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P61619

- S61A1_HUMAN

UniProt

P61619 - S61A1_HUMAN

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Protein
Protein transport protein Sec61 subunit alpha isoform 1
Gene
SEC61A1, SEC61A
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Plays a crucial role in the insertion of secretory and membrane polypeptides into the ER. Required for assembly of membrane and secretory proteins. Tightly associated with membrane-bound ribosomes, either directly or through adapter proteins.

GO - Molecular functioni

  1. protein binding Source: IntAct
  2. ribosome binding Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. SRP-dependent cotranslational protein targeting to membrane Source: MGI
  2. antigen processing and presentation of exogenous peptide antigen via MHC class I Source: Reactome
  3. antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent Source: Reactome
  4. antigen processing and presentation of peptide antigen via MHC class I Source: Reactome
  5. cell growth Source: MGI
  6. endoplasmic reticulum organization Source: MGI
  7. posttranslational protein targeting to membrane Source: MGI
  8. protein targeting to ER Source: UniProtKB
  9. response to interferon-gamma Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Protein transport, Translocation, Transport

Enzyme and pathway databases

ReactomeiREACT_111178. ER-Phagosome pathway.
REACT_115902. SRP-dependent cotranslational protein targeting to membrane.

Protein family/group databases

TCDBi3.A.5.9.1. the general secretory pathway (sec) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein transport protein Sec61 subunit alpha isoform 1
Short name:
Sec61 alpha-1
Gene namesi
Name:SEC61A1
Synonyms:SEC61A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:18276. SEC61A1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini2 – 3332Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei34 – 5320Helical; Reviewed prediction
Add
BLAST
Topological domaini54 – 7623Lumenal Reviewed prediction
Add
BLAST
Transmembranei77 – 9620Helical; Reviewed prediction
Add
BLAST
Topological domaini97 – 11721Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei118 – 13821Helical; Reviewed prediction
Add
BLAST
Topological domaini139 – 1446Lumenal Reviewed prediction
Transmembranei145 – 16521Helical; Reviewed prediction
Add
BLAST
Topological domaini166 – 1727Cytoplasmic Reviewed prediction
Transmembranei173 – 19321Helical; Reviewed prediction
Add
BLAST
Topological domaini194 – 24047Lumenal Reviewed prediction
Add
BLAST
Transmembranei241 – 26121Helical; Reviewed prediction
Add
BLAST
Topological domaini262 – 28827Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei289 – 30921Helical; Reviewed prediction
Add
BLAST
Topological domaini310 – 35445Lumenal Reviewed prediction
Add
BLAST
Transmembranei355 – 37521Helical; Reviewed prediction
Add
BLAST
Topological domaini376 – 42045Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei421 – 44121Helical; Reviewed prediction
Add
BLAST
Topological domaini442 – 4454Lumenal Reviewed prediction
Transmembranei446 – 46217Helical; Reviewed prediction
Add
BLAST
Topological domaini463 – 47614Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of endoplasmic reticulum membrane Source: UniProtKB
  2. membrane Source: MGI
  3. rough endoplasmic reticulum Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134901772.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 476475Protein transport protein Sec61 subunit alpha isoform 1
PRO_0000131791Add
BLAST

Proteomic databases

MaxQBiP61619.
PaxDbiP61619.
PeptideAtlasiP61619.
PRIDEiP61619.

PTM databases

PhosphoSiteiP61619.

Expressioni

Gene expression databases

ArrayExpressiP61619.
BgeeiP61619.
GenevestigatoriP61619.

Organism-specific databases

HPAiCAB022076.
HPA045070.

Interactioni

Subunit structurei

Heterotrimeric complex composed of SEC61-alpha, SEC61-beta and SEC61-gamma.

Binary interactionsi

WithEntry#Exp.IntActNotes
CANXP278243EBI-358919,EBI-355947
HSPA5P110213EBI-358919,EBI-354921

Protein-protein interaction databases

BioGridi118968. 26 interactions.
IntActiP61619. 18 interactions.
MINTiMINT-1133988.

Structurei

3D structure databases

ProteinModelPortaliP61619.
SMRiP61619. Positions 1-476.

Family & Domainsi

Sequence similaritiesi

Belongs to the SecY/SEC61-alpha family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0201.
HOVERGENiHBG055271.
InParanoidiP61619.
KOiK10956.
PhylomeDBiP61619.
TreeFamiTF300348.

Family and domain databases

Gene3Di1.10.3370.10. 1 hit.
InterProiIPR002208. SecY/SEC61-alpha.
IPR023201. SecY_su_dom.
IPR019561. Translocon_Sec61/SecY_plug_dom.
[Graphical view]
PANTHERiPTHR10906. PTHR10906. 1 hit.
PfamiPF10559. Plug_translocon. 1 hit.
PF00344. SecY. 1 hit.
[Graphical view]
PIRSFiPIRSF004557. SecY. 1 hit.
SUPFAMiSSF103491. SSF103491. 1 hit.
TIGRFAMsiTIGR00967. 3a0501s007. 1 hit.
PROSITEiPS00755. SECY_1. 1 hit.
PS00756. SECY_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P61619-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MAIKFLEVIK PFCVILPEIQ KPERKIQFKE KVLWTAITLF IFLVCCQIPL    50
FGIMSSDSAD PFYWMRVILA SNRGTLMELG ISPIVTSGLI MQLLAGAKII 100
EVGDTPKDRA LFNGAQKLFG MIITIGQSIV YVMTGMYGDP SEMGAGICLL 150
ITIQLFVAGL IVLLLDELLQ KGYGLGSGIS LFIATNICET IVWKAFSPTT 200
VNTGRGMEFE GAIIALFHLL ATRTDKVRAL REAFYRQNLP NLMNLIATIF 250
VFAVVIYFQG FRVDLPIKSA RYRGQYNTYP IKLFYTSNIP IILQSALVSN 300
LYVISQMLSA RFSGNLLVSL LGTWSDTSSG GPARAYPVGG LCYYLSPPES 350
FGSVLEDPVH AVVYIVFMLG SCAFFSKTWI EVSGSSAKDV AKQLKEQQMV 400
MRGHRETSMV HELNRYIPTA AAFGGLCIGA LSVLADFLGA IGSGTGILLA 450
VTIIYQYFEI FVKEQSEVGS MGALLF 476
Length:476
Mass (Da):52,265
Last modified:January 23, 2007 - v2
Checksum:i44A9B7B37C7C82E4
GO
Isoform 3 (identifier: P61619-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     2-120: Missing.

Note: No experimental confirmation available.

Show »
Length:357
Mass (Da):38,980
Checksum:iA3C282498CE920DF
GO

Sequence cautioni

The sequence BAC11283.1 differs from that shown. Reason: Erroneous initiation.
The sequence BAC11434.1 differs from that shown. Reason: Erroneous initiation.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei2 – 120119Missing in isoform 3.
VSP_013747Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti135 – 1351G → W in AAD27765. 1 Publication
Sequence conflicti234 – 2341F → L in BAC11298. 1 Publication
Sequence conflicti278 – 2781T → S in AAD27765. 1 Publication
Sequence conflicti310 – 3101A → V in AAD27765. 1 Publication
Sequence conflicti316 – 3161L → F in AAD27765. 1 Publication
Sequence conflicti319 – 3191S → N in AAD27765. 1 Publication
Sequence conflicti323 – 3297TWSDTSS → QWADVSG in AAD27765. 1 Publication
Sequence conflicti335 – 3351A → S in AAD27765. 1 Publication
Sequence conflicti351 – 3555FGSVL → MGAIF in AAD27765. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF077032 mRNA. Translation: AAD27765.1.
AF084458 mRNA. Translation: AAD39847.1.
AF346602 mRNA. Translation: AAK29083.1.
AK074907 mRNA. Translation: BAC11283.1. Different initiation.
AK074928 mRNA. Translation: BAC11298.1.
AK075148 mRNA. Translation: BAC11434.1. Different initiation.
AL831940 mRNA. Translation: CAD38592.1.
AL832821 mRNA. Translation: CAI46127.1.
CCDSiCCDS3046.1. [P61619-1]
RefSeqiNP_037468.1. NM_013336.3. [P61619-1]
UniGeneiHs.518236.

Genome annotation databases

EnsembliENST00000243253; ENSP00000243253; ENSG00000058262. [P61619-1]
ENST00000424880; ENSP00000411445; ENSG00000058262. [P61619-3]
GeneIDi29927.
KEGGihsa:29927.
UCSCiuc003ekb.3. human. [P61619-1]

Polymorphism databases

DMDMi48429109.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF077032 mRNA. Translation: AAD27765.1 .
AF084458 mRNA. Translation: AAD39847.1 .
AF346602 mRNA. Translation: AAK29083.1 .
AK074907 mRNA. Translation: BAC11283.1 . Different initiation.
AK074928 mRNA. Translation: BAC11298.1 .
AK075148 mRNA. Translation: BAC11434.1 . Different initiation.
AL831940 mRNA. Translation: CAD38592.1 .
AL832821 mRNA. Translation: CAI46127.1 .
CCDSi CCDS3046.1. [P61619-1 ]
RefSeqi NP_037468.1. NM_013336.3. [P61619-1 ]
UniGenei Hs.518236.

3D structure databases

ProteinModelPortali P61619.
SMRi P61619. Positions 1-476.
ModBasei Search...

Protein-protein interaction databases

BioGridi 118968. 26 interactions.
IntActi P61619. 18 interactions.
MINTi MINT-1133988.

Protein family/group databases

TCDBi 3.A.5.9.1. the general secretory pathway (sec) family.

PTM databases

PhosphoSitei P61619.

Polymorphism databases

DMDMi 48429109.

Proteomic databases

MaxQBi P61619.
PaxDbi P61619.
PeptideAtlasi P61619.
PRIDEi P61619.

Protocols and materials databases

DNASUi 29927.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000243253 ; ENSP00000243253 ; ENSG00000058262 . [P61619-1 ]
ENST00000424880 ; ENSP00000411445 ; ENSG00000058262 . [P61619-3 ]
GeneIDi 29927.
KEGGi hsa:29927.
UCSCi uc003ekb.3. human. [P61619-1 ]

Organism-specific databases

CTDi 29927.
GeneCardsi GC03P127770.
HGNCi HGNC:18276. SEC61A1.
HPAi CAB022076.
HPA045070.
MIMi 609213. gene.
neXtProti NX_P61619.
PharmGKBi PA134901772.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0201.
HOVERGENi HBG055271.
InParanoidi P61619.
KOi K10956.
PhylomeDBi P61619.
TreeFami TF300348.

Enzyme and pathway databases

Reactomei REACT_111178. ER-Phagosome pathway.
REACT_115902. SRP-dependent cotranslational protein targeting to membrane.

Miscellaneous databases

ChiTaRSi SEC61A1. human.
GeneWikii Sec61_alpha_1.
GenomeRNAii 29927.
NextBioi 52551.
PROi P61619.
SOURCEi Search...

Gene expression databases

ArrayExpressi P61619.
Bgeei P61619.
Genevestigatori P61619.

Family and domain databases

Gene3Di 1.10.3370.10. 1 hit.
InterProi IPR002208. SecY/SEC61-alpha.
IPR023201. SecY_su_dom.
IPR019561. Translocon_Sec61/SecY_plug_dom.
[Graphical view ]
PANTHERi PTHR10906. PTHR10906. 1 hit.
Pfami PF10559. Plug_translocon. 1 hit.
PF00344. SecY. 1 hit.
[Graphical view ]
PIRSFi PIRSF004557. SecY. 1 hit.
SUPFAMi SSF103491. SSF103491. 1 hit.
TIGRFAMsi TIGR00967. 3a0501s007. 1 hit.
PROSITEi PS00755. SECY_1. 1 hit.
PS00756. SECY_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Human sec61 homolog gene."
    Liu T., Zhang J., Ye M., Zhang Q., Fu G., Zhou J., Wu J., Shen Y., Yu M., Chen S., Mao M., Chen Z.
    Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Human sec61 homolog gene mRNA sequence."
    Li W., Liu T., Fu G., Zhang Q., Ye M., Zhou J., Wu J., Shen Y., Yu M., Chen S., Mao M., Chen Z.
    Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  3. "Sec61 alpha isoforms."
    Finke K., Prehn S., Hartmann E.
    Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Placenta and Teratocarcinoma.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Bone marrow and Lymph node.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiS61A1_HUMAN
AccessioniPrimary (citable) accession number: P61619
Secondary accession number(s): P38378
, P57726, Q5JPF8, Q8N0Z4, Q8N3U3, Q8NC71, Q9BU16, Q9Y2R3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: January 23, 2007
Last modified: September 3, 2014
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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