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Protein

Protein transport protein Sec61 subunit alpha isoform 1

Gene

Sec61a1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Plays a crucial role in the insertion of secretory and membrane polypeptides into the ER. Required for assembly of membrane and secretory proteins. Tightly associated with membrane-bound ribosomes, either directly or through adaptor proteins.

GO - Molecular functioni

  1. ribosome binding Source: Ensembl

GO - Biological processi

  1. cell growth Source: Ensembl
  2. endoplasmic reticulum organization Source: Ensembl
  3. posttranslational protein targeting to membrane Source: Ensembl
  4. response to interferon-gamma Source: RGD
  5. SRP-dependent cotranslational protein targeting to membrane Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Protein transport, Translocation, Transport

Enzyme and pathway databases

ReactomeiREACT_199197. ER-Phagosome pathway.
REACT_258344. SRP-dependent cotranslational protein targeting to membrane.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein transport protein Sec61 subunit alpha isoform 1
Short name:
Sec61 alpha-1
Gene namesi
Name:Sec61a1
Synonyms:Sec61a
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 4

Organism-specific databases

RGDi68321. Sec61a1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini2 – 3332CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei34 – 5320HelicalSequence AnalysisAdd
BLAST
Topological domaini54 – 7623LumenalSequence AnalysisAdd
BLAST
Transmembranei77 – 9620HelicalSequence AnalysisAdd
BLAST
Topological domaini97 – 11721CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei118 – 13821HelicalSequence AnalysisAdd
BLAST
Topological domaini139 – 1446LumenalSequence Analysis
Transmembranei145 – 16521HelicalSequence AnalysisAdd
BLAST
Topological domaini166 – 1727CytoplasmicSequence Analysis
Transmembranei173 – 19321HelicalSequence AnalysisAdd
BLAST
Topological domaini194 – 24047LumenalSequence AnalysisAdd
BLAST
Transmembranei241 – 26121HelicalSequence AnalysisAdd
BLAST
Topological domaini262 – 28827CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei289 – 30921HelicalSequence AnalysisAdd
BLAST
Topological domaini310 – 35445LumenalSequence AnalysisAdd
BLAST
Transmembranei355 – 37521HelicalSequence AnalysisAdd
BLAST
Topological domaini376 – 42045CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei421 – 44121HelicalSequence AnalysisAdd
BLAST
Topological domaini442 – 4454LumenalSequence Analysis
Transmembranei446 – 46217HelicalSequence AnalysisAdd
BLAST
Topological domaini463 – 47614CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
  3. rough endoplasmic reticulum Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 476475Protein transport protein Sec61 subunit alpha isoform 1PRO_0000131794Add
BLAST

Proteomic databases

PaxDbiP61621.
PRIDEiP61621.

Expressioni

Gene expression databases

GenevestigatoriP61621.

Interactioni

Subunit structurei

Heterotrimeric complex composed of SEC61-alpha, SEC61-beta and SEC61-gamma.

Protein-protein interaction databases

IntActiP61621. 1 interaction.
MINTiMINT-4579114.
STRINGi10116.ENSRNOP00000018455.

Structurei

3D structure databases

ProteinModelPortaliP61621.
SMRiP61621. Positions 1-476.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SecY/SEC61-alpha family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0201.
GeneTreeiENSGT00390000003721.
HOGENOMiHOG000231249.
HOVERGENiHBG055271.
InParanoidiP61621.
KOiK10956.
OMAiWEAREGS.
OrthoDBiEOG7BGHKH.
PhylomeDBiP61621.
TreeFamiTF300348.

Family and domain databases

Gene3Di1.10.3370.10. 1 hit.
InterProiIPR002208. SecY/SEC61-alpha.
IPR023201. SecY_su_dom.
IPR019561. Translocon_Sec61/SecY_plug_dom.
[Graphical view]
PANTHERiPTHR10906. PTHR10906. 1 hit.
PfamiPF10559. Plug_translocon. 1 hit.
PF00344. SecY. 1 hit.
[Graphical view]
PIRSFiPIRSF004557. SecY. 1 hit.
SUPFAMiSSF103491. SSF103491. 1 hit.
TIGRFAMsiTIGR00967. 3a0501s007. 1 hit.
PROSITEiPS00755. SECY_1. 1 hit.
PS00756. SECY_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P61621-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAIKFLEVIK PFCVILPEIQ KPERKIQFKE KVLWTAITLF IFLVCCQIPL
60 70 80 90 100
FGIMSSDSAD PFYWMRVILA SNRGTLMELG ISPIVTSGLI MQLLAGAKII
110 120 130 140 150
EVGDTPKDRA LFNGAQKLFG MIITIGQSIV YVMTGMYGDP SEMGAGICLL
160 170 180 190 200
ITIQLFVAGL IVLLLDELLQ KGYGLGSGIS LFIATNICET IVWKAFSPTT
210 220 230 240 250
VNTGRGMEFE GAIIALFHLL ATRTDKVRAL REAFYRQNLP NLMNLIATIF
260 270 280 290 300
VFAVVIYFQG FRVDLPIKSA RYRGQYNTYP IKLFYTSNIP IILQSALVSN
310 320 330 340 350
LYVISQMLSA RFSGNLLVSL LGTWSDTSSG GPARAYPVGG LCYYLSPPES
360 370 380 390 400
FGSVLEDPVH AVVYIVFMLG SCAFFSKTWI EVSGSSAKDV AKQLKEQQMV
410 420 430 440 450
MRGHRETSMV HELNRYIPTA AAFGGLCIGA LSVLADFLGA IGSGTGILLA
460 470
VTIIYQYFEI FVKEQSEVGS MGALLF
Length:476
Mass (Da):52,265
Last modified:January 23, 2007 - v2
Checksum:i44A9B7B37C7C82E4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M96630 mRNA. Translation: AAA42125.1.
BC094530 mRNA. Translation: AAH94530.1.
RefSeqiNP_954865.1. NM_199256.2.
UniGeneiRn.47029.

Genome annotation databases

EnsembliENSRNOT00000018454; ENSRNOP00000018455; ENSRNOG00000013743.
GeneIDi80843.
KEGGirno:80843.
UCSCiRGD:68321. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M96630 mRNA. Translation: AAA42125.1.
BC094530 mRNA. Translation: AAH94530.1.
RefSeqiNP_954865.1. NM_199256.2.
UniGeneiRn.47029.

3D structure databases

ProteinModelPortaliP61621.
SMRiP61621. Positions 1-476.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP61621. 1 interaction.
MINTiMINT-4579114.
STRINGi10116.ENSRNOP00000018455.

Proteomic databases

PaxDbiP61621.
PRIDEiP61621.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000018454; ENSRNOP00000018455; ENSRNOG00000013743.
GeneIDi80843.
KEGGirno:80843.
UCSCiRGD:68321. rat.

Organism-specific databases

CTDi29927.
RGDi68321. Sec61a1.

Phylogenomic databases

eggNOGiCOG0201.
GeneTreeiENSGT00390000003721.
HOGENOMiHOG000231249.
HOVERGENiHBG055271.
InParanoidiP61621.
KOiK10956.
OMAiWEAREGS.
OrthoDBiEOG7BGHKH.
PhylomeDBiP61621.
TreeFamiTF300348.

Enzyme and pathway databases

ReactomeiREACT_199197. ER-Phagosome pathway.
REACT_258344. SRP-dependent cotranslational protein targeting to membrane.

Miscellaneous databases

NextBioi614880.
PROiP61621.

Gene expression databases

GenevestigatoriP61621.

Family and domain databases

Gene3Di1.10.3370.10. 1 hit.
InterProiIPR002208. SecY/SEC61-alpha.
IPR023201. SecY_su_dom.
IPR019561. Translocon_Sec61/SecY_plug_dom.
[Graphical view]
PANTHERiPTHR10906. PTHR10906. 1 hit.
PfamiPF10559. Plug_translocon. 1 hit.
PF00344. SecY. 1 hit.
[Graphical view]
PIRSFiPIRSF004557. SecY. 1 hit.
SUPFAMiSSF103491. SSF103491. 1 hit.
TIGRFAMsiTIGR00967. 3a0501s007. 1 hit.
PROSITEiPS00755. SECY_1. 1 hit.
PS00756. SECY_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A mammalian homolog of SEC61p and SECYp is associated with ribosomes and nascent polypeptides during translocation."
    Goerlich D., Prehn S., Hartmann E., Kalies K.-U., Rapoport T.A.
    Cell 71:489-503(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiS61A1_RAT
AccessioniPrimary (citable) accession number: P61621
Secondary accession number(s): P38378, P57726, Q505I3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: January 23, 2007
Last modified: March 4, 2015
This is version 83 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.