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P61619

- S61A1_HUMAN

UniProt

P61619 - S61A1_HUMAN

Protein

Protein transport protein Sec61 subunit alpha isoform 1

Gene

SEC61A1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 107 (01 Oct 2014)
      Sequence version 2 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Plays a crucial role in the insertion of secretory and membrane polypeptides into the ER. Required for assembly of membrane and secretory proteins. Tightly associated with membrane-bound ribosomes, either directly or through adapter proteins.

    GO - Molecular functioni

    1. protein binding Source: IntAct
    2. ribosome binding Source: UniProtKB

    GO - Biological processi

    1. antigen processing and presentation of exogenous peptide antigen via MHC class I Source: Reactome
    2. antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent Source: Reactome
    3. antigen processing and presentation of peptide antigen via MHC class I Source: Reactome
    4. cell growth Source: MGI
    5. endoplasmic reticulum organization Source: MGI
    6. posttranslational protein targeting to membrane Source: MGI
    7. protein targeting to ER Source: UniProtKB
    8. response to interferon-gamma Source: Ensembl
    9. SRP-dependent cotranslational protein targeting to membrane Source: MGI

    Keywords - Biological processi

    Protein transport, Translocation, Transport

    Enzyme and pathway databases

    ReactomeiREACT_111178. ER-Phagosome pathway.
    REACT_115902. SRP-dependent cotranslational protein targeting to membrane.

    Protein family/group databases

    TCDBi3.A.5.9.1. the general secretory pathway (sec) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein transport protein Sec61 subunit alpha isoform 1
    Short name:
    Sec61 alpha-1
    Gene namesi
    Name:SEC61A1
    Synonyms:SEC61A
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:18276. SEC61A1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of endoplasmic reticulum membrane Source: UniProtKB
    2. membrane Source: MGI
    3. rough endoplasmic reticulum Source: Ensembl

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134901772.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 476475Protein transport protein Sec61 subunit alpha isoform 1PRO_0000131791Add
    BLAST

    Proteomic databases

    MaxQBiP61619.
    PaxDbiP61619.
    PeptideAtlasiP61619.
    PRIDEiP61619.

    PTM databases

    PhosphoSiteiP61619.

    Expressioni

    Gene expression databases

    ArrayExpressiP61619.
    BgeeiP61619.
    GenevestigatoriP61619.

    Organism-specific databases

    HPAiCAB022076.
    HPA045070.

    Interactioni

    Subunit structurei

    Heterotrimeric complex composed of SEC61-alpha, SEC61-beta and SEC61-gamma.

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    CANXP278243EBI-358919,EBI-355947
    HSPA5P110213EBI-358919,EBI-354921

    Protein-protein interaction databases

    BioGridi118968. 26 interactions.
    IntActiP61619. 18 interactions.
    MINTiMINT-1133988.

    Structurei

    3D structure databases

    ProteinModelPortaliP61619.
    SMRiP61619. Positions 1-476.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini2 – 3332CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini54 – 7623LumenalSequence AnalysisAdd
    BLAST
    Topological domaini97 – 11721CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini139 – 1446LumenalSequence Analysis
    Topological domaini166 – 1727CytoplasmicSequence Analysis
    Topological domaini194 – 24047LumenalSequence AnalysisAdd
    BLAST
    Topological domaini262 – 28827CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini310 – 35445LumenalSequence AnalysisAdd
    BLAST
    Topological domaini376 – 42045CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini442 – 4454LumenalSequence Analysis
    Topological domaini463 – 47614CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei34 – 5320HelicalSequence AnalysisAdd
    BLAST
    Transmembranei77 – 9620HelicalSequence AnalysisAdd
    BLAST
    Transmembranei118 – 13821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei145 – 16521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei173 – 19321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei241 – 26121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei289 – 30921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei355 – 37521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei421 – 44121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei446 – 46217HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the SecY/SEC61-alpha family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0201.
    HOVERGENiHBG055271.
    InParanoidiP61619.
    KOiK10956.
    PhylomeDBiP61619.
    TreeFamiTF300348.

    Family and domain databases

    Gene3Di1.10.3370.10. 1 hit.
    InterProiIPR002208. SecY/SEC61-alpha.
    IPR023201. SecY_su_dom.
    IPR019561. Translocon_Sec61/SecY_plug_dom.
    [Graphical view]
    PANTHERiPTHR10906. PTHR10906. 1 hit.
    PfamiPF10559. Plug_translocon. 1 hit.
    PF00344. SecY. 1 hit.
    [Graphical view]
    PIRSFiPIRSF004557. SecY. 1 hit.
    SUPFAMiSSF103491. SSF103491. 1 hit.
    TIGRFAMsiTIGR00967. 3a0501s007. 1 hit.
    PROSITEiPS00755. SECY_1. 1 hit.
    PS00756. SECY_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P61619-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAIKFLEVIK PFCVILPEIQ KPERKIQFKE KVLWTAITLF IFLVCCQIPL    50
    FGIMSSDSAD PFYWMRVILA SNRGTLMELG ISPIVTSGLI MQLLAGAKII 100
    EVGDTPKDRA LFNGAQKLFG MIITIGQSIV YVMTGMYGDP SEMGAGICLL 150
    ITIQLFVAGL IVLLLDELLQ KGYGLGSGIS LFIATNICET IVWKAFSPTT 200
    VNTGRGMEFE GAIIALFHLL ATRTDKVRAL REAFYRQNLP NLMNLIATIF 250
    VFAVVIYFQG FRVDLPIKSA RYRGQYNTYP IKLFYTSNIP IILQSALVSN 300
    LYVISQMLSA RFSGNLLVSL LGTWSDTSSG GPARAYPVGG LCYYLSPPES 350
    FGSVLEDPVH AVVYIVFMLG SCAFFSKTWI EVSGSSAKDV AKQLKEQQMV 400
    MRGHRETSMV HELNRYIPTA AAFGGLCIGA LSVLADFLGA IGSGTGILLA 450
    VTIIYQYFEI FVKEQSEVGS MGALLF 476
    Length:476
    Mass (Da):52,265
    Last modified:January 23, 2007 - v2
    Checksum:i44A9B7B37C7C82E4
    GO
    Isoform 3 (identifier: P61619-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         2-120: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:357
    Mass (Da):38,980
    Checksum:iA3C282498CE920DF
    GO

    Sequence cautioni

    The sequence BAC11283.1 differs from that shown. Reason: Erroneous initiation.
    The sequence BAC11434.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti135 – 1351G → W in AAD27765. 1 PublicationCurated
    Sequence conflicti234 – 2341F → L in BAC11298. (PubMed:14702039)Curated
    Sequence conflicti278 – 2781T → S in AAD27765. 1 PublicationCurated
    Sequence conflicti310 – 3101A → V in AAD27765. 1 PublicationCurated
    Sequence conflicti316 – 3161L → F in AAD27765. 1 PublicationCurated
    Sequence conflicti319 – 3191S → N in AAD27765. 1 PublicationCurated
    Sequence conflicti323 – 3297TWSDTSS → QWADVSG in AAD27765. 1 PublicationCurated
    Sequence conflicti335 – 3351A → S in AAD27765. 1 PublicationCurated
    Sequence conflicti351 – 3555FGSVL → MGAIF in AAD27765. 1 PublicationCurated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei2 – 120119Missing in isoform 3. 1 PublicationVSP_013747Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF077032 mRNA. Translation: AAD27765.1.
    AF084458 mRNA. Translation: AAD39847.1.
    AF346602 mRNA. Translation: AAK29083.1.
    AK074907 mRNA. Translation: BAC11283.1. Different initiation.
    AK074928 mRNA. Translation: BAC11298.1.
    AK075148 mRNA. Translation: BAC11434.1. Different initiation.
    AL831940 mRNA. Translation: CAD38592.1.
    AL832821 mRNA. Translation: CAI46127.1.
    CCDSiCCDS3046.1. [P61619-1]
    RefSeqiNP_037468.1. NM_013336.3. [P61619-1]
    UniGeneiHs.518236.

    Genome annotation databases

    EnsembliENST00000243253; ENSP00000243253; ENSG00000058262. [P61619-1]
    GeneIDi29927.
    KEGGihsa:29927.
    UCSCiuc003ekb.3. human. [P61619-1]

    Polymorphism databases

    DMDMi48429109.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF077032 mRNA. Translation: AAD27765.1 .
    AF084458 mRNA. Translation: AAD39847.1 .
    AF346602 mRNA. Translation: AAK29083.1 .
    AK074907 mRNA. Translation: BAC11283.1 . Different initiation.
    AK074928 mRNA. Translation: BAC11298.1 .
    AK075148 mRNA. Translation: BAC11434.1 . Different initiation.
    AL831940 mRNA. Translation: CAD38592.1 .
    AL832821 mRNA. Translation: CAI46127.1 .
    CCDSi CCDS3046.1. [P61619-1 ]
    RefSeqi NP_037468.1. NM_013336.3. [P61619-1 ]
    UniGenei Hs.518236.

    3D structure databases

    ProteinModelPortali P61619.
    SMRi P61619. Positions 1-476.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 118968. 26 interactions.
    IntActi P61619. 18 interactions.
    MINTi MINT-1133988.

    Protein family/group databases

    TCDBi 3.A.5.9.1. the general secretory pathway (sec) family.

    PTM databases

    PhosphoSitei P61619.

    Polymorphism databases

    DMDMi 48429109.

    Proteomic databases

    MaxQBi P61619.
    PaxDbi P61619.
    PeptideAtlasi P61619.
    PRIDEi P61619.

    Protocols and materials databases

    DNASUi 29927.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000243253 ; ENSP00000243253 ; ENSG00000058262 . [P61619-1 ]
    GeneIDi 29927.
    KEGGi hsa:29927.
    UCSCi uc003ekb.3. human. [P61619-1 ]

    Organism-specific databases

    CTDi 29927.
    GeneCardsi GC03P127770.
    HGNCi HGNC:18276. SEC61A1.
    HPAi CAB022076.
    HPA045070.
    MIMi 609213. gene.
    neXtProti NX_P61619.
    PharmGKBi PA134901772.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0201.
    HOVERGENi HBG055271.
    InParanoidi P61619.
    KOi K10956.
    PhylomeDBi P61619.
    TreeFami TF300348.

    Enzyme and pathway databases

    Reactomei REACT_111178. ER-Phagosome pathway.
    REACT_115902. SRP-dependent cotranslational protein targeting to membrane.

    Miscellaneous databases

    ChiTaRSi SEC61A1. human.
    GeneWikii Sec61_alpha_1.
    GenomeRNAii 29927.
    NextBioi 52551.
    PROi P61619.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P61619.
    Bgeei P61619.
    Genevestigatori P61619.

    Family and domain databases

    Gene3Di 1.10.3370.10. 1 hit.
    InterProi IPR002208. SecY/SEC61-alpha.
    IPR023201. SecY_su_dom.
    IPR019561. Translocon_Sec61/SecY_plug_dom.
    [Graphical view ]
    PANTHERi PTHR10906. PTHR10906. 1 hit.
    Pfami PF10559. Plug_translocon. 1 hit.
    PF00344. SecY. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF004557. SecY. 1 hit.
    SUPFAMi SSF103491. SSF103491. 1 hit.
    TIGRFAMsi TIGR00967. 3a0501s007. 1 hit.
    PROSITEi PS00755. SECY_1. 1 hit.
    PS00756. SECY_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Human sec61 homolog gene."
      Liu T., Zhang J., Ye M., Zhang Q., Fu G., Zhou J., Wu J., Shen Y., Yu M., Chen S., Mao M., Chen Z.
      Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Human sec61 homolog gene mRNA sequence."
      Li W., Liu T., Fu G., Zhang Q., Ye M., Zhou J., Wu J., Shen Y., Yu M., Chen S., Mao M., Chen Z.
      Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    3. "Sec61 alpha isoforms."
      Finke K., Prehn S., Hartmann E.
      Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Tissue: Placenta and Teratocarcinoma.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Bone marrow and Lymph node.
    6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiS61A1_HUMAN
    AccessioniPrimary (citable) accession number: P61619
    Secondary accession number(s): P38378
    , P57726, Q5JPF8, Q8N0Z4, Q8N3U3, Q8NC71, Q9BU16, Q9Y2R3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 7, 2004
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 107 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3