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P61750

- ARF4_MOUSE

UniProt

P61750 - ARF4_MOUSE

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Protein

ADP-ribosylation factor 4

Gene
Arf4
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi24 – 318GTP By similarity
Nucleotide bindingi67 – 715GTP By similarity
Nucleotide bindingi126 – 1294GTP By similarity

GO - Molecular functioni

  1. GTP binding Source: MGI
  2. protein binding Source: IntAct

GO - Biological processi

  1. brain development Source: Ensembl
  2. epidermal growth factor receptor signaling pathway Source: Ensembl
  3. protein transport Source: MGI
  4. response to axon injury Source: Ensembl
  5. small GTPase mediated signal transduction Source: InterPro
  6. vesicle-mediated transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

ER-Golgi transport, Protein transport, Transport

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ADP-ribosylation factor 4
Gene namesi
Name:Arf4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 14

Organism-specific databases

MGIiMGI:99433. Arf4.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. Golgi apparatus Source: UniProtKB-SubCell
  3. plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed Reviewed prediction
Chaini2 – 180179ADP-ribosylation factor 4PRO_0000207392Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi2 – 21N-myristoyl glycine Reviewed prediction

Keywords - PTMi

Lipoprotein, Myristate

Proteomic databases

MaxQBiP61750.
PaxDbiP61750.
PRIDEiP61750.

PTM databases

PhosphoSiteiP61750.

Expressioni

Gene expression databases

ArrayExpressiP61750.
BgeeiP61750.
CleanExiMM_ARF4.
GenevestigatoriP61750.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
Cadps2Q8BYR52EBI-7569554,EBI-7569313

Protein-protein interaction databases

BioGridi198187. 3 interactions.
IntActiP61750. 3 interactions.
MINTiMINT-1866425.

Structurei

3D structure databases

ProteinModelPortaliP61750.
SMRiP61750. Positions 4-178.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1100.
HOGENOMiHOG000163691.
HOVERGENiHBG002073.
KOiK07939.
OMAiGADELQK.
OrthoDBiEOG77WWDV.
PhylomeDBiP61750.
TreeFamiTF300808.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR024156. Small_GTPase_ARF.
IPR006689. Small_GTPase_ARF/SAR.
[Graphical view]
PfamiPF00025. Arf. 1 hit.
[Graphical view]
PRINTSiPR00328. SAR1GTPBP.
SMARTiSM00177. ARF. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51417. ARF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P61750-1 [UniParc]FASTAAdd to Basket

« Hide

MGLTISSLFS RLFGKKQMRI LMVGLDAAGK TTILYKLKLG EIVTTIPTIG    50
FNVETVEYKN ICFTVWDVGG QDKIRPLWRH YFQNTQGLIF VVDSNDRERI 100
QEGAAVLQKM LLEDELQDAV LLLFANKQDL PNAMAISEMT DKLGLQSLRN 150
RTWYVQATCA TQGTGLYEGL DWLSNELSKR 180
Length:180
Mass (Da):20,397
Last modified:January 23, 2007 - v2
Checksum:i09112917D8CE15D6
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti108 – 1081Q → E in BAB29041. 1 Publication
Sequence conflicti176 – 1761E → R in BAB29041. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D87901 mRNA. Translation: BAA13493.1.
AK013892 mRNA. Translation: BAB29041.1.
AK081686 mRNA. Translation: BAC38292.1.
AK153011 mRNA. Translation: BAE31650.1.
AK168793 mRNA. Translation: BAE40626.1.
CCDSiCCDS26881.1.
PIRiJC4948.
RefSeqiNP_031505.1. NM_007479.3.
UniGeneiMm.297768.

Genome annotation databases

EnsembliENSMUST00000022429; ENSMUSP00000022429; ENSMUSG00000021877.
GeneIDi11843.
KEGGimmu:11843.
UCSCiuc007sta.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D87901 mRNA. Translation: BAA13493.1 .
AK013892 mRNA. Translation: BAB29041.1 .
AK081686 mRNA. Translation: BAC38292.1 .
AK153011 mRNA. Translation: BAE31650.1 .
AK168793 mRNA. Translation: BAE40626.1 .
CCDSi CCDS26881.1.
PIRi JC4948.
RefSeqi NP_031505.1. NM_007479.3.
UniGenei Mm.297768.

3D structure databases

ProteinModelPortali P61750.
SMRi P61750. Positions 4-178.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 198187. 3 interactions.
IntActi P61750. 3 interactions.
MINTi MINT-1866425.

PTM databases

PhosphoSitei P61750.

Proteomic databases

MaxQBi P61750.
PaxDbi P61750.
PRIDEi P61750.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000022429 ; ENSMUSP00000022429 ; ENSMUSG00000021877 .
GeneIDi 11843.
KEGGi mmu:11843.
UCSCi uc007sta.1. mouse.

Organism-specific databases

CTDi 378.
MGIi MGI:99433. Arf4.

Phylogenomic databases

eggNOGi COG1100.
HOGENOMi HOG000163691.
HOVERGENi HBG002073.
KOi K07939.
OMAi GADELQK.
OrthoDBi EOG77WWDV.
PhylomeDBi P61750.
TreeFami TF300808.

Miscellaneous databases

NextBioi 279795.
PROi P61750.
SOURCEi Search...

Gene expression databases

ArrayExpressi P61750.
Bgeei P61750.
CleanExi MM_ARF4.
Genevestigatori P61750.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR024156. Small_GTPase_ARF.
IPR006689. Small_GTPase_ARF/SAR.
[Graphical view ]
Pfami PF00025. Arf. 1 hit.
[Graphical view ]
PRINTSi PR00328. SAR1GTPBP.
SMARTi SM00177. ARF. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00231. small_GTP. 1 hit.
PROSITEi PS51417. ARF. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Structure and intracellular localization of mouse ADP-ribosylation factors type 1 to type 6 (ARF1-ARF6)."
    Hosaka M., Toda K., Takatsu H., Torii S., Murakami K., Nakayama K.
    J. Biochem. 120:813-819(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: ICR.
    Tissue: Brain.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Bone marrow, Head and Heart.

Entry informationi

Entry nameiARF4_MOUSE
AccessioniPrimary (citable) accession number: P61750
Secondary accession number(s): P36403, Q3TGC2, Q9CXX3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: January 23, 2007
Last modified: July 9, 2014
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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