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Protein

Prefoldin subunit 3

Gene

Vbp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Names & Taxonomyi

Protein namesi
Recommended name:
Prefoldin subunit 3
Alternative name(s):
Von Hippel-Lindau-binding protein 1
Short name:
VBP-1
Short name:
VHL-binding protein 1
Gene namesi
Name:Vbp1
Synonyms:Pfdn3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:1333804. Vbp1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: MGI
  • intracellular membrane-bounded organelle Source: MGI
  • nucleus Source: MGI
  • prefoldin complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 196195Prefoldin subunit 3PRO_0000153653Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei58 – 581N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP61759.
MaxQBiP61759.
PaxDbiP61759.
PRIDEiP61759.

2D gel databases

REPRODUCTION-2DPAGEIPI00121851.
P61759.

PTM databases

iPTMnetiP61759.
PhosphoSiteiP61759.

Expressioni

Gene expression databases

BgeeiP61759.
CleanExiMM_VBP1.
ExpressionAtlasiP61759. baseline and differential.
GenevisibleiP61759. MM.

Interactioni

Subunit structurei

Heterohexamer of two PFD-alpha type and four PFD-beta type subunits. Binds to the C-terminal part of VHL.

Protein-protein interaction databases

BioGridi204503. 10 interactions.
IntActiP61759. 11 interactions.
MINTiMINT-1852392.
STRINGi10090.ENSMUSP00000033540.

Structurei

3D structure databases

ProteinModelPortaliP61759.
SMRiP61759. Positions 46-177.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the prefoldin subunit alpha family.Curated

Phylogenomic databases

eggNOGiKOG3313. Eukaryota.
ENOG410XRZ8. LUCA.
GeneTreeiENSGT00390000018904.
HOGENOMiHOG000184744.
HOVERGENiHBG053576.
InParanoidiP61759.
OMAiDEQHSKY.
PhylomeDBiP61759.
TreeFamiTF313706.

Family and domain databases

Gene3Di1.10.287.370. 1 hit.
InterProiIPR016655. PFD3.
IPR009053. Prefoldin.
IPR004127. Prefoldin_subunit_alpha.
[Graphical view]
PANTHERiPTHR12409. PTHR12409. 1 hit.
PfamiPF02996. Prefoldin. 1 hit.
[Graphical view]
PIRSFiPIRSF016396. Prefoldin_subunit_3. 1 hit.
SUPFAMiSSF46579. SSF46579. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P61759-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAKDGCGL ETAAGNGRRL HLGIPEAVFV EDVDSFMKQP GNETADTVLK
60 70 80 90 100
KLDEQYQKYK FMELNLAQKK RRLKGQIPEI KQTLEILKYM QKKKESTNSM
110 120 130 140 150
ETRFLLADNL YCKASVPPTD KVCLWLGANV MLEYDIDEAQ ALLEKNLSTA
160 170 180 190
TKNLDSLEED LDFLRDQFTT TEVNMARVYN WDVKRRNKDD STKNKA
Length:196
Mass (Da):22,436
Last modified:August 30, 2005 - v2
Checksum:iE5B9179296418DDE
GO

Sequence cautioni

The sequence AAC23908.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002282 mRNA. Translation: BAB21986.1.
AK008847 mRNA. Translation: BAB25926.1.
AK077923 mRNA. Translation: BAC37066.1.
AK151527 mRNA. Translation: BAE30475.1.
AK153069 mRNA. Translation: BAE31695.1.
AK159284 mRNA. Translation: BAE34961.1.
AK167064 mRNA. Translation: BAE39225.1.
AK169185 mRNA. Translation: BAE40962.1.
U96760 mRNA. Translation: AAC23908.1. Different initiation.
CCDSiCCDS41032.1.
RefSeqiNP_035822.2. NM_011692.2.
UniGeneiMm.8294.

Genome annotation databases

EnsembliENSMUST00000033540; ENSMUSP00000033540; ENSMUSG00000031197.
GeneIDi22327.
KEGGimmu:22327.
UCSCiuc009tqd.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002282 mRNA. Translation: BAB21986.1.
AK008847 mRNA. Translation: BAB25926.1.
AK077923 mRNA. Translation: BAC37066.1.
AK151527 mRNA. Translation: BAE30475.1.
AK153069 mRNA. Translation: BAE31695.1.
AK159284 mRNA. Translation: BAE34961.1.
AK167064 mRNA. Translation: BAE39225.1.
AK169185 mRNA. Translation: BAE40962.1.
U96760 mRNA. Translation: AAC23908.1. Different initiation.
CCDSiCCDS41032.1.
RefSeqiNP_035822.2. NM_011692.2.
UniGeneiMm.8294.

3D structure databases

ProteinModelPortaliP61759.
SMRiP61759. Positions 46-177.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204503. 10 interactions.
IntActiP61759. 11 interactions.
MINTiMINT-1852392.
STRINGi10090.ENSMUSP00000033540.

PTM databases

iPTMnetiP61759.
PhosphoSiteiP61759.

2D gel databases

REPRODUCTION-2DPAGEIPI00121851.
P61759.

Proteomic databases

EPDiP61759.
MaxQBiP61759.
PaxDbiP61759.
PRIDEiP61759.

Protocols and materials databases

DNASUi22327.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000033540; ENSMUSP00000033540; ENSMUSG00000031197.
GeneIDi22327.
KEGGimmu:22327.
UCSCiuc009tqd.1. mouse.

Organism-specific databases

CTDi7411.
MGIiMGI:1333804. Vbp1.

Phylogenomic databases

eggNOGiKOG3313. Eukaryota.
ENOG410XRZ8. LUCA.
GeneTreeiENSGT00390000018904.
HOGENOMiHOG000184744.
HOVERGENiHBG053576.
InParanoidiP61759.
OMAiDEQHSKY.
PhylomeDBiP61759.
TreeFamiTF313706.

Miscellaneous databases

ChiTaRSiVbp1. mouse.
NextBioi302561.
PROiP61759.
SOURCEiSearch...

Gene expression databases

BgeeiP61759.
CleanExiMM_VBP1.
ExpressionAtlasiP61759. baseline and differential.
GenevisibleiP61759. MM.

Family and domain databases

Gene3Di1.10.287.370. 1 hit.
InterProiIPR016655. PFD3.
IPR009053. Prefoldin.
IPR004127. Prefoldin_subunit_alpha.
[Graphical view]
PANTHERiPTHR12409. PTHR12409. 1 hit.
PfamiPF02996. Prefoldin. 1 hit.
[Graphical view]
PIRSFiPIRSF016396. Prefoldin_subunit_3. 1 hit.
SUPFAMiSSF46579. SSF46579. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Bone marrow, Kidney, Stomach and Testis.
  2. "Characterization of the gene (VBP1) and transcript for the von Hippel-Lindau binding protein and isolation of the highly conserved murine homologue."
    Brinke A., Green P.M., Giannelli F.
    Genomics 45:105-112(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 6-196.
    Strain: BALB/cJ.
    Tissue: Brain.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas, Spleen and Testis.

Entry informationi

Entry nameiPFD3_MOUSE
AccessioniPrimary (citable) accession number: P61759
Secondary accession number(s): O55228
, Q15765, Q3U6M9, Q9CPZ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: August 30, 2005
Last modified: May 11, 2016
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.