 B 21-119 [» ]
3GSU X-ray 1.80 B 21-119 [» ]
3GSV X-ray 1.90 B 21-119 [» ]
3GSW X-ray 1.81 B 21-119 [» ]
3GSX X-ray 2.10 B 21-119 [» ]
3H7B X-ray 1.88 B/E 21-119 [» ]
3H9H X-ray 2.00 B/E 21-119 [» ]
3H9S X-ray 2.70 B 21-119 [» ]
3HAE X-ray 2.90 B/E/K/Q 21-119 [» ]
3HCV X-ray 1.95 B 21-119 [» ]
3HG1 X-ray 3.00 B 21-119 [» ]
3HLA X-ray 2.60 B 21-119 [» ]
3HPJ X-ray 2.00 B/E 21-119 [» ]
3HUJ X-ray 2.50 B/D 21-119 [» ]
3I6G X-ray 2.20 B/E 21-119 [» ]
3I6K X-ray 2.80 B/F 21-119 [» ]
3I6L X-ray 2.40 E 21-119 [» ]
3IB4 X-ray 1.25 A 21-119 [» ]
3IXA X-ray 2.10 B/E 21-119 [» ]
3JTS X-ray 2.80 B/E/H 1-119 [» ]
3KLA X-ray 1.65 B/E 21-119 [» ]
3KPL X-ray 1.96 B 21-119 [» ]
3KPM X-ray 1.60 B 21-119 [» ]
3KPN X-ray 2.00 B 21-119 [» ]
3KPO X-ray 2.30 B 21-119 [» ]
3KPP X-ray 1.90 B 21-119 [» ]
3KPQ X-ray 1.84 B 21-119 [» ]
3KPR X-ray 2.60 B/G 21-119 [» ]
3KPS X-ray 2.70 B 21-119 [» ]
3KWW X-ray 2.18 B 21-119 [» ]
3KXF X-ray 3.10 B/F/J/L 21-119 [» ]
3KYN X-ray 2.40 B 21-119 [» ]
3KYO X-ray 1.70 B/D 21-119 [» ]
3L3D X-ray 1.80 B 21-119 [» ]
3L3G X-ray 2.10 B 21-119 [» ]
3L3I X-ray 1.70 B 21-119 [» ]
3L3J X-ray 2.40 B 21-119 [» ]
3L3K X-ray 2.60 B 21-119 [» ]
3LKN X-ray 2.00 B 21-119 [» ]
3LKO X-ray 1.80 B 21-119 [» ]
3LKP X-ray 1.80 B 21-119 [» ]
3LKQ X-ray 1.80 B 21-119 [» ]
3LKR X-ray 2.00 B 21-119 [» ]
3LKS X-ray 1.90 B 21-119 [» ]
3LN4 X-ray 1.30 B 21-119 [» ]
3LN5 X-ray 1.90 B 21-119 [» ]
3LOW X-ray 2.30 A/B 21-119 [» ]
3LOZ X-ray 1.80 A/B/C/D 74-79 [» ]
3LV3 X-ray 1.94 B 21-119 [» ]
3M17 X-ray 2.60 B/D/F/H 21-119 [» ]
3M1B X-ray 3.10 B/D/F/H 21-119 [» ]
3MGO X-ray 2.30 B/E/H/K 21-119 [» ]
3MGT X-ray 2.20 B/E/H/K 21-119 [» ]
3MR9 X-ray 1.93 B 21-119 [» ]
3MRB X-ray 1.40 B 21-119 [» ]
3MRC X-ray 1.80 B 21-119 [» ]
3MRD X-ray 1.70 B 21-119 [» ]
3MRE X-ray 1.10 B 21-119 [» ]
3MRF X-ray 2.30 B 21-119 [» ]
3MRG X-ray 1.30 B 21-119 [» ]
3MRH X-ray 2.40 B 21-119 [» ]
3MRI X-ray 2.10 B 21-119 [» ]
3MRJ X-ray 1.87 B 21-119 [» ]
3MRK X-ray 1.40 B 21-119 [» ]
3MRL X-ray 2.41 B 21-119 [» ]
3MRM X-ray 1.90 B 21-119 [» ]
3MRN X-ray 2.30 B 21-119 [» ]
3MRO X-ray 2.35 B 21-119 [» ]
3MRP X-ray 2.10 B 21-119 [» ]
3MRQ X-ray 2.20 B 21-119 [» ]
3MRR X-ray 1.60 B 21-119 [» ]
3MV7 X-ray 2.00 B 21-119 [» ]
3MV8 X-ray 2.10 B 21-119 [» ]
3MV9 X-ray 2.70 B 21-119 [» ]
3MYJ X-ray 1.89 B/E 21-119 [» ]
3MYZ X-ray 1.60 A/B 21-119 [» ]
3MZT X-ray 2.70 A/B/C/D/E/F 21-119 [» ]
3NA4 X-ray 1.90 A 21-119 [» ]
3NFN X-ray 2.39 B 21-119 [» ]
3O3A X-ray 1.80 B/E 21-119 [» ]
3O3B X-ray 1.90 B/E 21-119 [» ]
3O3D X-ray 1.70 B/E 21-119 [» ]
3O3E X-ray 1.85 B/E 21-119 [» ]
3O4L X-ray 2.54 B 21-119 [» ]
3OV6 X-ray 2.50 A 21-119 [» ]
3OX8 X-ray 2.16 B/E 21-119 [» ]
3OXR X-ray 1.70 B 21-119 [» ]
3OXS X-ray 1.75 B 21-119 [» ]
3PWJ X-ray 1.70 B/E 21-119 [» ]
3PWL X-ray 1.65 B/E 21-119 [» ]
3PWN X-ray 1.60 B/E 21-119 [» ]
3PWP X-ray 2.69 B 21-119 [» ]
3QDA X-ray 1.57 A 21-119 [» ]
3QDG X-ray 2.69 B 21-119 [» ]
3QDJ X-ray 2.30 B 21-119 [» ]
3QDM X-ray 2.80 B 21-119 [» ]
3QEQ X-ray 2.59 B 21-119 [» ]
3QFD X-ray 1.68 B/E 21-119 [» ]
3QFJ X-ray 2.29 B 21-119 [» ]
3QZW X-ray 2.80 B/E 21-119 [» ]
3REW X-ray 1.90 B/E 21-119 [» ]
3RL1 X-ray 2.00 B 21-119 [» ]
3RL2 X-ray 2.39 B 21-119 [» ]
3RWJ X-ray 2.70 B 21-119 [» ]
3S6C X-ray 2.90 A 21-119 [» ]
3SDX X-ray 3.12 B/D 21-119 [» ]
3SJV X-ray 3.10 B/G/L/Q 21-119 [» ]
3SKM X-ray 1.80 B 21-119 [» ]
3SKO X-ray 1.60 B 21-119 [» ]
3SPV X-ray 1.30 B 21-119 [» ]
3T8X X-ray 1.90 B/D 21-119 [» ]
3TID X-ray 1.65 B 21-119 [» ]
3TIE X-ray 2.25 B/E 21-119 [» ]
3TLR X-ray 2.45 A/B/C/D 21-119 [» ]
3TM6 X-ray 2.70 A/B/C/D/E/F/G/H 21-119 [» ]
3TO2 X-ray 2.60 B 21-119 [» ]
3TZV X-ray 3.06 D 21-119 [» ]
3U0P X-ray 2.80 B/D/F 21-119 [» ]
3UPR X-ray 2.00 B/D 21-119 [» ]
3UTQ X-ray 1.67 B 21-119 [» ]
3UTS X-ray 2.71 B/G 21-119 [» ]
3UTT X-ray 2.60 B/G 21-119 [» ]
3V5D X-ray 2.00 B/E 21-119 [» ]
3V5H X-ray 1.63 B/E 21-119 [» ]
3V5K X-ray 2.31 B/E 21-119 [» ]
3VCL X-ray 1.70 B 21-119 [» ]
3VFM X-ray 1.90 B 21-119 [» ]
3VFN X-ray 1.50 B 21-119 [» ]
3VFO X-ray 1.70 B 21-119 [» ]
3VFP X-ray 1.85 B 21-119 [» ]
3VFR X-ray 1.85 B 21-119 [» ]
3VFS X-ray 1.85 B 21-119 [» ]
3VFT X-ray 1.95 B 21-119 [» ]
3VFU X-ray 1.65 B 21-119 [» ]
3VFV X-ray 1.55 B 21-119 [» ]
3VFW X-ray 2.30 B 21-119 [» ]
3VH8 X-ray 1.80 B/E 21-119 [» ]
3VRI X-ray 1.60 B 21-119 [» ]
3VRJ X-ray 1.90 B 21-119 [» ]
3VWJ X-ray 3.09 B 21-119 [» ]
3VWK X-ray 2.94 B 21-119 [» ]
3VXM X-ray 2.50 B 21-119 [» ]
3VXN X-ray 1.95 B 21-119 [» ]
3VXO X-ray 2.61 B/E 21-119 [» ]
3VXP X-ray 2.50 B/E 21-119 [» ]
3VXR X-ray 2.40 B 21-119 [» ]
3VXS X-ray 1.80 B 21-119 [» ]
3VXU X-ray 2.70 B/G 21-119 [» ]
3W0W X-ray 2.60 B 21-119 [» ]
3W39 X-ray 3.10 B/E 21-119 [» ]
3WL9 X-ray 1.66 B 21-119 [» ]
3WLB X-ray 2.00 B 21-119 [» ]
3WUW X-ray 2.00 B 22-119 [» ]
4BEO X-ray 2.43 B/D 21-119 [» ]
4E0K X-ray 0.97 A/B/C/D 78-83 [» ]
4E0L X-ray 1.70 A/B/C/D 82-89 [» ]
4E5X X-ray 1.95 B/E 21-119 [» ]
4EN3 X-ray 2.57 D 21-119 [» ]
4EUP X-ray 2.88 B/E 21-119 [» ]
4EUQ X-ray 2.69 B/E 21-119 [» ]
4F7M X-ray 2.40 B/E 21-119 [» ]
4F7P X-ray 1.90 B 21-119 [» ]
4F7T X-ray 1.70 B/E 21-119 [» ]
4FTV X-ray 2.74 B 21-119 [» ]
4FXL X-ray 1.40 A 21-119 [» ]
4G8G X-ray 2.40 B 21-119 [» ]
4G8I X-ray 1.60 B 21-119 [» ]
4G9D X-ray 1.60 B 21-119 [» ]
4G9F X-ray 1.90 B 21-119 [» ]
4GKN X-ray 2.75 B/E 21-119 [» ]
4GKS X-ray 2.35 B/E 21-119 [» ]
4GUP X-ray 3.20 B/D 21-119 [» ]
4HKJ X-ray 3.00 B/F/J/N 21-119 [» ]
4HWZ X-ray 2.40 B 21-119 [» ]
4HX1 X-ray 1.80 B 21-119 [» ]
4I48 X-ray 2.80 B 21-119 [» ]
4I4W X-ray 1.77 B 21-119 [» ]
4JFD X-ray 2.46 B 21-119 [» ]
4JFE X-ray 2.70 B 21-119 [» ]
4JFF X-ray 2.43 B 21-119 [» ]
4JFO X-ray 2.11 B/E 21-119 [» ]
4JFP X-ray 1.91 B/E 21-119 [» ]
4JFQ X-ray 1.90 B/E 21-119 [» ]
4JQV X-ray 1.50 C 21-119 [» ]
4JQX X-ray 1.90 C 21-119 [» ]
4JRX X-ray 2.30 B 21-119 [» ]
4JRY X-ray 2.80 B 21-119 [» ]
4K71 X-ray 2.40 C/F 21-119 [» ]
4K7F X-ray 2.00 B/E 21-119 [» ]
4KDT X-ray 2.60 C/D 21-119 [» ]
4L29 X-ray 3.09 B/D/F/H/J/L/N/P/R/T/V/X/Z/b 21-119 [» ]
4L3C X-ray 2.64 B/D/F/H/J/L/N/P/R/T/V/X/Z/b 21-119 [» ]
4L3E X-ray 2.56 B 21-119 [» ]
4L4T X-ray 2.00 B/F 21-119 [» ]
4L4V X-ray 1.90 B/F 21-119 [» ]
4LCW X-ray 2.40 B/F 21-119 [» ]
4LHU X-ray 2.87 B 21-119 [» ]
4MJI X-ray 2.99 B/G 21-119 [» ]
4MNQ X-ray 2.74 B 21-119 [» ]
4N0F X-ray 3.02 B/F/I/L 21-119 [» ]
4N0U X-ray 3.80 B 21-119 [» ]
4N8V X-ray 2.50 B/E 21-119 [» ]
4NQC X-ray 2.50 B/F 21-119 [» ]
4NQD X-ray 2.20 B/F 21-119 [» ]
4NQE X-ray 2.10 B/F 21-119 [» ]
4NQV X-ray 2.39 B/D/F/H/J/L 21-119 [» ]
4NQX X-ray 2.00 B/D/F/H/J/L 21-119 [» ]
4PR5 X-ray 1.80 B 21-119 [» ]
4PRA X-ray 1.85 B 21-119 [» ]
4PRB X-ray 1.75 B 21-119 [» ]
4PRD X-ray 1.75 B 21-119 [» ]
4PRE X-ray 1.65 B 21-119 [» ]
4PRH X-ray 2.50 B 23-119 [» ]
4PRI X-ray 2.40 B 21-119 [» ]
4PRN X-ray 1.65 B 21-119 [» ]
4PRP X-ray 2.50 B 21-119 [» ]
ProteinModelPortali P61769.
SMRi P61769. Positions 21-119.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 107044. 15 interactions.
DIPi DIP-6055N.
IntActi P61769. 71 interactions.
MINTi MINT-85778.
STRINGi 9606.ENSP00000340858.

PTM databases

PhosphoSitei P61769.

Polymorphism databases

DMDMi 48428791.

2D gel databases

DOSAC-COBS-2DPAGE P61769.
OGPi P61769.
SWISS-2DPAGE P61769.

Proteomic databases

MaxQBi P61769.
PaxDbi P61769.
PeptideAtlasi P61769.
PRIDEi P61769.

Protocols and materials databases

DNASUi 567.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000558401 ; ENSP00000452780 ; ENSG00000166710 .
ENST00000559916 ; ENSP00000453350 ; ENSG00000166710 .
ENST00000561424 ; ENSP00000453191 ; ENSG00000166710 .
GeneIDi 567.
KEGGi hsa:567.
UCSCi uc001zuc.3. human.

Organism-specific databases

CTDi 567.
GeneCardsi GC15P045003.
HGNCi HGNC:914. B2M.
HPAi CAB002572.
HPA006361.
MIMi 109700. gene.
241600. phenotype.
neXtProti NX_P61769.
Orphaneti 314652. Autosomal dominant beta2-microglobulinic amyloidosis.
PharmGKBi PA25207.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG40777.
HOVERGENi HBG006197.
KOi K08055.
OrthoDBi EOG7RFTKJ.
PhylomeDBi P61769.
TreeFami TF334167.

Enzyme and pathway databases

Reactomei REACT_11103. Nef mediated downregulation of MHC class I complex cell surface expression.
REACT_111168. Endosomal/Vacuolar pathway.
REACT_111178. ER-Phagosome pathway.
REACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
REACT_147694. DAP12 interactions.
REACT_147814. DAP12 signaling.
REACT_25078. Interferon gamma signaling.
REACT_75795. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.
REACT_75925. Amyloids.

Miscellaneous databases

ChiTaRSi B2M. human.
EvolutionaryTracei P61769.
GeneWikii Beta-2_microglobulin.
GenomeRNAii 567.
NextBioi 2313.
PROi P61769.
SOURCEi Search...

Gene expression databases

ArrayExpressi P61769.
Bgeei P61769.
CleanExi HS_B2M.
Genevestigatori P61769.

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
[Graphical view ]
Pfami PF07654. C1-set. 1 hit.
[Graphical view ]
SMARTi SM00407. IGc1. 1 hit.
[Graphical view ]
PROSITEi PS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The human beta 2-microglobulin gene. Primary structure and definition of the transcriptional unit."
    Guessow D., Rein R., Ginjaar I., Hochstenbach F., Seemann G., Kottman A., Ploegh H.L.
    J. Immunol. 139:3132-3138(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Cloning of human beta-microglobulin gene and its high expression in Escherichia coli."
    He X.H., Xu L.H., Liu Y., Zeng Y.Y.
    Sheng Wu Gong Cheng Xue Bao 20:99-103(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Peripheral blood.
  3. "Human mRNA for beta 2-microglobulin."
    Matsumoto K., Minamitani T.
    Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Cervix carcinoma.
  4. "Genetic variation in immune response genes."
    Tan J., Ong R., Hibberd M.L., Seielstad M.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  5. "A novel gene from human dendritic cell."
    Zhao Z., Huang X., Li N., Zhu X., Cao X.
    Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Dendritic cell.
  6. "Pediatric leukemia cDNA sequencing project."
    Zhou J., Yu W., Tang H., Mei G., Tsang Y.T.M., Bouck J., Gibbs R.A., Margolin J.F.
    Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Leukemia.
  7. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  8. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Trachea.
  9. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  10. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Retina and Skin.
  11. "The beta-2-microglobulin mRNA in human Daudi cells has a mutated initiation codon but is still inducible by interferon."
    Rosa F., Berissi H., Weissenbach J., Maroteaux L., Fellous M., Revel M.
    EMBO J. 2:239-243(1983) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-21.
  12. "Use of synthetic oligonucleotides as hybridization probes: isolation of cloned cDNA sequences for human beta 2-microglobulin."
    Suggs S.V., Wallace R.B., Hirose T., Kawashima E.H., Itakura K.
    Proc. Natl. Acad. Sci. U.S.A. 78:6613-6617(1981) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 10-119.
  13. "The complete amino acid sequence of beta 2-microglobulin."
    Cunningham B.A., Wang J.L., Berggard I., Peterson P.A.
    Biochemistry 12:4811-4822(1973) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 21-119.
  14. "Polymerization of intact beta 2-microglobulin in tissue causes amyloidosis in patients on chronic hemodialysis."
    Gorevic P.D., Munoz P.C., Casey T.T., DiRaimondo C.R., Stone W.J., Prelli F.C., Rodrigues M.M., Poulik M.D., Frangione B.
    Proc. Natl. Acad. Sci. U.S.A. 83:7908-7912(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 21-119, SUBUNIT, INVOLVEMENT IN AMYLOIDOSIS.
  15. "Isolation of a granulocyte inhibitory protein from uraemic patients with homology of beta 2-microglobulin."
    Haag-Weber M., Mai B., Hoerl W.H.
    Nephrol. Dial. Transplant. 9:382-388(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 21-41.
    Tissue: Plasma.
  16. "Biochemical characterization of serum and urinary beta 2 microglobulin in end-stage renal disease patients."
    Argiles A., Derancourt J., Jauregui-Adell J., Mion C., Demaille J.G.
    Nephrol. Dial. Transplant. 7:1106-1110(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 21-40, SUBCELLULAR LOCATION.
  17. "Amino acid sequence of a modified beta 2-microglobulin in renal failure patient urine and long-term dialysis patient blood."
    Momoi T., Suzuki M., Titani K., Hisanaga S., Ogawa H., Saito A.
    Clin. Chim. Acta 236:135-144(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 22-119, SUBCELLULAR LOCATION, PYROGLUTAMATE FORMATION AT GLN-22 (FORM PI 5.3).
    Tissue: Urine.
  18. "Glycation of human beta 2-microglobulin in patients with hemodialysis-associated amyloidosis: identification of the glycated sites."
    Miyata T., Inagi R., Wada Y., Ueda Y., Iida Y., Takahashi M., Taniguchi N., Maeda K.
    Biochemistry 33:12215-12221(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: INVOLVEMENT IN AMYLOIDOSIS, GLYCATION AT ILE-21; LYS-39; LYS-61; LYS-68; LYS-78; LYS-111 AND LYS-114, IDENTIFICATION BY MASS SPECTROMETRY.
  19. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  20. "Structure of the human class I histocompatibility antigen, HLA-A2."
    Bjorkman P.J., Saper M.A., Samraoui B., Bennett W.S., Strominger J.L., Wiley D.C.
    Nature 329:506-512(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.5 ANGSTROMS).
  21. "Refined structure of the human histocompatibility antigen HLA-A2 at 2.6-A resolution."
    Saper M.A., Bjorkman P.J., Wiley D.C.
    J. Mol. Biol. 219:277-319(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS).
  22. "1H NMR assignments and secondary structure of human beta 2-microglobulin in solution."
    Okon M., Bray P., Vucelic D.
    Biochemistry 31:8906-8915(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR.
  23. "The three-dimensional structure of a class I major histocompatibility complex molecule missing the alpha 3 domain of the heavy chain."
    Collins E.J., Garboczi D.N., Karpusas M.N., Wiley D.C.
    Proc. Natl. Acad. Sci. U.S.A. 92:1218-1221(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS).
  24. "Bound water structure and polymorphic amino acids act together to allow the binding of different peptides to MHC class I HLA-B53."
    Smith K.J., Reid S.W., Harlos K., McMichael A.J., Stuart D.I., Bell J.I., Jones E.Y.
    Immunity 4:215-228(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS).
  25. "Crystal structure of monomeric human beta-2-microglobulin reveals clues to its amyloidogenic properties."
    Trinh C.H., Smith D.P., Kalverda A.P., Phillips S.E., Radford S.E.
    Proc. Natl. Acad. Sci. U.S.A. 99:9771-9776(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 21-119, DISULFIDE BOND.
  26. "A structural basis for immunodominant human T cell receptor recognition."
    Stewart-Jones G.B.E., McMichael A.J., Bell J.I., Stuart D.I., Jones E.Y.
    Nat. Immunol. 4:657-663(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.4 ANGSTROMS) OF 21-119 OF HLA-A/B2M HETERODIMER IN COMPLEX WITH TRAC AND TRBC1, DISULFIDE BOND.
  27. "Conformation of amyloid fibrils of beta2-microglobulin probed by tryptophan mutagenesis."
    Kihara M., Chatani E., Iwata K., Yamamoto K., Matsuura T., Nakagawa A., Naiki H., Goto Y.
    J. Biol. Chem. 281:31061-31069(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) OF 21-119, AMYLOID FORMATION, DISULFIDE BOND.
  28. "A native to amyloidogenic transition regulated by a backbone trigger."
    Eakin C.M., Berman A.J., Miranker A.D.
    Nat. Struct. Mol. Biol. 13:202-208(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) OF 21-119, DISULFIDE BOND.
  29. "High-resolution crystal structure of beta2-microglobulin formed at pH 7.0."
    Iwata K., Matsuura T., Sakurai K., Nakagawa A., Goto Y.
    J. Biochem. 142:413-419(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.13 ANGSTROMS) OF 21-119, DISULFIDE BOND.
  30. Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 21-119, MUTAGENESIS OF ASP-79, DISULFIDE BOND.
  31. "The controlling roles of Trp60 and Trp95 in beta2-microglobulin function, folding and amyloid aggregation properties."
    Esposito G., Ricagno S., Corazza A., Rennella E., Guemral D., Mimmi M.C., Betto E., Pucillo C.E., Fogolari F., Viglino P., Raimondi S., Giorgetti S., Bolognesi B., Merlini G., Stoppini M., Bolognesi M., Bellotti V.
    J. Mol. Biol. 378:887-897(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 21-119, MUTAGENESIS OF TRP-80, DISULFIDE BOND.
  32. "Human beta-2 microglobulin W60V mutant structure: Implications for stability and amyloid aggregation."
    Ricagno S., Raimondi S., Giorgetti S., Bellotti V., Bolognesi M.
    Biochem. Biophys. Res. Commun. 380:543-547(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 21-119, MUTAGENESIS OF TRP-80, DISULFIDE BOND.
  33. "Familial hypercatabolic hypoproteinemia caused by deficiency of the neonatal Fc receptor, FcRn, due to a mutant beta2-microglobulin gene."
    Wani M.A., Haynes L.D., Kim J., Bronson C.L., Chaudhury C., Mohanty S., Waldmann T.A., Robinson J.M., Anderson C.L.
    Proc. Natl. Acad. Sci. U.S.A. 103:5084-5089(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT HYCATHYP PRO-11, CHARACTERIZATION OF VARIANT HYCATHYP PRO-11.

Entry informationi

Entry nameiB2MG_HUMAN
AccessioniPrimary (citable) accession number: P61769
Secondary accession number(s): P01884
, Q540F8, Q6IAT8, Q9UCK0, Q9UD48, Q9UDF4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: September 3, 2014
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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