Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Prefoldin subunit 3

Gene

Vbp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone

Names & Taxonomyi

Protein namesi
Recommended name:
Prefoldin subunit 3
Alternative name(s):
von Hippel-Lindau-binding protein 1
Short name:
VBP-1
Short name:
VHL-binding protein 1
Gene namesi
Name:Vbp1
Synonyms:Pfdn3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:1333804. Vbp1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001536532 – 196Prefoldin subunit 3Add BLAST195

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei58N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP61759.
MaxQBiP61759.
PaxDbiP61759.
PRIDEiP61759.

2D gel databases

REPRODUCTION-2DPAGEiIPI00121851.
P61759.

PTM databases

iPTMnetiP61759.
PhosphoSitePlusiP61759.

Expressioni

Gene expression databases

BgeeiENSMUSG00000031197.
CleanExiMM_VBP1.
ExpressionAtlasiP61759. baseline and differential.
GenevisibleiP61759. MM.

Interactioni

Subunit structurei

Heterohexamer of two PFD-alpha type and four PFD-beta type subunits. Binds to the C-terminal part of VHL.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi204503. 10 interactors.
IntActiP61759. 11 interactors.
MINTiMINT-1852392.
STRINGi10090.ENSMUSP00000033540.

Structurei

3D structure databases

ProteinModelPortaliP61759.
SMRiP61759.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the prefoldin subunit alpha family.Curated

Phylogenomic databases

eggNOGiKOG3313. Eukaryota.
ENOG410XRZ8. LUCA.
GeneTreeiENSGT00390000018904.
HOGENOMiHOG000184744.
HOVERGENiHBG053576.
InParanoidiP61759.
OMAiTMEVNTA.
OrthoDBiEOG091G0P5N.
PhylomeDBiP61759.
TreeFamiTF313706.

Family and domain databases

InterProiView protein in InterPro
IPR016655. PFD3.
IPR004127. Prefoldin_subunit_alpha.
PANTHERiPTHR12409. PTHR12409. 1 hit.
PfamiView protein in Pfam
PF02996. Prefoldin. 1 hit.
PIRSFiPIRSF016396. Prefoldin_subunit_3. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P61759-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAKDGCGL ETAAGNGRRL HLGIPEAVFV EDVDSFMKQP GNETADTVLK
60 70 80 90 100
KLDEQYQKYK FMELNLAQKK RRLKGQIPEI KQTLEILKYM QKKKESTNSM
110 120 130 140 150
ETRFLLADNL YCKASVPPTD KVCLWLGANV MLEYDIDEAQ ALLEKNLSTA
160 170 180 190
TKNLDSLEED LDFLRDQFTT TEVNMARVYN WDVKRRNKDD STKNKA
Length:196
Mass (Da):22,436
Last modified:August 30, 2005 - v2
Checksum:iE5B9179296418DDE
GO

Sequence cautioni

The sequence AAC23908 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002282 mRNA. Translation: BAB21986.1.
AK008847 mRNA. Translation: BAB25926.1.
AK077923 mRNA. Translation: BAC37066.1.
AK151527 mRNA. Translation: BAE30475.1.
AK153069 mRNA. Translation: BAE31695.1.
AK159284 mRNA. Translation: BAE34961.1.
AK167064 mRNA. Translation: BAE39225.1.
AK169185 mRNA. Translation: BAE40962.1.
U96760 mRNA. Translation: AAC23908.1. Different initiation.
CCDSiCCDS41032.1.
RefSeqiNP_035822.2. NM_011692.2.
UniGeneiMm.8294.

Genome annotation databases

EnsembliENSMUST00000033540; ENSMUSP00000033540; ENSMUSG00000031197.
GeneIDi22327.
KEGGimmu:22327.
UCSCiuc009tqd.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiPFD3_MOUSE
AccessioniPrimary (citable) accession number: P61759
Secondary accession number(s): O55228
, Q15765, Q3U6M9, Q9CPZ0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: August 30, 2005
Last modified: September 27, 2017
This is version 113 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families