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Protein

Integrin alpha-11

Gene

Itga11

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Integrin alpha-11/beta-1 is a receptor for collagen.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi488 – 4969Sequence analysis
Calcium bindingi551 – 5599Sequence analysis
Calcium bindingi613 – 6219Sequence analysis

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Integrin, Receptor

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium, Magnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Integrin alpha-11
Gene namesi
Name:Itga11
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:2442114. Itga11.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini23 – 11411119ExtracellularSequence analysisAdd
BLAST
Transmembranei1142 – 116423HelicalSequence analysisAdd
BLAST
Topological domaini1165 – 118824CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence analysisAdd
BLAST
Chaini23 – 11881166Integrin alpha-11PRO_0000016319Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi76 ↔ 83By similarity
Glycosylationi82 – 821N-linked (GlcNAc...)Sequence analysis
Glycosylationi95 – 951N-linked (GlcNAc...)Sequence analysis
Disulfide bondi121 ↔ 139Sequence analysis
Disulfide bondi129 ↔ 159Sequence analysis
Glycosylationi291 – 2911N-linked (GlcNAc...)Sequence analysis
Glycosylationi331 – 3311N-linked (GlcNAc...)1 Publication
Glycosylationi358 – 3581N-linked (GlcNAc...)Sequence analysis
Glycosylationi449 – 4491N-linked (GlcNAc...)Sequence analysis
Glycosylationi462 – 4621N-linked (GlcNAc...)Sequence analysis
Glycosylationi528 – 5281N-linked (GlcNAc...)Sequence analysis
Glycosylationi642 – 6421N-linked (GlcNAc...)Sequence analysis
Disulfide bondi659 ↔ 668By similarity
Disulfide bondi674 ↔ 729By similarity
Glycosylationi694 – 6941N-linked (GlcNAc...)Sequence analysis
Disulfide bondi781 ↔ 787By similarity
Glycosylationi857 – 8571N-linked (GlcNAc...)Sequence analysis
Disulfide bondi881 ↔ 893By similarity
Glycosylationi894 – 8941N-linked (GlcNAc...)Sequence analysis
Glycosylationi973 – 9731N-linked (GlcNAc...)Sequence analysis
Glycosylationi1031 – 10311N-linked (GlcNAc...)Sequence analysis
Glycosylationi1039 – 10391N-linked (GlcNAc...)Sequence analysis
Glycosylationi1059 – 10591N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP61622.
PaxDbiP61622.
PRIDEiP61622.

PTM databases

iPTMnetiP61622.
PhosphoSiteiP61622.

Expressioni

Gene expression databases

CleanExiMM_ITGA11.

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit. Alpha-11 associates with beta-1 (By similarity). Interacts with RAB21 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000034774.

Structurei

3D structure databases

ProteinModelPortaliP61622.
SMRiP61622. Positions 23-1093.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati24 – 8562FG-GAP 1PROSITE-ProRule annotationAdd
BLAST
Repeati91 – 15161FG-GAP 2PROSITE-ProRule annotationAdd
BLAST
Domaini164 – 345182VWFAPROSITE-ProRule annotationAdd
BLAST
Repeati355 – 40652FG-GAP 3PROSITE-ProRule annotationAdd
BLAST
Repeati411 – 46151FG-GAP 4PROSITE-ProRule annotationAdd
BLAST
Repeati462 – 52766FG-GAP 5PROSITE-ProRule annotationAdd
BLAST
Repeati528 – 58659FG-GAP 6PROSITE-ProRule annotationAdd
BLAST
Repeati590 – 65061FG-GAP 7PROSITE-ProRule annotationAdd
BLAST

Domaini

The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.

Sequence similaritiesi

Belongs to the integrin alpha chain family.Curated
Contains 7 FG-GAP repeats.PROSITE-ProRule annotation
Contains 1 VWFA domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IPB8. Eukaryota.
ENOG410YTFZ. LUCA.
HOGENOMiHOG000059610.
HOVERGENiHBG006185.
InParanoidiP61622.
PhylomeDBiP61622.

Family and domain databases

InterProiIPR013519. Int_alpha_beta-p.
IPR000413. Integrin_alpha.
IPR013649. Integrin_alpha-2.
IPR032695. Integrin_dom.
IPR002035. VWF_A.
[Graphical view]
PfamiPF08441. Integrin_alpha2. 1 hit.
PF00092. VWA. 1 hit.
[Graphical view]
PRINTSiPR01185. INTEGRINA.
SMARTiSM00191. Int_alpha. 5 hits.
SM00327. VWA. 1 hit.
[Graphical view]
SUPFAMiSSF53300. SSF53300. 1 hit.
SSF69179. SSF69179. 4 hits.
PROSITEiPS51470. FG_GAP. 7 hits.
PS50234. VWFA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P61622-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDFPRGLLVA WTLSLWPGFT DTFNMDTRNP RVIAGPSAAF FGYTVQQHDI
60 70 80 90 100
SGKKWLVVGA PMETNGHQKT GDVYKCPVTQ GNCTKLNLGR VTLSNVSERK
110 120 130 140 150
DNMRLGLSLA TNPKDNSFLA CSPLWSHECG SSYYTTGMCS RANSNFRFSK
160 170 180 190 200
TVAPALQRCQ TYMDIVIVLD GSNSIYPWVE VQHFLINILK KFYIGPGQIQ
210 220 230 240 250
VGIVQYGEDA VHEFHLNDYR SVKDVVEAAS HIEQRGGTET RTAFGIEFAR
260 270 280 290 300
SEAFQKGGRK GAKKVMIVIT DGESHDSPDL EKVIRQSEKD NVTRYAVAVL
310 320 330 340 350
GYYNRRGINP ETFLNEIKYI ASDPDDKHFF NVTDEAALKD IVDALGDRIF
360 370 380 390 400
SLEGTNKNET SFGLEMSQTG FSSHVVEDGI LLGAVGAYDW NGAVLKETSA
410 420 430 440 450
GKVIPHRESY LKEFPEELKN HAAYLGYTVT SVVSSRQGRV YVAGAPRFNH
460 470 480 490 500
TGKVILFSMH NNRSLTIHQA LRGEQIGSYF GSEITSVDVN DDRVTDVLLV
510 520 530 540 550
GAPMYFSEGR ERGKVYVYNL RQNRFVYNGT LKDSHSYQNA RFGSCIASVQ
560 570 580 590 600
DLNQDSYNDV VVGAPLEDSH RGAIYIFHGF QTNILKKPMQ RITASELAPG
610 620 630 640 650
LQHFGCSIHG QLDLNEDGLV DLAVGALGNA VVLWARPVVQ INASLHFEPS
660 670 680 690 700
KINIFHKDCK RNGRDATCLA AFLCFIPIFL APHFQTATVG IRYNATMDER
710 720 730 740 750
RYMPRAHLDE GGDQFTNRAV LLSSGQEHCQ RINFHVLDTA DYVKPVAFSV
760 770 780 790 800
EYSLEDPDNG PMLDNGWPTT LRVSVPFWNG CNEDEHCVPD LVLDARSDLP
810 820 830 840 850
TAMEYCQRVL GRPAQDCSSY TLSFDTTVFI IESTRRRVAV EATLENRGEN
860 870 880 890 900
AYSAVLNISQ SENLQFASLI QKDDSDNSIE CVNEERRLHK KVCNVSYPFF
910 920 930 940 950
RAKAKVAFRL DFEFSKSVFL HHLQIHLGAG SDSHEQDSTA DDNTALLRFH
960 970 980 990 1000
LKYEADVLFT RSSSLSHFEV KANSSLESYD GIGPPFNCVF KVQNLGFFPI
1010 1020 1030 1040 1050
HGVMMKITVP IATRGGNRLL MLRDFFTDQG NTSCNIWGNS TEYRSTPTEE
1060 1070 1080 1090 1100
DLSHAPQRNH SNSDVVSIIC NLRLAPSQET SFYLVGNLWL TSLKALKYRS
1110 1120 1130 1140 1150
LKITVNAALQ RQFHSPFIFR EEDPSRQVTF EISKQEDWQV PIWIIVGSTL
1160 1170 1180
GGLLLLALLV LALWKLGFFK SAKRKREPGL GPIPKELK
Length:1,188
Mass (Da):133,012
Last modified:June 7, 2004 - v1
Checksum:i0B0313C90D65422E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC058716 mRNA. Translation: AAH58716.1.
CCDSiCCDS23265.1.
UniGeneiMm.34883.

Genome annotation databases

UCSCiuc009qal.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC058716 mRNA. Translation: AAH58716.1.
CCDSiCCDS23265.1.
UniGeneiMm.34883.

3D structure databases

ProteinModelPortaliP61622.
SMRiP61622. Positions 23-1093.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000034774.

PTM databases

iPTMnetiP61622.
PhosphoSiteiP61622.

Proteomic databases

MaxQBiP61622.
PaxDbiP61622.
PRIDEiP61622.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiuc009qal.2. mouse.

Organism-specific databases

MGIiMGI:2442114. Itga11.

Phylogenomic databases

eggNOGiENOG410IPB8. Eukaryota.
ENOG410YTFZ. LUCA.
HOGENOMiHOG000059610.
HOVERGENiHBG006185.
InParanoidiP61622.
PhylomeDBiP61622.

Miscellaneous databases

PROiP61622.
SOURCEiSearch...

Gene expression databases

CleanExiMM_ITGA11.

Family and domain databases

InterProiIPR013519. Int_alpha_beta-p.
IPR000413. Integrin_alpha.
IPR013649. Integrin_alpha-2.
IPR032695. Integrin_dom.
IPR002035. VWF_A.
[Graphical view]
PfamiPF08441. Integrin_alpha2. 1 hit.
PF00092. VWA. 1 hit.
[Graphical view]
PRINTSiPR01185. INTEGRINA.
SMARTiSM00191. Int_alpha. 5 hits.
SM00327. VWA. 1 hit.
[Graphical view]
SUPFAMiSSF53300. SSF53300. 1 hit.
SSF69179. SSF69179. 4 hits.
PROSITEiPS51470. FG_GAP. 7 hits.
PS50234. VWFA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Brain.
  2. "The mouse C2C12 myoblast cell surface N-linked glycoproteome: identification, glycosite occupancy, and membrane orientation."
    Gundry R.L., Raginski K., Tarasova Y., Tchernyshyov I., Bausch-Fluck D., Elliott S.T., Boheler K.R., Van Eyk J.E., Wollscheid B.
    Mol. Cell. Proteomics 8:2555-2569(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-331.
    Tissue: Myoblast.

Entry informationi

Entry nameiITA11_MOUSE
AccessioniPrimary (citable) accession number: P61622
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: June 7, 2004
Last modified: June 8, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.