Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Adenosylhomocysteinase

Gene

ahcY

Organism
Geobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.UniRule annotation

Catalytic activityi

S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine.UniRule annotation

Cofactori

NAD+UniRule annotationNote: Binds 1 NAD+ per subunit.UniRule annotation

Pathwayi: L-homocysteine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes L-homocysteine from S-adenosyl-L-homocysteine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Adenosylhomocysteinase (ahcY)
This subpathway is part of the pathway L-homocysteine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-homocysteine from S-adenosyl-L-homocysteine, the pathway L-homocysteine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei66SubstrateUniRule annotation1
Binding sitei141SubstrateUniRule annotation1
Binding sitei201SubstrateUniRule annotation1
Binding sitei231SubstrateUniRule annotation1
Binding sitei235SubstrateUniRule annotation1
Binding sitei236NADUniRule annotation1
Binding sitei288NADUniRule annotation1
Binding sitei323NADUniRule annotation1
Binding sitei389NADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi202 – 204NADUniRule annotation3
Nucleotide bindingi265 – 270NADUniRule annotation6
Nucleotide bindingi344 – 346NADUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processOne-carbon metabolism
LigandNAD

Enzyme and pathway databases

UniPathwayiUPA00314; UER00076.

Names & Taxonomyi

Protein namesi
Recommended name:
AdenosylhomocysteinaseUniRule annotation (EC:3.3.1.1UniRule annotation)
Alternative name(s):
S-adenosyl-L-homocysteine hydrolaseUniRule annotation
Short name:
AdoHcyaseUniRule annotation
Gene namesi
Name:ahcYUniRule annotation
Ordered Locus Names:GSU1875
OrganismiGeobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA)
Taxonomic identifieri243231 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfuromonadalesGeobacteraceaeGeobacter
Proteomesi
  • UP000000577 Componenti: Chromosome

Subcellular locationi

P61617:
  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001169631 – 475AdenosylhomocysteinaseAdd BLAST475

Proteomic databases

PRIDEiP61617.

Interactioni

Protein-protein interaction databases

STRINGi243231.GSU1875.

Structurei

3D structure databases

ProteinModelPortaliP61617.
SMRiP61617.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the adenosylhomocysteinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C3E. Bacteria.
COG0499. LUCA.
HOGENOMiHOG000227986.
InParanoidiP61617.
KOiK01251.
OMAiTGNRDII.
OrthoDBiPOG091H00W2.

Family and domain databases

CDDicd00401. SAHH. 1 hit.
HAMAPiMF_00563. AdoHcyase. 1 hit.
InterProiView protein in InterPro
IPR034373. Adenosylhomocysteinase.
IPR000043. Adenosylhomocysteinase-like.
IPR015878. Ado_hCys_hydrolase_NAD-bd.
IPR036291. NAD(P)-bd_dom_sf.
IPR020082. S-Ado-L-homoCys_hydrolase_CS.
PANTHERiPTHR23420. PTHR23420. 1 hit.
PfamiView protein in Pfam
PF05221. AdoHcyase. 1 hit.
PF00670. AdoHcyase_NAD. 1 hit.
PIRSFiPIRSF001109. Ad_hcy_hydrolase. 1 hit.
SMARTiView protein in SMART
SM00996. AdoHcyase. 1 hit.
SM00997. AdoHcyase_NAD. 1 hit.
SUPFAMiSSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR00936. ahcY. 1 hit.
PROSITEiView protein in PROSITE
PS00738. ADOHCYASE_1. 1 hit.
PS00739. ADOHCYASE_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P61617-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTQPVARDTA GTFSDYCISD ISLAAWGRKE MIIAETEMPG LMAIREEYAA
60 70 80 90 100
TRPLQGARIA GSLHMTIQTA MLIETLVALG AEVRWASCNI FSTQDHAAAA
110 120 130 140 150
IAAAGIPVFA YKGESLEEYW EFTHRIFEWH DGGTPNMILD DGGDATLLLH
160 170 180 190 200
LGSDAEKDPS VIANPTCEEE QYLFASIKKR LAEKPGWYSK TAAAIKGVTE
210 220 230 240 250
ETTTGVHRLY QMHEKGKLKF PAINVNDSVT KSKFDNIYGC RESLVDGIKR
260 270 280 290 300
ATDVMIAGKV AVICGYGEVG KGCAQAMRGL QAQVWVTEID PICALQAAME
310 320 330 340 350
GYRVVTMEYA ADKADIFVTT TGNINVITHD HMKAMRHNAI VCNIGHFDNE
360 370 380 390 400
IEVAALKQYQ WENIKPQVDH IIFPDSKRII LLAEGRLVNL GCATGHPSYV
410 420 430 440 450
MSSSFANQTL AQIELFCNPG KYPVGVYMLP KELDEKVARL QLKTLGAMLT
460 470
ELTDEQAAYI GVPKNGPYKS AHYRY
Length:475
Mass (Da):52,284
Last modified:May 24, 2004 - v1
Checksum:i525470CE91067817
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017180 Genomic DNA. Translation: AAR35251.1.
RefSeqiNP_952924.1. NC_002939.5.
WP_010942520.1. NC_002939.5.

Genome annotation databases

EnsemblBacteriaiAAR35251; AAR35251; GSU1875.
GeneIDi2685778.
KEGGigsu:GSU1875.
PATRICifig|243231.5.peg.1913.

Similar proteinsi

Entry informationi

Entry nameiSAHH_GEOSL
AccessioniPrimary (citable) accession number: P61617
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: May 24, 2004
Last modified: October 25, 2017
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families