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Protein

Retinol-binding protein 4

Gene

RBP4

Organism
Pan troglodytes (Chimpanzee)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Retinol-binding protein that mediates retinol transport in blood plasma. Delivers retinol from the liver stores to the peripheral tissues. Transfers the bound all-trans retinol to STRA6, that then facilitates retinol transport across the cell membrane.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei116SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTransport
LigandRetinol-binding, Vitamin A

Names & Taxonomyi

Protein namesi
Recommended name:
Retinol-binding protein 4
Alternative name(s):
Plasma retinol-binding protein
Short name:
PRBP
Short name:
RBP
Gene namesi
Name:RBP4
OrganismiPan troglodytes (Chimpanzee)
Taxonomic identifieri9598 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan
Proteomesi
  • UP000002277 Componenti: Chromosome 10

Organism-specific databases

VGNCiVGNC:5717 RBP4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18By similarityAdd BLAST18
ChainiPRO_000001796719 – 201Retinol-binding protein 4Add BLAST183

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi22 ↔ 178By similarity
Disulfide bondi88 ↔ 192By similarity
Disulfide bondi138 ↔ 147By similarity
Modified residuei139Omega-N-methylarginineBy similarity1

Keywords - PTMi

Disulfide bond, Methylation

Proteomic databases

PaxDbiP61641

Expressioni

Gene expression databases

BgeeiENSPTRG00000002768

Interactioni

Subunit structurei

Interacts with TTR. Interaction with TTR prevents its loss by filtration through the kidney glomeruli. Interacts with STRA6.By similarity

Protein-protein interaction databases

STRINGi9598.ENSPTRP00000004830

Structurei

3D structure databases

ProteinModelPortaliP61641
SMRiP61641
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the calycin superfamily. Lipocalin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IJHC Eukaryota
ENOG4111K1Y LUCA
GeneTreeiENSGT00510000047107
HOGENOMiHOG000293156
HOVERGENiHBG004493
InParanoidiP61641
KOiK18271
OMAiGHMSATA
OrthoDBiEOG091G0KIM
TreeFamiTF331445

Family and domain databases

Gene3Di2.40.128.20, 1 hit
InterProiView protein in InterPro
IPR012674 Calycin
IPR022271 Lipocalin_ApoD
IPR022272 Lipocalin_CS
IPR000566 Lipocln_cytosolic_FA-bd_dom
IPR002449 Retinol-bd/Purpurin
PANTHERiPTHR11873 PTHR11873, 1 hit
PfamiView protein in Pfam
PF00061 Lipocalin, 1 hit
PIRSFiPIRSF036893 Lipocalin_ApoD, 1 hit
PIRSF500204 RBP_purpurin, 1 hit
PRINTSiPR01174 RETINOLBNDNG
SUPFAMiSSF50814 SSF50814, 1 hit
PROSITEiView protein in PROSITE
PS00213 LIPOCALIN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P61641-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKWVWALLLL AALGSGRAER DCRVSSFRVK ENFDKARFSG TWYAMAKKDP
60 70 80 90 100
EGLFLQDNIV AEFSVDETGQ MSATAKGRVR LLNNWDVCAD MVGTFTDTED
110 120 130 140 150
PAKFKMKYWG VASFLQKGND DHWIVDTDYD TYAVQYSCRL LNLDGTCADS
160 170 180 190 200
YSFVFSRDPN GLPPEAQKIV RQRQEELCLA RQYRLIVHNG YCDGRSERNL

L
Length:201
Mass (Da):23,010
Last modified:June 7, 2004 - v1
Checksum:i660C6DD8CC9B811A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB124586 Genomic DNA Translation: BAD16621.1
RefSeqiNP_001038960.1, NM_001045495.1
XP_009457151.1, XM_009458876.2
XP_009457152.1, XM_009458877.2
UniGeneiPtr.6203

Genome annotation databases

EnsembliENSPTRT00000005226; ENSPTRP00000004830; ENSPTRG00000002768
GeneIDi450617
KEGGiptr:450617

Similar proteinsi

Entry informationi

Entry nameiRET4_PANTR
AccessioniPrimary (citable) accession number: P61641
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: June 7, 2004
Last modified: March 28, 2018
This is version 101 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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