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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Nanoarchaeum equitans (strain Kin4-M)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei702ATPBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:NEQ239
OrganismiNanoarchaeum equitans (strain Kin4-M)
Taxonomic identifieri228908 [NCBI]
Taxonomic lineageiArchaeaNanoarchaeotaNanoarchaealesNanoarchaeaceaeNanoarchaeum
Proteomesi
  • UP000000578 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001521361 – 977Leucine--tRNA ligaseAdd BLAST977

Interactioni

Protein-protein interaction databases

STRINGi228908.NEQ239

Structurei

3D structure databases

ProteinModelPortaliP61760
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni220 – 318InsertAdd BLAST99

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi11 – 21"HIGH" regionAdd BLAST11
Motifi699 – 703"KMSKS" region5

Sequence similaritiesi

Phylogenomic databases

eggNOGiarCOG00809 Archaea
COG0495 LUCA
HOGENOMiHOG000216620
KOiK01869
OMAiHVTGTPI

Family and domain databases

Gene3Di3.40.50.620, 2 hits
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002300 aa-tRNA-synth_Ia
IPR004493 Leu-tRNA-synth_Ia_arc/euk
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR11946:SF51 PTHR11946:SF51, 1 hit
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF00133 tRNA-synt_1, 2 hits
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 3 hits
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

P61760-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKFFVTAAF PYVNGYLHLG HLVTYIKAEI TARYKKMRGY DVLFPMGFHA
60 70 80 90 100
TGAPIYAAAY KVSIGDPKQI ETLKKMGIKD IEKFKDPAYW VEYFSKAAKE
110 120 130 140 150
DLSKLGFMIE WERSFTTVFN KPFHKFVEWQ YHRLREKGYI YRGAHPIVWD
160 170 180 190 200
PKVNMVIGDH DRPDDYAGIR PIEGVIIKFY SKDLDAYLPA FTLRPETVFG
210 220 230 240 250
VVNIWVNPET EYVLAKVKKV FYVYELYSLY KKFGRLPLNI ENRDKLEKLI
260 270 280 290 300
QDYNNLLDRL KQYEKGIDLI AHAEEIAYKP KEEFVKELKE FAEKEGIKIE
310 320 330 340 350
EKDIELLYEY YNTKVETQEE KWILPNTIVI EELKNQDFEI EIIGKIDKLI
360 370 380 390 400
KTLAENPVTK ELVPVLPAKF VDPEVGTGIV MSVPSHAPYD YVGLLDLIKT
410 420 430 440 450
ELKEFAEQAL KNVRPVVKVE GFSEMPAKDI VESMNITSQE ERDKLEKATQ
460 470 480 490 500
RLYSKEFYHG VLTEHAQQFQ GLPVKEAKMK IAEYLMENGY GYIYYTLPVR
510 520 530 540 550
FKSRYGNKVV VKLVKGQWFI KYSDKQWKEL AHKAVENMKF YPPQVKELIK
560 570 580 590 600
EKIDWYDDWA FTHQKELGTA LPWDPKWVIE SLSDSTIYTA YYTIAHILQH
610 620 630 640 650
PEKYNIDWDK LTIDVFDYVF LGKGDPKEIA KKTGISEEIL KEMRNQFEYW
660 670 680 690 700
YPVDIRFSAQ DLIANHLVFY IFHHVAIFPE SKWPRGIAVS GFVTVNGEKM
710 720 730 740 750
SKSKGNFITI REAIQRYGRD AVRLAAAYAG NAELVDQNID LEFMEKAKNE
760 770 780 790 800
IIPRIESYLD MEGYDRDENS LDKWIVNRIR LYFKKLEEYY ENIRPRDVIN
810 820 830 840 850
EFFKLENDFN FYRALVLEKP HKRAIEYFKK AVKALWPIIP HVVREPAWIG
860 870 880 890 900
KEEPDEPWIR VGQYVDQVIK DLANTLKLVR ISMARNVSHR LADLVKLYYE
910 920 930 940 950
GAKLTEEEKE EIREFIEWKP VRIKIIYKNP SEFDILRDII PYIEKVFGGK
960 970
VVLELASESK EEKAKRAKEF KPAFVIE
Length:977
Mass (Da):115,023
Last modified:June 7, 2004 - v1
Checksum:i3B5F2A6AE3236ABF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017199 Genomic DNA Translation: AAR39092.1

Genome annotation databases

EnsemblBacteriaiAAR39092; AAR39092; NEQ239
KEGGineq:NEQ239
PATRICifig|228908.8.peg.244

Entry informationi

Entry nameiSYL_NANEQ
AccessioniPrimary (citable) accession number: P61760
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: June 7, 2004
Last modified: March 28, 2018
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health