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P61676 (MURC_BDEBA) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
UDP-N-acetylmuramate--L-alanine ligase
EC=6.3.2.8
Alternative name(s):
UDP-N-acetylmuramoyl-L-alanine synthetase
Gene names
Name:murC
Ordered Locus Names:Bd3196
OrganismBdellovibrio bacteriovorus (strain ATCC 15356 / DSM 50701 / NCIB 9529 / HD100) [Complete proteome] [HAMAP]
Taxonomic identifier264462 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Deltaproteobacteria › Bdellovibrionales › Bdellovibrionaceae › Bdellovibrio

Protein attributes

Sequence length453 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP MF_00046

Catalytic activity

ATP + UDP-N-acetylmuramate + L-alanine = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanine. HAMAP MF_00046

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_00046

Subcellular location

Cytoplasm By similarity HAMAP MF_00046.

Sequence similarities

Belongs to the MurCDEF family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 453453UDP-N-acetylmuramate--L-alanine ligase HAMAP MF_00046
PRO_0000182058

Regions

Nucleotide binding112 – 1187ATP Potential

Sequences

Sequence LengthMass (Da)Tools
P61676 [UniParc].

Last modified June 7, 2004. Version 1.
Checksum: EF82DE8B52C6A66E

FASTA45350,080
        10         20         30         40         50         60 
MKLQHAKFHF VGVGGIGMCG LAELLHNIGA KVSGSDQAEN ANTERLKELG VKVFKGHASS 

        70         80         90        100        110        120 
NVGDADVVVY SSAIQYGNPE ISEARARQIP LIPRAEALAE IMRLKRGIAV AGTHGKTTTT 

       130        140        150        160        170        180 
SMTSAIFLEA NLSPTIVIGG RFELIKSTAM LGSGEWLVAE ADESDGSFHK LSPEIAIITN 

       190        200        210        220        230        240 
IDSDHLEHFK TFENVQKSFH DFALKVPFYG KVIVCGDDPL VRQIFENFPK RILFYGFDEK 

       250        260        270        280        290        300 
NDLVVTGEHG HYAVHRNDRL LGTKHLVGEF DLKVPGRHNA LNAVAAICAG VAAGIPFATC 

       310        320        330        340        350        360 
AKGLQRYEGV DRRFHFKGEK KGIKVYDDYG HHPTEVRAVL QAFREKYPKQ RLVVFFQPHR 

       370        380        390        400        410        420 
YSRTQHCWHD FTTAFMEADQ VLLTDIYPAG EAPIPGVTSE KLASEMKHEH AQYFVRDDKA 

       430        440        450 
TQKILGMLKE GDVFVTLGAG DGWKLGLEVL NQL

« Hide

References

[1]"A predator unmasked: life cycle of Bdellovibrio bacteriovorus from a genomic perspective."
Rendulic S., Jagtap P., Rosinus A., Eppinger M., Baar C., Lanz C., Keller H., Lambert C., Evans K.J., Goesmann A., Meyer F., Sockett R.E., Schuster S.C.
Science 303:689-692(2004) [PubMed: 14752164] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 15356 / DSM 50701 / NCIB 9529 / HD100.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BX842654 Genomic DNA. Translation: CAE80951.1.
RefSeqNP_969958.1. NC_005363.1.

3D structure databases

ProteinModelPortalP61676.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2736811.
GenomeReviewsGene locus Bd3196 in contig BX842601_GR.
KEGGbba:Bd3196.
NMPDRfig|264462.1.peg.2931.
PATRIC21080740. VBIBdeBac73187_2925.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG476594.
OMAYQPHRYS.
PhylomeDBP61676.

Enzyme and pathway databases

BioCycBBAC264462:BD3196-MONOMER.

Family and domain databases

HAMAPMF_00046. MurC.
[Tree]
InterProIPR004101. Mur_ligase_C.
IPR013221. Mur_ligase_cen.
IPR000713. Mur_ligase_N.
IPR016040. NAD(P)-bd_dom.
IPR005758. UDP-N-AcMur_Ala_ligase.
[Graphical view]
Gene3DG3DSA:3.90.190.20. Mur_ligase_C. 1 hit.
G3DSA:3.40.1190.10. Mur_ligase_cen. 1 hit.
G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KOK01924.
PANTHERPTHR23135:SF5. PTHR23135:SF5. 1 hit.
PfamPF01225. Mur_ligase. 1 hit.
PF02875. Mur_ligase_C. 1 hit.
PF08245. Mur_ligase_M. 1 hit.
[Graphical view]
SUPFAMSSF53244. Mur_ligase_C. 1 hit.
SSF53623. Mur_ligase_cen. 1 hit.
TIGRFAMsTIGR01082. MurC. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMURC_BDEBA
AccessionPrimary (citable) accession number: P61676
Entry history
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: June 7, 2004
Last modified: January 25, 2012
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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