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Protein

Glycerol-3-phosphate dehydrogenase 1 [NAD(P)+]

Gene

gpsA1

Organism
Mycobacterium paratuberculosis (strain ATCC BAA-968 / K-10)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

sn-glycerol 3-phosphate + NAD(P)+ = glycerone phosphate + NAD(P)H.UniRule annotation

Pathwayi: glycerophospholipid metabolism

This protein is involved in the pathway glycerophospholipid metabolism, which is part of Membrane lipid metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway glycerophospholipid metabolism and in Membrane lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei103NAD; via amide nitrogenUniRule annotation1
Binding sitei103SubstrateUniRule annotation1
Binding sitei137NAD; via amide nitrogenUniRule annotation1
Active sitei188Proton acceptorUniRule annotation1
Binding sitei252NADUniRule annotation1
Binding sitei283NADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi2 – 7NADUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processLipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism
LigandNAD

Enzyme and pathway databases

UniPathwayiUPA00940

Names & Taxonomyi

Protein namesi
Recommended name:
Glycerol-3-phosphate dehydrogenase 1 [NAD(P)+] (EC:1.1.1.94UniRule annotation)
Alternative name(s):
NAD(P)H-dependent glycerol-3-phosphate dehydrogenase 1UniRule annotation
Gene namesi
Name:gpsA1UniRule annotation
Ordered Locus Names:MAP_3020c
OrganismiMycobacterium paratuberculosis (strain ATCC BAA-968 / K-10)
Taxonomic identifieri262316 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium avium complex (MAC)
Proteomesi
  • UP000000580 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001379931 – 333Glycerol-3-phosphate dehydrogenase 1 [NAD(P)+]Add BLAST333

Interactioni

Protein-protein interaction databases

STRINGi262316.MAP3020c

Structurei

3D structure databases

ProteinModelPortaliP61743
SMRiP61743
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni252 – 253Substrate bindingUniRule annotation2

Sequence similaritiesi

Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CSF Bacteria
COG0240 LUCA
KOiK00057
OMAiWLCKGFE
OrthoDBiPOG091H060E

Family and domain databases

Gene3Di1.10.1040.10, 1 hit
HAMAPiMF_00394 NAD_Glyc3P_dehydrog, 1 hit
InterProiView protein in InterPro
IPR008927 6-PGluconate_DH-like_C_sf
IPR013328 6PGD_dom2
IPR006168 G3P_DH_NAD-dep
IPR006109 G3P_DH_NAD-dep_C
IPR011128 G3P_DH_NAD-dep_N
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF07479 NAD_Gly3P_dh_C, 1 hit
PF01210 NAD_Gly3P_dh_N, 1 hit
PIRSFiPIRSF000114 Glycerol-3-P_dh, 1 hit
PRINTSiPR00077 GPDHDRGNASE
SUPFAMiSSF48179 SSF48179, 1 hit
SSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00957 NAD_G3PDH, 1 hit

Sequencei

Sequence statusi: Complete.

P61743-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGAGAWGTAL AKVLVDAGGP GTEVTLWARR PELAERINAT RSNPDYLPGT
60 70 80 90 100
SLPPGIHATA DAGEALRDAT TVLLGVPAQA MRANLERWAP LLRDGATLVS
110 120 130 140 150
LAKGIELGTL MRMSQVIVSV TGVDPAQVAV ISGPNLASEI AACQPAATVV
160 170 180 190 200
ACSDSGRAVA LQRMLNSGYF RPYTNSDVVG TEIGGACKNV IALACGMAAG
210 220 230 240 250
VGLGENTAAA IITRGLAEIM RLGIALGAKG ATLAGLAGVG DLVATCSSPH
260 270 280 290 300
SRNRSLGERL GRGATIGSVL AGSPDGGDGH VVEGVTSCQS VLALAASYDV
310 320 330
EMPLTDAVHR VCHKGLSVDE AMALLLGRRT KPE
Length:333
Mass (Da):33,689
Last modified:June 7, 2004 - v1
Checksum:iFBB8C68EC684F399
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016958 Genomic DNA Translation: AAS05568.1

Genome annotation databases

EnsemblBacteriaiAAS05568; AAS05568; MAP_3020c
KEGGimpa:MAP_3020c

Similar proteinsi

Entry informationi

Entry nameiGPDA1_MYCPA
AccessioniPrimary (citable) accession number: P61743
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: June 7, 2004
Last modified: March 28, 2018
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health