Reviewed,
UniProtKB/Swiss-Prot P61758 (PFD3_HUMAN)
Last modified
June 16, 2009.
Version 49.
History...
Clusters with 100%,
90%,
50% identity |
Documents (5) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Prefoldin subunit 3 Alternative name(s): Von Hippel-Lindau-binding protein 1 Short name=VHL-binding protein 1 Short name=VBP-1 HIBBJ46 | ||||
| Gene names |
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| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 197 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. Ref.2 |
| Subunit structure | Heterohexamer of two PFD-alpha type and four PFD-beta type subunits. Binds to the C-terminal part of VHL. |
| Subcellular location | Cytoplasm. Nucleus. Note: In complex with VHL can translocate to the nucleus. |
| Tissue specificity | Ubiquitous. |
| Sequence similarities | Belongs to the prefoldin subunit alpha family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Cytoplasm Nucleus |
| Coding sequence diversity | Polymorphism |
| Molecular function | Chaperone |
| Gene Ontology (GO) | |
| Biological process | protein folding Inferred from electronic annotation. Source: InterPro |
| Cellular component | nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell prefoldin complexInferred from electronic annotation. Source: InterPro |
| Molecular function | unfolded protein binding Inferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Characterization of the gene (VBP1) and transcript for the von Hippel-Lindau binding protein and isolation of the highly conserved murine homologue." Brinke A., Green P.M., Giannelli F. Genomics 45:105-112(1997) [PubMed: 9339366] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT VAL-123. Tissue: Brain. |
| [2] | "Prefoldin, a chaperone that delivers unfolded proteins to cytosolic chaperonin." Vainberg I.E., Lewis S.A., Rommelaere H., Ampe C., Vandekerckhove J., Klein H.L., Cowan N.J. Cell 93:863-873(1998) [PubMed: 9630229] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT VAL-123, FUNCTION. |
| [3] | "Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. Sugano S.Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-123. Tissue: Cerebellum. |
| [4] | "Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-123. |
| [5] | "The DNA sequence of the human X chromosome." Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C. Bentley D.R.Nature 434:325-337(2005) [PubMed: 15772651] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [6] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-123. Tissue: Lung. |
| [7] | "Identification of a novel protein (VBP-1) binding to the von Hippel-Lindau (VHL) tumor suppressor gene product." Tsuchiya H., Iseda T., Hino O. Cancer Res. 56:2881-2885(1996) [PubMed: 8674032] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 32-197, VARIANT VAL-123. |
| [8] | Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| U96759 mRNA. Translation: AAC23907.1. Different initiation. Y17394 mRNA. Translation: CAA76761.1. AK313420 mRNA. Translation: BAG36212.1. BT019604 mRNA. Translation: AAV38411.1. AL356738 Genomic DNA. Translation: CAI41469.1. BC046094 mRNA. Translation: AAH46094.1. U56833 mRNA. Translation: AAC50617.1. | |
| IPI | IPI00334159. |
| RefSeq | NP_003363.1. |
| UniGene | Hs.436803 |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | P61758. 2 interactions. |
2-D gel databases | |
| OGP | P61758. |
Proteomic databases | |
| PRIDE | P61758. |
Genome annotation databases | |
| Ensembl | ENSG00000155959. Homo sapiens. [Contig view] |
| GeneID | 7411. |
| KEGG | hsa:7411. |
| NMPDR | fig|9606.3.peg.33684. |
Organism-specific databases | |
| GeneCards | GC0XP154097. |
| H-InvDB | HIX0028363. |
| HGNC | HGNC:12662. VBP1. |
| HPA | CAB006260. |
| MIM | 300133. gene. |
| PharmGKB | PA37285. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOGENOM | P61758. |
| HOVERGEN | P61758. |
| OMA | P61758. QITTTEV. |
Gene expression databases | |
| ArrayExpress | P61758. |
| Bgee | P61758. |
| CleanEx | HS_VBP1. |
| GermOnline | ENSG00000155959. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR004127. PFD_alpha-like. IPR016655. Prefoldin_su-3. [Graphical view] |
| Pfam | PF02996. Prefoldin. 1 hit. [Graphical view] |
| PIRSF | PIRSF016396. Prefoldin_subunit_3. 1 hit. |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 29016. |
| SOURCE | Search... |
Entry information
| Entry name | PFD3_HUMAN | ||||||||
| Accession | Primary (citable) accession number: P61758 Secondary accession number(s): B2R8L5 Q86X96 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome X Human chromosome X: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


