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P61604

- CH10_HUMAN

UniProt

P61604 - CH10_HUMAN

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Protein

10 kDa heat shock protein, mitochondrial

Gene
HSPE1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Eukaryotic CPN10 homolog which is essential for mitochondrial protein biogenesis, together with CPN60. Binds to CPN60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter.UniRule annotation

GO - Molecular functioni

  1. ATP binding Source: InterPro
  2. chaperone binding Source: UniProtKB
  3. poly(A) RNA binding Source: UniProtKB
  4. protein binding Source: UniProtKB
  5. unfolded protein binding Source: UniProtKB

GO - Biological processi

  1. activation of cysteine-type endopeptidase activity involved in apoptotic process Source: UniProtKB
  2. osteoblast differentiation Source: UniProt
  3. protein folding Source: ProtInc
  4. response to unfolded protein Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Stress response

Names & Taxonomyi

Protein namesi
Recommended name:
10 kDa heat shock protein, mitochondrial
Short name:
Hsp10
Alternative name(s):
10 kDa chaperonin
Chaperonin 10
Short name:
CPN10
Early-pregnancy factor
Short name:
EPF
Gene namesi
Name:HSPE1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:5269. HSPE1.

Subcellular locationi

GO - Cellular componenti

  1. extracellular vesicular exosome Source: UniProt
  2. membrane Source: UniProt
  3. mitochondrial matrix Source: UniProtKB-SubCell
  4. mitochondrion Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29535.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 10210110 kDa heat shock protein, mitochondrialUniRule annotationPRO_0000174917Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine1 Publication
Modified residuei8 – 81N6-acetyllysine By similarity
Modified residuei28 – 281N6-succinyllysine By similarity
Modified residuei40 – 401N6-acetyllysine; alternate By similarity
Modified residuei40 – 401N6-malonyllysine; alternate1 Publication
Modified residuei40 – 401N6-succinyllysine; alternate By similarity
Modified residuei54 – 541N6-malonyllysine; alternate1 Publication
Modified residuei54 – 541N6-succinyllysine; alternate By similarity
Modified residuei56 – 561N6-acetyllysine; alternate1 Publication
Modified residuei56 – 561N6-malonyllysine; alternate1 Publication
Modified residuei56 – 561N6-succinyllysine; alternate By similarity
Modified residuei66 – 661N6-acetyllysine; alternate By similarity
Modified residuei66 – 661N6-succinyllysine; alternate By similarity
Modified residuei70 – 701N6-acetyllysine; alternate By similarity
Modified residuei70 – 701N6-succinyllysine; alternate By similarity
Modified residuei79 – 791Phosphothreonine1 Publication
Modified residuei80 – 801N6-acetyllysine; alternate By similarity
Modified residuei80 – 801N6-succinyllysine; alternate By similarity
Modified residuei86 – 861N6-acetyllysine; alternate1 Publication
Modified residuei86 – 861N6-succinyllysine; alternate By similarity
Modified residuei99 – 991N6-acetyllysine1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiP61604.
PaxDbiP61604.
PeptideAtlasiP61604.
PRIDEiP61604.

2D gel databases

UCD-2DPAGEP61604.

PTM databases

PhosphoSiteiP61604.

Expressioni

Inductioni

By stress.UniRule annotation

Gene expression databases

ArrayExpressiP61604.
BgeeiP61604.
CleanExiHS_HSPE1.
GenevestigatoriP61604.

Organism-specific databases

HPAiCAB017366.
HPA038755.

Interactioni

Subunit structurei

Homohexamer.

Binary interactionsi

WithEntry#Exp.IntActNotes
FHITP497894EBI-711483,EBI-741760

Protein-protein interaction databases

BioGridi109568. 37 interactions.
IntActiP61604. 25 interactions.
MINTiMINT-1373857.
STRINGi9606.ENSP00000233893.

Structurei

3D structure databases

ProteinModelPortaliP61604.
SMRiP61604. Positions 11-98.

Family & Domainsi

Sequence similaritiesi

Belongs to the GroES chaperonin family.

Phylogenomic databases

eggNOGiCOG0234.
HOGENOMiHOG000133897.
HOVERGENiHBG000385.
InParanoidiP61604.
KOiK04078.
OMAiEEYQLFR.
OrthoDBiEOG71CFPD.
PhylomeDBiP61604.
TreeFamiTF313814.

Family and domain databases

Gene3Di2.30.33.40. 1 hit.
HAMAPiMF_00580. CH10.
InterProiIPR020818. Chaperonin_Cpn10.
IPR018369. Chaprnonin_Cpn10_CS.
IPR011032. GroES-like.
[Graphical view]
PANTHERiPTHR10772. PTHR10772. 1 hit.
PfamiPF00166. Cpn10. 1 hit.
[Graphical view]
PRINTSiPR00297. CHAPERONIN10.
SMARTiSM00883. Cpn10. 1 hit.
[Graphical view]
SUPFAMiSSF50129. SSF50129. 1 hit.
PROSITEiPS00681. CHAPERONINS_CPN10. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P61604-1 [UniParc]FASTAAdd to Basket

« Hide

MAGQAFRKFL PLFDRVLVER SAAETVTKGG IMLPEKSQGK VLQATVVAVG    50
SGSKGKGGEI QPVSVKVGDK VLLPEYGGTK VVLDDKDYFL FRDGDILGKY 100
VD 102
Length:102
Mass (Da):10,932
Last modified:January 23, 2007 - v2
Checksum:i1F3192C81F6EDB78
GO

Mass spectrometryi

Molecular mass is 10843.5±0.2 Da from positions 2 - 102. Determined by ESI. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X75821 mRNA. Translation: CAA53455.1.
U07550 mRNA. Translation: AAA50953.1.
AJ250915 Genomic DNA. Translation: CAB75425.1.
AK312104 mRNA. Translation: BAG35040.1.
CR407688 mRNA. Translation: CAG28616.1.
AC020550 Genomic DNA. Translation: AAX93146.1.
CH471063 Genomic DNA. Translation: EAW70163.1.
BC023518 mRNA. Translation: AAH23518.1.
AH007060 Genomic DNA. Translation: AAC95387.1.
CCDSiCCDS2320.1.
PIRiS47532.
RefSeqiNP_002148.1. NM_002157.2.
UniGeneiHs.1197.

Genome annotation databases

EnsembliENST00000233893; ENSP00000233893; ENSG00000115541.
GeneIDi3336.
KEGGihsa:3336.
UCSCiuc002uul.3. human.

Polymorphism databases

DMDMi47606335.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X75821 mRNA. Translation: CAA53455.1 .
U07550 mRNA. Translation: AAA50953.1 .
AJ250915 Genomic DNA. Translation: CAB75425.1 .
AK312104 mRNA. Translation: BAG35040.1 .
CR407688 mRNA. Translation: CAG28616.1 .
AC020550 Genomic DNA. Translation: AAX93146.1 .
CH471063 Genomic DNA. Translation: EAW70163.1 .
BC023518 mRNA. Translation: AAH23518.1 .
AH007060 Genomic DNA. Translation: AAC95387.1 .
CCDSi CCDS2320.1.
PIRi S47532.
RefSeqi NP_002148.1. NM_002157.2.
UniGenei Hs.1197.

3D structure databases

ProteinModelPortali P61604.
SMRi P61604. Positions 11-98.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 109568. 37 interactions.
IntActi P61604. 25 interactions.
MINTi MINT-1373857.
STRINGi 9606.ENSP00000233893.

PTM databases

PhosphoSitei P61604.

Polymorphism databases

DMDMi 47606335.

2D gel databases

UCD-2DPAGE P61604.

Proteomic databases

MaxQBi P61604.
PaxDbi P61604.
PeptideAtlasi P61604.
PRIDEi P61604.

Protocols and materials databases

DNASUi 3336.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000233893 ; ENSP00000233893 ; ENSG00000115541 .
GeneIDi 3336.
KEGGi hsa:3336.
UCSCi uc002uul.3. human.

Organism-specific databases

CTDi 3336.
GeneCardsi GC02P198328.
HGNCi HGNC:5269. HSPE1.
HPAi CAB017366.
HPA038755.
MIMi 600141. gene.
neXtProti NX_P61604.
PharmGKBi PA29535.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0234.
HOGENOMi HOG000133897.
HOVERGENi HBG000385.
InParanoidi P61604.
KOi K04078.
OMAi EEYQLFR.
OrthoDBi EOG71CFPD.
PhylomeDBi P61604.
TreeFami TF313814.

Miscellaneous databases

GeneWikii GroES.
GenomeRNAii 3336.
NextBioi 13204.
PROi P61604.
SOURCEi Search...

Gene expression databases

ArrayExpressi P61604.
Bgeei P61604.
CleanExi HS_HSPE1.
Genevestigatori P61604.

Family and domain databases

Gene3Di 2.30.33.40. 1 hit.
HAMAPi MF_00580. CH10.
InterProi IPR020818. Chaperonin_Cpn10.
IPR018369. Chaprnonin_Cpn10_CS.
IPR011032. GroES-like.
[Graphical view ]
PANTHERi PTHR10772. PTHR10772. 1 hit.
Pfami PF00166. Cpn10. 1 hit.
[Graphical view ]
PRINTSi PR00297. CHAPERONIN10.
SMARTi SM00883. Cpn10. 1 hit.
[Graphical view ]
SUPFAMi SSF50129. SSF50129. 1 hit.
PROSITEi PS00681. CHAPERONINS_CPN10. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and cloning of human chaperonin 10 homologue."
    Monzini N., Legname G., Marcucci F., Gromo G., Modena D.
    Biochim. Biophys. Acta 1218:478-480(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Isolation, sequence analysis and characterization of a cDNA encoding human chaperonin 10."
    Chen J.J., McNealy D.J., Dalal S., Androphy E.J.
    Biochim. Biophys. Acta 1219:189-190(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Genomic structure of the human mitochondrial chaperonin genes: HSP60 and HSP10 are localised head to head on chromosome 2 separated by a bidirectional promoter."
    Hansen J.J., Bross P., Westergaard M., Nielsen M.N., Eiberg H., Boerglum A.D., Mogensen J., Kristiansen K., Bolund L., Gregersen N.
    Hum. Genet. 112:71-77(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  5. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  6. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Uterus.
  9. "Mapping and characterization of the eukaryotic early pregnancy factor/chaperonin 10 gene family."
    Summers K.M., Fletcher B.H., Macaranas D.D., Somodevilla-Torres M.J., Murphy R.M., Osborne M.J., Spurr N.K., Cassady A.I., Cavanagh A.C.
    Somat. Cell Mol. Genet. 24:315-326(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-100.
  10. Bienvenut W.V.
    Submitted (MAR-2005) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 2-15; 41-54; 57-66 AND 81-92, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: B-cell lymphoma.
  11. "The purification of early-pregnancy factor to homogeneity from human platelets and identification as chaperonin 10."
    Cavanagh A.C., Morton H.
    Eur. J. Biochem. 222:551-560(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 8-19; 28-54 AND 70-102, MASS SPECTROMETRY.
    Tissue: Platelet.
  12. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-56; LYS-86 AND LYS-99, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  13. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-79, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  14. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  15. Cited for: MALONYLATION AT LYS-40; LYS-54 AND LYS-56.

Entry informationi

Entry nameiCH10_HUMAN
AccessioniPrimary (citable) accession number: P61604
Secondary accession number(s): O95421
, Q04984, Q53X54, Q9UDH0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: January 23, 2007
Last modified: September 3, 2014
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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