Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Nanoarchaeum equitans (strain Kin4-M)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei702 – 7021ATPBy similarity

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-KW
  3. leucine-tRNA ligase activity Source: UniProtKB-EC

GO - Biological processi

  1. tRNA aminoacylation for protein translation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciNEQU228908:GJB6-254-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:NEQ239
OrganismiNanoarchaeum equitans (strain Kin4-M)
Taxonomic identifieri228908 [NCBI]
Taxonomic lineageiArchaeaNanoarchaeotaNanoarchaeum
ProteomesiUP000000578: Chromosome

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 977977Leucine--tRNA ligasePRO_0000152136Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi228908.NEQ239.

Structurei

3D structure databases

ProteinModelPortaliP61760.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni220 – 31899InsertAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi11 – 2111"HIGH" regionAdd
BLAST
Motifi699 – 7035"KMSKS" region

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000216620.
KOiK01869.
OMAiNCFVEHE.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 2 hits.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR013155. M/V/L/I-tRNA-synth_anticd-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
[Graphical view]
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 3 hits.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P61760-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKFFVTAAF PYVNGYLHLG HLVTYIKAEI TARYKKMRGY DVLFPMGFHA
60 70 80 90 100
TGAPIYAAAY KVSIGDPKQI ETLKKMGIKD IEKFKDPAYW VEYFSKAAKE
110 120 130 140 150
DLSKLGFMIE WERSFTTVFN KPFHKFVEWQ YHRLREKGYI YRGAHPIVWD
160 170 180 190 200
PKVNMVIGDH DRPDDYAGIR PIEGVIIKFY SKDLDAYLPA FTLRPETVFG
210 220 230 240 250
VVNIWVNPET EYVLAKVKKV FYVYELYSLY KKFGRLPLNI ENRDKLEKLI
260 270 280 290 300
QDYNNLLDRL KQYEKGIDLI AHAEEIAYKP KEEFVKELKE FAEKEGIKIE
310 320 330 340 350
EKDIELLYEY YNTKVETQEE KWILPNTIVI EELKNQDFEI EIIGKIDKLI
360 370 380 390 400
KTLAENPVTK ELVPVLPAKF VDPEVGTGIV MSVPSHAPYD YVGLLDLIKT
410 420 430 440 450
ELKEFAEQAL KNVRPVVKVE GFSEMPAKDI VESMNITSQE ERDKLEKATQ
460 470 480 490 500
RLYSKEFYHG VLTEHAQQFQ GLPVKEAKMK IAEYLMENGY GYIYYTLPVR
510 520 530 540 550
FKSRYGNKVV VKLVKGQWFI KYSDKQWKEL AHKAVENMKF YPPQVKELIK
560 570 580 590 600
EKIDWYDDWA FTHQKELGTA LPWDPKWVIE SLSDSTIYTA YYTIAHILQH
610 620 630 640 650
PEKYNIDWDK LTIDVFDYVF LGKGDPKEIA KKTGISEEIL KEMRNQFEYW
660 670 680 690 700
YPVDIRFSAQ DLIANHLVFY IFHHVAIFPE SKWPRGIAVS GFVTVNGEKM
710 720 730 740 750
SKSKGNFITI REAIQRYGRD AVRLAAAYAG NAELVDQNID LEFMEKAKNE
760 770 780 790 800
IIPRIESYLD MEGYDRDENS LDKWIVNRIR LYFKKLEEYY ENIRPRDVIN
810 820 830 840 850
EFFKLENDFN FYRALVLEKP HKRAIEYFKK AVKALWPIIP HVVREPAWIG
860 870 880 890 900
KEEPDEPWIR VGQYVDQVIK DLANTLKLVR ISMARNVSHR LADLVKLYYE
910 920 930 940 950
GAKLTEEEKE EIREFIEWKP VRIKIIYKNP SEFDILRDII PYIEKVFGGK
960 970
VVLELASESK EEKAKRAKEF KPAFVIE
Length:977
Mass (Da):115,023
Last modified:June 7, 2004 - v1
Checksum:i3B5F2A6AE3236ABF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017199 Genomic DNA. Translation: AAR39092.1.
RefSeqiNP_963531.1. NC_005213.1.
WP_011153233.1. NC_005213.1.

Genome annotation databases

EnsemblBacteriaiAAR39092; AAR39092; NEQ239.
GeneIDi2654518.
KEGGineq:NEQ239.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017199 Genomic DNA. Translation: AAR39092.1.
RefSeqiNP_963531.1. NC_005213.1.
WP_011153233.1. NC_005213.1.

3D structure databases

ProteinModelPortaliP61760.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi228908.NEQ239.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAR39092; AAR39092; NEQ239.
GeneIDi2654518.
KEGGineq:NEQ239.

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000216620.
KOiK01869.
OMAiNCFVEHE.

Enzyme and pathway databases

BioCyciNEQU228908:GJB6-254-MONOMER.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 2 hits.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR013155. M/V/L/I-tRNA-synth_anticd-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
[Graphical view]
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 3 hits.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Kin4-M.

Entry informationi

Entry nameiSYL_NANEQ
AccessioniPrimary (citable) accession number: P61760
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: June 7, 2004
Last modified: March 4, 2015
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.