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Protein

Beta-2-microglobulin

Gene

B2M

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. Exogenously applied M.tuberculosis EsxA or EsxA-EsxB (or EsxA expressed in host) binds B2M and decreases its export to the cell surface (total protein levels do not change), probably leading to defects in class I antigen presentation (PubMed:25356553).1 Publication

GO - Molecular functioni

  • glycoprotein binding Source: BHF-UCL
  • identical protein binding Source: IntAct

GO - Biological processi

  • antibacterial humoral response Source: UniProtKB
  • antigen processing and presentation of endogenous peptide antigen via MHC class I Source: BHF-UCL
  • antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent Source: Reactome
  • antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent Source: Reactome
  • antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent Source: Ensembl
  • antigen processing and presentation of peptide antigen via MHC class I Source: Reactome
  • cellular protein metabolic process Source: Reactome
  • cellular response to iron ion Source: BHF-UCL
  • cellular response to lipopolysaccharide Source: UniProtKB
  • defense response to Gram-negative bacterium Source: UniProtKB
  • defense response to Gram-positive bacterium Source: UniProtKB
  • innate immune response Source: UniProtKB
  • interferon-gamma-mediated signaling pathway Source: Reactome
  • iron ion homeostasis Source: BHF-UCL
  • negative regulation of neuron projection development Source: Ensembl
  • negative regulation of receptor binding Source: BHF-UCL
  • positive regulation of ferrous iron binding Source: BHF-UCL
  • positive regulation of ferrous iron import into cell Source: BHF-UCL
  • positive regulation of protein binding Source: BHF-UCL
  • positive regulation of receptor binding Source: BHF-UCL
  • positive regulation of receptor-mediated endocytosis Source: BHF-UCL
  • positive regulation of T cell cytokine production Source: BHF-UCL
  • positive regulation of T cell mediated cytotoxicity Source: Ensembl
  • positive regulation of transferrin receptor binding Source: BHF-UCL
  • protein refolding Source: Ensembl
  • regulation of defense response to virus by virus Source: Reactome
  • regulation of immune response Source: Reactome
  • regulation of membrane depolarization Source: UniProtKB
  • response to cadmium ion Source: Ensembl
  • response to drug Source: Ensembl
  • retina homeostasis Source: UniProtKB
  • T cell differentiation in thymus Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Immunity

Enzyme and pathway databases

BioCyciZFISH:ENSG00000166710-MONOMER.
ReactomeiR-HSA-1236974. ER-Phagosome pathway.
R-HSA-1236977. Endosomal/Vacuolar pathway.
R-HSA-164940. Nef mediated downregulation of MHC class I complex cell surface expression.
R-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
R-HSA-2172127. DAP12 interactions.
R-HSA-2424491. DAP12 signaling.
R-HSA-6798695. Neutrophil degranulation.
R-HSA-877300. Interferon gamma signaling.
R-HSA-977225. Amyloid fiber formation.
R-HSA-983170. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-2-microglobulin
Cleaved into the following chain:
Gene namesi
Name:B2M
ORF Names:CDABP0092, HDCMA22P
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:914. B2M.

Subcellular locationi


    Note: (Microbial infection) In the presence of M.tuberculosis EsxA-EsxB complex decreased amounts of B2M are found on the cell surface (PubMed:25356553).1 Publication

GO - Cellular componenti

  • cytoplasm Source: HPA
  • early endosome lumen Source: Reactome
  • early endosome membrane Source: Reactome
  • endoplasmic reticulum lumen Source: Reactome
  • ER to Golgi transport vesicle membrane Source: Reactome
  • external side of plasma membrane Source: Ensembl
  • extracellular exosome Source: UniProtKB
  • extracellular region Source: Reactome
  • extracellular space Source: UniProtKB
  • focal adhesion Source: UniProtKB
  • Golgi apparatus Source: HPA
  • Golgi membrane Source: Reactome
  • HFE-transferrin receptor complex Source: BHF-UCL
  • membrane Source: UniProtKB
  • MHC class I protein complex Source: UniProtKB-KW
  • phagocytic vesicle membrane Source: Reactome
  • plasma membrane Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Amyloid, MHC I, Secreted

Pathology & Biotechi

Involvement in diseasei

Immunodeficiency 43 (IMD43)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder characterized by marked reduction in serum concentrations of immunoglobulins and albumin, and hypoproteinemia due to hypercatabolism. Patients may suffer from recurrent respiratory tract infections and severe skin disease.
See also OMIM:241600
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03066011A → P in IMD43; lower levels of B2M, MHC class I and FCGRT proteins. 1 PublicationCorresponds to variant rs104894481dbSNPEnsembl.1
Amyloidosis 8 (AMYL8)1 Publication
The disease is caused by mutations affecting the gene represented in this entry. Apart from the presence of causative mutations, beta-2-microglobulin may adopt the fibrillar configuration of amyloid when its serum levels are persistently high. High beta(2)-microglobulin serum levels result in amyloidosis in patients on long-term hemodialysis (PubMed:7918443). In contrast to patients with dialysis-related amyloidosis, patients with hereditary amyloidosis have normal circulating concentrations of beta2-microglobulin (PubMed:22693999).2 Publications
Disease descriptionA form of hereditary generalized amyloidosis. Clinical features include extensive visceral amyloid deposits, renal amyloidosis resulting in nephrotic syndrome, arterial hypertension, hepatosplenomegaly, cholestasis, petechial skin rash. There is no involvement of the nervous system.
See also OMIM:105200
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07669196D → N in AMYL8; reduced stability; in contrast to the wild-type, the mutant aggregates into fibrils with classic amyloid-like properties under physiologic solvent conditions. 1 Publication1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi79D → P: Increases tendency towards amyloid formation. 1 Publication1
Mutagenesisi80W → G: Decreases tendency towards amyloid formation. 2 Publications1
Mutagenesisi80W → V: Increases tendency towards amyloid formation. 2 Publications1

Keywords - Diseasei

Amyloidosis, Disease mutation

Organism-specific databases

DisGeNETi567.
MalaCardsiB2M.
MIMi105200. phenotype.
241600. phenotype.
OpenTargetsiENSG00000166710.
ENSG00000273686.
Orphaneti314652. Autosomal dominant beta2-microglobulinic amyloidosis.
PharmGKBiPA25207.

Chemistry databases

DrugBankiDB00254. Doxycycline.

Polymorphism and mutation databases

BioMutaiB2M.
DMDMi48428791.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 205 PublicationsAdd BLAST20
ChainiPRO_000001877921 – 119Beta-2-microglobulinAdd BLAST99
ChainiPRO_000001878022 – 119Beta-2-microglobulin form pI 5.3Add BLAST98

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi21N-linked (Glc) (glycation); in hemodialysis-associated amyloidosis1
Modified residuei22Pyrrolidone carboxylic acid; in form pI 5.31 Publication1
Glycosylationi39N-linked (Glc) (glycation); in vitro1
Disulfide bondi45 ↔ 100PROSITE-ProRule annotation8 Publications
Glycosylationi61N-linked (Glc) (glycation); in vitro1
Glycosylationi68N-linked (Glc) (glycation); in vitro1
Glycosylationi78N-linked (Glc) (glycation); in vitro1
Glycosylationi111N-linked (Glc) (glycation); in vitro1
Glycosylationi114N-linked (Glc) (glycation); in vitro1

Post-translational modificationi

Glycation of Ile-21 is observed in long-term hemodialysis patients.

Keywords - PTMi

Disulfide bond, Glycation, Glycoprotein, Pyrrolidone carboxylic acid

Proteomic databases

EPDiP61769.
MaxQBiP61769.
PaxDbiP61769.
PeptideAtlasiP61769.
PRIDEiP61769.
TopDownProteomicsiP61769.

2D gel databases

DOSAC-COBS-2DPAGEP61769.
OGPiP61769.
SWISS-2DPAGEP61769.

PTM databases

iPTMnetiP61769.
PhosphoSitePlusiP61769.

Expressioni

Gene expression databases

BgeeiENSG00000166710.
CleanExiHS_B2M.
ExpressionAtlasiP61769. baseline and differential.
GenevisibleiP61769. HS.

Organism-specific databases

HPAiCAB002572.
HPA006361.

Interactioni

Subunit structurei

Heterodimer of an alpha chain and a beta chain. Beta-2-microglobulin is the beta-chain of major histocompatibility complex class I molecules. Polymers of beta 2-microglobulin can be found in tissues from patients on long-term hemodialysis. B2M alone (not in complex with HLA-I) interacts with M.tuberculosis EsxA (ESAT-6) and an EsxA-EsxB (CFP-10) complex; the tripartite complex can be detected in the host endoplasmic reticulum (PubMed:25356553). The B2M-EsxA complex can be detected in patients with pleural tuberculosis and is stable from pH 4.0 to 8.0 and in the presence of 2M NaCl (PubMed:25356553).3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
itself9EBI-714718,EBI-714718
CD1AP061262EBI-714718,EBI-1036766
CD1BP290163EBI-714718,EBI-1033762
HFEQ302015EBI-714718,EBI-1028850

GO - Molecular functioni

  • identical protein binding Source: IntAct

Protein-protein interaction databases

BioGridi107044. 41 interactors.
DIPiDIP-6055N.
IntActiP61769. 72 interactors.
MINTiMINT-85778.
STRINGi9606.ENSP00000452780.

Chemistry databases

BindingDBiP61769.

Structurei

Secondary structure

1119
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi26 – 33Combined sources8
Helixi35 – 37Combined sources3
Beta strandi41 – 53Combined sources13
Beta strandi56 – 61Combined sources6
Beta strandi64 – 66Combined sources3
Beta strandi71 – 78Combined sources8
Beta strandi79 – 82Combined sources4
Beta strandi86 – 90Combined sources5
Turni93 – 95Combined sources3
Beta strandi98 – 103Combined sources6
Beta strandi107 – 109Combined sources3
Beta strandi111 – 114Combined sources4
Helixi117 – 119Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1A1MX-ray2.30B21-119[»]
1A1NX-ray2.00B21-119[»]
1A1OX-ray2.30B21-119[»]
1A6ZX-ray2.60B/D21-119[»]
1A9BX-ray3.20B/E21-119[»]
1A9EX-ray2.50B21-119[»]
1AGBX-ray2.20B21-119[»]
1AGCX-ray2.10B21-119[»]
1AGDX-ray2.05B21-119[»]
1AGEX-ray2.30B21-119[»]
1AGFX-ray2.20B21-119[»]
1AKJX-ray2.65B21-119[»]
1AO7X-ray2.60B21-119[»]
1B0GX-ray2.50B/E21-119[»]
1B0RX-ray2.90B21-119[»]
1BD2X-ray2.50B21-119[»]
1C16X-ray3.10B/D/F/H21-119[»]
1CE6X-ray2.90B21-119[»]
1CG9X-ray2.70B21-119[»]
1DE4X-ray2.80B/E/H21-119[»]
1DUYX-ray2.15B/E21-119[»]
1DUZX-ray1.80B/E21-119[»]
1E27X-ray2.20B21-119[»]
1E28X-ray3.00B21-119[»]
1EEYX-ray2.25B/E21-119[»]
1EEZX-ray2.30B/E21-119[»]
1EFXX-ray3.00B21-119[»]
1EXUX-ray2.70B21-119[»]
1GZPX-ray2.80B21-119[»]
1GZQX-ray2.26B21-119[»]
1HHGX-ray2.60B/E21-119[»]
1HHHX-ray3.00B21-119[»]
1HHIX-ray2.50B/E21-119[»]
1HHJX-ray2.50B/E21-119[»]
1HHKX-ray2.50B/E21-119[»]
1HLAX-ray3.50M21-117[»]
1HSAX-ray2.10B/E21-119[»]
1HSBX-ray1.90B21-119[»]
1I1FX-ray2.80B/E21-119[»]
1I1YX-ray2.20B/E21-119[»]
1I4FX-ray1.40B21-119[»]
1I7RX-ray2.20B/E21-119[»]
1I7TX-ray2.80B/E21-119[»]
1I7UX-ray1.80B/E21-119[»]
1IM3X-ray2.20B/F/J/N21-119[»]
1IM9X-ray2.80B/F21-119[»]
1JF1X-ray1.85B21-119[»]
1JGDX-ray1.90B21-119[»]
1JGEX-ray2.10B21-119[»]
1JHTX-ray2.15B21-119[»]
1JNJNMR-A21-119[»]
1K5NX-ray1.09B21-119[»]
1KPRX-ray2.80B/D21-119[»]
1KTLX-ray3.10B/D21-119[»]
1LDSX-ray1.80A21-119[»]
1LP9X-ray2.00B/I21-119[»]
1M05X-ray1.90B/D21-119[»]
1M6OX-ray1.60B21-119[»]
1MHEX-ray2.85B/D21-119[»]
1MI5X-ray2.50B21-119[»]
1N2RX-ray1.70B21-119[»]
1OF2X-ray2.20B21-119[»]
1OGAX-ray1.40B21-119[»]
1OGTX-ray1.47B21-119[»]
1ONQX-ray2.15B/D21-119[»]
1P7QX-ray3.40B21-119[»]
1PY4X-ray2.90A/B/C/D21-119[»]
1Q94X-ray2.40B/E21-119[»]
1QEWX-ray2.20B21-119[»]
1QLFX-ray2.65B21-119[»]
1QQDX-ray2.70B21-118[»]
1QR1X-ray2.40B/E20-119[»]
1QRNX-ray2.80B21-119[»]
1QSEX-ray2.80B20-119[»]
1QSFX-ray2.80B20-119[»]
1QVOX-ray2.22B/E21-119[»]
1R3HX-ray2.50B/D/F/H21-119[»]
1S8DX-ray2.20B21-119[»]
1S9WX-ray2.20B21-119[»]
1S9XX-ray2.50B21-119[»]
1S9YX-ray2.30B21-119[»]
1SYSX-ray2.40B21-119[»]
1SYVX-ray1.70B21-119[»]
1T1WX-ray2.20B21-119[»]
1T1XX-ray2.20B21-119[»]
1T1YX-ray2.00B21-119[»]
1T1ZX-ray1.90B21-119[»]
1T20X-ray2.20B21-119[»]
1T21X-ray2.19B21-119[»]
1T22X-ray2.20B21-119[»]
1TMCX-ray2.30B21-119[»]
1TVBX-ray1.80B/E21-119[»]
1TVHX-ray1.80B/E21-119[»]
1UQSX-ray3.10B21-119[»]
1UR7model-B21-119[»]
1UXSX-ray1.55B21-119[»]
1UXWX-ray1.71B21-119[»]
1VGKX-ray2.06B21-119[»]
1W0VX-ray2.27B21-119[»]
1W0WX-ray2.10B21-119[»]
1W72X-ray2.15B/E21-119[»]
1X7QX-ray1.45B21-119[»]
1XH3X-ray1.48B21-119[»]
1XR8X-ray2.30B21-119[»]
1XR9X-ray1.79B21-119[»]
1XZ0X-ray2.80B/D21-119[»]
1YDPX-ray1.90B21-119[»]
1YPZX-ray3.40B/D21-119[»]
1ZHKX-ray1.60B21-119[»]
1ZHLX-ray1.50B21-119[»]
1ZS8X-ray3.00B/D/F/H/J21-119[»]
1ZSDX-ray1.70B21-119[»]
1ZT4X-ray3.00B/D21-119[»]
1ZVSX-ray2.80B/E21-119[»]
2A83X-ray1.40B21-119[»]
2AK4X-ray2.50B/G/L/R21-119[»]
2AV1X-ray1.95B/E21-119[»]
2AV7X-ray2.05B/E21-119[»]
2AXFX-ray1.80B21-119[»]
2AXGX-ray2.00B21-119[»]
2BCKX-ray2.80B/E21-119[»]
2BNQX-ray1.70B21-119[»]
2BNRX-ray1.90B21-119[»]
2BSRX-ray2.30B21-119[»]
2BSSX-ray2.00B21-119[»]
2BSTX-ray2.10B21-119[»]
2BVOX-ray1.65B21-119[»]
2BVPX-ray1.35B21-119[»]
2BVQX-ray2.00B21-119[»]
2C7UX-ray2.38B/E21-119[»]
2CIIX-ray2.55B21-119[»]
2CIKX-ray1.75B21-119[»]
2CLRX-ray2.00B/E21-119[»]
2D31X-ray3.20B/E21-119[»]
2D4DX-ray2.10A21-119[»]
2D4FX-ray1.70A21-119[»]
2DYPX-ray2.50B21-119[»]
2E8DNMR-A/B/C/D40-61[»]
2ESVX-ray2.60B21-119[»]
2F53X-ray2.10B21-119[»]
2F54X-ray2.70B/G21-119[»]
2F74X-ray2.70B/E21-119[»]
2F8OX-ray1.70A/B21-119[»]
2FYYX-ray1.50B21-119[»]
2FZ3X-ray1.90B21-119[»]
2GITX-ray1.70B/E21-119[»]
2GJ6X-ray2.56B21-119[»]
2GT9X-ray1.75B/E21-119[»]
2GTWX-ray1.55B/E21-119[»]
2GTZX-ray1.70B/E21-119[»]
2GUOX-ray1.90B/E21-119[»]
2H26X-ray1.80B21-119[»]
2H6PX-ray1.90B21-119[»]
2HJKX-ray1.85B21-119[»]
2HJLX-ray1.50B21-119[»]
2HLAX-ray2.60B21-119[»]
2HN7X-ray1.60B21-119[»]
2J8UX-ray2.88B/I21-119[»]
2JCCX-ray2.50B/I21-119[»]
2NW3X-ray1.70B21-119[»]
2NX5X-ray2.70B/G/L/R21-119[»]
2P5EX-ray1.89B21-119[»]
2P5WX-ray2.20B21-119[»]
2PO6X-ray3.20B/F21-119[»]
2PYEX-ray2.30B21-119[»]
2RFXX-ray2.50B21-119[»]
2UWEX-ray2.40B/I21-119[»]
2V2WX-ray1.60B/E21-119[»]
2V2XX-ray1.60B/E21-119[»]
2VB5NMR-A21-119[»]
2VLJX-ray2.40B21-119[»]
2VLKX-ray2.50B21-119[»]
2VLLX-ray1.60B/E21-119[»]
2VLRX-ray2.30B/G21-119[»]
2X4NX-ray2.34B/E21-119[»]
2X4OX-ray2.30B/E21-119[»]
2X4PX-ray2.30B/E21-119[»]
2X4QX-ray1.90B/E21-119[»]
2X4RX-ray2.30B/E21-119[»]
2X4SX-ray2.55B/E21-119[»]
2X4TX-ray2.30B/E21-119[»]
2X4UX-ray2.10B/E21-119[»]
2X70X-ray2.00B/E21-119[»]
2X89X-ray2.16D/E/F/G27-119[»]
2XKSNMR-A21-119[»]
2XKUNMR-A27-119[»]
2XPGX-ray2.60B22-118[»]
2YPKX-ray1.95B21-119[»]
2YPLX-ray2.40B21-119[»]
2YXFX-ray1.13A21-119[»]
2Z9TX-ray1.80A21-119[»]
3AM8X-ray2.80C/D21-119[»]
3B3IX-ray1.86B21-119[»]
3B6SX-ray1.80B21-119[»]
3BGMX-ray1.60B21-119[»]
3BH8X-ray1.65B21-119[»]
3BH9X-ray1.70B21-119[»]
3BHBX-ray2.20B22-119[»]
3BO8X-ray1.80B21-119[»]
3BP4X-ray1.85B21-119[»]
3BP7X-ray1.80B21-119[»]
3BVNX-ray2.55B/E21-119[»]
3BW9X-ray1.75B21-119[»]
3BWAX-ray1.30B21-119[»]
3BXNX-ray1.86B21-119[»]
3BZEX-ray2.50B/D/F/H21-119[»]
3BZFX-ray2.50B/D23-119[»]
3C9NX-ray1.87B21-119[»]
3CDGX-ray3.40B/D21-119[»]
3CIIX-ray4.41B/E21-119[»]
3CIQX-ray2.90A/B/C/D/E/F/G/H/I/J/K/L21-119[»]
3CZFX-ray1.20B21-119[»]
3D18X-ray1.74B21-119[»]
3D25X-ray1.30B22-119[»]
3D2UX-ray2.21B/F21-119[»]
3D39X-ray2.81B21-119[»]
3D3VX-ray2.80B21-119[»]
3DBXX-ray2.00B21-119[»]
3DHJX-ray2.00A21-119[»]
3DHMX-ray1.80A21-119[»]
3DTXX-ray2.10B21-119[»]
3DX6X-ray1.70B21-119[»]
3DX7X-ray1.60B21-119[»]
3DX8X-ray2.10B21-119[»]
3DXAX-ray3.50B/G/L21-119[»]
3EKCX-ray1.80A21-119[»]
3FFCX-ray2.80B/G21-119[»]
3FQNX-ray1.65B22-119[»]
3FQRX-ray1.70B22-119[»]
3FQTX-ray1.80B22-119[»]
3FQUX-ray1.80B22-119[»]
3FQWX-ray1.93B22-119[»]
3FQXX-ray1.70B22-119[»]
3FT2X-ray1.80B21-119[»]
3FT3X-ray1.95B21-119[»]
3FT4X-ray1.90B21-119[»]
3GIVX-ray2.00B/E21-119[»]
3GJFX-ray1.90B/E21-119[»]
3GSNX-ray2.80L21-119[»]
3GSOX-ray1.60B21-119[»]
3GSQX-ray2.12B21-119[»]
3GSRX-ray1.95B21-119[»]
3GSUX-ray1.80B21-119[»]
3GSVX-ray1.90B21-119[»]
3GSWX-ray1.81B21-119[»]
3GSXX-ray2.10B21-119[»]
3H7BX-ray1.88B/E21-119[»]
3H9HX-ray2.00B/E21-119[»]
3H9SX-ray2.70B21-119[»]
3HAEX-ray2.90B/E/K/Q21-119[»]
3HCVX-ray1.95B21-119[»]
3HG1X-ray3.00B21-119[»]
3HLAX-ray2.60B21-119[»]
3HPJX-ray2.00B/E21-119[»]
3HUJX-ray2.50B/D21-119[»]
3I6GX-ray2.20B/E21-119[»]
3I6KX-ray2.80B/F21-119[»]
3I6LX-ray2.40E21-119[»]
3IB4X-ray1.25A21-119[»]
3IXAX-ray2.10B/E21-119[»]
3JTSX-ray2.80B/E/H1-119[»]
3KLAX-ray1.65B/E21-119[»]
3KPLX-ray1.96B21-119[»]
3KPMX-ray1.60B21-119[»]
3KPNX-ray2.00B21-119[»]
3KPOX-ray2.30B21-119[»]
3KPPX-ray1.90B21-119[»]
3KPQX-ray1.84B21-119[»]
3KPRX-ray2.60B/G21-119[»]
3KPSX-ray2.70B21-119[»]
3KWWX-ray2.18B21-119[»]
3KXFX-ray3.10B/F/J/L21-119[»]
3KYNX-ray2.40B21-119[»]
3KYOX-ray1.70B/D21-119[»]
3L3DX-ray1.80B21-119[»]
3L3GX-ray2.10B21-119[»]
3L3IX-ray1.70B21-119[»]
3L3JX-ray2.40B21-119[»]
3L3KX-ray2.60B21-119[»]
3LKNX-ray2.00B21-119[»]
3LKOX-ray1.80B21-119[»]
3LKPX-ray1.80B21-119[»]
3LKQX-ray1.80B21-119[»]
3LKRX-ray2.00B21-119[»]
3LKSX-ray1.90B21-119[»]
3LN4X-ray1.30B21-119[»]
3LN5X-ray1.90B21-119[»]
3LOWX-ray2.30A/B21-119[»]
3LOZX-ray1.80A/B/C/D74-79[»]
3LV3X-ray1.94B21-119[»]
3M17X-ray2.60B/D/F/H21-119[»]
3M1BX-ray3.10B/D/F/H21-119[»]
3MGOX-ray2.30B/E/H/K21-119[»]
3MGTX-ray2.20B/E/H/K21-119[»]
3MR9X-ray1.93B21-119[»]
3MRBX-ray1.40B21-119[»]
3MRCX-ray1.80B21-119[»]
3MRDX-ray1.70B21-119[»]
3MREX-ray1.10B21-119[»]
3MRFX-ray2.30B21-119[»]
3MRGX-ray1.30B21-119[»]
3MRHX-ray2.40B21-119[»]
3MRIX-ray2.10B21-119[»]
3MRJX-ray1.87B21-119[»]
3MRKX-ray1.40B21-119[»]
3MRLX-ray2.41B21-119[»]
3MRMX-ray1.90B21-119[»]
3MRNX-ray2.30B21-119[»]
3MROX-ray2.35B21-119[»]
3MRPX-ray2.10B21-119[»]
3MRQX-ray2.20B21-119[»]
3MRRX-ray1.60B21-119[»]
3MV7X-ray2.00B21-119[»]
3MV8X-ray2.10B21-119[»]
3MV9X-ray2.70B21-119[»]
3MYJX-ray1.89B/E21-119[»]
3MYZX-ray1.60A/B21-119[»]
3MZTX-ray2.70A/B/C/D/E/F21-119[»]
3NA4X-ray1.90A21-119[»]
3NFNX-ray2.39B21-119[»]
3O3AX-ray1.80B/E21-119[»]
3O3BX-ray1.90B/E21-119[»]
3O3DX-ray1.70B/E21-119[»]
3O3EX-ray1.85B/E21-119[»]
3O4LX-ray2.54B21-119[»]
3OV6X-ray2.50A21-119[»]
3OX8X-ray2.16B/E21-119[»]
3OXRX-ray1.70B21-119[»]
3OXSX-ray1.75B21-119[»]
3PWJX-ray1.70B/E21-119[»]
3PWLX-ray1.65B/E21-119[»]
3PWNX-ray1.60B/E21-119[»]
3PWPX-ray2.69B21-119[»]
3QDAX-ray1.57A21-119[»]
3QDGX-ray2.69B21-119[»]
3QDJX-ray2.30B21-119[»]
3QDMX-ray2.80B21-119[»]
3QEQX-ray2.59B21-119[»]
3QFDX-ray1.68B/E21-119[»]
3QFJX-ray2.29B21-119[»]
3QZWX-ray2.80B/E21-119[»]
3REWX-ray1.90B/E21-119[»]
3RL1X-ray2.00B21-119[»]
3RL2X-ray2.39B21-119[»]
3RWJX-ray2.70B21-119[»]
3S6CX-ray2.90A21-119[»]
3SDXX-ray3.12B/D21-119[»]
3SJVX-ray3.10B/G/L/Q21-119[»]
3SKMX-ray1.80B21-119[»]
3SKOX-ray1.60B21-119[»]
3SPVX-ray1.30B21-119[»]
3T8XX-ray1.90B/D21-119[»]
3TIDX-ray1.65B21-119[»]
3TIEX-ray2.25B/E21-119[»]
3TLRX-ray2.45A/B/C/D21-119[»]
3TM6X-ray2.70A/B/C/D/E/F/G/H21-119[»]
3TO2X-ray2.60B21-119[»]
3TZVX-ray3.06D21-119[»]
3U0PX-ray2.80B/D/F21-119[»]
3UPRX-ray2.00B/D21-119[»]
3UTQX-ray1.67B21-119[»]
3UTSX-ray2.71B/G21-119[»]
3UTTX-ray2.60B/G21-119[»]
3V5DX-ray2.00B/E21-119[»]
3V5HX-ray1.63B/E21-119[»]
3V5KX-ray2.31B/E21-119[»]
3VCLX-ray1.70B21-119[»]
3VFMX-ray1.90B21-119[»]
3VFNX-ray1.50B21-119[»]
3VFOX-ray1.70B21-119[»]
3VFPX-ray1.85B21-119[»]
3VFRX-ray1.85B21-119[»]
3VFSX-ray1.85B21-119[»]
3VFTX-ray1.95B21-119[»]
3VFUX-ray1.65B21-119[»]
3VFVX-ray1.55B21-119[»]
3VFWX-ray2.30B21-119[»]
3VH8X-ray1.80B/E21-119[»]
3VRIX-ray1.60B21-119[»]
3VRJX-ray1.90B21-119[»]
3VWJX-ray3.09B21-119[»]
3VWKX-ray2.94B21-119[»]
3VXMX-ray2.50B21-119[»]
3VXNX-ray1.95B21-119[»]
3VXOX-ray2.61B/E21-119[»]
3VXPX-ray2.50B/E21-119[»]
3VXRX-ray2.40B21-119[»]
3VXSX-ray1.80B21-119[»]
3VXUX-ray2.70B/G21-119[»]
3W0WX-ray2.60B21-119[»]
3W39X-ray3.10B/E21-119[»]
3WL9X-ray1.66B21-119[»]
3WLBX-ray2.00B21-119[»]
3WUWX-ray2.00B22-119[»]
3X11X-ray2.15B21-119[»]
3X12X-ray1.80B21-119[»]
3X13X-ray1.80B21-119[»]
3X14X-ray2.00B21-119[»]
4E0KX-ray0.97A/B/C/D78-83[»]
4E0LX-ray1.70A/B/C/D82-89[»]
4E5XX-ray1.95B/E21-119[»]
4EN3X-ray2.57D21-119[»]
4EUPX-ray2.88B/E21-119[»]
4F7MX-ray2.40B/E21-119[»]
4F7PX-ray1.90B21-119[»]
4F7TX-ray1.70B/E21-119[»]
4FTVX-ray2.74B21-119[»]
4FXLX-ray1.40A21-119[»]
4G8GX-ray2.40B21-119[»]
4G8IX-ray1.60B21-119[»]
4G9DX-ray1.60B21-119[»]
4G9FX-ray1.90B21-119[»]
4GKNX-ray2.75B/E21-119[»]
4GKSX-ray2.35B/E21-119[»]
4GUPX-ray3.20B/D21-119[»]
4HKJX-ray3.00B/F/J/N21-119[»]
4HWZX-ray2.40B21-119[»]
4HX1X-ray1.80B21-119[»]
4I48X-ray2.80B21-119[»]
4I4WX-ray1.77B21-119[»]
4JFDX-ray2.46B21-119[»]
4JFEX-ray2.70B21-119[»]
4JFFX-ray2.43B21-119[»]
4JFOX-ray2.11B/E21-119[»]
4JFPX-ray1.91B/E21-119[»]
4JFQX-ray1.90B/E21-119[»]
4JQVX-ray1.50C21-119[»]
4JQXX-ray1.90C21-119[»]
4JRXX-ray2.30B21-119[»]
4JRYX-ray2.80B21-119[»]
4K71X-ray2.40C/F21-119[»]
4K7FX-ray2.00B/E21-119[»]
4KDTX-ray2.60C/D21-119[»]
4L29X-ray3.09B/D/F/H/J/L/N/P/R/T/V/X/Z/b21-119[»]
4L3CX-ray2.64B/D/F/H/J/L/N/P/R/T/V/X/Z/b21-119[»]
4L3EX-ray2.56B21-119[»]
4L4TX-ray2.00B/F21-119[»]
4L4VX-ray1.90B/F21-119[»]
4LCWX-ray2.40B/F21-119[»]
4LCYX-ray1.60B/H21-119[»]
4LHUX-ray2.87B21-119[»]
4LNRX-ray2.00B21-119[»]
4M8VX-ray1.95A/B21-119[»]
4MJ5X-ray2.40B21-119[»]
4MJ6X-ray2.57B21-119[»]
4MJIX-ray2.99B/G21-119[»]
4MNQX-ray2.74B21-119[»]
4N0FX-ray3.02B/F/I/L21-119[»]
4N0UX-ray3.80B21-119[»]
4N8VX-ray2.50B/E21-119[»]
4NNXX-ray2.10B21-119[»]
4NNYX-ray1.90B21-119[»]
4NO0X-ray2.70B21-119[»]
4NO2X-ray2.00B21-119[»]
4NO3X-ray1.70B21-119[»]
4NO5X-ray2.10B22-119[»]
4NQCX-ray2.50B/F21-119[»]
4NQDX-ray2.20B/F21-119[»]
4NQEX-ray2.10B/F21-119[»]
4NQVX-ray2.39B/D/F/H/J/L21-119[»]
4NQXX-ray2.00B/D/F/H/J/L21-119[»]
4NT6X-ray1.84B21-118[»]
4O2CX-ray1.80B21-119[»]
4O2EX-ray1.98B/E21-119[»]
4O2FX-ray1.90B/E21-119[»]
4ONOX-ray2.70A21-119[»]
4PJ5X-ray2.00B/F21-119[»]
4PJ7X-ray2.50B/D21-119[»]
4PJ8X-ray3.30B21-119[»]
4PJ9X-ray2.00B21-119[»]
4PJAX-ray2.68B/D21-119[»]
4PJBX-ray2.85B/D21-119[»]
4PJCX-ray2.50B/D21-119[»]
4PJDX-ray2.78B/D21-119[»]
4PJEX-ray1.95B/D21-119[»]
4PJFX-ray2.45B/D21-119[»]
4PJGX-ray2.40B/D21-119[»]
4PJHX-ray2.00B/D21-119[»]
4PJIX-ray2.50B/D21-119[»]
4PJXX-ray2.25B/D21-119[»]
4PR5X-ray1.80B21-119[»]
4PRAX-ray1.85B21-119[»]
4PRBX-ray1.75B21-119[»]
4PRDX-ray1.75B21-119[»]
4PREX-ray1.65B21-119[»]
4PRHX-ray2.50B23-119[»]
4PRIX-ray2.40B21-119[»]
4PRNX-ray1.65B21-119[»]
4PRPX-ray2.50B21-119[»]
4QOKX-ray3.00B21-119[»]
4QRPX-ray2.90B/G21-119[»]
4QRQX-ray1.70B21-119[»]
4QRRX-ray3.00B21-119[»]
4QRSX-ray1.40B22-119[»]
4QRTX-ray1.40B21-119[»]
4QRUX-ray1.60B21-119[»]
4R9HX-ray1.90A/B/C/D21-119[»]
4RA3X-ray2.80A/B/C/D21-119[»]
4RAHX-ray1.40A21-119[»]
4RMQX-ray1.46A21-119[»]
4RMRX-ray1.53A21-119[»]
4RMSX-ray1.70A21-119[»]
4RMTX-ray1.24A21-117[»]
4RMUX-ray1.40A21-119[»]
4RMVX-ray1.46A21-119[»]
4RMWX-ray1.40A21-119[»]
4U1HX-ray1.59B21-119[»]
4U1IX-ray1.92B21-119[»]
4U1JX-ray1.38B21-119[»]
4U1KX-ray2.09B/E21-119[»]
4U1LX-ray2.06B/E21-119[»]
4U1MX-ray1.18B21-119[»]
4U1NX-ray1.77B21-119[»]
4U1SX-ray1.76B21-119[»]
4U6XX-ray1.68B21-119[»]
4U6YX-ray1.47B21-119[»]
4UQ2X-ray2.43B/D21-119[»]
4UQ3X-ray2.10B/D21-119[»]
4WDIX-ray2.31B/E21-119[»]
4WJ5X-ray1.65B/E21-119[»]
4WO4X-ray2.50B21-119[»]
4WU5X-ray2.40B/E21-119[»]
4WU7X-ray2.30B/E21-119[»]
4WUUX-ray3.05B21-119[»]
4WW2X-ray2.48F21-119[»]
4WWKX-ray3.10D1-119[»]
4X6CX-ray2.80B/D21-119[»]
4X6DX-ray2.98B/D21-119[»]
4X6EX-ray2.10B21-119[»]
4X6FX-ray1.91B21-119[»]
4XXCX-ray1.43C21-119[»]
4Z76X-ray1.88B/E21-119[»]
4Z77X-ray1.85B/E21-119[»]
4Z78X-ray2.30B/E/H21-119[»]
4ZEZX-ray2.40B/E21-119[»]
5B38X-ray2.30B21-119[»]
5B39X-ray2.50B21-119[»]
5BRZX-ray2.62B21-119[»]
5BS0X-ray2.40B21-119[»]
5BXFX-ray2.85B/D1-119[»]
5C07X-ray2.11B/G21-119[»]
5C08X-ray2.33B/G21-119[»]
5C09X-ray2.48B/G21-119[»]
5C0AX-ray2.46B/G21-119[»]
5C0BX-ray2.03B/G21-119[»]
5C0CX-ray1.97B/G21-119[»]
5C0DX-ray1.68B21-119[»]
5C0EX-ray1.49B21-119[»]
5C0FX-ray1.46B21-119[»]
5C0GX-ray1.37B21-119[»]
5C0HX-ray1.37B21-119[»]
5C0IX-ray1.53B21-119[»]
5C0JX-ray1.64B21-119[»]
5C9JX-ray2.40B21-118[»]
5CFHX-ray1.49A21-119[»]
5CKAX-ray1.70A21-119[»]
5CKGX-ray1.75A/B21-119[»]
5CS7X-ray2.10A21-119[»]
5CSBX-ray1.72A21-119[»]
5CSGX-ray1.50A21-119[»]
5D2LX-ray3.51B/D/H/N21-119[»]
5D2NX-ray2.10B/L21-119[»]
5D5MX-ray2.20B/D21-119[»]
5D7IX-ray2.00B/D21-119[»]
5D7JX-ray1.97D/F21-119[»]
5D7LX-ray3.40B/F21-119[»]
5D9SX-ray1.87B21-119[»]
5DDHX-ray1.50B21-119[»]
5DEFX-ray1.60B21-119[»]
5DEGX-ray1.83B21-119[»]
5E6IX-ray4.00D/J/N/U21-119[»]
5E9DX-ray2.51B/G21-119[»]
5EO0X-ray1.70B21-119[»]
5EO1X-ray1.85B21-119[»]
5EU3X-ray1.97B21-119[»]
5EU4X-ray2.12B/E21-119[»]
5EU5X-ray1.54B21-119[»]
5EU6X-ray2.02B21-119[»]
5HGAX-ray2.20B/E21-119[»]
5HGBX-ray2.40B/E/H/K21-119[»]
5HGDX-ray2.07B/E21-119[»]
5HGHX-ray2.39B21-119[»]
5HHMX-ray2.50B/G21-119[»]
5HHNX-ray2.03B21-119[»]
5HHOX-ray2.95B21-119[»]
5HHPX-ray1.90B21-119[»]
5HHQX-ray2.10B21-119[»]
5HYJX-ray3.06B/G21-119[»]
5IM7X-ray2.50B/D21-119[»]
5INCX-ray2.88B/D21-119[»]
5INDX-ray2.13B/D21-119[»]
5IROX-ray2.64C/G/K/O/S/W21-119[»]
5J1AX-ray1.86B1-119[»]
5SWQX-ray2.00B21-119[»]
ProteinModelPortaliP61769.
SMRiP61769.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP61769.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 113Ig-like C1-typeAdd BLAST89

Sequence similaritiesi

Belongs to the beta-2-microglobulin family.Curated

Keywords - Domaini

Immunoglobulin domain, Signal

Phylogenomic databases

eggNOGiENOG410J15A. Eukaryota.
ENOG410YTDG. LUCA.
GeneTreeiENSGT00690000102227.
HOVERGENiHBG006197.
InParanoidiP61769.
KOiK08055.
OMAiITIDLLC.
OrthoDBiEOG091G0ZOW.
PhylomeDBiP61769.
TreeFamiTF334167.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR015707. B2Microglobulin.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
[Graphical view]
PANTHERiPTHR19944:SF62. PTHR19944:SF62. 1 hit.
PfamiPF07654. C1-set. 1 hit.
[Graphical view]
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P61769-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRSVALAVL ALLSLSGLEA IQRTPKIQVY SRHPAENGKS NFLNCYVSGF
60 70 80 90 100
HPSDIEVDLL KNGERIEKVE HSDLSFSKDW SFYLLYYTEF TPTEKDEYAC
110
RVNHVTLSQP KIVKWDRDM
Length:119
Mass (Da):13,715
Last modified:July 21, 1986 - v1
Checksum:iAFD2DBEF07DCEF27
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti20A → G in AAA51811 (PubMed:3312414).Curated1
Sequence conflicti52P → Q in AAA51811 (PubMed:3312414).Curated1
Sequence conflicti119M → I in CAG33347 (Ref. 7) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03066011A → P in IMD43; lower levels of B2M, MHC class I and FCGRT proteins. 1 PublicationCorresponds to variant rs104894481dbSNPEnsembl.1
Natural variantiVAR_07669196D → N in AMYL8; reduced stability; in contrast to the wild-type, the mutant aggregates into fibrils with classic amyloid-like properties under physiologic solvent conditions. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M17987, M17986 Genomic DNA. Translation: AAA51811.1.
AY187687 mRNA. Translation: AAO20842.1.
AB021288 mRNA. Translation: BAA35182.1.
DQ217933 Genomic DNA. Translation: ABB01003.1.
AF072097 mRNA. Translation: AAD48083.1.
AY007153 mRNA. Translation: AAG02006.1.
CR457066 mRNA. Translation: CAG33347.1.
AK315776 mRNA. Translation: BAG38125.1.
CH471082 Genomic DNA. Translation: EAW77277.1.
BC032589 mRNA. Translation: AAH32589.1.
BC064910 mRNA. Translation: AAH64910.1.
V00567 mRNA. Translation: CAA23830.1.
CCDSiCCDS10113.1.
PIRiA90976. MGHUB2.
RefSeqiNP_004039.1. NM_004048.2.
UniGeneiHs.534255.

Genome annotation databases

EnsembliENST00000558401; ENSP00000452780; ENSG00000166710.
ENST00000559916; ENSP00000453350; ENSG00000166710.
ENST00000561424; ENSP00000453191; ENSG00000166710.
ENST00000617605; ENSP00000481426; ENSG00000273686.
ENST00000631573; ENSP00000488548; ENSG00000273686.
ENST00000631728; ENSP00000488321; ENSG00000273686.
GeneIDi567.
KEGGihsa:567.
UCSCiuc001zuc.4. human.

Cross-referencesi

Web resourcesi

Wikipedia

Beta-2-microglobulin entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M17987, M17986 Genomic DNA. Translation: AAA51811.1.
AY187687 mRNA. Translation: AAO20842.1.
AB021288 mRNA. Translation: BAA35182.1.
DQ217933 Genomic DNA. Translation: ABB01003.1.
AF072097 mRNA. Translation: AAD48083.1.
AY007153 mRNA. Translation: AAG02006.1.
CR457066 mRNA. Translation: CAG33347.1.
AK315776 mRNA. Translation: BAG38125.1.
CH471082 Genomic DNA. Translation: EAW77277.1.
BC032589 mRNA. Translation: AAH32589.1.
BC064910 mRNA. Translation: AAH64910.1.
V00567 mRNA. Translation: CAA23830.1.
CCDSiCCDS10113.1.
PIRiA90976. MGHUB2.
RefSeqiNP_004039.1. NM_004048.2.
UniGeneiHs.534255.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1A1MX-ray2.30B21-119[»]
1A1NX-ray2.00B21-119[»]
1A1OX-ray2.30B21-119[»]
1A6ZX-ray2.60B/D21-119[»]
1A9BX-ray3.20B/E21-119[»]
1A9EX-ray2.50B21-119[»]
1AGBX-ray2.20B21-119[»]
1AGCX-ray2.10B21-119[»]
1AGDX-ray2.05B21-119[»]
1AGEX-ray2.30B21-119[»]
1AGFX-ray2.20B21-119[»]
1AKJX-ray2.65B21-119[»]
1AO7X-ray2.60B21-119[»]
1B0GX-ray2.50B/E21-119[»]
1B0RX-ray2.90B21-119[»]
1BD2X-ray2.50B21-119[»]
1C16X-ray3.10B/D/F/H21-119[»]
1CE6X-ray2.90B21-119[»]
1CG9X-ray2.70B21-119[»]
1DE4X-ray2.80B/E/H21-119[»]
1DUYX-ray2.15B/E21-119[»]
1DUZX-ray1.80B/E21-119[»]
1E27X-ray2.20B21-119[»]
1E28X-ray3.00B21-119[»]
1EEYX-ray2.25B/E21-119[»]
1EEZX-ray2.30B/E21-119[»]
1EFXX-ray3.00B21-119[»]
1EXUX-ray2.70B21-119[»]
1GZPX-ray2.80B21-119[»]
1GZQX-ray2.26B21-119[»]
1HHGX-ray2.60B/E21-119[»]
1HHHX-ray3.00B21-119[»]
1HHIX-ray2.50B/E21-119[»]
1HHJX-ray2.50B/E21-119[»]
1HHKX-ray2.50B/E21-119[»]
1HLAX-ray3.50M21-117[»]
1HSAX-ray2.10B/E21-119[»]
1HSBX-ray1.90B21-119[»]
1I1FX-ray2.80B/E21-119[»]
1I1YX-ray2.20B/E21-119[»]
1I4FX-ray1.40B21-119[»]
1I7RX-ray2.20B/E21-119[»]
1I7TX-ray2.80B/E21-119[»]
1I7UX-ray1.80B/E21-119[»]
1IM3X-ray2.20B/F/J/N21-119[»]
1IM9X-ray2.80B/F21-119[»]
1JF1X-ray1.85B21-119[»]
1JGDX-ray1.90B21-119[»]
1JGEX-ray2.10B21-119[»]
1JHTX-ray2.15B21-119[»]
1JNJNMR-A21-119[»]
1K5NX-ray1.09B21-119[»]
1KPRX-ray2.80B/D21-119[»]
1KTLX-ray3.10B/D21-119[»]
1LDSX-ray1.80A21-119[»]
1LP9X-ray2.00B/I21-119[»]
1M05X-ray1.90B/D21-119[»]
1M6OX-ray1.60B21-119[»]
1MHEX-ray2.85B/D21-119[»]
1MI5X-ray2.50B21-119[»]
1N2RX-ray1.70B21-119[»]
1OF2X-ray2.20B21-119[»]
1OGAX-ray1.40B21-119[»]
1OGTX-ray1.47B21-119[»]
1ONQX-ray2.15B/D21-119[»]
1P7QX-ray3.40B21-119[»]
1PY4X-ray2.90A/B/C/D21-119[»]
1Q94X-ray2.40B/E21-119[»]
1QEWX-ray2.20B21-119[»]
1QLFX-ray2.65B21-119[»]
1QQDX-ray2.70B21-118[»]
1QR1X-ray2.40B/E20-119[»]
1QRNX-ray2.80B21-119[»]
1QSEX-ray2.80B20-119[»]
1QSFX-ray2.80B20-119[»]
1QVOX-ray2.22B/E21-119[»]
1R3HX-ray2.50B/D/F/H21-119[»]
1S8DX-ray2.20B21-119[»]
1S9WX-ray2.20B21-119[»]
1S9XX-ray2.50B21-119[»]
1S9YX-ray2.30B21-119[»]
1SYSX-ray2.40B21-119[»]
1SYVX-ray1.70B21-119[»]
1T1WX-ray2.20B21-119[»]
1T1XX-ray2.20B21-119[»]
1T1YX-ray2.00B21-119[»]
1T1ZX-ray1.90B21-119[»]
1T20X-ray2.20B21-119[»]
1T21X-ray2.19B21-119[»]
1T22X-ray2.20B21-119[»]
1TMCX-ray2.30B21-119[»]
1TVBX-ray1.80B/E21-119[»]
1TVHX-ray1.80B/E21-119[»]
1UQSX-ray3.10B21-119[»]
1UR7model-B21-119[»]
1UXSX-ray1.55B21-119[»]
1UXWX-ray1.71B21-119[»]
1VGKX-ray2.06B21-119[»]
1W0VX-ray2.27B21-119[»]
1W0WX-ray2.10B21-119[»]
1W72X-ray2.15B/E21-119[»]
1X7QX-ray1.45B21-119[»]
1XH3X-ray1.48B21-119[»]
1XR8X-ray2.30B21-119[»]
1XR9X-ray1.79B21-119[»]
1XZ0X-ray2.80B/D21-119[»]
1YDPX-ray1.90B21-119[»]
1YPZX-ray3.40B/D21-119[»]
1ZHKX-ray1.60B21-119[»]
1ZHLX-ray1.50B21-119[»]
1ZS8X-ray3.00B/D/F/H/J21-119[»]
1ZSDX-ray1.70B21-119[»]
1ZT4X-ray3.00B/D21-119[»]
1ZVSX-ray2.80B/E21-119[»]
2A83X-ray1.40B21-119[»]
2AK4X-ray2.50B/G/L/R21-119[»]
2AV1X-ray1.95B/E21-119[»]
2AV7X-ray2.05B/E21-119[»]
2AXFX-ray1.80B21-119[»]
2AXGX-ray2.00B21-119[»]
2BCKX-ray2.80B/E21-119[»]
2BNQX-ray1.70B21-119[»]
2BNRX-ray1.90B21-119[»]
2BSRX-ray2.30B21-119[»]
2BSSX-ray2.00B21-119[»]
2BSTX-ray2.10B21-119[»]
2BVOX-ray1.65B21-119[»]
2BVPX-ray1.35B21-119[»]
2BVQX-ray2.00B21-119[»]
2C7UX-ray2.38B/E21-119[»]
2CIIX-ray2.55B21-119[»]
2CIKX-ray1.75B21-119[»]
2CLRX-ray2.00B/E21-119[»]
2D31X-ray3.20B/E21-119[»]
2D4DX-ray2.10A21-119[»]
2D4FX-ray1.70A21-119[»]
2DYPX-ray2.50B21-119[»]
2E8DNMR-A/B/C/D40-61[»]
2ESVX-ray2.60B21-119[»]
2F53X-ray2.10B21-119[»]
2F54X-ray2.70B/G21-119[»]
2F74X-ray2.70B/E21-119[»]
2F8OX-ray1.70A/B21-119[»]
2FYYX-ray1.50B21-119[»]
2FZ3X-ray1.90B21-119[»]
2GITX-ray1.70B/E21-119[»]
2GJ6X-ray2.56B21-119[»]
2GT9X-ray1.75B/E21-119[»]
2GTWX-ray1.55B/E21-119[»]
2GTZX-ray1.70B/E21-119[»]
2GUOX-ray1.90B/E21-119[»]
2H26X-ray1.80B21-119[»]
2H6PX-ray1.90B21-119[»]
2HJKX-ray1.85B21-119[»]
2HJLX-ray1.50B21-119[»]
2HLAX-ray2.60B21-119[»]
2HN7X-ray1.60B21-119[»]
2J8UX-ray2.88B/I21-119[»]
2JCCX-ray2.50B/I21-119[»]
2NW3X-ray1.70B21-119[»]
2NX5X-ray2.70B/G/L/R21-119[»]
2P5EX-ray1.89B21-119[»]
2P5WX-ray2.20B21-119[»]
2PO6X-ray3.20B/F21-119[»]
2PYEX-ray2.30B21-119[»]
2RFXX-ray2.50B21-119[»]
2UWEX-ray2.40B/I21-119[»]
2V2WX-ray1.60B/E21-119[»]
2V2XX-ray1.60B/E21-119[»]
2VB5NMR-A21-119[»]
2VLJX-ray2.40B21-119[»]
2VLKX-ray2.50B21-119[»]
2VLLX-ray1.60B/E21-119[»]
2VLRX-ray2.30B/G21-119[»]
2X4NX-ray2.34B/E21-119[»]
2X4OX-ray2.30B/E21-119[»]
2X4PX-ray2.30B/E21-119[»]
2X4QX-ray1.90B/E21-119[»]
2X4RX-ray2.30B/E21-119[»]
2X4SX-ray2.55B/E21-119[»]
2X4TX-ray2.30B/E21-119[»]
2X4UX-ray2.10B/E21-119[»]
2X70X-ray2.00B/E21-119[»]
2X89X-ray2.16D/E/F/G27-119[»]
2XKSNMR-A21-119[»]
2XKUNMR-A27-119[»]
2XPGX-ray2.60B22-118[»]
2YPKX-ray1.95B21-119[»]
2YPLX-ray2.40B21-119[»]
2YXFX-ray1.13A21-119[»]
2Z9TX-ray1.80A21-119[»]
3AM8X-ray2.80C/D21-119[»]
3B3IX-ray1.86B21-119[»]
3B6SX-ray1.80B21-119[»]
3BGMX-ray1.60B21-119[»]
3BH8X-ray1.65B21-119[»]
3BH9X-ray1.70B21-119[»]
3BHBX-ray2.20B22-119[»]
3BO8X-ray1.80B21-119[»]
3BP4X-ray1.85B21-119[»]
3BP7X-ray1.80B21-119[»]
3BVNX-ray2.55B/E21-119[»]
3BW9X-ray1.75B21-119[»]
3BWAX-ray1.30B21-119[»]
3BXNX-ray1.86B21-119[»]
3BZEX-ray2.50B/D/F/H21-119[»]
3BZFX-ray2.50B/D23-119[»]
3C9NX-ray1.87B21-119[»]
3CDGX-ray3.40B/D21-119[»]
3CIIX-ray4.41B/E21-119[»]
3CIQX-ray2.90A/B/C/D/E/F/G/H/I/J/K/L21-119[»]
3CZFX-ray1.20B21-119[»]
3D18X-ray1.74B21-119[»]
3D25X-ray1.30B22-119[»]
3D2UX-ray2.21B/F21-119[»]
3D39X-ray2.81B21-119[»]
3D3VX-ray2.80B21-119[»]
3DBXX-ray2.00B21-119[»]
3DHJX-ray2.00A21-119[»]
3DHMX-ray1.80A21-119[»]
3DTXX-ray2.10B21-119[»]
3DX6X-ray1.70B21-119[»]
3DX7X-ray1.60B21-119[»]
3DX8X-ray2.10B21-119[»]
3DXAX-ray3.50B/G/L21-119[»]
3EKCX-ray1.80A21-119[»]
3FFCX-ray2.80B/G21-119[»]
3FQNX-ray1.65B22-119[»]
3FQRX-ray1.70B22-119[»]
3FQTX-ray1.80B22-119[»]
3FQUX-ray1.80B22-119[»]
3FQWX-ray1.93B22-119[»]
3FQXX-ray1.70B22-119[»]
3FT2X-ray1.80B21-119[»]
3FT3X-ray1.95B21-119[»]
3FT4X-ray1.90B21-119[»]
3GIVX-ray2.00B/E21-119[»]
3GJFX-ray1.90B/E21-119[»]
3GSNX-ray2.80L21-119[»]
3GSOX-ray1.60B21-119[»]
3GSQX-ray2.12B21-119[»]
3GSRX-ray1.95B21-119[»]
3GSUX-ray1.80B21-119[»]
3GSVX-ray1.90B21-119[»]
3GSWX-ray1.81B21-119[»]
3GSXX-ray2.10B21-119[»]
3H7BX-ray1.88B/E21-119[»]
3H9HX-ray2.00B/E21-119[»]
3H9SX-ray2.70B21-119[»]
3HAEX-ray2.90B/E/K/Q21-119[»]
3HCVX-ray1.95B21-119[»]
3HG1X-ray3.00B21-119[»]
3HLAX-ray2.60B21-119[»]
3HPJX-ray2.00B/E21-119[»]
3HUJX-ray2.50B/D21-119[»]
3I6GX-ray2.20B/E21-119[»]
3I6KX-ray2.80B/F21-119[»]
3I6LX-ray2.40E21-119[»]
3IB4X-ray1.25A21-119[»]
3IXAX-ray2.10B/E21-119[»]
3JTSX-ray2.80B/E/H1-119[»]
3KLAX-ray1.65B/E21-119[»]
3KPLX-ray1.96B21-119[»]
3KPMX-ray1.60B21-119[»]
3KPNX-ray2.00B21-119[»]
3KPOX-ray2.30B21-119[»]
3KPPX-ray1.90B21-119[»]
3KPQX-ray1.84B21-119[»]
3KPRX-ray2.60B/G21-119[»]
3KPSX-ray2.70B21-119[»]
3KWWX-ray2.18B21-119[»]
3KXFX-ray3.10B/F/J/L21-119[»]
3KYNX-ray2.40B21-119[»]
3KYOX-ray1.70B/D21-119[»]
3L3DX-ray1.80B21-119[»]
3L3GX-ray2.10B21-119[»]
3L3IX-ray1.70B21-119[»]
3L3JX-ray2.40B21-119[»]
3L3KX-ray2.60B21-119[»]
3LKNX-ray2.00B21-119[»]
3LKOX-ray1.80B21-119[»]
3LKPX-ray1.80B21-119[»]
3LKQX-ray1.80B21-119[»]
3LKRX-ray2.00B21-119[»]
3LKSX-ray1.90B21-119[»]
3LN4X-ray1.30B21-119[»]
3LN5X-ray1.90B21-119[»]
3LOWX-ray2.30A/B21-119[»]
3LOZX-ray1.80A/B/C/D74-79[»]
3LV3X-ray1.94B21-119[»]
3M17X-ray2.60B/D/F/H21-119[»]
3M1BX-ray3.10B/D/F/H21-119[»]
3MGOX-ray2.30B/E/H/K21-119[»]
3MGTX-ray2.20B/E/H/K21-119[»]
3MR9X-ray1.93B21-119[»]
3MRBX-ray1.40B21-119[»]
3MRCX-ray1.80B21-119[»]
3MRDX-ray1.70B21-119[»]
3MREX-ray1.10B21-119[»]
3MRFX-ray2.30B21-119[»]
3MRGX-ray1.30B21-119[»]
3MRHX-ray2.40B21-119[»]
3MRIX-ray2.10B21-119[»]
3MRJX-ray1.87B21-119[»]
3MRKX-ray1.40B21-119[»]
3MRLX-ray2.41B21-119[»]
3MRMX-ray1.90B21-119[»]
3MRNX-ray2.30B21-119[»]
3MROX-ray2.35B21-119[»]
3MRPX-ray2.10B21-119[»]
3MRQX-ray2.20B21-119[»]
3MRRX-ray1.60B21-119[»]
3MV7X-ray2.00B21-119[»]
3MV8X-ray2.10B21-119[»]
3MV9X-ray2.70B21-119[»]
3MYJX-ray1.89B/E21-119[»]
3MYZX-ray1.60A/B21-119[»]
3MZTX-ray2.70A/B/C/D/E/F21-119[»]
3NA4X-ray1.90A21-119[»]
3NFNX-ray2.39B21-119[»]
3O3AX-ray1.80B/E21-119[»]
3O3BX-ray1.90B/E21-119[»]
3O3DX-ray1.70B/E21-119[»]
3O3EX-ray1.85B/E21-119[»]
3O4LX-ray2.54B21-119[»]
3OV6X-ray2.50A21-119[»]
3OX8X-ray2.16B/E21-119[»]
3OXRX-ray1.70B21-119[»]
3OXSX-ray1.75B21-119[»]
3PWJX-ray1.70B/E21-119[»]
3PWLX-ray1.65B/E21-119[»]
3PWNX-ray1.60B/E21-119[»]
3PWPX-ray2.69B21-119[»]
3QDAX-ray1.57A21-119[»]
3QDGX-ray2.69B21-119[»]
3QDJX-ray2.30B21-119[»]
3QDMX-ray2.80B21-119[»]
3QEQX-ray2.59B21-119[»]
3QFDX-ray1.68B/E21-119[»]
3QFJX-ray2.29B21-119[»]
3QZWX-ray2.80B/E21-119[»]
3REWX-ray1.90B/E21-119[»]
3RL1X-ray2.00B21-119[»]
3RL2X-ray2.39B21-119[»]
3RWJX-ray2.70B21-119[»]
3S6CX-ray2.90A21-119[»]
3SDXX-ray3.12B/D21-119[»]
3SJVX-ray3.10B/G/L/Q21-119[»]
3SKMX-ray1.80B21-119[»]
3SKOX-ray1.60B21-119[»]
3SPVX-ray1.30B21-119[»]
3T8XX-ray1.90B/D21-119[»]
3TIDX-ray1.65B21-119[»]
3TIEX-ray2.25B/E21-119[»]
3TLRX-ray2.45A/B/C/D21-119[»]
3TM6X-ray2.70A/B/C/D/E/F/G/H21-119[»]
3TO2X-ray2.60B21-119[»]
3TZVX-ray3.06D21-119[»]
3U0PX-ray2.80B/D/F21-119[»]
3UPRX-ray2.00B/D21-119[»]
3UTQX-ray1.67B21-119[»]
3UTSX-ray2.71B/G21-119[»]
3UTTX-ray2.60B/G21-119[»]
3V5DX-ray2.00B/E21-119[»]
3V5HX-ray1.63B/E21-119[»]
3V5KX-ray2.31B/E21-119[»]
3VCLX-ray1.70B21-119[»]
3VFMX-ray1.90B21-119[»]
3VFNX-ray1.50B21-119[»]
3VFOX-ray1.70B21-119[»]
3VFPX-ray1.85B21-119[»]
3VFRX-ray1.85B21-119[»]
3VFSX-ray1.85B21-119[»]
3VFTX-ray1.95B21-119[»]
3VFUX-ray1.65B21-119[»]
3VFVX-ray1.55B21-119[»]
3VFWX-ray2.30B21-119[»]
3VH8X-ray1.80B/E21-119[»]
3VRIX-ray1.60B21-119[»]
3VRJX-ray1.90B21-119[»]
3VWJX-ray3.09B21-119[»]
3VWKX-ray2.94B21-119[»]
3VXMX-ray2.50B21-119[»]
3VXNX-ray1.95B21-119[»]
3VXOX-ray2.61B/E21-119[»]
3VXPX-ray2.50B/E21-119[»]
3VXRX-ray2.40B21-119[»]
3VXSX-ray1.80B21-119[»]
3VXUX-ray2.70B/G21-119[»]
3W0WX-ray2.60B21-119[»]
3W39X-ray3.10B/E21-119[»]
3WL9X-ray1.66B21-119[»]
3WLBX-ray2.00B21-119[»]
3WUWX-ray2.00B22-119[»]
3X11X-ray2.15B21-119[»]
3X12X-ray1.80B21-119[»]
3X13X-ray1.80B21-119[»]
3X14X-ray2.00B21-119[»]
4E0KX-ray0.97A/B/C/D78-83[»]
4E0LX-ray1.70A/B/C/D82-89[»]
4E5XX-ray1.95B/E21-119[»]
4EN3X-ray2.57D21-119[»]
4EUPX-ray2.88B/E21-119[»]
4F7MX-ray2.40B/E21-119[»]
4F7PX-ray1.90B21-119[»]
4F7TX-ray1.70B/E21-119[»]
4FTVX-ray2.74B21-119[»]
4FXLX-ray1.40A21-119[»]
4G8GX-ray2.40B21-119[»]
4G8IX-ray1.60B21-119[»]
4G9DX-ray1.60B21-119[»]
4G9FX-ray1.90B21-119[»]
4GKNX-ray2.75B/E21-119[»]
4GKSX-ray2.35B/E21-119[»]
4GUPX-ray3.20B/D21-119[»]
4HKJX-ray3.00B/F/J/N21-119[»]
4HWZX-ray2.40B21-119[»]
4HX1X-ray1.80B21-119[»]
4I48X-ray2.80B21-119[»]
4I4WX-ray1.77B21-119[»]
4JFDX-ray2.46B21-119[»]
4JFEX-ray2.70B21-119[»]
4JFFX-ray2.43B21-119[»]
4JFOX-ray2.11B/E21-119[»]
4JFPX-ray1.91B/E21-119[»]
4JFQX-ray1.90B/E21-119[»]
4JQVX-ray1.50C21-119[»]
4JQXX-ray1.90C21-119[»]
4JRXX-ray2.30B21-119[»]
4JRYX-ray2.80B21-119[»]
4K71X-ray2.40C/F21-119[»]
4K7FX-ray2.00B/E21-119[»]
4KDTX-ray2.60C/D21-119[»]
4L29X-ray3.09B/D/F/H/J/L/N/P/R/T/V/X/Z/b21-119[»]
4L3CX-ray2.64B/D/F/H/J/L/N/P/R/T/V/X/Z/b21-119[»]
4L3EX-ray2.56B21-119[»]
4L4TX-ray2.00B/F21-119[»]
4L4VX-ray1.90B/F21-119[»]
4LCWX-ray2.40B/F21-119[»]
4LCYX-ray1.60B/H21-119[»]
4LHUX-ray2.87B21-119[»]
4LNRX-ray2.00B21-119[»]
4M8VX-ray1.95A/B21-119[»]
4MJ5X-ray2.40B21-119[»]
4MJ6X-ray2.57B21-119[»]
4MJIX-ray2.99B/G21-119[»]
4MNQX-ray2.74B21-119[»]
4N0FX-ray3.02B/F/I/L21-119[»]
4N0UX-ray3.80B21-119[»]
4N8VX-ray2.50B/E21-119[»]
4NNXX-ray2.10B21-119[»]
4NNYX-ray1.90B21-119[»]
4NO0X-ray2.70B21-119[»]
4NO2X-ray2.00B21-119[»]
4NO3X-ray1.70B21-119[»]
4NO5X-ray2.10B22-119[»]
4NQCX-ray2.50B/F21-119[»]
4NQDX-ray2.20B/F21-119[»]
4NQEX-ray2.10B/F21-119[»]
4NQVX-ray2.39B/D/F/H/J/L21-119[»]
4NQXX-ray2.00B/D/F/H/J/L21-119[»]
4NT6X-ray1.84B21-118[»]
4O2CX-ray1.80B21-119[»]
4O2EX-ray1.98B/E21-119[»]
4O2FX-ray1.90B/E21-119[»]
4ONOX-ray2.70A21-119[»]
4PJ5X-ray2.00B/F21-119[»]
4PJ7X-ray2.50B/D21-119[»]
4PJ8X-ray3.30B21-119[»]
4PJ9X-ray2.00B21-119[»]
4PJAX-ray2.68B/D21-119[»]
4PJBX-ray2.85B/D21-119[»]
4PJCX-ray2.50B/D21-119[»]
4PJDX-ray2.78B/D21-119[»]
4PJEX-ray1.95B/D21-119[»]
4PJFX-ray2.45B/D21-119[»]
4PJGX-ray2.40B/D21-119[»]
4PJHX-ray2.00B/D21-119[»]
4PJIX-ray2.50B/D21-119[»]
4PJXX-ray2.25B/D21-119[»]
4PR5X-ray1.80B21-119[»]
4PRAX-ray1.85B21-119[»]
4PRBX-ray1.75B21-119[»]
4PRDX-ray1.75B21-119[»]
4PREX-ray1.65B21-119[»]
4PRHX-ray2.50B23-119[»]
4PRIX-ray2.40B21-119[»]
4PRNX-ray1.65B21-119[»]
4PRPX-ray2.50B21-119[»]
4QOKX-ray3.00B21-119[»]
4QRPX-ray2.90B/G21-119[»]
4QRQX-ray1.70B21-119[»]
4QRRX-ray3.00B21-119[»]
4QRSX-ray1.40B22-119[»]
4QRTX-ray1.40B21-119[»]
4QRUX-ray1.60B21-119[»]
4R9HX-ray1.90A/B/C/D21-119[»]
4RA3X-ray2.80A/B/C/D21-119[»]
4RAHX-ray1.40A21-119[»]
4RMQX-ray1.46A21-119[»]
4RMRX-ray1.53A21-119[»]
4RMSX-ray1.70A21-119[»]
4RMTX-ray1.24A21-117[»]
4RMUX-ray1.40A21-119[»]
4RMVX-ray1.46A21-119[»]
4RMWX-ray1.40A21-119[»]
4U1HX-ray1.59B21-119[»]
4U1IX-ray1.92B21-119[»]
4U1JX-ray1.38B21-119[»]
4U1KX-ray2.09B/E21-119[»]
4U1LX-ray2.06B/E21-119[»]
4U1MX-ray1.18B21-119[»]
4U1NX-ray1.77B21-119[»]
4U1SX-ray1.76B21-119[»]
4U6XX-ray1.68B21-119[»]
4U6YX-ray1.47B21-119[»]
4UQ2X-ray2.43B/D21-119[»]
4UQ3X-ray2.10B/D21-119[»]
4WDIX-ray2.31B/E21-119[»]
4WJ5X-ray1.65B/E21-119[»]
4WO4X-ray2.50B21-119[»]
4WU5X-ray2.40B/E21-119[»]
4WU7X-ray2.30B/E21-119[»]
4WUUX-ray3.05B21-119[»]
4WW2X-ray2.48F21-119[»]
4WWKX-ray3.10D1-119[»]
4X6CX-ray2.80B/D21-119[»]
4X6DX-ray2.98B/D21-119[»]
4X6EX-ray2.10B21-119[»]
4X6FX-ray1.91B21-119[»]
4XXCX-ray1.43C21-119[»]
4Z76X-ray1.88B/E21-119[»]
4Z77X-ray1.85B/E21-119[»]
4Z78X-ray2.30B/E/H21-119[»]
4ZEZX-ray2.40B/E21-119[»]
5B38X-ray2.30B21-119[»]
5B39X-ray2.50B21-119[»]
5BRZX-ray2.62B21-119[»]
5BS0X-ray2.40B21-119[»]
5BXFX-ray2.85B/D1-119[»]
5C07X-ray2.11B/G21-119[»]
5C08X-ray2.33B/G21-119[»]
5C09X-ray2.48B/G21-119[»]
5C0AX-ray2.46B/G21-119[»]
5C0BX-ray2.03B/G21-119[»]
5C0CX-ray1.97B/G21-119[»]
5C0DX-ray1.68B21-119[»]
5C0EX-ray1.49B21-119[»]
5C0FX-ray1.46B21-119[»]
5C0GX-ray1.37B21-119[»]
5C0HX-ray1.37B21-119[»]
5C0IX-ray1.53B21-119[»]
5C0JX-ray1.64B21-119[»]
5C9JX-ray2.40B21-118[»]
5CFHX-ray1.49A21-119[»]
5CKAX-ray1.70A21-119[»]
5CKGX-ray1.75A/B21-119[»]
5CS7X-ray2.10A21-119[»]
5CSBX-ray1.72A21-119[»]
5CSGX-ray1.50A21-119[»]
5D2LX-ray3.51B/D/H/N21-119[»]
5D2NX-ray2.10B/L21-119[»]
5D5MX-ray2.20B/D21-119[»]
5D7IX-ray2.00B/D21-119[»]
5D7JX-ray1.97D/F21-119[»]
5D7LX-ray3.40B/F21-119[»]
5D9SX-ray1.87B21-119[»]
5DDHX-ray1.50B21-119[»]
5DEFX-ray1.60B21-119[»]
5DEGX-ray1.83B21-119[»]
5E6IX-ray4.00D/J/N/U21-119[»]
5E9DX-ray2.51B/G21-119[»]
5EO0X-ray1.70B21-119[»]
5EO1X-ray1.85B21-119[»]
5EU3X-ray1.97B21-119[»]
5EU4X-ray2.12B/E21-119[»]
5EU5X-ray1.54B21-119[»]
5EU6X-ray2.02B21-119[»]
5HGAX-ray2.20B/E21-119[»]
5HGBX-ray2.40B/E/H/K21-119[»]
5HGDX-ray2.07B/E21-119[»]
5HGHX-ray2.39B21-119[»]
5HHMX-ray2.50B/G21-119[»]
5HHNX-ray2.03B21-119[»]
5HHOX-ray2.95B21-119[»]
5HHPX-ray1.90B21-119[»]
5HHQX-ray2.10B21-119[»]
5HYJX-ray3.06B/G21-119[»]
5IM7X-ray2.50B/D21-119[»]
5INCX-ray2.88B/D21-119[»]
5INDX-ray2.13B/D21-119[»]
5IROX-ray2.64C/G/K/O/S/W21-119[»]
5J1AX-ray1.86B1-119[»]
5SWQX-ray2.00B21-119[»]
ProteinModelPortaliP61769.
SMRiP61769.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107044. 41 interactors.
DIPiDIP-6055N.
IntActiP61769. 72 interactors.
MINTiMINT-85778.
STRINGi9606.ENSP00000452780.

Chemistry databases

BindingDBiP61769.
DrugBankiDB00254. Doxycycline.

PTM databases

iPTMnetiP61769.
PhosphoSitePlusiP61769.

Polymorphism and mutation databases

BioMutaiB2M.
DMDMi48428791.

2D gel databases

DOSAC-COBS-2DPAGEP61769.
OGPiP61769.
SWISS-2DPAGEP61769.

Proteomic databases

EPDiP61769.
MaxQBiP61769.
PaxDbiP61769.
PeptideAtlasiP61769.
PRIDEiP61769.
TopDownProteomicsiP61769.

Protocols and materials databases

DNASUi567.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000558401; ENSP00000452780; ENSG00000166710.
ENST00000559916; ENSP00000453350; ENSG00000166710.
ENST00000561424; ENSP00000453191; ENSG00000166710.
ENST00000617605; ENSP00000481426; ENSG00000273686.
ENST00000631573; ENSP00000488548; ENSG00000273686.
ENST00000631728; ENSP00000488321; ENSG00000273686.
GeneIDi567.
KEGGihsa:567.
UCSCiuc001zuc.4. human.

Organism-specific databases

CTDi567.
DisGeNETi567.
GeneCardsiB2M.
HGNCiHGNC:914. B2M.
HPAiCAB002572.
HPA006361.
MalaCardsiB2M.
MIMi105200. phenotype.
109700. gene.
241600. phenotype.
neXtProtiNX_P61769.
OpenTargetsiENSG00000166710.
ENSG00000273686.
Orphaneti314652. Autosomal dominant beta2-microglobulinic amyloidosis.
PharmGKBiPA25207.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J15A. Eukaryota.
ENOG410YTDG. LUCA.
GeneTreeiENSGT00690000102227.
HOVERGENiHBG006197.
InParanoidiP61769.
KOiK08055.
OMAiITIDLLC.
OrthoDBiEOG091G0ZOW.
PhylomeDBiP61769.
TreeFamiTF334167.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000166710-MONOMER.
ReactomeiR-HSA-1236974. ER-Phagosome pathway.
R-HSA-1236977. Endosomal/Vacuolar pathway.
R-HSA-164940. Nef mediated downregulation of MHC class I complex cell surface expression.
R-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
R-HSA-2172127. DAP12 interactions.
R-HSA-2424491. DAP12 signaling.
R-HSA-6798695. Neutrophil degranulation.
R-HSA-877300. Interferon gamma signaling.
R-HSA-977225. Amyloid fiber formation.
R-HSA-983170. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.

Miscellaneous databases

ChiTaRSiB2M. human.
EvolutionaryTraceiP61769.
GeneWikiiBeta-2_microglobulin.
GenomeRNAii567.
PROiP61769.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000166710.
CleanExiHS_B2M.
ExpressionAtlasiP61769. baseline and differential.
GenevisibleiP61769. HS.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR015707. B2Microglobulin.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
[Graphical view]
PANTHERiPTHR19944:SF62. PTHR19944:SF62. 1 hit.
PfamiPF07654. C1-set. 1 hit.
[Graphical view]
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiB2MG_HUMAN
AccessioniPrimary (citable) accession number: P61769
Secondary accession number(s): P01884
, Q540F8, Q6IAT8, Q9UCK0, Q9UD48, Q9UDF4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: November 30, 2016
This is version 155 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.