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Protein

ADP-ribosylation factor 4

Gene

Arf4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi24 – 31GTPBy similarity8
Nucleotide bindingi67 – 71GTPBy similarity5
Nucleotide bindingi126 – 129GTPBy similarity4

GO - Molecular functioni

GO - Biological processi

  • activation of phospholipase D activity Source: MGI
  • apical protein localization Source: MGI
  • brain development Source: Ensembl
  • cell migration Source: MGI
  • dendritic spine development Source: MGI
  • epidermal growth factor receptor signaling pathway Source: Ensembl
  • establishment or maintenance of epithelial cell apical/basal polarity Source: MGI
  • learning Source: MGI
  • negative regulation of apoptotic process Source: MGI
  • positive regulation of transcription by RNA polymerase II Source: MGI
  • protein ADP-ribosylation Source: MGI
  • protein localization to cilium Source: MGI
  • protein transport Source: UniProtKB-KW
  • regulation of reactive oxygen species metabolic process Source: MGI
  • response to axon injury Source: Ensembl
  • retrograde vesicle-mediated transport, Golgi to ER Source: MGI

Keywordsi

Biological processER-Golgi transport, Protein transport, Transport
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-5620916 VxPx cargo-targeting to cilium
R-MMU-6807878 COPI-mediated anterograde transport
R-MMU-6811434 COPI-dependent Golgi-to-ER retrograde traffic

Names & Taxonomyi

Protein namesi
Recommended name:
ADP-ribosylation factor 4
Gene namesi
Name:Arf4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:99433 Arf4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002073922 – 180ADP-ribosylation factor 4Add BLAST179

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycineBy similarity1
Modified residuei147PhosphoserineBy similarity1

Keywords - PTMi

Lipoprotein, Myristate, Phosphoprotein

Proteomic databases

EPDiP61750
PaxDbiP61750
PeptideAtlasiP61750
PRIDEiP61750

PTM databases

iPTMnetiP61750
PhosphoSitePlusiP61750
SwissPalmiP61750

Expressioni

Gene expression databases

BgeeiENSMUSG00000021877
CleanExiMM_ARF4
ExpressionAtlasiP61750 baseline and differential
GenevisibleiP61750 MM

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
Cadps2Q8BYR52EBI-7569554,EBI-7569313

GO - Molecular functioni

Protein-protein interaction databases

BioGridi198187, 6 interactors
IntActiP61750, 4 interactors
MINTiP61750
STRINGi10090.ENSMUSP00000022429

Structurei

3D structure databases

ProteinModelPortaliP61750
SMRiP61750
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the small GTPase superfamily. Arf family.Curated

Phylogenomic databases

eggNOGiKOG0070 Eukaryota
COG1100 LUCA
GeneTreeiENSGT00780000121855
HOGENOMiHOG000163691
HOVERGENiHBG002073
InParanoidiP61750
KOiK07939
OMAiWHIESTC
OrthoDBiEOG091G0S7S
PhylomeDBiP61750
TreeFamiTF300808

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR024156 Small_GTPase_ARF
IPR006689 Small_GTPase_ARF/SAR
PfamiView protein in Pfam
PF00025 Arf, 1 hit
PRINTSiPR00328 SAR1GTPBP
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51417 ARF, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P61750-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLTISSLFS RLFGKKQMRI LMVGLDAAGK TTILYKLKLG EIVTTIPTIG
60 70 80 90 100
FNVETVEYKN ICFTVWDVGG QDKIRPLWRH YFQNTQGLIF VVDSNDRERI
110 120 130 140 150
QEGAAVLQKM LLEDELQDAV LLLFANKQDL PNAMAISEMT DKLGLQSLRN
160 170 180
RTWYVQATCA TQGTGLYEGL DWLSNELSKR
Length:180
Mass (Da):20,397
Last modified:January 23, 2007 - v2
Checksum:i09112917D8CE15D6
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti108Q → E in BAB29041 (PubMed:16141072).Curated1
Sequence conflicti176E → R in BAB29041 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D87901 mRNA Translation: BAA13493.1
AK013892 mRNA Translation: BAB29041.1
AK081686 mRNA Translation: BAC38292.1
AK153011 mRNA Translation: BAE31650.1
AK168793 mRNA Translation: BAE40626.1
CCDSiCCDS26881.1
PIRiJC4948
RefSeqiNP_031505.1, NM_007479.3
UniGeneiMm.297768

Genome annotation databases

EnsembliENSMUST00000022429; ENSMUSP00000022429; ENSMUSG00000021877
GeneIDi11843
KEGGimmu:11843
UCSCiuc007sta.1 mouse

Similar proteinsi

Entry informationi

Entry nameiARF4_MOUSE
AccessioniPrimary (citable) accession number: P61750
Secondary accession number(s): P36403, Q3TGC2, Q9CXX3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 127 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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