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P61647

- SIA8F_HUMAN

UniProt

P61647 - SIA8F_HUMAN

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Protein

Alpha-2,8-sialyltransferase 8F

Gene

ST8SIA6

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Prefers O-glycans to N-glycans or glycolipids as acceptor substrates. The minimal acceptor substrate is the NeuAc-alpha-2,36-Gal sequence at the non-reducing end of their carbohydrate groups (By similarity).By similarity

Pathwayi

GO - Molecular functioni

  1. sialyltransferase activity Source: BHF-UCL

GO - Biological processi

  1. carbohydrate biosynthetic process Source: BHF-UCL
  2. cellular protein metabolic process Source: Reactome
  3. ganglioside biosynthetic process Source: BHF-UCL
  4. glycolipid biosynthetic process Source: BHF-UCL
  5. glycoprotein metabolic process Source: BHF-UCL
  6. oligosaccharide metabolic process Source: BHF-UCL
  7. post-translational protein modification Source: Reactome
  8. protein N-linked glycosylation via asparagine Source: Reactome
  9. protein O-linked glycosylation Source: BHF-UCL
  10. sialylation Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

ReactomeiREACT_200874. Sialic acid metabolism.
REACT_25085. N-Glycan antennae elongation.
UniPathwayiUPA00378.

Protein family/group databases

CAZyiGT29. Glycosyltransferase Family 29.

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-2,8-sialyltransferase 8F (EC:2.4.99.-)
Alternative name(s):
Sialyltransferase 8F
Short name:
SIAT8-F
Sialyltransferase St8Sia VI
Short name:
ST8SiaVI
Gene namesi
Name:ST8SIA6
Synonyms:SIAT8F
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 10

Organism-specific databases

HGNCiHGNC:23317. ST8SIA6.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 33CytoplasmicSequence Analysis
Transmembranei4 – 2421Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
BLAST
Topological domaini25 – 398374LumenalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. Golgi membrane Source: Reactome
  2. integral component of Golgi membrane Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134909138.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 398398Alpha-2,8-sialyltransferase 8FPRO_0000149299Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi66 – 661N-linked (GlcNAc...)Sequence Analysis
Glycosylationi93 – 931N-linked (GlcNAc...)Sequence Analysis
Glycosylationi151 – 1511N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi186 ↔ 335By similarity
Glycosylationi196 – 1961N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP61647.
PRIDEiP61647.

PTM databases

PhosphoSiteiP61647.

Expressioni

Gene expression databases

BgeeiP61647.
CleanExiHS_ST8SIA6.
GenevestigatoriP61647.

Organism-specific databases

HPAiHPA011635.

Interactioni

Protein-protein interaction databases

BioGridi130764. 1 interaction.
STRINGi9606.ENSP00000366827.

Structurei

3D structure databases

ProteinModelPortaliP61647.
SMRiP61647. Positions 185-361.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 29 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG323775.
GeneTreeiENSGT00550000074407.
HOGENOMiHOG000090201.
HOVERGENiHBG106106.
InParanoidiP61647.
KOiK06615.
OMAiNMSYEVE.
PhylomeDBiP61647.
TreeFamiTF323961.

Family and domain databases

InterProiIPR001675. Glyco_trans_29.
IPR012163. Sialyl_trans.
[Graphical view]
PfamiPF00777. Glyco_transf_29. 1 hit.
[Graphical view]
PIRSFiPIRSF005557. Sialyl_trans. 1 hit.

Sequencei

Sequence statusi: Complete.

P61647-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRPGGALLAL LASLLLLLLL RLLWCPADAP GRARILVEES REATHGTPAA
60 70 80 90 100
LRTLRSPATA VPRATNSTYL NEKSLQLTEK CKNLQYGIES FSNKTKGYSE
110 120 130 140 150
NDYLQIITDI QSCPWKRQAE EYANFRAKLA SCCDAVQNFV VSQNNTPVGT
160 170 180 190 200
NMSYEVESKK EIPIKKNIFH MFPVSQPFVD YPYNQCAVVG NGGILNKSLC
210 220 230 240 250
GTEIDKSDFV FRCNLPPTTG DVSKDVGSKT NLVTINPSII TLKYGNLKEK
260 270 280 290 300
KALFLEDIAT YGDAFFLLPA FSFRANTGTS FKVYYTLEES KARQKVLFFH
310 320 330 340 350
PKYLKDLALF WRTKGVTAYR LSTGLMITSV AVELCKNVKL YGFWPFSKTV
360 370 380 390
EDIPVSHHYY DNKLPKHGFH QMPKEYSQIL QLHMKGILKL QFSKCEVA
Length:398
Mass (Da):44,836
Last modified:June 7, 2004 - v1
Checksum:i48F58B82E4B69A26
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ621583 mRNA. Translation: CAF21722.1.
EF445032 Genomic DNA. Translation: ACA06074.1.
EF445032 Genomic DNA. Translation: ACA06075.1.
AL158164, AL160289 Genomic DNA. Translation: CAI40658.1.
AL160289, AL158164 Genomic DNA. Translation: CAH70722.1.
BC137102 mRNA. Translation: AAI37103.1.
BC137103 mRNA. Translation: AAI37104.1.
CCDSiCCDS31158.1.
RefSeqiNP_001004470.1. NM_001004470.1.
UniGeneiHs.677766.

Genome annotation databases

EnsembliENST00000377602; ENSP00000366827; ENSG00000148488.
GeneIDi338596.
KEGGihsa:338596.
UCSCiuc001ipd.3. human.

Polymorphism databases

DMDMi48428578.

Cross-referencesi

Web resourcesi

GGDB

GlycoGene database

Functional Glycomics Gateway - GTase

ST8Sia VI

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ621583 mRNA. Translation: CAF21722.1 .
EF445032 Genomic DNA. Translation: ACA06074.1 .
EF445032 Genomic DNA. Translation: ACA06075.1 .
AL158164 , AL160289 Genomic DNA. Translation: CAI40658.1 .
AL160289 , AL158164 Genomic DNA. Translation: CAH70722.1 .
BC137102 mRNA. Translation: AAI37103.1 .
BC137103 mRNA. Translation: AAI37104.1 .
CCDSi CCDS31158.1.
RefSeqi NP_001004470.1. NM_001004470.1.
UniGenei Hs.677766.

3D structure databases

ProteinModelPortali P61647.
SMRi P61647. Positions 185-361.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 130764. 1 interaction.
STRINGi 9606.ENSP00000366827.

Protein family/group databases

CAZyi GT29. Glycosyltransferase Family 29.

PTM databases

PhosphoSitei P61647.

Polymorphism databases

DMDMi 48428578.

Proteomic databases

PaxDbi P61647.
PRIDEi P61647.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000377602 ; ENSP00000366827 ; ENSG00000148488 .
GeneIDi 338596.
KEGGi hsa:338596.
UCSCi uc001ipd.3. human.

Organism-specific databases

CTDi 338596.
GeneCardsi GC10M017360.
HGNCi HGNC:23317. ST8SIA6.
HPAi HPA011635.
MIMi 610139. gene.
neXtProti NX_P61647.
PharmGKBi PA134909138.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG323775.
GeneTreei ENSGT00550000074407.
HOGENOMi HOG000090201.
HOVERGENi HBG106106.
InParanoidi P61647.
KOi K06615.
OMAi NMSYEVE.
PhylomeDBi P61647.
TreeFami TF323961.

Enzyme and pathway databases

UniPathwayi UPA00378 .
Reactomei REACT_200874. Sialic acid metabolism.
REACT_25085. N-Glycan antennae elongation.

Miscellaneous databases

ChiTaRSi ST8SIA6. human.
GenomeRNAii 338596.
NextBioi 97053.
PROi P61647.
SOURCEi Search...

Gene expression databases

Bgeei P61647.
CleanExi HS_ST8SIA6.
Genevestigatori P61647.

Family and domain databases

InterProi IPR001675. Glyco_trans_29.
IPR012163. Sialyl_trans.
[Graphical view ]
Pfami PF00777. Glyco_transf_29. 1 hit.
[Graphical view ]
PIRSFi PIRSF005557. Sialyl_trans. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and expression of a sixth human alpha2,8-sialyltransferase (hST8SiaVI)."
    Teintenier-Lelievre M., Delannoy P., Harduin-Lepers A.
    Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. NHLBI resequencing and genotyping service (RS&G)
    Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiSIA8F_HUMAN
AccessioniPrimary (citable) accession number: P61647
Secondary accession number(s): B0YJ97, B9EH72, Q5VZH4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: June 7, 2004
Last modified: October 29, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3