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P61647

- SIA8F_HUMAN

UniProt

P61647 - SIA8F_HUMAN

Protein

Alpha-2,8-sialyltransferase 8F

Gene

ST8SIA6

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 86 (01 Oct 2014)
      Sequence version 1 (07 Jun 2004)
      Previous versions | rss
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    Functioni

    Prefers O-glycans to N-glycans or glycolipids as acceptor substrates. The minimal acceptor substrate is the NeuAc-alpha-2,36-Gal sequence at the non-reducing end of their carbohydrate groups By similarity.By similarity

    Pathwayi

    GO - Molecular functioni

    1. sialyltransferase activity Source: BHF-UCL

    GO - Biological processi

    1. carbohydrate biosynthetic process Source: BHF-UCL
    2. cellular protein metabolic process Source: Reactome
    3. ganglioside biosynthetic process Source: BHF-UCL
    4. glycolipid biosynthetic process Source: BHF-UCL
    5. glycoprotein metabolic process Source: BHF-UCL
    6. oligosaccharide metabolic process Source: BHF-UCL
    7. post-translational protein modification Source: Reactome
    8. protein N-linked glycosylation via asparagine Source: Reactome
    9. protein O-linked glycosylation Source: BHF-UCL
    10. sialylation Source: GOC

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Enzyme and pathway databases

    ReactomeiREACT_200874. Sialic acid metabolism.
    REACT_25085. N-Glycan antennae elongation.
    UniPathwayiUPA00378.

    Protein family/group databases

    CAZyiGT29. Glycosyltransferase Family 29.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alpha-2,8-sialyltransferase 8F (EC:2.4.99.-)
    Alternative name(s):
    Sialyltransferase 8F
    Short name:
    SIAT8-F
    Sialyltransferase St8Sia VI
    Short name:
    ST8SiaVI
    Gene namesi
    Name:ST8SIA6
    Synonyms:SIAT8F
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 10

    Organism-specific databases

    HGNCiHGNC:23317. ST8SIA6.

    Subcellular locationi

    GO - Cellular componenti

    1. Golgi membrane Source: Reactome
    2. integral component of Golgi membrane Source: InterPro

    Keywords - Cellular componenti

    Golgi apparatus, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134909138.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 398398Alpha-2,8-sialyltransferase 8FPRO_0000149299Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi66 – 661N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi93 – 931N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi151 – 1511N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi186 ↔ 335By similarity
    Glycosylationi196 – 1961N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiP61647.
    PRIDEiP61647.

    PTM databases

    PhosphoSiteiP61647.

    Expressioni

    Gene expression databases

    BgeeiP61647.
    CleanExiHS_ST8SIA6.
    GenevestigatoriP61647.

    Organism-specific databases

    HPAiHPA011635.

    Interactioni

    Protein-protein interaction databases

    BioGridi130764. 1 interaction.
    STRINGi9606.ENSP00000366827.

    Structurei

    3D structure databases

    ProteinModelPortaliP61647.
    SMRiP61647. Positions 185-361.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 33CytoplasmicSequence Analysis
    Topological domaini25 – 398374LumenalSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei4 – 2421Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyltransferase 29 family.Curated

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG323775.
    HOGENOMiHOG000090201.
    HOVERGENiHBG106106.
    InParanoidiP61647.
    KOiK06615.
    OMAiNMSYEVE.
    PhylomeDBiP61647.
    TreeFamiTF323961.

    Family and domain databases

    InterProiIPR001675. Glyco_trans_29.
    IPR012163. Sialyl_trans.
    [Graphical view]
    PfamiPF00777. Glyco_transf_29. 1 hit.
    [Graphical view]
    PIRSFiPIRSF005557. Sialyl_trans. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P61647-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRPGGALLAL LASLLLLLLL RLLWCPADAP GRARILVEES REATHGTPAA    50
    LRTLRSPATA VPRATNSTYL NEKSLQLTEK CKNLQYGIES FSNKTKGYSE 100
    NDYLQIITDI QSCPWKRQAE EYANFRAKLA SCCDAVQNFV VSQNNTPVGT 150
    NMSYEVESKK EIPIKKNIFH MFPVSQPFVD YPYNQCAVVG NGGILNKSLC 200
    GTEIDKSDFV FRCNLPPTTG DVSKDVGSKT NLVTINPSII TLKYGNLKEK 250
    KALFLEDIAT YGDAFFLLPA FSFRANTGTS FKVYYTLEES KARQKVLFFH 300
    PKYLKDLALF WRTKGVTAYR LSTGLMITSV AVELCKNVKL YGFWPFSKTV 350
    EDIPVSHHYY DNKLPKHGFH QMPKEYSQIL QLHMKGILKL QFSKCEVA 398
    Length:398
    Mass (Da):44,836
    Last modified:June 7, 2004 - v1
    Checksum:i48F58B82E4B69A26
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ621583 mRNA. Translation: CAF21722.1.
    EF445032 Genomic DNA. Translation: ACA06074.1.
    EF445032 Genomic DNA. Translation: ACA06075.1.
    AL158164, AL160289 Genomic DNA. Translation: CAI40658.1.
    AL160289, AL158164 Genomic DNA. Translation: CAH70722.1.
    BC137102 mRNA. Translation: AAI37103.1.
    BC137103 mRNA. Translation: AAI37104.1.
    CCDSiCCDS31158.1.
    RefSeqiNP_001004470.1. NM_001004470.1.
    UniGeneiHs.677766.

    Genome annotation databases

    EnsembliENST00000377602; ENSP00000366827; ENSG00000148488.
    GeneIDi338596.
    KEGGihsa:338596.
    UCSCiuc001ipd.3. human.

    Polymorphism databases

    DMDMi48428578.

    Cross-referencesi

    Web resourcesi

    GGDB

    GlycoGene database

    Functional Glycomics Gateway - GTase

    ST8Sia VI

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ621583 mRNA. Translation: CAF21722.1 .
    EF445032 Genomic DNA. Translation: ACA06074.1 .
    EF445032 Genomic DNA. Translation: ACA06075.1 .
    AL158164 , AL160289 Genomic DNA. Translation: CAI40658.1 .
    AL160289 , AL158164 Genomic DNA. Translation: CAH70722.1 .
    BC137102 mRNA. Translation: AAI37103.1 .
    BC137103 mRNA. Translation: AAI37104.1 .
    CCDSi CCDS31158.1.
    RefSeqi NP_001004470.1. NM_001004470.1.
    UniGenei Hs.677766.

    3D structure databases

    ProteinModelPortali P61647.
    SMRi P61647. Positions 185-361.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 130764. 1 interaction.
    STRINGi 9606.ENSP00000366827.

    Protein family/group databases

    CAZyi GT29. Glycosyltransferase Family 29.

    PTM databases

    PhosphoSitei P61647.

    Polymorphism databases

    DMDMi 48428578.

    Proteomic databases

    PaxDbi P61647.
    PRIDEi P61647.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000377602 ; ENSP00000366827 ; ENSG00000148488 .
    GeneIDi 338596.
    KEGGi hsa:338596.
    UCSCi uc001ipd.3. human.

    Organism-specific databases

    CTDi 338596.
    GeneCardsi GC10M017360.
    HGNCi HGNC:23317. ST8SIA6.
    HPAi HPA011635.
    MIMi 610139. gene.
    neXtProti NX_P61647.
    PharmGKBi PA134909138.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG323775.
    HOGENOMi HOG000090201.
    HOVERGENi HBG106106.
    InParanoidi P61647.
    KOi K06615.
    OMAi NMSYEVE.
    PhylomeDBi P61647.
    TreeFami TF323961.

    Enzyme and pathway databases

    UniPathwayi UPA00378 .
    Reactomei REACT_200874. Sialic acid metabolism.
    REACT_25085. N-Glycan antennae elongation.

    Miscellaneous databases

    ChiTaRSi ST8SIA6. human.
    GenomeRNAii 338596.
    NextBioi 97053.
    PROi P61647.
    SOURCEi Search...

    Gene expression databases

    Bgeei P61647.
    CleanExi HS_ST8SIA6.
    Genevestigatori P61647.

    Family and domain databases

    InterProi IPR001675. Glyco_trans_29.
    IPR012163. Sialyl_trans.
    [Graphical view ]
    Pfami PF00777. Glyco_transf_29. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF005557. Sialyl_trans. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and expression of a sixth human alpha2,8-sialyltransferase (hST8SiaVI)."
      Teintenier-Lelievre M., Delannoy P., Harduin-Lepers A.
      Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. NHLBI resequencing and genotyping service (RS&G)
      Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
      , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
      Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.

    Entry informationi

    Entry nameiSIA8F_HUMAN
    AccessioniPrimary (citable) accession number: P61647
    Secondary accession number(s): B0YJ97, B9EH72, Q5VZH4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 7, 2004
    Last sequence update: June 7, 2004
    Last modified: October 1, 2014
    This is version 86 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 10
      Human chromosome 10: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3