Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P61750

- ARF4_MOUSE

UniProt

P61750 - ARF4_MOUSE

Protein

ADP-ribosylation factor 4

Gene

Arf4

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 2 (23 Jan 2007)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi24 – 318GTPBy similarity
    Nucleotide bindingi67 – 715GTPBy similarity
    Nucleotide bindingi126 – 1294GTPBy similarity

    GO - Molecular functioni

    1. GTP binding Source: MGI
    2. protein binding Source: IntAct

    GO - Biological processi

    1. brain development Source: Ensembl
    2. epidermal growth factor receptor signaling pathway Source: Ensembl
    3. protein transport Source: MGI
    4. response to axon injury Source: Ensembl
    5. small GTPase mediated signal transduction Source: InterPro
    6. vesicle-mediated transport Source: UniProtKB-KW

    Keywords - Biological processi

    ER-Golgi transport, Protein transport, Transport

    Keywords - Ligandi

    GTP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ADP-ribosylation factor 4
    Gene namesi
    Name:Arf4
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 14

    Organism-specific databases

    MGIiMGI:99433. Arf4.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: MGI
    2. Golgi apparatus Source: UniProtKB-SubCell
    3. plasma membrane Source: MGI

    Keywords - Cellular componenti

    Golgi apparatus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedSequence Analysis
    Chaini2 – 180179ADP-ribosylation factor 4PRO_0000207392Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Lipidationi2 – 21N-myristoyl glycineSequence Analysis

    Keywords - PTMi

    Lipoprotein, Myristate

    Proteomic databases

    MaxQBiP61750.
    PaxDbiP61750.
    PRIDEiP61750.

    PTM databases

    PhosphoSiteiP61750.

    Expressioni

    Gene expression databases

    ArrayExpressiP61750.
    BgeeiP61750.
    CleanExiMM_ARF4.
    GenevestigatoriP61750.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Cadps2Q8BYR52EBI-7569554,EBI-7569313

    Protein-protein interaction databases

    BioGridi198187. 3 interactions.
    IntActiP61750. 3 interactions.
    MINTiMINT-1866425.

    Structurei

    3D structure databases

    ProteinModelPortaliP61750.
    SMRiP61750. Positions 4-178.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the small GTPase superfamily. Arf family.Curated

    Phylogenomic databases

    eggNOGiCOG1100.
    HOGENOMiHOG000163691.
    HOVERGENiHBG002073.
    KOiK07939.
    OMAiGADELQK.
    OrthoDBiEOG77WWDV.
    PhylomeDBiP61750.
    TreeFamiTF300808.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR024156. Small_GTPase_ARF.
    IPR006689. Small_GTPase_ARF/SAR.
    [Graphical view]
    PfamiPF00025. Arf. 1 hit.
    [Graphical view]
    PRINTSiPR00328. SAR1GTPBP.
    SMARTiSM00177. ARF. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00231. small_GTP. 1 hit.
    PROSITEiPS51417. ARF. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P61750-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGLTISSLFS RLFGKKQMRI LMVGLDAAGK TTILYKLKLG EIVTTIPTIG    50
    FNVETVEYKN ICFTVWDVGG QDKIRPLWRH YFQNTQGLIF VVDSNDRERI 100
    QEGAAVLQKM LLEDELQDAV LLLFANKQDL PNAMAISEMT DKLGLQSLRN 150
    RTWYVQATCA TQGTGLYEGL DWLSNELSKR 180
    Length:180
    Mass (Da):20,397
    Last modified:January 23, 2007 - v2
    Checksum:i09112917D8CE15D6
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti108 – 1081Q → E in BAB29041. (PubMed:16141072)Curated
    Sequence conflicti176 – 1761E → R in BAB29041. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D87901 mRNA. Translation: BAA13493.1.
    AK013892 mRNA. Translation: BAB29041.1.
    AK081686 mRNA. Translation: BAC38292.1.
    AK153011 mRNA. Translation: BAE31650.1.
    AK168793 mRNA. Translation: BAE40626.1.
    CCDSiCCDS26881.1.
    PIRiJC4948.
    RefSeqiNP_031505.1. NM_007479.3.
    UniGeneiMm.297768.

    Genome annotation databases

    EnsembliENSMUST00000022429; ENSMUSP00000022429; ENSMUSG00000021877.
    GeneIDi11843.
    KEGGimmu:11843.
    UCSCiuc007sta.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D87901 mRNA. Translation: BAA13493.1 .
    AK013892 mRNA. Translation: BAB29041.1 .
    AK081686 mRNA. Translation: BAC38292.1 .
    AK153011 mRNA. Translation: BAE31650.1 .
    AK168793 mRNA. Translation: BAE40626.1 .
    CCDSi CCDS26881.1.
    PIRi JC4948.
    RefSeqi NP_031505.1. NM_007479.3.
    UniGenei Mm.297768.

    3D structure databases

    ProteinModelPortali P61750.
    SMRi P61750. Positions 4-178.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 198187. 3 interactions.
    IntActi P61750. 3 interactions.
    MINTi MINT-1866425.

    PTM databases

    PhosphoSitei P61750.

    Proteomic databases

    MaxQBi P61750.
    PaxDbi P61750.
    PRIDEi P61750.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000022429 ; ENSMUSP00000022429 ; ENSMUSG00000021877 .
    GeneIDi 11843.
    KEGGi mmu:11843.
    UCSCi uc007sta.1. mouse.

    Organism-specific databases

    CTDi 378.
    MGIi MGI:99433. Arf4.

    Phylogenomic databases

    eggNOGi COG1100.
    HOGENOMi HOG000163691.
    HOVERGENi HBG002073.
    KOi K07939.
    OMAi GADELQK.
    OrthoDBi EOG77WWDV.
    PhylomeDBi P61750.
    TreeFami TF300808.

    Miscellaneous databases

    NextBioi 279795.
    PROi P61750.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P61750.
    Bgeei P61750.
    CleanExi MM_ARF4.
    Genevestigatori P61750.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR024156. Small_GTPase_ARF.
    IPR006689. Small_GTPase_ARF/SAR.
    [Graphical view ]
    Pfami PF00025. Arf. 1 hit.
    [Graphical view ]
    PRINTSi PR00328. SAR1GTPBP.
    SMARTi SM00177. ARF. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00231. small_GTP. 1 hit.
    PROSITEi PS51417. ARF. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Structure and intracellular localization of mouse ADP-ribosylation factors type 1 to type 6 (ARF1-ARF6)."
      Hosaka M., Toda K., Takatsu H., Torii S., Murakami K., Nakayama K.
      J. Biochem. 120:813-819(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: ICR.
      Tissue: Brain.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Bone marrow, Head and Heart.

    Entry informationi

    Entry nameiARF4_MOUSE
    AccessioniPrimary (citable) accession number: P61750
    Secondary accession number(s): P36403, Q3TGC2, Q9CXX3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 7, 2004
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 97 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3