Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P61760 (SYL_NANEQ) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Leucine--tRNA ligase

EC=6.1.1.4
Alternative name(s):
Leucyl-tRNA synthetase
Short name=LeuRS
Gene names
Name:leuS
Ordered Locus Names:NEQ239
OrganismNanoarchaeum equitans (strain Kin4-M) [Reference proteome] [HAMAP]
Taxonomic identifier228908 [NCBI]
Taxonomic lineageArchaeaNanoarchaeotaNanoarchaeum

Protein attributes

Sequence length977 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processtRNA aminoacylation for protein translation

Inferred from electronic annotation. Source: InterPro

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

aminoacyl-tRNA editing activity

Inferred from electronic annotation. Source: InterPro

leucine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 977977Leucine--tRNA ligase
PRO_0000152136

Regions

Region220 – 31899Insert
Motif11 – 2111"HIGH" region
Motif699 – 7035"KMSKS" region

Sites

Binding site7021ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
P61760 [UniParc].

Last modified June 7, 2004. Version 1.
Checksum: 3B5F2A6AE3236ABF

FASTA977115,023
        10         20         30         40         50         60 
MKKFFVTAAF PYVNGYLHLG HLVTYIKAEI TARYKKMRGY DVLFPMGFHA TGAPIYAAAY 

        70         80         90        100        110        120 
KVSIGDPKQI ETLKKMGIKD IEKFKDPAYW VEYFSKAAKE DLSKLGFMIE WERSFTTVFN 

       130        140        150        160        170        180 
KPFHKFVEWQ YHRLREKGYI YRGAHPIVWD PKVNMVIGDH DRPDDYAGIR PIEGVIIKFY 

       190        200        210        220        230        240 
SKDLDAYLPA FTLRPETVFG VVNIWVNPET EYVLAKVKKV FYVYELYSLY KKFGRLPLNI 

       250        260        270        280        290        300 
ENRDKLEKLI QDYNNLLDRL KQYEKGIDLI AHAEEIAYKP KEEFVKELKE FAEKEGIKIE 

       310        320        330        340        350        360 
EKDIELLYEY YNTKVETQEE KWILPNTIVI EELKNQDFEI EIIGKIDKLI KTLAENPVTK 

       370        380        390        400        410        420 
ELVPVLPAKF VDPEVGTGIV MSVPSHAPYD YVGLLDLIKT ELKEFAEQAL KNVRPVVKVE 

       430        440        450        460        470        480 
GFSEMPAKDI VESMNITSQE ERDKLEKATQ RLYSKEFYHG VLTEHAQQFQ GLPVKEAKMK 

       490        500        510        520        530        540 
IAEYLMENGY GYIYYTLPVR FKSRYGNKVV VKLVKGQWFI KYSDKQWKEL AHKAVENMKF 

       550        560        570        580        590        600 
YPPQVKELIK EKIDWYDDWA FTHQKELGTA LPWDPKWVIE SLSDSTIYTA YYTIAHILQH 

       610        620        630        640        650        660 
PEKYNIDWDK LTIDVFDYVF LGKGDPKEIA KKTGISEEIL KEMRNQFEYW YPVDIRFSAQ 

       670        680        690        700        710        720 
DLIANHLVFY IFHHVAIFPE SKWPRGIAVS GFVTVNGEKM SKSKGNFITI REAIQRYGRD 

       730        740        750        760        770        780 
AVRLAAAYAG NAELVDQNID LEFMEKAKNE IIPRIESYLD MEGYDRDENS LDKWIVNRIR 

       790        800        810        820        830        840 
LYFKKLEEYY ENIRPRDVIN EFFKLENDFN FYRALVLEKP HKRAIEYFKK AVKALWPIIP 

       850        860        870        880        890        900 
HVVREPAWIG KEEPDEPWIR VGQYVDQVIK DLANTLKLVR ISMARNVSHR LADLVKLYYE 

       910        920        930        940        950        960 
GAKLTEEEKE EIREFIEWKP VRIKIIYKNP SEFDILRDII PYIEKVFGGK VVLELASESK 

       970 
EEKAKRAKEF KPAFVIE 

« Hide

References

[1]"The genome of Nanoarchaeum equitans: insights into early archaeal evolution and derived parasitism."
Waters E., Hohn M.J., Ahel I., Graham D.E., Adams M.D., Barnstead M., Beeson K.Y., Bibbs L., Bolanos R., Keller M., Kretz K., Lin X., Mathur E., Ni J., Podar M., Richardson T., Sutton G.G., Simon M. expand/collapse author list , Soell D., Stetter K.O., Short J.M., Noorderwier M.
Proc. Natl. Acad. Sci. U.S.A. 100:12984-12988(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Kin4-M.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE017199 Genomic DNA. Translation: AAR39092.1.
RefSeqNP_963531.1. NC_005213.1.

3D structure databases

ProteinModelPortalP61760.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING228908.NEQ239.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAR39092; AAR39092; NEQ239.
GeneID2654518.
KEGGneq:NEQ239.

Phylogenomic databases

eggNOGCOG0495.
HOGENOMHOG000216620.
KOK01869.
OMAHAPFDYL.
ProtClustDBPRK12300.

Enzyme and pathway databases

BioCycNEQU228908:GJB6-254-MONOMER.

Family and domain databases

Gene3D1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 2 hits.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PfamPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
[Graphical view]
SUPFAMSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 3 hits.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYL_NANEQ
AccessionPrimary (citable) accession number: P61760
Entry history
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: June 7, 2004
Last modified: April 16, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries