P61758 (PFD3_HUMAN) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 72.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Prefoldin subunit 3 Alternative name(s): HIBBJ46 Von Hippel-Lindau-binding protein 1 Short name=VBP-1 Short name=VHL-binding protein 1 | ||||
| Gene names |
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| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 197 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Function | Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. Ref.2 |
| Subunit structure | Heterohexamer of two PFD-alpha type and four PFD-beta type subunits. Binds to the C-terminal part of VHL. |
| Subcellular location | Cytoplasm. Nucleus. Note: In complex with VHL can translocate to the nucleus. |
| Tissue specificity | Ubiquitous. |
| Sequence similarities | Belongs to the prefoldin subunit alpha family. |
| Sequence caution | The sequence AAC23907.1 differs from that shown. Reason: Erroneous initiation. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Cytoplasm Nucleus |
| Coding sequence diversity | Polymorphism |
| Molecular function | Chaperone |
| PTM | Acetylation |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological process | 'de novo' posttranslational protein folding Traceable author statement. Source: Reactome |
| Cellular component | nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell prefoldin complexInferred from electronic annotation. Source: InterPro |
| Molecular function | unfolded protein binding Inferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 197 | 197 | Prefoldin subunit 3 | PRO_0000153652 | |||||
Amino acid modifications | |||||||||
| Modified residue | 59 | 1 | N6-acetyllysine Ref.8 | ||||||
Natural variations | |||||||||
| Natural variant | 123 | 1 | M → V. Ref.1 Ref.2 Ref.3 Ref.4 Ref.6 Ref.7 Corresponds to variant rs572013 [ dbSNP | Ensembl ]. | VAR_023371 | |||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Characterization of the gene (VBP1) and transcript for the von Hippel-Lindau binding protein and isolation of the highly conserved murine homologue." Brinke A., Green P.M., Giannelli F. Genomics 45:105-112(1997) [PubMed: 9339366] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT VAL-123. Tissue: Brain. |
| [2] | "Prefoldin, a chaperone that delivers unfolded proteins to cytosolic chaperonin." Vainberg I.E., Lewis S.A., Rommelaere H., Ampe C., Vandekerckhove J., Klein H.L., Cowan N.J. Cell 93:863-873(1998) [PubMed: 9630229] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT VAL-123, FUNCTION. |
| [3] | "Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. Sugano S.Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-123. Tissue: Cerebellum. |
| [4] | "Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-123. |
| [5] | "The DNA sequence of the human X chromosome." Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C. Bentley D.R.Nature 434:325-337(2005) [PubMed: 15772651] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [6] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-123. Tissue: Lung. |
| [7] | "Identification of a novel protein (VBP-1) binding to the von Hippel-Lindau (VHL) tumor suppressor gene product." Tsuchiya H., Iseda T., Hino O. Cancer Res. 56:2881-2885(1996) [PubMed: 8674032] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 32-197, VARIANT VAL-123. |
| [8] | "Lysine acetylation targets protein complexes and co-regulates major cellular functions." Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T., Olsen J.V., Mann M. Science 325:834-840(2009) [PubMed: 19608861] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-59, MASS SPECTROMETRY. |
| [9] | "Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed: 21269460] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | U96759 mRNA. Translation: AAC23907.1. Different initiation. Y17394 mRNA. Translation: CAA76761.1. AK313420 mRNA. Translation: BAG36212.1. BT019604 mRNA. Translation: AAV38411.1. AL356738 Genomic DNA. Translation: CAI41469.1. BC046094 mRNA. Translation: AAH46094.1. U56833 mRNA. Translation: AAC50617.1. |
| IPI | IPI00334159. |
| RefSeq | NP_003363.1. NM_003372.5. |
| UniGene | Hs.436803. |
3D structure databases | |
| ProteinModelPortal | P61758. |
| SMR | P61758. Positions 47-178. |
| ModBase | Search... |
Protein-protein interaction databases | |
| DIP | DIP-46479N. |
| IntAct | P61758. 5 interactions. |
| MINT | MINT-1148501. |
| STRING | P61758. |
PTM databases | |
| PhosphoSite | P61758. |
Polymorphism databases | |
| DMDM | 125987848. |
2D gel databases | |
| OGP | P61758. |
Proteomic databases | |
| PRIDE | P61758. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| Ensembl | ENST00000286428; ENSP00000286428; ENSG00000155959. |
| GeneID | 7411. |
| KEGG | hsa:7411. |
| NMPDR | fig|9606.3.peg.33684. |
| UCSC | uc004fnc.1. human. |
Organism-specific databases | |
| CTD | 7411. |
| GeneCards | GC0XP154444. |
| HGNC | HGNC:12662. VBP1. |
| HPA | CAB006260. HPA023230. |
| MIM | 300133. gene. |
| neXtProt | NX_P61758. |
| PharmGKB | PA37285. |
| GenAtlas | Search... |
Phylogenomic databases | |
| eggNOG | prNOG04614. |
| HOGENOM | HBG631514. |
| HOVERGEN | HBG053576. |
| InParanoid | P61758. |
| OMA | QITTTEV. |
| OrthoDB | EOG4DBTFP. |
| PhylomeDB | P61758. |
Enzyme and pathway databases | |
| Reactome | REACT_17015. Metabolism of proteins. |
Gene expression databases | |
| ArrayExpress | P61758. |
| Bgee | P61758. |
| CleanEx | HS_VBP1. |
| Genevestigator | P61758. |
| GermOnline | ENSG00000155959. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR009053. Prefoldin. IPR016655. Prefoldin_su-3. IPR004127. Prefoldin_subunit. [Graphical view] |
| PANTHER | PTHR12409. PTHR12409. 1 hit. |
| Pfam | PF02996. Prefoldin. 1 hit. [Graphical view] |
| PIRSF | PIRSF016396. Prefoldin_subunit_3. 1 hit. |
| SUPFAM | SSF46579. Prefoldin. 1 hit. |
| ProtoNet | Search... |
Other | |
| NextBio | 29016. |
| SOURCE | Search... |
Entry information
| Entry name | PFD3_HUMAN | ||||||||
| Accession | Primary (citable) accession number: P61758 Secondary accession number(s): B2R8L5 Q86X96 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome X Human chromosome X: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with