Reviewed, UniProtKB/Swiss-Prot P61733 (PHS_MYCPA)

Names and origin

Protein names

Recommended name:
    Putative pterin-4-alpha-carbinolamine dehydratase
      Short name=PHS
    EC=4.2.1.96
Alternative name(s):
    4-alpha-hydroxy-tetrahydropterin dehydratase
    Pterin carbinolamine dehydratase
      Short name=PCD

Gene names

Ordered Locus Names:

MAP_2623

Organism

Mycobacterium paratuberculosis [Complete proteome] [HAMAP]

Taxonomic identifier

1770 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium avium complex (MAC)

Protein attributes

Sequence length	94 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	(6R)-6-(L-erythro-1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-4a-hydroxypterin = (6R)-6-(L-erythro-1,2-dihydroxypropyl)-7,8-dihydro-6H-pterin + H2O. HAMAP MF_00434
Sequence similarities	Belongs to the pterin-4-alpha-carbinolamine dehydratase family.

Ontologies

Keywords
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	tetrahydrobiopterin biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	4-alpha-hydroxytetrahydrobiopterin dehydratase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 94	94	Putative pterin-4-alpha-carbinolamine dehydratase HAMAP MF_00434		PRO_0000063083

Sequences

	Sequence		Length	Mass (Da)
	P61733-1 [UniParc]. Last modified June 7, 2004. Version 1. Checksum: C1655503D4C604A8	FASTA	94	10,414
	10 20 30 40 50 60 MAVLTDEQID AAMPDLDGWE RADGALRRSI KFPSFLDGID AVRRVAEHAE SKDHHPDIDI 70 80 90 RWRTVTFALV THSEGGITQN DVDMARDING IVGS

References

[1]

"The complete genome sequence of Mycobacterium avium subspecies paratuberculosis." Li L., Bannantine J.P., Zhang Q., Amonsin A., May B.J., Alt D., Banerji N., Kanjilal S., Kapur V. Proc. Natl. Acad. Sci. U.S.A. 102:12344-12349(2005) [PubMed: 16116077] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-968 / K-10.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE016958 Genomic DNA. Translation: AAS04940.1. Different initiation.
RefSeq	NP_961557.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	2721423.
GenomeReviews	Gene locus MAP_2623 in contig AE016958_GR.
KEGG	mpa:MAP2623.
NMPDR	fig|262316.1.peg.2623.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	P61733.
Enzyme and pathway databases
BRENDA	4.2.1.96. 189774.
Family and domain databases
HAMAP	MF_00434. [Tree]
InterPro	IPR001533. Trans/pterin_deHydtase. [Graphical view]
Gene3D	G3DSA:3.30.1360.20. Trans_pterinDh. 1 hit.
PANTHER	PTHR12599. Trans_pterinDh. 1 hit.
Pfam	PF01329. Pterin_4a. 1 hit. [Graphical view]
ProDom	PD007262. Trans_pterinDh. 1 hit. [Graphical view] [Entries sharing at least one domain]
ProtoNet	Search...

Entry information

Entry name

PHS_MYCPA

Accession

Primary (citable) accession number: P61733

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 7, 2004
Last sequence update:	June 7, 2004
Last modified:	March 3, 2009
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)