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P61621 (S61A1_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Protein transport protein Sec61 subunit alpha isoform 1
Short name=Sec61 alpha-1
Gene names
Name:Sec61a1
Synonyms:Sec61a
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length476 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Plays a crucial role in the insertion of secretory and membrane polypeptides into the ER. Required for assembly of membrane and secretory proteins. Tightly associated with membrane-bound ribosomes, either directly or through adaptor proteins.

Subunit structure

Heterotrimeric complex composed of SEC61-alpha, SEC61-beta and SEC61-gamma.

Subcellular location

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the SecY/SEC61-alpha family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 476475Protein transport protein Sec61 subunit alpha isoform 1
PRO_0000131794

Regions

Topological domain2 – 3332Cytoplasmic Potential
Transmembrane34 – 5320Helical; Potential
Topological domain54 – 7623Lumenal Potential
Transmembrane77 – 9620Helical; Potential
Topological domain97 – 11721Cytoplasmic Potential
Transmembrane118 – 13821Helical; Potential
Topological domain139 – 1446Lumenal Potential
Transmembrane145 – 16521Helical; Potential
Topological domain166 – 1727Cytoplasmic Potential
Transmembrane173 – 19321Helical; Potential
Topological domain194 – 24047Lumenal Potential
Transmembrane241 – 26121Helical; Potential
Topological domain262 – 28827Cytoplasmic Potential
Transmembrane289 – 30921Helical; Potential
Topological domain310 – 35445Lumenal Potential
Transmembrane355 – 37521Helical; Potential
Topological domain376 – 42045Cytoplasmic Potential
Transmembrane421 – 44121Helical; Potential
Topological domain442 – 4454Lumenal Potential
Transmembrane446 – 46217Helical; Potential
Topological domain463 – 47614Cytoplasmic Potential

Sequences

Sequence LengthMass (Da)Tools
P61621 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: 44A9B7B37C7C82E4

FASTA47652,265
        10         20         30         40         50         60 
MAIKFLEVIK PFCVILPEIQ KPERKIQFKE KVLWTAITLF IFLVCCQIPL FGIMSSDSAD 

        70         80         90        100        110        120 
PFYWMRVILA SNRGTLMELG ISPIVTSGLI MQLLAGAKII EVGDTPKDRA LFNGAQKLFG 

       130        140        150        160        170        180 
MIITIGQSIV YVMTGMYGDP SEMGAGICLL ITIQLFVAGL IVLLLDELLQ KGYGLGSGIS 

       190        200        210        220        230        240 
LFIATNICET IVWKAFSPTT VNTGRGMEFE GAIIALFHLL ATRTDKVRAL REAFYRQNLP 

       250        260        270        280        290        300 
NLMNLIATIF VFAVVIYFQG FRVDLPIKSA RYRGQYNTYP IKLFYTSNIP IILQSALVSN 

       310        320        330        340        350        360 
LYVISQMLSA RFSGNLLVSL LGTWSDTSSG GPARAYPVGG LCYYLSPPES FGSVLEDPVH 

       370        380        390        400        410        420 
AVVYIVFMLG SCAFFSKTWI EVSGSSAKDV AKQLKEQQMV MRGHRETSMV HELNRYIPTA 

       430        440        450        460        470 
AAFGGLCIGA LSVLADFLGA IGSGTGILLA VTIIYQYFEI FVKEQSEVGS MGALLF

« Hide

References

« Hide 'large scale' references
[1]"A mammalian homolog of SEC61p and SECYp is associated with ribosomes and nascent polypeptides during translocation."
Goerlich D., Prehn S., Hartmann E., Kalies K.-U., Rapoport T.A.
Cell 71:489-503(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Liver.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		M96630 mRNA. Translation: AAA42125.1.
BC094530 mRNA. Translation: AAH94530.1.
IPIIPI00231341.
RefSeqNP_954865.1. NM_199256.2.
UniGeneRn.47029.

3D structure databases

ProteinModelPortalP61621.
ModBaseSearch...

Protein-protein interaction databases

IntActP61621. 1 interaction.
STRING10116.ENSRNOP00000018455.

Proteomic databases

PaxDbP61621.
PRIDEP61621.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000018454; ENSRNOP00000018455; ENSRNOG00000013743.
GeneID80843.
KEGGrno:80843.
UCSCRGD:68321. rat.

Organism-specific databases

CTD29927.
RGD68321. Sec61a1.

Phylogenomic databases

eggNOGCOG0201.
GeneTreeENSGT00390000003721.
HOGENOMHOG000231249.
HOVERGENHBG055271.
InParanoidP61621.
KOK10956.
OrthoDBEOG4HHP26.

Gene expression databases

GenevestigatorP61621.
GermOnlineENSRNOG00000013743. Rattus norvegicus.

Family and domain databases

Gene3D1.10.3370.10. 1 hit.
InterProIPR002208. SecY/SEC61-alpha.
IPR023201. SecY_su_dom.
IPR019561. Translocon_Sec61/SecY_plug_dom.
[Graphical view]
PANTHERPTHR10906. PTHR10906. 1 hit.
PfamPF10559. Plug_translocon. 1 hit.
PF00344. SecY. 1 hit.
[Graphical view]
PIRSFPIRSF004557. SecY. 1 hit.
SUPFAMSSF103491. SecY. 1 hit.
TIGRFAMsTIGR00967. 3a0501s007. 1 hit.
PROSITEPS00755. SECY_1. 1 hit.
PS00756. SECY_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio614880.

Entry information

Entry nameS61A1_RAT
AccessionPrimary (citable) accession number: P61621
Secondary accession number(s): P38378, P57726, Q505I3
Entry history
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: January 23, 2007
Last modified: May 1, 2013
This is version 69 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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