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P61760

- SYL_NANEQ

UniProt

P61760 - SYL_NANEQ

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Nanoarchaeum equitans (strain Kin4-M)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 1 (07 Jun 2004)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei702 – 7021ATPBy similarity

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-KW
    3. leucine-tRNA ligase activity Source: UniProtKB-EC

    GO - Biological processi

    1. tRNA aminoacylation for protein translation Source: InterPro

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciNEQU228908:GJB6-254-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligase (EC:6.1.1.4)
    Alternative name(s):
    Leucyl-tRNA synthetase
    Short name:
    LeuRS
    Gene namesi
    Name:leuS
    Ordered Locus Names:NEQ239
    OrganismiNanoarchaeum equitans (strain Kin4-M)
    Taxonomic identifieri228908 [NCBI]
    Taxonomic lineageiArchaeaNanoarchaeotaNanoarchaeum
    ProteomesiUP000000578: Chromosome

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 977977Leucine--tRNA ligasePRO_0000152136Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi228908.NEQ239.

    Structurei

    3D structure databases

    ProteinModelPortaliP61760.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni220 – 31899InsertAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi11 – 2111"HIGH" regionAdd
    BLAST
    Motifi699 – 7035"KMSKS" region

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000216620.
    KOiK01869.
    OMAiIDKWLLH.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 2 hits.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    [Graphical view]
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 3 hits.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P61760-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKKFFVTAAF PYVNGYLHLG HLVTYIKAEI TARYKKMRGY DVLFPMGFHA    50
    TGAPIYAAAY KVSIGDPKQI ETLKKMGIKD IEKFKDPAYW VEYFSKAAKE 100
    DLSKLGFMIE WERSFTTVFN KPFHKFVEWQ YHRLREKGYI YRGAHPIVWD 150
    PKVNMVIGDH DRPDDYAGIR PIEGVIIKFY SKDLDAYLPA FTLRPETVFG 200
    VVNIWVNPET EYVLAKVKKV FYVYELYSLY KKFGRLPLNI ENRDKLEKLI 250
    QDYNNLLDRL KQYEKGIDLI AHAEEIAYKP KEEFVKELKE FAEKEGIKIE 300
    EKDIELLYEY YNTKVETQEE KWILPNTIVI EELKNQDFEI EIIGKIDKLI 350
    KTLAENPVTK ELVPVLPAKF VDPEVGTGIV MSVPSHAPYD YVGLLDLIKT 400
    ELKEFAEQAL KNVRPVVKVE GFSEMPAKDI VESMNITSQE ERDKLEKATQ 450
    RLYSKEFYHG VLTEHAQQFQ GLPVKEAKMK IAEYLMENGY GYIYYTLPVR 500
    FKSRYGNKVV VKLVKGQWFI KYSDKQWKEL AHKAVENMKF YPPQVKELIK 550
    EKIDWYDDWA FTHQKELGTA LPWDPKWVIE SLSDSTIYTA YYTIAHILQH 600
    PEKYNIDWDK LTIDVFDYVF LGKGDPKEIA KKTGISEEIL KEMRNQFEYW 650
    YPVDIRFSAQ DLIANHLVFY IFHHVAIFPE SKWPRGIAVS GFVTVNGEKM 700
    SKSKGNFITI REAIQRYGRD AVRLAAAYAG NAELVDQNID LEFMEKAKNE 750
    IIPRIESYLD MEGYDRDENS LDKWIVNRIR LYFKKLEEYY ENIRPRDVIN 800
    EFFKLENDFN FYRALVLEKP HKRAIEYFKK AVKALWPIIP HVVREPAWIG 850
    KEEPDEPWIR VGQYVDQVIK DLANTLKLVR ISMARNVSHR LADLVKLYYE 900
    GAKLTEEEKE EIREFIEWKP VRIKIIYKNP SEFDILRDII PYIEKVFGGK 950
    VVLELASESK EEKAKRAKEF KPAFVIE 977
    Length:977
    Mass (Da):115,023
    Last modified:June 7, 2004 - v1
    Checksum:i3B5F2A6AE3236ABF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017199 Genomic DNA. Translation: AAR39092.1.
    RefSeqiNP_963531.1. NC_005213.1.
    WP_011153233.1. NC_005213.1.

    Genome annotation databases

    EnsemblBacteriaiAAR39092; AAR39092; NEQ239.
    GeneIDi2654518.
    KEGGineq:NEQ239.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017199 Genomic DNA. Translation: AAR39092.1 .
    RefSeqi NP_963531.1. NC_005213.1.
    WP_011153233.1. NC_005213.1.

    3D structure databases

    ProteinModelPortali P61760.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 228908.NEQ239.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAR39092 ; AAR39092 ; NEQ239 .
    GeneIDi 2654518.
    KEGGi neq:NEQ239.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000216620.
    KOi K01869.
    OMAi IDKWLLH.

    Enzyme and pathway databases

    BioCyci NEQU228908:GJB6-254-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 2 hits.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    [Graphical view ]
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 3 hits.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Kin4-M.

    Entry informationi

    Entry nameiSYL_NANEQ
    AccessioniPrimary (citable) accession number: P61760
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 7, 2004
    Last sequence update: June 7, 2004
    Last modified: October 1, 2014
    This is version 67 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3