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P61769

- B2MG_HUMAN

UniProt

P61769 - B2MG_HUMAN

Protein

Beta-2-microglobulin

Gene

B2M

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.

    GO - Molecular functioni

    1. identical protein binding Source: IntAct
    2. protein binding Source: IntAct

    GO - Biological processi

    1. antigen processing and presentation of exogenous peptide antigen via MHC class I Source: Reactome
    2. antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent Source: Reactome
    3. antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent Source: Reactome
    4. antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent Source: Ensembl
    5. antigen processing and presentation of peptide antigen via MHC class I Source: Reactome
    6. cytokine-mediated signaling pathway Source: Reactome
    7. innate immune response Source: Reactome
    8. interferon-gamma-mediated signaling pathway Source: Reactome
    9. positive regulation of T cell mediated cytotoxicity Source: Ensembl
    10. protein refolding Source: Ensembl
    11. regulation of defense response to virus by virus Source: Reactome
    12. regulation of immune response Source: Reactome
    13. response to cadmium ion Source: Ensembl
    14. response to drug Source: Ensembl
    15. response to molecule of bacterial origin Source: Ensembl
    16. retina homeostasis Source: UniProt
    17. T cell differentiation in thymus Source: Ensembl
    18. viral process Source: Reactome

    Keywords - Biological processi

    Immunity

    Enzyme and pathway databases

    ReactomeiREACT_11103. Nef mediated downregulation of MHC class I complex cell surface expression.
    REACT_111168. Endosomal/Vacuolar pathway.
    REACT_111178. ER-Phagosome pathway.
    REACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
    REACT_147694. DAP12 interactions.
    REACT_147814. DAP12 signaling.
    REACT_25078. Interferon gamma signaling.
    REACT_75795. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.
    REACT_75925. Amyloids.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Beta-2-microglobulin
    Cleaved into the following chain:
    Gene namesi
    Name:B2M
    ORF Names:CDABP0092, HDCMA22P
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 15

    Organism-specific databases

    HGNCiHGNC:914. B2M.

    Subcellular locationi

    Secreted 2 Publications
    Note: Detected in serum and urine.

    GO - Cellular componenti

    1. cytoplasm Source: HPA
    2. early endosome lumen Source: Reactome
    3. early endosome membrane Source: Reactome
    4. endoplasmic reticulum lumen Source: Reactome
    5. ER to Golgi transport vesicle membrane Source: Reactome
    6. external side of plasma membrane Source: Ensembl
    7. extracellular region Source: Reactome
    8. extracellular space Source: UniProt
    9. extracellular vesicular exosome Source: UniProt
    10. Golgi apparatus Source: HPA
    11. Golgi membrane Source: Reactome
    12. membrane Source: UniProtKB
    13. MHC class I protein complex Source: UniProtKB-KW
    14. phagocytic vesicle membrane Source: Reactome
    15. plasma membrane Source: HPA

    Keywords - Cellular componenti

    Amyloid, MHC I, Secreted

    Pathology & Biotechi

    Involvement in diseasei

    Hypercatabolic hypoproteinemia (HYCATHYP) [MIM:241600]: Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti11 – 111A → P in HYCATHYP; lower levels of B2M, MHC class I and FCGRT proteins. 1 Publication
    VAR_030660
    Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi79 – 791D → P: Increases tendency towards amyloid formation. 1 Publication
    Mutagenesisi80 – 801W → G: Decreases tendency towards amyloid formation. 2 Publications
    Mutagenesisi80 – 801W → V: Increases tendency towards amyloid formation. 2 Publications

    Keywords - Diseasei

    Amyloidosis, Disease mutation

    Organism-specific databases

    MIMi241600. phenotype.
    Orphaneti314652. Autosomal dominant beta2-microglobulinic amyloidosis.
    PharmGKBiPA25207.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 20204 PublicationsAdd
    BLAST
    Chaini21 – 11999Beta-2-microglobulinPRO_0000018779Add
    BLAST
    Chaini22 – 11998Beta-2-microglobulin form pI 5.3PRO_0000018780Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi21 – 211N-linked (Glc) (glycation); in hemodialysis-associated amyloidosis
    Modified residuei22 – 221Pyrrolidone carboxylic acid; in form pI 5.31 Publication
    Glycosylationi39 – 391N-linked (Glc) (glycation); in vitro
    Disulfide bondi45 ↔ 1008 PublicationsPROSITE-ProRule annotation
    Glycosylationi61 – 611N-linked (Glc) (glycation); in vitro
    Glycosylationi68 – 681N-linked (Glc) (glycation); in vitro
    Glycosylationi78 – 781N-linked (Glc) (glycation); in vitro
    Glycosylationi111 – 1111N-linked (Glc) (glycation); in vitro
    Glycosylationi114 – 1141N-linked (Glc) (glycation); in vitro

    Post-translational modificationi

    Glycation of Ile-21 is observed in long-term hemodialysis patients.

    Keywords - PTMi

    Disulfide bond, Glycation, Glycoprotein, Pyrrolidone carboxylic acid

    Proteomic databases

    MaxQBiP61769.
    PaxDbiP61769.
    PeptideAtlasiP61769.
    PRIDEiP61769.

    2D gel databases

    DOSAC-COBS-2DPAGEP61769.
    OGPiP61769.
    SWISS-2DPAGEP61769.

    PTM databases

    PhosphoSiteiP61769.

    Expressioni

    Gene expression databases

    ArrayExpressiP61769.
    BgeeiP61769.
    CleanExiHS_B2M.
    GenevestigatoriP61769.

    Organism-specific databases

    HPAiCAB002572.
    HPA006361.

    Interactioni

    Subunit structurei

    Heterodimer of an alpha chain and a beta chain. Beta-2-microglobulin is the beta-chain of major histocompatibility complex class I molecules. Polymers of beta 2-microglobulin can be found in tissues from patients on long-term hemodialysis.2 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    itself9EBI-714718,EBI-714718
    CD1AP061262EBI-714718,EBI-1036766
    CD1BP290163EBI-714718,EBI-1033762
    HFEQ302013EBI-714718,EBI-1028850

    Protein-protein interaction databases

    BioGridi107044. 15 interactions.
    DIPiDIP-6055N.
    IntActiP61769. 72 interactions.
    MINTiMINT-85778.
    STRINGi9606.ENSP00000340858.

    Structurei

    Secondary structure

    1
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi26 – 338
    Helixi35 – 373
    Beta strandi41 – 5313
    Beta strandi56 – 616
    Beta strandi64 – 663
    Beta strandi71 – 788
    Beta strandi79 – 824
    Beta strandi86 – 905
    Beta strandi98 – 1036
    Beta strandi107 – 1093
    Beta strandi111 – 1144
    Helixi117 – 1193

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1A1MX-ray2.30B21-119[»]
    1A1NX-ray2.00B21-119[»]
    1A1OX-ray2.30B21-119[»]
    1A6ZX-ray2.60B/D21-119[»]
    1A9BX-ray3.20B/E21-119[»]
    1A9EX-ray2.50B21-119[»]
    1AGBX-ray2.20B21-119[»]
    1AGCX-ray2.10B21-119[»]
    1AGDX-ray2.05B21-119[»]
    1AGEX-ray2.30B21-119[»]
    1AGFX-ray2.20B21-119[»]
    1AKJX-ray2.65B21-119[»]
    1AO7X-ray2.60B21-119[»]
    1B0GX-ray2.50B/E21-119[»]
    1B0RX-ray2.90B21-119[»]
    1BD2X-ray2.50B21-119[»]
    1C16X-ray3.10B/D/F/H21-119[»]
    1CE6X-ray2.90B21-119[»]
    1CG9X-ray2.70B21-119[»]
    1DE4X-ray2.80B/E/H21-119[»]
    1DUYX-ray2.15B/E21-119[»]
    1DUZX-ray1.80B/E21-119[»]
    1E27X-ray2.20B21-119[»]
    1E28X-ray3.00B21-119[»]
    1EEYX-ray2.25B/E21-119[»]
    1EEZX-ray2.30B/E21-119[»]
    1EFXX-ray3.00B21-119[»]
    1EXUX-ray2.70B21-119[»]
    1GZPX-ray2.80B21-119[»]
    1GZQX-ray2.26B21-119[»]
    1HHGX-ray2.60B/E21-119[»]
    1HHHX-ray3.00B21-119[»]
    1HHIX-ray2.50B/E21-119[»]
    1HHJX-ray2.50B/E21-119[»]
    1HHKX-ray2.50B/E21-119[»]
    1HLAX-ray3.50M21-117[»]
    1HSAX-ray2.10B/E21-119[»]
    1HSBX-ray1.90B21-119[»]
    1I1FX-ray2.80B/E21-119[»]
    1I1YX-ray2.20B/E21-119[»]
    1I4FX-ray1.40B21-119[»]
    1I7RX-ray2.20B/E21-119[»]
    1I7TX-ray2.80B/E21-119[»]
    1I7UX-ray1.80B/E21-119[»]
    1IM3X-ray2.20B/F/J/N21-119[»]
    1IM9X-ray2.80B/F21-119[»]
    1JF1X-ray1.85B21-119[»]
    1JGDX-ray1.90B21-119[»]
    1JGEX-ray2.10B21-119[»]
    1JHTX-ray2.15B21-119[»]
    1JNJNMR-A21-119[»]
    1K5NX-ray1.09B21-119[»]
    1KPRX-ray2.80B/D21-119[»]
    1KTLX-ray3.10B/D21-119[»]
    1LDSX-ray1.80A21-119[»]
    1LP9X-ray2.00B/I21-119[»]
    1M05X-ray1.90B/D21-119[»]
    1M6OX-ray1.60B21-119[»]
    1MHEX-ray2.85B/D21-119[»]
    1MI5X-ray2.50B21-119[»]
    1N2RX-ray1.70B21-119[»]
    1OF2X-ray2.20B21-119[»]
    1OGAX-ray1.40B21-119[»]
    1OGTX-ray1.47B21-119[»]
    1ONQX-ray2.15B/D21-119[»]
    1P7QX-ray3.40B21-119[»]
    1PY4X-ray2.90A/B/C/D21-119[»]
    1Q94X-ray2.40B/E21-119[»]
    1QEWX-ray2.20B21-119[»]
    1QLFX-ray2.65B21-119[»]
    1QQDX-ray2.70B21-118[»]
    1QR1X-ray2.40B/E20-119[»]
    1QRNX-ray2.80B21-119[»]
    1QSEX-ray2.80B20-119[»]
    1QSFX-ray2.80B20-119[»]
    1QVOX-ray2.22B/E21-119[»]
    1R3HX-ray2.50B/D/F/H21-119[»]
    1S8DX-ray2.20B21-119[»]
    1S9WX-ray2.20B21-119[»]
    1S9XX-ray2.50B21-119[»]
    1S9YX-ray2.30B21-119[»]
    1SYSX-ray2.40B21-119[»]
    1SYVX-ray1.70B21-119[»]
    1T1WX-ray2.20B21-119[»]
    1T1XX-ray2.20B21-119[»]
    1T1YX-ray2.00B21-119[»]
    1T1ZX-ray1.90B21-119[»]
    1T20X-ray2.20B21-119[»]
    1T21X-ray2.19B21-119[»]
    1T22X-ray2.20B21-119[»]
    1TMCX-ray2.30B21-119[»]
    1TVBX-ray1.80B/E21-119[»]
    1TVHX-ray1.80B/E21-119[»]
    1UQSX-ray3.10B21-119[»]
    1UR7model-B21-119[»]
    1UXSX-ray1.55B21-119[»]
    1UXWX-ray1.71B21-119[»]
    1VGKX-ray2.06B21-119[»]
    1W0VX-ray2.27B21-119[»]
    1W0WX-ray2.10B21-119[»]
    1W72X-ray2.15B/E21-119[»]
    1X7QX-ray1.45B21-119[»]
    1XH3X-ray1.48B21-119[»]
    1XR8X-ray2.30B21-119[»]
    1XR9X-ray1.79B21-119[»]
    1XZ0X-ray2.80B/D21-119[»]
    1YDPX-ray1.90B21-119[»]
    1YPZX-ray3.40B/D21-119[»]
    1ZHKX-ray1.60B21-119[»]
    1ZHLX-ray1.50B21-119[»]
    1ZS8X-ray3.00B/D/F/H/J21-119[»]
    1ZSDX-ray1.70B21-119[»]
    1ZT4X-ray3.00B/D21-119[»]
    1ZVSX-ray2.80B/E21-119[»]
    2A83X-ray1.40B21-119[»]
    2AK4X-ray2.50B/G/L/R21-119[»]
    2AV1X-ray1.95B/E21-119[»]
    2AV7X-ray2.05B/E21-119[»]
    2AXFX-ray1.80B21-119[»]
    2AXGX-ray2.00B21-119[»]
    2BCKX-ray2.80B/E21-119[»]
    2BNQX-ray1.70B21-119[»]
    2BNRX-ray1.90B21-119[»]
    2BSRX-ray2.30B21-119[»]
    2BSSX-ray2.00B21-119[»]
    2BSTX-ray2.10B21-119[»]
    2BVOX-ray1.65B21-119[»]
    2BVPX-ray1.35B21-119[»]
    2BVQX-ray2.00B21-119[»]
    2C7UX-ray2.38B/E21-119[»]
    2CIIX-ray2.55B21-119[»]
    2CIKX-ray1.75B21-119[»]
    2CLRX-ray2.00B/E21-119[»]
    2D31X-ray3.20B/E21-119[»]
    2D4DX-ray2.10A21-119[»]
    2D4FX-ray1.70A21-119[»]
    2DYPX-ray2.50B21-119[»]
    2E8DNMR-A/B/C/D40-61[»]
    2ESVX-ray2.60B21-119[»]
    2F53X-ray2.10B21-119[»]
    2F54X-ray2.70B/G21-119[»]
    2F74X-ray2.70B/E21-119[»]
    2F8OX-ray1.70A/B21-119[»]
    2FYYX-ray1.50B21-119[»]
    2FZ3X-ray1.90B21-119[»]
    2GITX-ray1.70B/E21-119[»]
    2GJ6X-ray2.56B21-119[»]
    2GT9X-ray1.75B/E21-119[»]
    2GTWX-ray1.55B/E21-119[»]
    2GTZX-ray1.70B/E21-119[»]
    2GUOX-ray1.90B/E21-119[»]
    2H26X-ray1.80B21-119[»]
    2H6PX-ray1.90B21-119[»]
    2HJKX-ray1.85B21-119[»]
    2HJLX-ray1.50B21-119[»]
    2HLAX-ray2.60B21-119[»]
    2HN7X-ray1.60B21-119[»]
    2J8UX-ray2.88B/I21-119[»]
    2JCCX-ray2.50B/I21-119[»]
    2NW3X-ray1.70B21-119[»]
    2NX5X-ray2.70B/G/L/R21-119[»]
    2P5EX-ray1.89B21-119[»]
    2P5WX-ray2.20B21-119[»]
    2PO6X-ray3.20B/F21-119[»]
    2PYEX-ray2.30B21-119[»]
    2RFXX-ray2.50B21-119[»]
    2UWEX-ray2.40B/I21-119[»]
    2V2WX-ray1.60B/E21-119[»]
    2V2XX-ray1.60B/E21-119[»]
    2VB5NMR-A21-119[»]
    2VLJX-ray2.40B21-119[»]
    2VLKX-ray2.50B21-119[»]
    2VLLX-ray1.60B/E21-119[»]
    2VLRX-ray2.30B/G21-119[»]
    2X4NX-ray2.34B/E21-119[»]
    2X4OX-ray2.30B/E21-119[»]
    2X4PX-ray2.30B/E21-119[»]
    2X4QX-ray1.90B/E21-119[»]
    2X4RX-ray2.30B/E21-119[»]
    2X4SX-ray2.55B/E21-119[»]
    2X4TX-ray2.30B/E21-119[»]
    2X4UX-ray2.10B/E21-119[»]
    2X70X-ray2.00B/E21-119[»]
    2X89X-ray2.16D/E/F/G27-119[»]
    2XKSNMR-A21-119[»]
    2XKUNMR-A27-119[»]
    2XPGX-ray2.60B22-118[»]
    2YPKX-ray1.95B21-119[»]
    2YPLX-ray2.40B21-119[»]
    2YXFX-ray1.13A21-119[»]
    2Z9TX-ray1.80A21-119[»]
    3AM8X-ray2.80C/D21-119[»]
    3B3IX-ray1.86B21-119[»]
    3B6SX-ray1.80B21-119[»]
    3BGMX-ray1.60B21-119[»]
    3BH8X-ray1.65B21-119[»]
    3BH9X-ray1.70B21-119[»]
    3BHBX-ray2.20B22-119[»]
    3BO8X-ray1.80B21-119[»]
    3BP4X-ray1.85B21-119[»]
    3BP7X-ray1.80B21-119[»]
    3BVNX-ray2.55B/E21-119[»]
    3BW9X-ray1.75B21-119[»]
    3BWAX-ray1.30B21-119[»]
    3BXNX-ray1.86B21-119[»]
    3BZEX-ray2.50B/D/F/H21-119[»]
    3BZFX-ray2.50B/D23-119[»]
    3C9NX-ray1.87B21-119[»]
    3CDGX-ray3.40B/D21-119[»]
    3CIIX-ray4.41B/E21-119[»]
    3CIQX-ray2.90A/B/C/D/E/F/G/H/I/J/K/L21-119[»]
    3CZFX-ray1.20B21-119[»]
    3D18X-ray1.74B21-119[»]
    3D25X-ray1.30B22-119[»]
    3D2UX-ray2.21B/F21-119[»]
    3D39X-ray2.81B21-119[»]
    3D3VX-ray2.80B21-119[»]
    3DBXX-ray2.00B21-119[»]
    3DHJX-ray2.00A21-119[»]
    3DHMX-ray1.80A21-119[»]
    3DTXX-ray2.10B21-119[»]
    3DX6X-ray1.70B21-119[»]
    3DX7X-ray1.60B21-119[»]
    3DX8X-ray2.10B21-119[»]
    3DXAX-ray3.50B/G/L21-119[»]
    3EKCX-ray1.80A21-119[»]
    3FFCX-ray2.80B/G21-119[»]
    3FQNX-ray1.65B22-119[»]
    3FQRX-ray1.70B22-119[»]
    3FQTX-ray1.80B22-119[»]
    3FQUX-ray1.80B22-119[»]
    3FQWX-ray1.93B22-119[»]
    3FQXX-ray1.70B22-119[»]
    3FT2X-ray1.80B21-119[»]
    3FT3X-ray1.95B21-119[»]
    3FT4X-ray1.90B21-119[»]
    3GIVX-ray2.00B/E21-119[»]
    3GJFX-ray1.90B/E21-119[»]
    3GSNX-ray2.80L21-119[»]
    3GSOX-ray1.60B21-119[»]
    3GSQX-ray2.12B21-119[»]
    3GSRX-ray1.95B21-119[»]
    3GSUX-ray1.80B21-119[»]
    3GSVX-ray1.90B21-119[»]
    3GSWX-ray1.81B21-119[»]
    3GSXX-ray2.10B21-119[»]
    3H7BX-ray1.88B/E21-119[»]
    3H9HX-ray2.00B/E21-119[»]
    3H9SX-ray2.70B21-119[»]
    3HAEX-ray2.90B/E/K/Q21-119[»]
    3HCVX-ray1.95B21-119[»]
    3HG1X-ray3.00B21-119[»]
    3HLAX-ray2.60B21-119[»]
    3HPJX-ray2.00B/E21-119[»]
    3HUJX-ray2.50B/D21-119[»]
    3I6GX-ray2.20B/E21-119[»]
    3I6KX-ray2.80B/F21-119[»]
    3I6LX-ray2.40E21-119[»]
    3IB4X-ray1.25A21-119[»]
    3IXAX-ray2.10B/E21-119[»]
    3JTSX-ray2.80B/E/H1-119[»]
    3KLAX-ray1.65B/E21-119[»]
    3KPLX-ray1.96B21-119[»]
    3KPMX-ray1.60B21-119[»]
    3KPNX-ray2.00B21-119[»]
    3KPOX-ray2.30B21-119[»]
    3KPPX-ray1.90B21-119[»]
    3KPQX-ray1.84B21-119[»]
    3KPRX-ray2.60B/G21-119[»]
    3KPSX-ray2.70B21-119[»]
    3KWWX-ray2.18B21-119[»]
    3KXFX-ray3.10B/F/J/L21-119[»]
    3KYNX-ray2.40B21-119[»]
    3KYOX-ray1.70B/D21-119[»]
    3L3DX-ray1.80B21-119[»]
    3L3GX-ray2.10B21-119[»]
    3L3IX-ray1.70B21-119[»]
    3L3JX-ray2.40B21-119[»]
    3L3KX-ray2.60B21-119[»]
    3LKNX-ray2.00B21-119[»]
    3LKOX-ray1.80B21-119[»]
    3LKPX-ray1.80B21-119[»]
    3LKQX-ray1.80B21-119[»]
    3LKRX-ray2.00B21-119[»]
    3LKSX-ray1.90B21-119[»]
    3LN4X-ray1.30B21-119[»]
    3LN5X-ray1.90B21-119[»]
    3LOWX-ray2.30A/B21-119[»]
    3LOZX-ray1.80A/B/C/D74-79[»]
    3LV3X-ray1.94B21-119[»]
    3M17X-ray2.60B/D/F/H21-119[»]
    3M1BX-ray3.10B/D/F/H21-119[»]
    3MGOX-ray2.30B/E/H/K21-119[»]
    3MGTX-ray2.20B/E/H/K21-119[»]
    3MR9X-ray1.93B21-119[»]
    3MRBX-ray1.40B21-119[»]
    3MRCX-ray1.80B21-119[»]
    3MRDX-ray1.70B21-119[»]
    3MREX-ray1.10B21-119[»]
    3MRFX-ray2.30B21-119[»]
    3MRGX-ray1.30B21-119[»]
    3MRHX-ray2.40B21-119[»]
    3MRIX-ray2.10B21-119[»]
    3MRJX-ray1.87B21-119[»]
    3MRKX-ray1.40B21-119[»]
    3MRLX-ray2.41B21-119[»]
    3MRMX-ray1.90B21-119[»]
    3MRNX-ray2.30B21-119[»]
    3MROX-ray2.35B21-119[»]
    3MRPX-ray2.10B21-119[»]
    3MRQX-ray2.20B21-119[»]
    3MRRX-ray1.60B21-119[»]
    3MV7X-ray2.00B21-119[»]
    3MV8X-ray2.10B21-119[»]
    3MV9X-ray2.70B21-119[»]
    3MYJX-ray1.89B/E21-119[»]
    3MYZX-ray1.60A/B21-119[»]
    3MZTX-ray2.70A/B/C/D/E/F21-119[»]
    3NA4X-ray1.90A21-119[»]
    3NFNX-ray2.39B21-119[»]
    3O3AX-ray1.80B/E21-119[»]
    3O3BX-ray1.90B/E21-119[»]
    3O3DX-ray1.70B/E21-119[»]
    3O3EX-ray1.85B/E21-119[»]
    3O4LX-ray2.54B21-119[»]
    3OV6X-ray2.50A21-119[»]
    3OX8X-ray2.16B/E21-119[»]
    3OXRX-ray1.70B21-119[»]
    3OXSX-ray1.75B21-119[»]
    3PWJX-ray1.70B/E21-119[»]
    3PWLX-ray1.65B/E21-119[»]
    3PWNX-ray1.60B/E21-119[»]
    3PWPX-ray2.69B21-119[»]
    3QDAX-ray1.57A21-119[»]
    3QDGX-ray2.69B21-119[»]
    3QDJX-ray2.30B21-119[»]
    3QDMX-ray2.80B21-119[»]
    3QEQX-ray2.59B21-119[»]
    3QFDX-ray1.68B/E21-119[»]
    3QFJX-ray2.29B21-119[»]
    3QZWX-ray2.80B/E21-119[»]
    3REWX-ray1.90B/E21-119[»]
    3RL1X-ray2.00B21-119[»]
    3RL2X-ray2.39B21-119[»]
    3RWJX-ray2.70B21-119[»]
    3S6CX-ray2.90A21-119[»]
    3SDXX-ray3.12B/D21-119[»]
    3SJVX-ray3.10B/G/L/Q21-119[»]
    3SKMX-ray1.80B21-119[»]
    3SKOX-ray1.60B21-119[»]
    3SPVX-ray1.30B21-119[»]
    3T8XX-ray1.90B/D21-119[»]
    3TIDX-ray1.65B21-119[»]
    3TIEX-ray2.25B/E21-119[»]
    3TLRX-ray2.45A/B/C/D21-119[»]
    3TM6X-ray2.70A/B/C/D/E/F/G/H21-119[»]
    3TO2X-ray2.60B21-119[»]
    3TZVX-ray3.06D21-119[»]
    3U0PX-ray2.80B/D/F21-119[»]
    3UPRX-ray2.00B/D21-119[»]
    3UTQX-ray1.67B21-119[»]
    3UTSX-ray2.71B/G21-119[»]
    3UTTX-ray2.60B/G21-119[»]
    3V5DX-ray2.00B/E21-119[»]
    3V5HX-ray1.63B/E21-119[»]
    3V5KX-ray2.31B/E21-119[»]
    3VCLX-ray1.70B21-119[»]
    3VFMX-ray1.90B21-119[»]
    3VFNX-ray1.50B21-119[»]
    3VFOX-ray1.70B21-119[»]
    3VFPX-ray1.85B21-119[»]
    3VFRX-ray1.85B21-119[»]
    3VFSX-ray1.85B21-119[»]
    3VFTX-ray1.95B21-119[»]
    3VFUX-ray1.65B21-119[»]
    3VFVX-ray1.55B21-119[»]
    3VFWX-ray2.30B21-119[»]
    3VH8X-ray1.80B/E21-119[»]
    3VRIX-ray1.60B21-119[»]
    3VRJX-ray1.90B21-119[»]
    3VWJX-ray3.09B21-119[»]
    3VWKX-ray2.94B21-119[»]
    3VXMX-ray2.50B21-119[»]
    3VXNX-ray1.95B21-119[»]
    3VXOX-ray2.61B/E21-119[»]
    3VXPX-ray2.50B/E21-119[»]
    3VXRX-ray2.40B21-119[»]
    3VXSX-ray1.80B21-119[»]
    3VXUX-ray2.70B/G21-119[»]
    3W0WX-ray2.60B21-119[»]
    3W39X-ray3.10B/E21-119[»]
    3WL9X-ray1.66B21-119[»]
    3WLBX-ray2.00B21-119[»]
    3WUWX-ray2.00B22-119[»]
    4BEOX-ray2.43B/D21-119[»]
    4E0KX-ray0.97A/B/C/D78-83[»]
    4E0LX-ray1.70A/B/C/D82-89[»]
    4E5XX-ray1.95B/E21-119[»]
    4EN3X-ray2.57D21-119[»]
    4EUPX-ray2.88B/E21-119[»]
    4EUQX-ray2.69B/E21-119[»]
    4F7MX-ray2.40B/E21-119[»]
    4F7PX-ray1.90B21-119[»]
    4F7TX-ray1.70B/E21-119[»]
    4FTVX-ray2.74B21-119[»]
    4FXLX-ray1.40A21-119[»]
    4G8GX-ray2.40B21-119[»]
    4G8IX-ray1.60B21-119[»]
    4G9DX-ray1.60B21-119[»]
    4G9FX-ray1.90B21-119[»]
    4GKNX-ray2.75B/E21-119[»]
    4GKSX-ray2.35B/E21-119[»]
    4GUPX-ray3.20B/D21-119[»]
    4HKJX-ray3.00B/F/J/N21-119[»]
    4HWZX-ray2.40B21-119[»]
    4HX1X-ray1.80B21-119[»]
    4I48X-ray2.80B21-119[»]
    4I4WX-ray1.77B21-119[»]
    4JFDX-ray2.46B21-119[»]
    4JFEX-ray2.70B21-119[»]
    4JFFX-ray2.43B21-119[»]
    4JFOX-ray2.11B/E21-119[»]
    4JFPX-ray1.91B/E21-119[»]
    4JFQX-ray1.90B/E21-119[»]
    4JQVX-ray1.50C21-119[»]
    4JQXX-ray1.90C21-119[»]
    4JRXX-ray2.30B21-119[»]
    4JRYX-ray2.80B21-119[»]
    4K71X-ray2.40C/F21-119[»]
    4K7FX-ray2.00B/E21-119[»]
    4KDTX-ray2.60C/D21-119[»]
    4L29X-ray3.09B/D/F/H/J/L/N/P/R/T/V/X/Z/b21-119[»]
    4L3CX-ray2.64B/D/F/H/J/L/N/P/R/T/V/X/Z/b21-119[»]
    4L3EX-ray2.56B21-119[»]
    4L4TX-ray2.00B/F21-119[»]
    4L4VX-ray1.90B/F21-119[»]
    4LCWX-ray2.40B/F21-119[»]
    4LHUX-ray2.87B21-119[»]
    4MJIX-ray2.99B/G21-119[»]
    4MNQX-ray2.74B21-119[»]
    4N0FX-ray3.02B/F/I/L21-119[»]
    4N0UX-ray3.80B21-119[»]
    4N8VX-ray2.50B/E21-119[»]
    4NQCX-ray2.50B/F21-119[»]
    4NQDX-ray2.20B/F21-119[»]
    4NQEX-ray2.10B/F21-119[»]
    4NQVX-ray2.39B/D/F/H/J/L21-119[»]
    4NQXX-ray2.00B/D/F/H/J/L21-119[»]
    4PR5X-ray1.80B21-119[»]
    4PRAX-ray1.85B21-119[»]
    4PRBX-ray1.75B21-119[»]
    4PRDX-ray1.75B21-119[»]
    4PREX-ray1.65B21-119[»]
    4PRHX-ray2.50B23-119[»]
    4PRIX-ray2.40B21-119[»]
    4PRNX-ray1.65B21-119[»]
    4PRPX-ray2.50B21-119[»]
    ProteinModelPortaliP61769.
    SMRiP61769. Positions 21-119.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP61769.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini25 – 11389Ig-like C1-typeAdd
    BLAST

    Sequence similaritiesi

    Belongs to the beta-2-microglobulin family.Curated

    Keywords - Domaini

    Immunoglobulin domain, Signal

    Phylogenomic databases

    eggNOGiNOG40777.
    HOVERGENiHBG006197.
    KOiK08055.
    OrthoDBiEOG7RFTKJ.
    PhylomeDBiP61769.
    TreeFamiTF334167.

    Family and domain databases

    Gene3Di2.60.40.10. 1 hit.
    InterProiIPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003006. Ig/MHC_CS.
    IPR003597. Ig_C1-set.
    [Graphical view]
    PfamiPF07654. C1-set. 1 hit.
    [Graphical view]
    SMARTiSM00407. IGc1. 1 hit.
    [Graphical view]
    PROSITEiPS50835. IG_LIKE. 1 hit.
    PS00290. IG_MHC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P61769-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSRSVALAVL ALLSLSGLEA IQRTPKIQVY SRHPAENGKS NFLNCYVSGF    50
    HPSDIEVDLL KNGERIEKVE HSDLSFSKDW SFYLLYYTEF TPTEKDEYAC 100
    RVNHVTLSQP KIVKWDRDM 119
    Length:119
    Mass (Da):13,715
    Last modified:July 21, 1986 - v1
    Checksum:iAFD2DBEF07DCEF27
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti20 – 201A → G in AAA51811. (PubMed:3312414)Curated
    Sequence conflicti52 – 521P → Q in AAA51811. (PubMed:3312414)Curated
    Sequence conflicti119 – 1191M → I in CAG33347. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti11 – 111A → P in HYCATHYP; lower levels of B2M, MHC class I and FCGRT proteins. 1 Publication
    VAR_030660

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M17987, M17986 Genomic DNA. Translation: AAA51811.1.
    AY187687 mRNA. Translation: AAO20842.1.
    AB021288 mRNA. Translation: BAA35182.1.
    DQ217933 Genomic DNA. Translation: ABB01003.1.
    AF072097 mRNA. Translation: AAD48083.1.
    AY007153 mRNA. Translation: AAG02006.1.
    CR457066 mRNA. Translation: CAG33347.1.
    AK315776 mRNA. Translation: BAG38125.1.
    CH471082 Genomic DNA. Translation: EAW77277.1.
    BC032589 mRNA. Translation: AAH32589.1.
    BC064910 mRNA. Translation: AAH64910.1.
    V00567 mRNA. Translation: CAA23830.1.
    CCDSiCCDS10113.1.
    PIRiA90976. MGHUB2.
    RefSeqiNP_004039.1. NM_004048.2.
    UniGeneiHs.534255.

    Genome annotation databases

    EnsembliENST00000558401; ENSP00000452780; ENSG00000166710.
    ENST00000559916; ENSP00000453350; ENSG00000166710.
    ENST00000561424; ENSP00000453191; ENSG00000166710.
    GeneIDi567.
    KEGGihsa:567.
    UCSCiuc001zuc.3. human.

    Polymorphism databases

    DMDMi48428791.

    Cross-referencesi

    Web resourcesi

    Wikipedia

    Beta-2-microglobulin entry

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M17987 , M17986 Genomic DNA. Translation: AAA51811.1 .
    AY187687 mRNA. Translation: AAO20842.1 .
    AB021288 mRNA. Translation: BAA35182.1 .
    DQ217933 Genomic DNA. Translation: ABB01003.1 .
    AF072097 mRNA. Translation: AAD48083.1 .
    AY007153 mRNA. Translation: AAG02006.1 .
    CR457066 mRNA. Translation: CAG33347.1 .
    AK315776 mRNA. Translation: BAG38125.1 .
    CH471082 Genomic DNA. Translation: EAW77277.1 .
    BC032589 mRNA. Translation: AAH32589.1 .
    BC064910 mRNA. Translation: AAH64910.1 .
    V00567 mRNA. Translation: CAA23830.1 .
    CCDSi CCDS10113.1.
    PIRi A90976. MGHUB2.
    RefSeqi NP_004039.1. NM_004048.2.
    UniGenei Hs.534255.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1A1M X-ray 2.30 B 21-119 [» ]
    1A1N X-ray 2.00 B 21-119 [» ]
    1A1O X-ray 2.30 B 21-119 [» ]
    1A6Z X-ray 2.60 B/D 21-119 [» ]
    1A9B X-ray 3.20 B/E 21-119 [» ]
    1A9E X-ray 2.50 B 21-119 [» ]
    1AGB X-ray 2.20 B 21-119 [» ]
    1AGC X-ray 2.10 B 21-119 [» ]
    1AGD X-ray 2.05 B 21-119 [» ]
    1AGE X-ray 2.30 B 21-119 [» ]
    1AGF X-ray 2.20 B 21-119 [» ]
    1AKJ X-ray 2.65 B 21-119 [» ]
    1AO7 X-ray 2.60 B 21-119 [» ]
    1B0G X-ray 2.50 B/E 21-119 [» ]
    1B0R X-ray 2.90 B 21-119 [» ]
    1BD2 X-ray 2.50 B 21-119 [» ]
    1C16 X-ray 3.10 B/D/F/H 21-119 [» ]
    1CE6 X-ray 2.90 B 21-119 [» ]
    1CG9 X-ray 2.70 B 21-119 [» ]
    1DE4 X-ray 2.80 B/E/H 21-119 [» ]
    1DUY X-ray 2.15 B/E 21-119 [» ]
    1DUZ X-ray 1.80 B/E 21-119 [» ]
    1E27 X-ray 2.20 B 21-119 [» ]
    1E28 X-ray 3.00 B 21-119 [» ]
    1EEY X-ray 2.25 B/E 21-119 [» ]
    1EEZ X-ray 2.30 B/E 21-119 [» ]
    1EFX X-ray 3.00 B 21-119 [» ]
    1EXU X-ray 2.70 B 21-119 [» ]
    1GZP X-ray 2.80 B 21-119 [» ]
    1GZQ X-ray 2.26 B 21-119 [» ]
    1HHG X-ray 2.60 B/E 21-119 [» ]
    1HHH X-ray 3.00 B 21-119 [» ]
    1HHI X-ray 2.50 B/E 21-119 [» ]
    1HHJ X-ray 2.50 B/E 21-119 [» ]
    1HHK X-ray 2.50 B/E 21-119 [» ]
    1HLA X-ray 3.50 M 21-117 [» ]
    1HSA X-ray 2.10 B/E 21-119 [» ]
    1HSB X-ray 1.90 B 21-119 [» ]
    1I1F X-ray 2.80 B/E 21-119 [» ]
    1I1Y X-ray 2.20 B/E 21-119 [» ]
    1I4F X-ray 1.40 B 21-119 [» ]
    1I7R X-ray 2.20 B/E 21-119 [» ]
    1I7T X-ray 2.80 B/E 21-119 [» ]
    1I7U X-ray 1.80 B/E 21-119 [» ]
    1IM3 X-ray 2.20 B/F/J/N 21-119 [» ]
    1IM9 X-ray 2.80 B/F 21-119 [» ]
    1JF1 X-ray 1.85 B 21-119 [» ]
    1JGD X-ray 1.90 B 21-119 [» ]
    1JGE X-ray 2.10 B 21-119 [» ]
    1JHT X-ray 2.15 B 21-119 [» ]
    1JNJ NMR - A 21-119 [» ]
    1K5N X-ray 1.09 B 21-119 [» ]
    1KPR X-ray 2.80 B/D 21-119 [» ]
    1KTL X-ray 3.10 B/D 21-119 [» ]
    1LDS X-ray 1.80 A 21-119 [» ]
    1LP9 X-ray 2.00 B/I 21-119 [» ]
    1M05 X-ray 1.90 B/D 21-119 [» ]
    1M6O X-ray 1.60 B 21-119 [» ]
    1MHE X-ray 2.85 B/D 21-119 [» ]
    1MI5 X-ray 2.50 B 21-119 [» ]
    1N2R X-ray 1.70 B 21-119 [» ]
    1OF2 X-ray 2.20 B 21-119 [» ]
    1OGA X-ray 1.40 B 21-119 [» ]
    1OGT X-ray 1.47 B 21-119 [» ]
    1ONQ X-ray 2.15 B/D 21-119 [» ]
    1P7Q X-ray 3.40 B 21-119 [» ]
    1PY4 X-ray 2.90 A/B/C/D 21-119 [» ]
    1Q94 X-ray 2.40 B/E 21-119 [» ]
    1QEW X-ray 2.20 B 21-119 [» ]
    1QLF X-ray 2.65 B 21-119 [» ]
    1QQD X-ray 2.70 B 21-118 [» ]
    1QR1 X-ray 2.40 B/E 20-119 [» ]
    1QRN X-ray 2.80 B 21-119 [» ]
    1QSE X-ray 2.80 B 20-119 [» ]
    1QSF X-ray 2.80 B 20-119 [» ]
    1QVO X-ray 2.22 B/E 21-119 [» ]
    1R3H X-ray 2.50 B/D/F/H 21-119 [» ]
    1S8D X-ray 2.20 B 21-119 [» ]
    1S9W X-ray 2.20 B 21-119 [» ]
    1S9X X-ray 2.50 B 21-119 [» ]
    1S9Y X-ray 2.30 B 21-119 [» ]
    1SYS X-ray 2.40 B 21-119 [» ]
    1SYV X-ray 1.70 B 21-119 [» ]
    1T1W X-ray 2.20 B 21-119 [» ]
    1T1X X-ray 2.20 B 21-119 [» ]
    1T1Y X-ray 2.00 B 21-119 [» ]
    1T1Z X-ray 1.90 B 21-119 [» ]
    1T20 X-ray 2.20 B 21-119 [» ]
    1T21 X-ray 2.19 B 21-119 [» ]
    1T22 X-ray 2.20 B 21-119 [» ]
    1TMC X-ray 2.30 B 21-119 [» ]
    1TVB X-ray 1.80 B/E 21-119 [» ]
    1TVH X-ray 1.80 B/E 21-119 [» ]
    1UQS X-ray 3.10 B 21-119 [» ]
    1UR7 model - B 21-119 [» ]
    1UXS X-ray 1.55 B 21-119 [» ]
    1UXW X-ray 1.71 B 21-119 [» ]
    1VGK X-ray 2.06 B 21-119 [» ]
    1W0V X-ray 2.27 B 21-119 [» ]
    1W0W X-ray 2.10 B 21-119 [» ]
    1W72 X-ray 2.15 B/E 21-119 [» ]
    1X7Q X-ray 1.45 B 21-119 [» ]
    1XH3 X-ray 1.48 B 21-119 [» ]
    1XR8 X-ray 2.30 B 21-119 [» ]
    1XR9 X-ray 1.79 B 21-119 [» ]
    1XZ0 X-ray 2.80 B/D 21-119 [» ]
    1YDP X-ray 1.90 B 21-119 [» ]
    1YPZ X-ray 3.40 B/D 21-119 [» ]
    1ZHK X-ray 1.60 B 21-119 [» ]
    1ZHL X-ray 1.50 B 21-119 [» ]
    1ZS8 X-ray 3.00 B/D/F/H/J 21-119 [» ]
    1ZSD X-ray 1.70 B 21-119 [» ]
    1ZT4 X-ray 3.00 B/D 21-119 [» ]
    1ZVS X-ray 2.80 B/E 21-119 [» ]
    2A83 X-ray 1.40 B 21-119 [» ]
    2AK4 X-ray 2.50 B/G/L/R 21-119 [» ]
    2AV1 X-ray 1.95 B/E 21-119 [» ]
    2AV7 X-ray 2.05 B/E 21-119 [» ]
    2AXF X-ray 1.80 B 21-119 [» ]
    2AXG X-ray 2.00 B 21-119 [» ]
    2BCK X-ray 2.80 B/E 21-119 [» ]
    2BNQ X-ray 1.70 B 21-119 [» ]
    2BNR X-ray 1.90 B 21-119 [» ]
    2BSR X-ray 2.30 B 21-119 [» ]
    2BSS X-ray 2.00 B 21-119 [» ]
    2BST X-ray 2.10 B 21-119 [» ]
    2BVO X-ray 1.65 B 21-119 [» ]
    2BVP X-ray 1.35 B 21-119 [» ]
    2BVQ X-ray 2.00 B 21-119 [» ]
    2C7U X-ray 2.38 B/E 21-119 [» ]
    2CII X-ray 2.55 B 21-119 [» ]
    2CIK X-ray 1.75 B 21-119 [» ]
    2CLR X-ray 2.00 B/E 21-119 [» ]
    2D31 X-ray 3.20 B/E 21-119 [» ]
    2D4D X-ray 2.10 A 21-119 [» ]
    2D4F X-ray 1.70 A 21-119 [» ]
    2DYP X-ray 2.50 B 21-119 [» ]
    2E8D NMR - A/B/C/D 40-61 [» ]
    2ESV X-ray 2.60 B 21-119 [» ]
    2F53 X-ray 2.10 B 21-119 [» ]
    2F54 X-ray 2.70 B/G 21-119 [» ]
    2F74 X-ray 2.70 B/E 21-119 [» ]
    2F8O X-ray 1.70 A/B 21-119 [» ]
    2FYY X-ray 1.50 B 21-119 [» ]
    2FZ3 X-ray 1.90 B 21-119 [» ]
    2GIT X-ray 1.70 B/E 21-119 [» ]
    2GJ6 X-ray 2.56 B 21-119 [» ]
    2GT9 X-ray 1.75 B/E 21-119 [» ]
    2GTW X-ray 1.55 B/E 21-119 [» ]
    2GTZ X-ray 1.70 B/E 21-119 [» ]
    2GUO X-ray 1.90 B/E 21-119 [» ]
    2H26 X-ray 1.80 B 21-119 [» ]
    2H6P X-ray 1.90 B 21-119 [» ]
    2HJK X-ray 1.85 B 21-119 [» ]
    2HJL X-ray 1.50 B 21-119 [» ]
    2HLA X-ray 2.60 B 21-119 [» ]
    2HN7 X-ray 1.60 B 21-119 [» ]
    2J8U X-ray 2.88 B/I 21-119 [» ]
    2JCC X-ray 2.50 B/I 21-119 [» ]
    2NW3 X-ray 1.70 B 21-119 [» ]
    2NX5 X-ray 2.70 B/G/L/R 21-119 [» ]
    2P5E X-ray 1.89 B 21-119 [» ]
    2P5W X-ray 2.20 B 21-119 [» ]
    2PO6 X-ray 3.20 B/F 21-119 [» ]
    2PYE X-ray 2.30 B 21-119 [» ]
    2RFX X-ray 2.50 B 21-119 [» ]
    2UWE X-ray 2.40 B/I 21-119 [» ]
    2V2W X-ray 1.60 B/E 21-119 [» ]
    2V2X X-ray 1.60 B/E 21-119 [» ]
    2VB5 NMR - A 21-119 [» ]
    2VLJ X-ray 2.40 B 21-119 [» ]
    2VLK X-ray 2.50 B 21-119 [» ]
    2VLL X-ray 1.60 B/E 21-119 [» ]
    2VLR X-ray 2.30 B/G 21-119 [» ]
    2X4N X-ray 2.34 B/E 21-119 [» ]
    2X4O X-ray 2.30 B/E 21-119 [» ]
    2X4P X-ray 2.30 B/E 21-119 [» ]
    2X4Q X-ray 1.90 B/E 21-119 [» ]
    2X4R X-ray 2.30 B/E 21-119 [» ]
    2X4S X-ray 2.55 B/E 21-119 [» ]
    2X4T X-ray 2.30 B/E 21-119 [» ]
    2X4U X-ray 2.10 B/E 21-119 [» ]
    2X70 X-ray 2.00 B/E 21-119 [» ]
    2X89 X-ray 2.16 D/E/F/G 27-119 [» ]
    2XKS NMR - A 21-119 [» ]
    2XKU NMR - A 27-119 [» ]
    2XPG X-ray 2.60 B 22-118 [» ]
    2YPK X-ray 1.95 B 21-119 [» ]
    2YPL X-ray 2.40 B 21-119 [» ]
    2YXF X-ray 1.13 A 21-119 [» ]
    2Z9T X-ray 1.80 A 21-119 [» ]
    3AM8 X-ray 2.80 C/D 21-119 [» ]
    3B3I X-ray 1.86 B 21-119 [» ]
    3B6S X-ray 1.80 B 21-119 [» ]
    3BGM X-ray 1.60 B 21-119 [» ]
    3BH8 X-ray 1.65 B 21-119 [» ]
    3BH9 X-ray 1.70 B 21-119 [» ]
    3BHB X-ray 2.20 B 22-119 [» ]
    3BO8 X-ray 1.80 B 21-119 [» ]
    3BP4 X-ray 1.85 B 21-119 [» ]
    3BP7 X-ray 1.80 B 21-119 [» ]
    3BVN X-ray 2.55 B/E 21-119 [» ]
    3BW9 X-ray 1.75 B 21-119 [» ]
    3BWA X-ray 1.30 B 21-119 [» ]
    3BXN X-ray 1.86 B 21-119 [» ]
    3BZE X-ray 2.50 B/D/F/H 21-119 [» ]
    3BZF X-ray 2.50 B/D 23-119 [» ]
    3C9N X-ray 1.87 B 21-119 [» ]
    3CDG X-ray 3.40 B/D 21-119 [» ]
    3CII X-ray 4.41 B/E 21-119 [» ]
    3CIQ X-ray 2.90 A/B/C/D/E/F/G/H/I/J/K/L 21-119 [» ]
    3CZF X-ray 1.20 B 21-119 [» ]
    3D18 X-ray 1.74 B 21-119 [» ]
    3D25 X-ray 1.30 B 22-119 [» ]
    3D2U X-ray 2.21 B/F 21-119 [» ]
    3D39 X-ray 2.81 B 21-119 [» ]
    3D3V X-ray 2.80 B 21-119 [» ]
    3DBX X-ray 2.00 B 21-119 [» ]
    3DHJ X-ray 2.00 A 21-119 [» ]
    3DHM X-ray 1.80 A 21-119 [» ]
    3DTX X-ray 2.10 B 21-119 [» ]
    3DX6 X-ray 1.70 B 21-119 [» ]
    3DX7 X-ray 1.60 B 21-119 [» ]
    3DX8 X-ray 2.10 B 21-119 [» ]
    3DXA X-ray 3.50 B/G/L 21-119 [» ]
    3EKC X-ray 1.80 A 21-119 [» ]
    3FFC X-ray 2.80 B/G 21-119 [» ]
    3FQN X-ray 1.65 B 22-119 [» ]
    3FQR X-ray 1.70 B 22-119 [» ]
    3FQT X-ray 1.80 B 22-119 [» ]
    3FQU X-ray 1.80 B 22-119 [» ]
    3FQW X-ray 1.93 B 22-119 [» ]
    3FQX X-ray 1.70 B 22-119 [» ]
    3FT2 X-ray 1.80 B 21-119 [» ]
    3FT3 X-ray 1.95 B 21-119 [» ]
    3FT4 X-ray 1.90 B 21-119 [» ]
    3GIV X-ray 2.00 B/E 21-119 [» ]
    3GJF X-ray 1.90 B/E 21-119 [» ]
    3GSN X-ray 2.80 L 21-119 [» ]
    3GSO X-ray 1.60 B 21-119 [» ]
    3GSQ X-ray 2.12 B 21-119 [» ]
    3GSR X-ray 1.95 B 21-119 [» ]
    3GSU X-ray 1.80 B 21-119 [» ]
    3GSV X-ray 1.90 B 21-119 [» ]
    3GSW X-ray 1.81 B 21-119 [» ]
    3GSX X-ray 2.10 B 21-119 [» ]
    3H7B X-ray 1.88 B/E 21-119 [» ]
    3H9H X-ray 2.00 B/E 21-119 [» ]
    3H9S X-ray 2.70 B 21-119 [» ]
    3HAE X-ray 2.90 B/E/K/Q 21-119 [» ]
    3HCV X-ray 1.95 B 21-119 [» ]
    3HG1 X-ray 3.00 B 21-119 [» ]
    3HLA X-ray 2.60 B 21-119 [» ]
    3HPJ X-ray 2.00 B/E 21-119 [» ]
    3HUJ X-ray 2.50 B/D 21-119 [» ]
    3I6G X-ray 2.20 B/E 21-119 [» ]
    3I6K X-ray 2.80 B/F 21-119 [» ]
    3I6L X-ray 2.40 E 21-119 [» ]
    3IB4 X-ray 1.25 A 21-119 [» ]
    3IXA X-ray 2.10 B/E 21-119 [» ]
    3JTS X-ray 2.80 B/E/H 1-119 [» ]
    3KLA X-ray 1.65 B/E 21-119 [» ]
    3KPL X-ray 1.96 B 21-119 [» ]
    3KPM X-ray 1.60 B 21-119 [» ]
    3KPN X-ray 2.00 B 21-119 [» ]
    3KPO X-ray 2.30 B 21-119 [» ]
    3KPP X-ray 1.90 B 21-119 [» ]
    3KPQ X-ray 1.84 B 21-119 [» ]
    3KPR X-ray 2.60 B/G 21-119 [» ]
    3KPS X-ray 2.70 B 21-119 [» ]
    3KWW X-ray 2.18 B 21-119 [» ]
    3KXF X-ray 3.10 B/F/J/L 21-119 [» ]
    3KYN X-ray 2.40 B 21-119 [» ]
    3KYO X-ray 1.70 B/D 21-119 [» ]
    3L3D X-ray 1.80 B 21-119 [» ]
    3L3G X-ray 2.10 B 21-119 [» ]
    3L3I X-ray 1.70 B 21-119 [» ]
    3L3J X-ray 2.40 B 21-119 [» ]
    3L3K X-ray 2.60 B 21-119 [» ]
    3LKN X-ray 2.00 B 21-119 [» ]
    3LKO X-ray 1.80 B 21-119 [» ]
    3LKP X-ray 1.80 B 21-119 [» ]
    3LKQ X-ray 1.80 B 21-119 [» ]
    3LKR X-ray 2.00 B 21-119 [» ]
    3LKS X-ray 1.90 B 21-119 [» ]
    3LN4 X-ray 1.30 B 21-119 [» ]
    3LN5 X-ray 1.90 B 21-119 [» ]
    3LOW X-ray 2.30 A/B 21-119 [» ]
    3LOZ X-ray 1.80 A/B/C/D 74-79 [» ]
    3LV3 X-ray 1.94 B 21-119 [» ]
    3M17 X-ray 2.60 B/D/F/H 21-119 [» ]
    3M1B X-ray 3.10 B/D/F/H 21-119 [» ]
    3MGO X-ray 2.30 B/E/H/K 21-119 [» ]
    3MGT X-ray 2.20 B/E/H/K 21-119 [» ]
    3MR9 X-ray 1.93 B 21-119 [» ]
    3MRB X-ray 1.40 B 21-119 [» ]
    3MRC X-ray 1.80 B 21-119 [» ]
    3MRD X-ray 1.70 B 21-119 [» ]
    3MRE X-ray 1.10 B 21-119 [» ]
    3MRF X-ray 2.30 B 21-119 [» ]
    3MRG X-ray 1.30 B 21-119 [» ]
    3MRH X-ray 2.40 B 21-119 [» ]
    3MRI X-ray 2.10 B 21-119 [» ]
    3MRJ X-ray 1.87 B 21-119 [» ]
    3MRK X-ray 1.40 B 21-119 [» ]
    3MRL X-ray 2.41 B 21-119 [» ]
    3MRM X-ray 1.90 B 21-119 [» ]
    3MRN X-ray 2.30 B 21-119 [» ]
    3MRO X-ray 2.35 B 21-119 [» ]
    3MRP X-ray 2.10 B 21-119 [» ]
    3MRQ X-ray 2.20 B 21-119 [» ]
    3MRR X-ray 1.60 B 21-119 [» ]
    3MV7 X-ray 2.00 B 21-119 [» ]
    3MV8 X-ray 2.10 B 21-119 [» ]
    3MV9 X-ray 2.70 B 21-119 [» ]
    3MYJ X-ray 1.89 B/E 21-119 [» ]
    3MYZ X-ray 1.60 A/B 21-119 [» ]
    3MZT X-ray 2.70 A/B/C/D/E/F 21-119 [» ]
    3NA4 X-ray 1.90 A 21-119 [» ]
    3NFN X-ray 2.39 B 21-119 [» ]
    3O3A X-ray 1.80 B/E 21-119 [» ]
    3O3B X-ray 1.90 B/E 21-119 [» ]
    3O3D X-ray 1.70 B/E 21-119 [» ]
    3O3E X-ray 1.85 B/E 21-119 [» ]
    3O4L X-ray 2.54 B 21-119 [» ]
    3OV6 X-ray 2.50 A 21-119 [» ]
    3OX8 X-ray 2.16 B/E 21-119 [» ]
    3OXR X-ray 1.70 B 21-119 [» ]
    3OXS X-ray 1.75 B 21-119 [» ]
    3PWJ X-ray 1.70 B/E 21-119 [» ]
    3PWL X-ray 1.65 B/E 21-119 [» ]
    3PWN X-ray 1.60 B/E 21-119 [» ]
    3PWP X-ray 2.69 B 21-119 [» ]
    3QDA X-ray 1.57 A 21-119 [» ]
    3QDG X-ray 2.69 B 21-119 [» ]
    3QDJ X-ray 2.30 B 21-119 [» ]
    3QDM X-ray 2.80 B 21-119 [» ]
    3QEQ X-ray 2.59 B 21-119 [» ]
    3QFD X-ray 1.68 B/E 21-119 [» ]
    3QFJ X-ray 2.29 B 21-119 [» ]
    3QZW X-ray 2.80 B/E 21-119 [» ]
    3REW X-ray 1.90 B/E 21-119 [» ]
    3RL1 X-ray 2.00 B 21-119 [» ]
    3RL2 X-ray 2.39 B 21-119 [» ]
    3RWJ X-ray 2.70 B 21-119 [» ]
    3S6C X-ray 2.90 A 21-119 [» ]
    3SDX X-ray 3.12 B/D 21-119 [» ]
    3SJV X-ray 3.10 B/G/L/Q 21-119 [» ]
    3SKM X-ray 1.80 B 21-119 [» ]
    3SKO X-ray 1.60 B 21-119 [» ]
    3SPV X-ray 1.30 B 21-119 [» ]
    3T8X X-ray 1.90 B/D 21-119 [» ]
    3TID X-ray 1.65 B 21-119 [» ]
    3TIE X-ray 2.25 B/E 21-119 [» ]
    3TLR X-ray 2.45 A/B/C/D 21-119 [» ]
    3TM6 X-ray 2.70 A/B/C/D/E/F/G/H 21-119 [» ]
    3TO2 X-ray 2.60 B 21-119 [» ]
    3TZV X-ray 3.06 D 21-119 [» ]
    3U0P X-ray 2.80 B/D/F 21-119 [» ]
    3UPR X-ray 2.00 B/D 21-119 [» ]
    3UTQ X-ray 1.67 B 21-119 [» ]
    3UTS X-ray 2.71 B/G 21-119 [» ]
    3UTT X-ray 2.60 B/G 21-119 [» ]
    3V5D X-ray 2.00 B/E 21-119 [» ]
    3V5H X-ray 1.63 B/E 21-119 [» ]
    3V5K X-ray 2.31 B/E 21-119 [» ]
    3VCL X-ray 1.70 B 21-119 [» ]
    3VFM X-ray 1.90 B 21-119 [» ]
    3VFN X-ray 1.50 B 21-119 [» ]
    3VFO X-ray 1.70 B 21-119 [» ]
    3VFP X-ray 1.85 B 21-119 [» ]
    3VFR X-ray 1.85 B 21-119 [» ]
    3VFS X-ray 1.85 B 21-119 [» ]
    3VFT X-ray 1.95 B 21-119 [» ]
    3VFU X-ray 1.65 B 21-119 [» ]
    3VFV X-ray 1.55 B 21-119 [» ]
    3VFW X-ray 2.30 B 21-119 [» ]
    3VH8 X-ray 1.80 B/E 21-119 [» ]
    3VRI X-ray 1.60 B 21-119 [» ]
    3VRJ X-ray 1.90 B 21-119 [» ]
    3VWJ X-ray 3.09 B 21-119 [» ]
    3VWK X-ray 2.94 B 21-119 [» ]
    3VXM X-ray 2.50 B 21-119 [» ]
    3VXN X-ray 1.95 B 21-119 [» ]
    3VXO X-ray 2.61 B/E 21-119 [» ]
    3VXP X-ray 2.50 B/E 21-119 [» ]
    3VXR X-ray 2.40 B 21-119 [» ]
    3VXS X-ray 1.80 B 21-119 [» ]
    3VXU X-ray 2.70 B/G 21-119 [» ]
    3W0W X-ray 2.60 B 21-119 [» ]
    3W39 X-ray 3.10 B/E 21-119 [» ]
    3WL9 X-ray 1.66 B 21-119 [» ]
    3WLB X-ray 2.00 B 21-119 [» ]
    3WUW X-ray 2.00 B 22-119 [» ]
    4BEO X-ray 2.43 B/D 21-119 [» ]
    4E0K X-ray 0.97 A/B/C/D 78-83 [» ]
    4E0L X-ray 1.70 A/B/C/D 82-89 [» ]
    4E5X X-ray 1.95 B/E 21-119 [» ]
    4EN3 X-ray 2.57 D 21-119 [» ]
    4EUP X-ray 2.88 B/E 21-119 [» ]
    4EUQ X-ray 2.69 B/E 21-119 [» ]
    4F7M X-ray 2.40 B/E 21-119 [» ]
    4F7P X-ray 1.90 B 21-119 [» ]
    4F7T X-ray 1.70 B/E 21-119 [» ]
    4FTV X-ray 2.74 B 21-119 [» ]
    4FXL X-ray 1.40 A 21-119 [» ]
    4G8G X-ray 2.40 B 21-119 [» ]
    4G8I X-ray 1.60 B 21-119 [» ]
    4G9D X-ray 1.60 B 21-119 [» ]
    4G9F X-ray 1.90 B 21-119 [» ]
    4GKN X-ray 2.75 B/E 21-119 [» ]
    4GKS X-ray 2.35 B/E 21-119 [» ]
    4GUP X-ray 3.20 B/D 21-119 [» ]
    4HKJ X-ray 3.00 B/F/J/N 21-119 [» ]
    4HWZ X-ray 2.40 B 21-119 [» ]
    4HX1 X-ray 1.80 B 21-119 [» ]
    4I48 X-ray 2.80 B 21-119 [» ]
    4I4W X-ray 1.77 B 21-119 [» ]
    4JFD X-ray 2.46 B 21-119 [» ]
    4JFE X-ray 2.70 B 21-119 [» ]
    4JFF X-ray 2.43 B 21-119 [» ]
    4JFO X-ray 2.11 B/E 21-119 [» ]
    4JFP X-ray 1.91 B/E 21-119 [» ]
    4JFQ X-ray 1.90 B/E 21-119 [» ]
    4JQV X-ray 1.50 C 21-119 [» ]
    4JQX X-ray 1.90 C 21-119 [» ]
    4JRX X-ray 2.30 B 21-119 [» ]
    4JRY X-ray 2.80 B 21-119 [» ]
    4K71 X-ray 2.40 C/F 21-119 [» ]
    4K7F X-ray 2.00 B/E 21-119 [» ]
    4KDT X-ray 2.60 C/D 21-119 [» ]
    4L29 X-ray 3.09 B/D/F/H/J/L/N/P/R/T/V/X/Z/b 21-119 [» ]
    4L3C X-ray 2.64 B/D/F/H/J/L/N/P/R/T/V/X/Z/b 21-119 [» ]
    4L3E X-ray 2.56 B 21-119 [» ]
    4L4T X-ray 2.00 B/F 21-119 [» ]
    4L4V X-ray 1.90 B/F 21-119 [» ]
    4LCW X-ray 2.40 B/F 21-119 [» ]
    4LHU X-ray 2.87 B 21-119 [» ]
    4MJI X-ray 2.99 B/G 21-119 [» ]
    4MNQ X-ray 2.74 B 21-119 [» ]
    4N0F X-ray 3.02 B/F/I/L 21-119 [» ]
    4N0U X-ray 3.80 B 21-119 [» ]
    4N8V X-ray 2.50 B/E 21-119 [» ]
    4NQC X-ray 2.50 B/F 21-119 [» ]
    4NQD X-ray 2.20 B/F 21-119 [» ]
    4NQE X-ray 2.10 B/F 21-119 [» ]
    4NQV X-ray 2.39 B/D/F/H/J/L 21-119 [» ]
    4NQX X-ray 2.00 B/D/F/H/J/L 21-119 [» ]
    4PR5 X-ray 1.80 B 21-119 [» ]
    4PRA X-ray 1.85 B 21-119 [» ]
    4PRB X-ray 1.75 B 21-119 [» ]
    4PRD X-ray 1.75 B 21-119 [» ]
    4PRE X-ray 1.65 B 21-119 [» ]
    4PRH X-ray 2.50 B 23-119 [» ]
    4PRI X-ray 2.40 B 21-119 [» ]
    4PRN X-ray 1.65 B 21-119 [» ]
    4PRP X-ray 2.50 B 21-119 [» ]
    ProteinModelPortali P61769.
    SMRi P61769. Positions 21-119.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 107044. 15 interactions.
    DIPi DIP-6055N.
    IntActi P61769. 72 interactions.
    MINTi MINT-85778.
    STRINGi 9606.ENSP00000340858.

    PTM databases

    PhosphoSitei P61769.

    Polymorphism databases

    DMDMi 48428791.

    2D gel databases

    DOSAC-COBS-2DPAGE P61769.
    OGPi P61769.
    SWISS-2DPAGE P61769.

    Proteomic databases

    MaxQBi P61769.
    PaxDbi P61769.
    PeptideAtlasi P61769.
    PRIDEi P61769.

    Protocols and materials databases

    DNASUi 567.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000558401 ; ENSP00000452780 ; ENSG00000166710 .
    ENST00000559916 ; ENSP00000453350 ; ENSG00000166710 .
    ENST00000561424 ; ENSP00000453191 ; ENSG00000166710 .
    GeneIDi 567.
    KEGGi hsa:567.
    UCSCi uc001zuc.3. human.

    Organism-specific databases

    CTDi 567.
    GeneCardsi GC15P045003.
    HGNCi HGNC:914. B2M.
    HPAi CAB002572.
    HPA006361.
    MIMi 109700. gene.
    241600. phenotype.
    neXtProti NX_P61769.
    Orphaneti 314652. Autosomal dominant beta2-microglobulinic amyloidosis.
    PharmGKBi PA25207.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG40777.
    HOVERGENi HBG006197.
    KOi K08055.
    OrthoDBi EOG7RFTKJ.
    PhylomeDBi P61769.
    TreeFami TF334167.

    Enzyme and pathway databases

    Reactomei REACT_11103. Nef mediated downregulation of MHC class I complex cell surface expression.
    REACT_111168. Endosomal/Vacuolar pathway.
    REACT_111178. ER-Phagosome pathway.
    REACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
    REACT_147694. DAP12 interactions.
    REACT_147814. DAP12 signaling.
    REACT_25078. Interferon gamma signaling.
    REACT_75795. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.
    REACT_75925. Amyloids.

    Miscellaneous databases

    ChiTaRSi B2M. human.
    EvolutionaryTracei P61769.
    GeneWikii Beta-2_microglobulin.
    GenomeRNAii 567.
    NextBioi 2313.
    PROi P61769.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P61769.
    Bgeei P61769.
    CleanExi HS_B2M.
    Genevestigatori P61769.

    Family and domain databases

    Gene3Di 2.60.40.10. 1 hit.
    InterProi IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003006. Ig/MHC_CS.
    IPR003597. Ig_C1-set.
    [Graphical view ]
    Pfami PF07654. C1-set. 1 hit.
    [Graphical view ]
    SMARTi SM00407. IGc1. 1 hit.
    [Graphical view ]
    PROSITEi PS50835. IG_LIKE. 1 hit.
    PS00290. IG_MHC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The human beta 2-microglobulin gene. Primary structure and definition of the transcriptional unit."
      Guessow D., Rein R., Ginjaar I., Hochstenbach F., Seemann G., Kottman A., Ploegh H.L.
      J. Immunol. 139:3132-3138(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Cloning of human beta-microglobulin gene and its high expression in Escherichia coli."
      He X.H., Xu L.H., Liu Y., Zeng Y.Y.
      Sheng Wu Gong Cheng Xue Bao 20:99-103(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Peripheral blood.
    3. "Human mRNA for beta 2-microglobulin."
      Matsumoto K., Minamitani T.
      Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Cervix carcinoma.
    4. "Genetic variation in immune response genes."
      Tan J., Ong R., Hibberd M.L., Seielstad M.
      Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    5. "A novel gene from human dendritic cell."
      Zhao Z., Huang X., Li N., Zhu X., Cao X.
      Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Dendritic cell.
    6. "Pediatric leukemia cDNA sequencing project."
      Zhou J., Yu W., Tang H., Mei G., Tsang Y.T.M., Bouck J., Gibbs R.A., Margolin J.F.
      Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Leukemia.
    7. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    8. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Trachea.
    9. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    10. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Retina and Skin.
    11. "The beta-2-microglobulin mRNA in human Daudi cells has a mutated initiation codon but is still inducible by interferon."
      Rosa F., Berissi H., Weissenbach J., Maroteaux L., Fellous M., Revel M.
      EMBO J. 2:239-243(1983) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-21.
    12. "Use of synthetic oligonucleotides as hybridization probes: isolation of cloned cDNA sequences for human beta 2-microglobulin."
      Suggs S.V., Wallace R.B., Hirose T., Kawashima E.H., Itakura K.
      Proc. Natl. Acad. Sci. U.S.A. 78:6613-6617(1981) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 10-119.
    13. "The complete amino acid sequence of beta 2-microglobulin."
      Cunningham B.A., Wang J.L., Berggard I., Peterson P.A.
      Biochemistry 12:4811-4822(1973) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 21-119.
    14. "Polymerization of intact beta 2-microglobulin in tissue causes amyloidosis in patients on chronic hemodialysis."
      Gorevic P.D., Munoz P.C., Casey T.T., DiRaimondo C.R., Stone W.J., Prelli F.C., Rodrigues M.M., Poulik M.D., Frangione B.
      Proc. Natl. Acad. Sci. U.S.A. 83:7908-7912(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 21-119, SUBUNIT, INVOLVEMENT IN AMYLOIDOSIS.
    15. "Isolation of a granulocyte inhibitory protein from uraemic patients with homology of beta 2-microglobulin."
      Haag-Weber M., Mai B., Hoerl W.H.
      Nephrol. Dial. Transplant. 9:382-388(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 21-41.
      Tissue: Plasma.
    16. "Biochemical characterization of serum and urinary beta 2 microglobulin in end-stage renal disease patients."
      Argiles A., Derancourt J., Jauregui-Adell J., Mion C., Demaille J.G.
      Nephrol. Dial. Transplant. 7:1106-1110(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 21-40, SUBCELLULAR LOCATION.
    17. "Amino acid sequence of a modified beta 2-microglobulin in renal failure patient urine and long-term dialysis patient blood."
      Momoi T., Suzuki M., Titani K., Hisanaga S., Ogawa H., Saito A.
      Clin. Chim. Acta 236:135-144(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 22-119, SUBCELLULAR LOCATION, PYROGLUTAMATE FORMATION AT GLN-22 (FORM PI 5.3).
      Tissue: Urine.
    18. "Glycation of human beta 2-microglobulin in patients with hemodialysis-associated amyloidosis: identification of the glycated sites."
      Miyata T., Inagi R., Wada Y., Ueda Y., Iida Y., Takahashi M., Taniguchi N., Maeda K.
      Biochemistry 33:12215-12221(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: INVOLVEMENT IN AMYLOIDOSIS, GLYCATION AT ILE-21; LYS-39; LYS-61; LYS-68; LYS-78; LYS-111 AND LYS-114, IDENTIFICATION BY MASS SPECTROMETRY.
    19. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    20. "Structure of the human class I histocompatibility antigen, HLA-A2."
      Bjorkman P.J., Saper M.A., Samraoui B., Bennett W.S., Strominger J.L., Wiley D.C.
      Nature 329:506-512(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.5 ANGSTROMS).
    21. "Refined structure of the human histocompatibility antigen HLA-A2 at 2.6-A resolution."
      Saper M.A., Bjorkman P.J., Wiley D.C.
      J. Mol. Biol. 219:277-319(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS).
    22. "1H NMR assignments and secondary structure of human beta 2-microglobulin in solution."
      Okon M., Bray P., Vucelic D.
      Biochemistry 31:8906-8915(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR.
    23. "The three-dimensional structure of a class I major histocompatibility complex molecule missing the alpha 3 domain of the heavy chain."
      Collins E.J., Garboczi D.N., Karpusas M.N., Wiley D.C.
      Proc. Natl. Acad. Sci. U.S.A. 92:1218-1221(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS).
    24. "Bound water structure and polymorphic amino acids act together to allow the binding of different peptides to MHC class I HLA-B53."
      Smith K.J., Reid S.W., Harlos K., McMichael A.J., Stuart D.I., Bell J.I., Jones E.Y.
      Immunity 4:215-228(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS).
    25. "Crystal structure of monomeric human beta-2-microglobulin reveals clues to its amyloidogenic properties."
      Trinh C.H., Smith D.P., Kalverda A.P., Phillips S.E., Radford S.E.
      Proc. Natl. Acad. Sci. U.S.A. 99:9771-9776(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 21-119, DISULFIDE BOND.
    26. "A structural basis for immunodominant human T cell receptor recognition."
      Stewart-Jones G.B.E., McMichael A.J., Bell J.I., Stuart D.I., Jones E.Y.
      Nat. Immunol. 4:657-663(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.4 ANGSTROMS) OF 21-119 OF HLA-A/B2M HETERODIMER IN COMPLEX WITH TRAC AND TRBC1, DISULFIDE BOND.
    27. "Conformation of amyloid fibrils of beta2-microglobulin probed by tryptophan mutagenesis."
      Kihara M., Chatani E., Iwata K., Yamamoto K., Matsuura T., Nakagawa A., Naiki H., Goto Y.
      J. Biol. Chem. 281:31061-31069(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) OF 21-119, AMYLOID FORMATION, DISULFIDE BOND.
    28. "A native to amyloidogenic transition regulated by a backbone trigger."
      Eakin C.M., Berman A.J., Miranker A.D.
      Nat. Struct. Mol. Biol. 13:202-208(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) OF 21-119, DISULFIDE BOND.
    29. "High-resolution crystal structure of beta2-microglobulin formed at pH 7.0."
      Iwata K., Matsuura T., Sakurai K., Nakagawa A., Goto Y.
      J. Biochem. 142:413-419(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.13 ANGSTROMS) OF 21-119, DISULFIDE BOND.
    30. Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 21-119, MUTAGENESIS OF ASP-79, DISULFIDE BOND.
    31. "The controlling roles of Trp60 and Trp95 in beta2-microglobulin function, folding and amyloid aggregation properties."
      Esposito G., Ricagno S., Corazza A., Rennella E., Guemral D., Mimmi M.C., Betto E., Pucillo C.E., Fogolari F., Viglino P., Raimondi S., Giorgetti S., Bolognesi B., Merlini G., Stoppini M., Bolognesi M., Bellotti V.
      J. Mol. Biol. 378:887-897(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 21-119, MUTAGENESIS OF TRP-80, DISULFIDE BOND.
    32. "Human beta-2 microglobulin W60V mutant structure: Implications for stability and amyloid aggregation."
      Ricagno S., Raimondi S., Giorgetti S., Bellotti V., Bolognesi M.
      Biochem. Biophys. Res. Commun. 380:543-547(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 21-119, MUTAGENESIS OF TRP-80, DISULFIDE BOND.
    33. "Familial hypercatabolic hypoproteinemia caused by deficiency of the neonatal Fc receptor, FcRn, due to a mutant beta2-microglobulin gene."
      Wani M.A., Haynes L.D., Kim J., Bronson C.L., Chaudhury C., Mohanty S., Waldmann T.A., Robinson J.M., Anderson C.L.
      Proc. Natl. Acad. Sci. U.S.A. 103:5084-5089(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT HYCATHYP PRO-11, CHARACTERIZATION OF VARIANT HYCATHYP PRO-11.

    Entry informationi

    Entry nameiB2MG_HUMAN
    AccessioniPrimary (citable) accession number: P61769
    Secondary accession number(s): P01884
    , Q540F8, Q6IAT8, Q9UCK0, Q9UD48, Q9UDF4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: July 21, 1986
    Last modified: October 1, 2014
    This is version 131 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 15
      Human chromosome 15: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3