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P61619

- S61A1_HUMAN

UniProt

P61619 - S61A1_HUMAN

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Protein

Protein transport protein Sec61 subunit alpha isoform 1

Gene

SEC61A1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Plays a crucial role in the insertion of secretory and membrane polypeptides into the ER. Required for assembly of membrane and secretory proteins. Tightly associated with membrane-bound ribosomes, either directly or through adapter proteins.

GO - Molecular functioni

  1. ribosome binding Source: UniProtKB

GO - Biological processi

  1. antigen processing and presentation of exogenous peptide antigen via MHC class I Source: Reactome
  2. antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent Source: Reactome
  3. antigen processing and presentation of peptide antigen via MHC class I Source: Reactome
  4. cell growth Source: MGI
  5. endoplasmic reticulum organization Source: MGI
  6. posttranslational protein targeting to membrane Source: MGI
  7. protein targeting to ER Source: UniProtKB
  8. response to interferon-gamma Source: Ensembl
  9. SRP-dependent cotranslational protein targeting to membrane Source: MGI
Complete GO annotation...

Keywords - Biological processi

Protein transport, Translocation, Transport

Enzyme and pathway databases

ReactomeiREACT_111178. ER-Phagosome pathway.
REACT_115902. SRP-dependent cotranslational protein targeting to membrane.

Protein family/group databases

TCDBi3.A.5.9.1. the general secretory pathway (sec) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein transport protein Sec61 subunit alpha isoform 1
Short name:
Sec61 alpha-1
Gene namesi
Name:SEC61A1
Synonyms:SEC61A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:18276. SEC61A1.

Subcellular locationi

GO - Cellular componenti

  1. integral component of endoplasmic reticulum membrane Source: UniProtKB
  2. membrane Source: MGI
  3. rough endoplasmic reticulum Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134901772.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 476475Protein transport protein Sec61 subunit alpha isoform 1PRO_0000131791Add
BLAST

Proteomic databases

MaxQBiP61619.
PaxDbiP61619.
PeptideAtlasiP61619.
PRIDEiP61619.

PTM databases

PhosphoSiteiP61619.

Expressioni

Gene expression databases

BgeeiP61619.
ExpressionAtlasiP61619. baseline and differential.
GenevestigatoriP61619.

Organism-specific databases

HPAiCAB022076.
HPA045070.

Interactioni

Subunit structurei

Heterotrimeric complex composed of SEC61-alpha, SEC61-beta and SEC61-gamma.

Binary interactionsi

WithEntry#Exp.IntActNotes
CANXP278243EBI-358919,EBI-355947
HSPA5P110213EBI-358919,EBI-354921

Protein-protein interaction databases

BioGridi118968. 27 interactions.
IntActiP61619. 18 interactions.
MINTiMINT-1133988.

Structurei

3D structure databases

ProteinModelPortaliP61619.
SMRiP61619. Positions 1-476.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini2 – 3332CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini54 – 7623LumenalSequence AnalysisAdd
BLAST
Topological domaini97 – 11721CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini139 – 1446LumenalSequence Analysis
Topological domaini166 – 1727CytoplasmicSequence Analysis
Topological domaini194 – 24047LumenalSequence AnalysisAdd
BLAST
Topological domaini262 – 28827CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini310 – 35445LumenalSequence AnalysisAdd
BLAST
Topological domaini376 – 42045CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini442 – 4454LumenalSequence Analysis
Topological domaini463 – 47614CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei34 – 5320HelicalSequence AnalysisAdd
BLAST
Transmembranei77 – 9620HelicalSequence AnalysisAdd
BLAST
Transmembranei118 – 13821HelicalSequence AnalysisAdd
BLAST
Transmembranei145 – 16521HelicalSequence AnalysisAdd
BLAST
Transmembranei173 – 19321HelicalSequence AnalysisAdd
BLAST
Transmembranei241 – 26121HelicalSequence AnalysisAdd
BLAST
Transmembranei289 – 30921HelicalSequence AnalysisAdd
BLAST
Transmembranei355 – 37521HelicalSequence AnalysisAdd
BLAST
Transmembranei421 – 44121HelicalSequence AnalysisAdd
BLAST
Transmembranei446 – 46217HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the SecY/SEC61-alpha family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0201.
GeneTreeiENSGT00390000003721.
HOVERGENiHBG055271.
InParanoidiP61619.
KOiK10956.
PhylomeDBiP61619.
TreeFamiTF300348.

Family and domain databases

Gene3Di1.10.3370.10. 1 hit.
InterProiIPR002208. SecY/SEC61-alpha.
IPR023201. SecY_su_dom.
IPR019561. Translocon_Sec61/SecY_plug_dom.
[Graphical view]
PANTHERiPTHR10906. PTHR10906. 1 hit.
PfamiPF10559. Plug_translocon. 1 hit.
PF00344. SecY. 1 hit.
[Graphical view]
PIRSFiPIRSF004557. SecY. 1 hit.
SUPFAMiSSF103491. SSF103491. 1 hit.
TIGRFAMsiTIGR00967. 3a0501s007. 1 hit.
PROSITEiPS00755. SECY_1. 1 hit.
PS00756. SECY_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P61619-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAIKFLEVIK PFCVILPEIQ KPERKIQFKE KVLWTAITLF IFLVCCQIPL
60 70 80 90 100
FGIMSSDSAD PFYWMRVILA SNRGTLMELG ISPIVTSGLI MQLLAGAKII
110 120 130 140 150
EVGDTPKDRA LFNGAQKLFG MIITIGQSIV YVMTGMYGDP SEMGAGICLL
160 170 180 190 200
ITIQLFVAGL IVLLLDELLQ KGYGLGSGIS LFIATNICET IVWKAFSPTT
210 220 230 240 250
VNTGRGMEFE GAIIALFHLL ATRTDKVRAL REAFYRQNLP NLMNLIATIF
260 270 280 290 300
VFAVVIYFQG FRVDLPIKSA RYRGQYNTYP IKLFYTSNIP IILQSALVSN
310 320 330 340 350
LYVISQMLSA RFSGNLLVSL LGTWSDTSSG GPARAYPVGG LCYYLSPPES
360 370 380 390 400
FGSVLEDPVH AVVYIVFMLG SCAFFSKTWI EVSGSSAKDV AKQLKEQQMV
410 420 430 440 450
MRGHRETSMV HELNRYIPTA AAFGGLCIGA LSVLADFLGA IGSGTGILLA
460 470
VTIIYQYFEI FVKEQSEVGS MGALLF
Length:476
Mass (Da):52,265
Last modified:January 23, 2007 - v2
Checksum:i44A9B7B37C7C82E4
GO
Isoform 3 (identifier: P61619-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     2-120: Missing.

Note: No experimental confirmation available.

Show »
Length:357
Mass (Da):38,980
Checksum:iA3C282498CE920DF
GO

Sequence cautioni

The sequence BAC11283.1 differs from that shown. Reason: Erroneous initiation.
The sequence BAC11434.1 differs from that shown. Reason: Erroneous initiation.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti135 – 1351G → W in AAD27765. 1 PublicationCurated
Sequence conflicti234 – 2341F → L in BAC11298. (PubMed:14702039)Curated
Sequence conflicti278 – 2781T → S in AAD27765. 1 PublicationCurated
Sequence conflicti310 – 3101A → V in AAD27765. 1 PublicationCurated
Sequence conflicti316 – 3161L → F in AAD27765. 1 PublicationCurated
Sequence conflicti319 – 3191S → N in AAD27765. 1 PublicationCurated
Sequence conflicti323 – 3297TWSDTSS → QWADVSG in AAD27765. 1 PublicationCurated
Sequence conflicti335 – 3351A → S in AAD27765. 1 PublicationCurated
Sequence conflicti351 – 3555FGSVL → MGAIF in AAD27765. 1 PublicationCurated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei2 – 120119Missing in isoform 3. 1 PublicationVSP_013747Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF077032 mRNA. Translation: AAD27765.1.
AF084458 mRNA. Translation: AAD39847.1.
AF346602 mRNA. Translation: AAK29083.1.
AK074907 mRNA. Translation: BAC11283.1. Different initiation.
AK074928 mRNA. Translation: BAC11298.1.
AK075148 mRNA. Translation: BAC11434.1. Different initiation.
AL831940 mRNA. Translation: CAD38592.1.
AL832821 mRNA. Translation: CAI46127.1.
CCDSiCCDS3046.1. [P61619-1]
RefSeqiNP_037468.1. NM_013336.3. [P61619-1]
UniGeneiHs.518236.

Genome annotation databases

EnsembliENST00000243253; ENSP00000243253; ENSG00000058262. [P61619-1]
GeneIDi29927.
KEGGihsa:29927.
UCSCiuc003ekb.3. human. [P61619-1]

Polymorphism databases

DMDMi48429109.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF077032 mRNA. Translation: AAD27765.1 .
AF084458 mRNA. Translation: AAD39847.1 .
AF346602 mRNA. Translation: AAK29083.1 .
AK074907 mRNA. Translation: BAC11283.1 . Different initiation.
AK074928 mRNA. Translation: BAC11298.1 .
AK075148 mRNA. Translation: BAC11434.1 . Different initiation.
AL831940 mRNA. Translation: CAD38592.1 .
AL832821 mRNA. Translation: CAI46127.1 .
CCDSi CCDS3046.1. [P61619-1 ]
RefSeqi NP_037468.1. NM_013336.3. [P61619-1 ]
UniGenei Hs.518236.

3D structure databases

ProteinModelPortali P61619.
SMRi P61619. Positions 1-476.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 118968. 27 interactions.
IntActi P61619. 18 interactions.
MINTi MINT-1133988.

Protein family/group databases

TCDBi 3.A.5.9.1. the general secretory pathway (sec) family.

PTM databases

PhosphoSitei P61619.

Polymorphism databases

DMDMi 48429109.

Proteomic databases

MaxQBi P61619.
PaxDbi P61619.
PeptideAtlasi P61619.
PRIDEi P61619.

Protocols and materials databases

DNASUi 29927.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000243253 ; ENSP00000243253 ; ENSG00000058262 . [P61619-1 ]
GeneIDi 29927.
KEGGi hsa:29927.
UCSCi uc003ekb.3. human. [P61619-1 ]

Organism-specific databases

CTDi 29927.
GeneCardsi GC03P127770.
HGNCi HGNC:18276. SEC61A1.
HPAi CAB022076.
HPA045070.
MIMi 609213. gene.
neXtProti NX_P61619.
PharmGKBi PA134901772.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0201.
GeneTreei ENSGT00390000003721.
HOVERGENi HBG055271.
InParanoidi P61619.
KOi K10956.
PhylomeDBi P61619.
TreeFami TF300348.

Enzyme and pathway databases

Reactomei REACT_111178. ER-Phagosome pathway.
REACT_115902. SRP-dependent cotranslational protein targeting to membrane.

Miscellaneous databases

ChiTaRSi SEC61A1. human.
GeneWikii Sec61_alpha_1.
GenomeRNAii 29927.
NextBioi 52551.
PROi P61619.
SOURCEi Search...

Gene expression databases

Bgeei P61619.
ExpressionAtlasi P61619. baseline and differential.
Genevestigatori P61619.

Family and domain databases

Gene3Di 1.10.3370.10. 1 hit.
InterProi IPR002208. SecY/SEC61-alpha.
IPR023201. SecY_su_dom.
IPR019561. Translocon_Sec61/SecY_plug_dom.
[Graphical view ]
PANTHERi PTHR10906. PTHR10906. 1 hit.
Pfami PF10559. Plug_translocon. 1 hit.
PF00344. SecY. 1 hit.
[Graphical view ]
PIRSFi PIRSF004557. SecY. 1 hit.
SUPFAMi SSF103491. SSF103491. 1 hit.
TIGRFAMsi TIGR00967. 3a0501s007. 1 hit.
PROSITEi PS00755. SECY_1. 1 hit.
PS00756. SECY_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Human sec61 homolog gene."
    Liu T., Zhang J., Ye M., Zhang Q., Fu G., Zhou J., Wu J., Shen Y., Yu M., Chen S., Mao M., Chen Z.
    Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Human sec61 homolog gene mRNA sequence."
    Li W., Liu T., Fu G., Zhang Q., Ye M., Zhou J., Wu J., Shen Y., Yu M., Chen S., Mao M., Chen Z.
    Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  3. "Sec61 alpha isoforms."
    Finke K., Prehn S., Hartmann E.
    Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Placenta and Teratocarcinoma.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Bone marrow and Lymph node.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiS61A1_HUMAN
AccessioniPrimary (citable) accession number: P61619
Secondary accession number(s): P38378
, P57726, Q5JPF8, Q8N0Z4, Q8N3U3, Q8NC71, Q9BU16, Q9Y2R3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3