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Protein

Protein transport protein Sec61 subunit alpha isoform 1

Gene

Sec61a1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Plays a crucial role in the insertion of secretory and membrane polypeptides into the ER. Required for assembly of membrane and secretory proteins. Tightly associated with membrane-bound ribosomes, either directly or through adapter proteins. Plays a role in pronephric kidney tubule development (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processProtein transport, Translocation, Transport

Enzyme and pathway databases

ReactomeiR-RNO-381038. XBP1(S) activates chaperone genes.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein transport protein Sec61 subunit alpha isoform 1
Short name:
Sec61 alpha-1
Gene namesi
Name:Sec61a1
Synonyms:Sec61a
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi68321. Sec61a1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 33CytoplasmicSequence analysisAdd BLAST33
Transmembranei34 – 53HelicalSequence analysisAdd BLAST20
Topological domaini54 – 76LumenalSequence analysisAdd BLAST23
Transmembranei77 – 96HelicalSequence analysisAdd BLAST20
Topological domaini97 – 117CytoplasmicSequence analysisAdd BLAST21
Transmembranei118 – 138HelicalSequence analysisAdd BLAST21
Topological domaini139 – 144LumenalSequence analysis6
Transmembranei145 – 165HelicalSequence analysisAdd BLAST21
Topological domaini166 – 172CytoplasmicSequence analysis7
Transmembranei173 – 193HelicalSequence analysisAdd BLAST21
Topological domaini194 – 240LumenalSequence analysisAdd BLAST47
Transmembranei241 – 261HelicalSequence analysisAdd BLAST21
Topological domaini262 – 288CytoplasmicSequence analysisAdd BLAST27
Transmembranei289 – 309HelicalSequence analysisAdd BLAST21
Topological domaini310 – 354LumenalSequence analysisAdd BLAST45
Transmembranei355 – 375HelicalSequence analysisAdd BLAST21
Topological domaini376 – 420CytoplasmicSequence analysisAdd BLAST45
Transmembranei421 – 441HelicalSequence analysisAdd BLAST21
Topological domaini442 – 445LumenalSequence analysis4
Transmembranei446 – 462HelicalSequence analysisAdd BLAST17
Topological domaini463 – 476CytoplasmicSequence analysisAdd BLAST14

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001317941 – 476Protein transport protein Sec61 subunit alpha isoform 1Add BLAST476

Proteomic databases

PaxDbiP61621.
PRIDEiP61621.

PTM databases

iPTMnetiP61621.
PhosphoSitePlusiP61621.

Expressioni

Gene expression databases

BgeeiENSRNOG00000013743.
GenevisibleiP61621. RN.

Interactioni

Subunit structurei

Heterotrimeric complex composed of SEC61-alpha, SEC61-beta and SEC61-gamma.

Protein-protein interaction databases

IntActiP61621. 2 interactors.
MINTiMINT-4579114.
STRINGi10116.ENSRNOP00000018455.

Structurei

3D structure databases

ProteinModelPortaliP61621.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SecY/SEC61-alpha family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1373. Eukaryota.
COG0201. LUCA.
GeneTreeiENSGT00390000003721.
HOGENOMiHOG000231249.
HOVERGENiHBG055271.
InParanoidiP61621.
KOiK10956.
OMAiKWGIGSG.
OrthoDBiEOG091G05FO.
PhylomeDBiP61621.
TreeFamiTF300348.

Family and domain databases

Gene3Di1.10.3370.10. 1 hit.
InterProiView protein in InterPro
IPR002208. SecY/SEC61-alpha.
IPR030659. SecY_CS.
IPR023201. SecY_su_dom.
IPR019561. Translocon_Sec61/SecY_plug_dom.
PANTHERiPTHR10906. PTHR10906. 1 hit.
PfamiView protein in Pfam
PF10559. Plug_translocon. 1 hit.
PF00344. SecY. 1 hit.
PIRSFiPIRSF004557. SecY. 1 hit.
SUPFAMiSSF103491. SSF103491. 1 hit.
TIGRFAMsiTIGR00967. 3a0501s007. 1 hit.
PROSITEiView protein in PROSITE
PS00755. SECY_1. 1 hit.
PS00756. SECY_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P61621-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAIKFLEVIK PFCVILPEIQ KPERKIQFKE KVLWTAITLF IFLVCCQIPL
60 70 80 90 100
FGIMSSDSAD PFYWMRVILA SNRGTLMELG ISPIVTSGLI MQLLAGAKII
110 120 130 140 150
EVGDTPKDRA LFNGAQKLFG MIITIGQSIV YVMTGMYGDP SEMGAGICLL
160 170 180 190 200
ITIQLFVAGL IVLLLDELLQ KGYGLGSGIS LFIATNICET IVWKAFSPTT
210 220 230 240 250
VNTGRGMEFE GAIIALFHLL ATRTDKVRAL REAFYRQNLP NLMNLIATIF
260 270 280 290 300
VFAVVIYFQG FRVDLPIKSA RYRGQYNTYP IKLFYTSNIP IILQSALVSN
310 320 330 340 350
LYVISQMLSA RFSGNLLVSL LGTWSDTSSG GPARAYPVGG LCYYLSPPES
360 370 380 390 400
FGSVLEDPVH AVVYIVFMLG SCAFFSKTWI EVSGSSAKDV AKQLKEQQMV
410 420 430 440 450
MRGHRETSMV HELNRYIPTA AAFGGLCIGA LSVLADFLGA IGSGTGILLA
460 470
VTIIYQYFEI FVKEQSEVGS MGALLF
Length:476
Mass (Da):52,265
Last modified:January 23, 2007 - v2
Checksum:i44A9B7B37C7C82E4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M96630 mRNA. Translation: AAA42125.1.
BC094530 mRNA. Translation: AAH94530.1.
RefSeqiNP_954865.1. NM_199256.2.
UniGeneiRn.47029.

Genome annotation databases

EnsembliENSRNOT00000018454; ENSRNOP00000018455; ENSRNOG00000013743.
GeneIDi80843.
KEGGirno:80843.
UCSCiRGD:68321. rat.

Similar proteinsi

Entry informationi

Entry nameiS61A1_RAT
AccessioniPrimary (citable) accession number: P61621
Secondary accession number(s): P38378, P57726, Q505I3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: January 23, 2007
Last modified: October 25, 2017
This is version 102 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families