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P61621

- S61A1_RAT

UniProt

P61621 - S61A1_RAT

Protein

Protein transport protein Sec61 subunit alpha isoform 1

Gene

Sec61a1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 79 (01 Oct 2014)
      Sequence version 2 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Plays a crucial role in the insertion of secretory and membrane polypeptides into the ER. Required for assembly of membrane and secretory proteins. Tightly associated with membrane-bound ribosomes, either directly or through adaptor proteins.

    GO - Molecular functioni

    1. ribosome binding Source: Ensembl

    GO - Biological processi

    1. cell growth Source: Ensembl
    2. endoplasmic reticulum organization Source: Ensembl
    3. posttranslational protein targeting to membrane Source: Ensembl
    4. response to interferon-gamma Source: RGD
    5. SRP-dependent cotranslational protein targeting to membrane Source: Ensembl

    Keywords - Biological processi

    Protein transport, Translocation, Transport

    Enzyme and pathway databases

    ReactomeiREACT_199197. ER-Phagosome pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein transport protein Sec61 subunit alpha isoform 1
    Short name:
    Sec61 alpha-1
    Gene namesi
    Name:Sec61a1
    Synonyms:Sec61a
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 4

    Organism-specific databases

    RGDi68321. Sec61a1.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW
    3. rough endoplasmic reticulum Source: RGD

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 476475Protein transport protein Sec61 subunit alpha isoform 1PRO_0000131794Add
    BLAST

    Proteomic databases

    PaxDbiP61621.
    PRIDEiP61621.

    Expressioni

    Gene expression databases

    GenevestigatoriP61621.

    Interactioni

    Subunit structurei

    Heterotrimeric complex composed of SEC61-alpha, SEC61-beta and SEC61-gamma.

    Protein-protein interaction databases

    IntActiP61621. 1 interaction.
    MINTiMINT-4579114.
    STRINGi10116.ENSRNOP00000018455.

    Structurei

    3D structure databases

    ProteinModelPortaliP61621.
    SMRiP61621. Positions 1-476.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini2 – 3332CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini54 – 7623LumenalSequence AnalysisAdd
    BLAST
    Topological domaini97 – 11721CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini139 – 1446LumenalSequence Analysis
    Topological domaini166 – 1727CytoplasmicSequence Analysis
    Topological domaini194 – 24047LumenalSequence AnalysisAdd
    BLAST
    Topological domaini262 – 28827CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini310 – 35445LumenalSequence AnalysisAdd
    BLAST
    Topological domaini376 – 42045CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini442 – 4454LumenalSequence Analysis
    Topological domaini463 – 47614CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei34 – 5320HelicalSequence AnalysisAdd
    BLAST
    Transmembranei77 – 9620HelicalSequence AnalysisAdd
    BLAST
    Transmembranei118 – 13821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei145 – 16521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei173 – 19321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei241 – 26121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei289 – 30921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei355 – 37521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei421 – 44121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei446 – 46217HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the SecY/SEC61-alpha family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0201.
    GeneTreeiENSGT00390000003721.
    HOGENOMiHOG000231249.
    HOVERGENiHBG055271.
    InParanoidiP61621.
    KOiK10956.
    OMAiCMELGIS.
    OrthoDBiEOG7BGHKH.
    PhylomeDBiP61621.
    TreeFamiTF300348.

    Family and domain databases

    Gene3Di1.10.3370.10. 1 hit.
    InterProiIPR002208. SecY/SEC61-alpha.
    IPR023201. SecY_su_dom.
    IPR019561. Translocon_Sec61/SecY_plug_dom.
    [Graphical view]
    PANTHERiPTHR10906. PTHR10906. 1 hit.
    PfamiPF10559. Plug_translocon. 1 hit.
    PF00344. SecY. 1 hit.
    [Graphical view]
    PIRSFiPIRSF004557. SecY. 1 hit.
    SUPFAMiSSF103491. SSF103491. 1 hit.
    TIGRFAMsiTIGR00967. 3a0501s007. 1 hit.
    PROSITEiPS00755. SECY_1. 1 hit.
    PS00756. SECY_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P61621-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAIKFLEVIK PFCVILPEIQ KPERKIQFKE KVLWTAITLF IFLVCCQIPL    50
    FGIMSSDSAD PFYWMRVILA SNRGTLMELG ISPIVTSGLI MQLLAGAKII 100
    EVGDTPKDRA LFNGAQKLFG MIITIGQSIV YVMTGMYGDP SEMGAGICLL 150
    ITIQLFVAGL IVLLLDELLQ KGYGLGSGIS LFIATNICET IVWKAFSPTT 200
    VNTGRGMEFE GAIIALFHLL ATRTDKVRAL REAFYRQNLP NLMNLIATIF 250
    VFAVVIYFQG FRVDLPIKSA RYRGQYNTYP IKLFYTSNIP IILQSALVSN 300
    LYVISQMLSA RFSGNLLVSL LGTWSDTSSG GPARAYPVGG LCYYLSPPES 350
    FGSVLEDPVH AVVYIVFMLG SCAFFSKTWI EVSGSSAKDV AKQLKEQQMV 400
    MRGHRETSMV HELNRYIPTA AAFGGLCIGA LSVLADFLGA IGSGTGILLA 450
    VTIIYQYFEI FVKEQSEVGS MGALLF 476
    Length:476
    Mass (Da):52,265
    Last modified:January 23, 2007 - v2
    Checksum:i44A9B7B37C7C82E4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M96630 mRNA. Translation: AAA42125.1.
    BC094530 mRNA. Translation: AAH94530.1.
    RefSeqiNP_954865.1. NM_199256.2.
    UniGeneiRn.47029.

    Genome annotation databases

    EnsembliENSRNOT00000018454; ENSRNOP00000018455; ENSRNOG00000013743.
    GeneIDi80843.
    KEGGirno:80843.
    UCSCiRGD:68321. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M96630 mRNA. Translation: AAA42125.1 .
    BC094530 mRNA. Translation: AAH94530.1 .
    RefSeqi NP_954865.1. NM_199256.2.
    UniGenei Rn.47029.

    3D structure databases

    ProteinModelPortali P61621.
    SMRi P61621. Positions 1-476.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P61621. 1 interaction.
    MINTi MINT-4579114.
    STRINGi 10116.ENSRNOP00000018455.

    Proteomic databases

    PaxDbi P61621.
    PRIDEi P61621.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000018454 ; ENSRNOP00000018455 ; ENSRNOG00000013743 .
    GeneIDi 80843.
    KEGGi rno:80843.
    UCSCi RGD:68321. rat.

    Organism-specific databases

    CTDi 29927.
    RGDi 68321. Sec61a1.

    Phylogenomic databases

    eggNOGi COG0201.
    GeneTreei ENSGT00390000003721.
    HOGENOMi HOG000231249.
    HOVERGENi HBG055271.
    InParanoidi P61621.
    KOi K10956.
    OMAi CMELGIS.
    OrthoDBi EOG7BGHKH.
    PhylomeDBi P61621.
    TreeFami TF300348.

    Enzyme and pathway databases

    Reactomei REACT_199197. ER-Phagosome pathway.

    Miscellaneous databases

    NextBioi 614880.
    PROi P61621.

    Gene expression databases

    Genevestigatori P61621.

    Family and domain databases

    Gene3Di 1.10.3370.10. 1 hit.
    InterProi IPR002208. SecY/SEC61-alpha.
    IPR023201. SecY_su_dom.
    IPR019561. Translocon_Sec61/SecY_plug_dom.
    [Graphical view ]
    PANTHERi PTHR10906. PTHR10906. 1 hit.
    Pfami PF10559. Plug_translocon. 1 hit.
    PF00344. SecY. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF004557. SecY. 1 hit.
    SUPFAMi SSF103491. SSF103491. 1 hit.
    TIGRFAMsi TIGR00967. 3a0501s007. 1 hit.
    PROSITEi PS00755. SECY_1. 1 hit.
    PS00756. SECY_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A mammalian homolog of SEC61p and SECYp is associated with ribosomes and nascent polypeptides during translocation."
      Goerlich D., Prehn S., Hartmann E., Kalies K.-U., Rapoport T.A.
      Cell 71:489-503(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Liver.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiS61A1_RAT
    AccessioniPrimary (citable) accession number: P61621
    Secondary accession number(s): P38378, P57726, Q505I3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 7, 2004
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 79 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3