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Protein

Neurocalcin-delta

Gene

NCALD

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in the calcium-dependent regulation of rhodopsin phosphorylation. Binds three calcium ions.

Miscellaneous

Five isoprotein forms of neurocalcin are designated alpha, beta, gamma1, gamma2 and delta.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi73 – 841PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi109 – 1202PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi157 – 1683PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

  • actin binding Source: UniProtKB
  • calcium ion binding Source: UniProtKB
  • clathrin binding Source: UniProtKB
  • tubulin binding Source: UniProtKB

GO - Biological processi

Keywordsi

LigandCalcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-BTA-451308 Activation of Ca-permeable Kainate Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
Neurocalcin-delta
Gene namesi
Name:NCALD
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 14

Organism-specific databases

VGNCiVGNC:31897 NCALD

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved
ChainiPRO_00000737812 – 193Neurocalcin-deltaAdd BLAST192

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycine1 Publication1

Keywords - PTMi

Lipoprotein, Myristate

Proteomic databases

PaxDbiP61602
PRIDEiP61602

PTM databases

iPTMnetiP61602

Expressioni

Tissue specificityi

Retina, cerebrum, cerebellum, brain stem, spinal cord, testis, ovary and small intestine.

Gene expression databases

BgeeiENSBTAG00000026963

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
PDE1AP141002EBI-908133,EBI-907809

GO - Molecular functioni

Protein-protein interaction databases

IntActiP61602, 2 interactors
STRINGi9913.ENSBTAP00000038404

Structurei

Secondary structure

1193
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi10 – 19Combined sources10
Helixi24 – 37Combined sources14
Beta strandi41 – 44Combined sources4
Helixi45 – 52Combined sources8
Turni53 – 55Combined sources3
Beta strandi56 – 59Combined sources4
Helixi62 – 72Combined sources11
Beta strandi77 – 81Combined sources5
Helixi82 – 92Combined sources11
Helixi97 – 108Combined sources12
Helixi118 – 129Combined sources12
Turni135 – 137Combined sources3
Helixi140 – 142Combined sources3
Helixi145 – 155Combined sources11
Beta strandi161 – 164Combined sources4
Helixi166 – 175Combined sources10
Helixi178 – 181Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BJFX-ray2.40A/B1-193[»]
ProteinModelPortaliP61602
SMRiP61602
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP61602

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 58EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini60 – 95EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini96 – 131EF-hand 3PROSITE-ProRule annotationAdd BLAST36
Domaini144 – 179EF-hand 4PROSITE-ProRule annotationAdd BLAST36

Sequence similaritiesi

Belongs to the recoverin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0044 Eukaryota
COG5126 LUCA
GeneTreeiENSGT00760000118820
HOVERGENiHBG108179
InParanoidiP61602
KOiK19695
OMAiCCNPIPS
OrthoDBiEOG091G11T4
TreeFamiTF300009

Family and domain databases

CDDicd00051 EFh, 2 hits
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
PfamiView protein in Pfam
PF13499 EF-hand_7, 1 hit
PF13833 EF-hand_8, 1 hit
SMARTiView protein in SMART
SM00054 EFh, 3 hits
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 3 hits
PS50222 EF_HAND_2, 4 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P61602-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKQNSKLRP EVMQDLLEST DFTEHEIQEW YKGFLRDCPS GHLSMEEFKK
60 70 80 90 100
IYGNFFPYGD ASKFAEHVFR TFDANGDGTI DFREFIIALS VTSRGKLEQK
110 120 130 140 150
LKWAFSMYDL DGNGYISKAE MLEIVQAIYK MVSSVMKMPE DESTPEKRTE
160 170 180 190
KIFRQMDTNR DGKLSLEEFI RGAKSDPSIV RLLQCDPSSA GQF
Length:193
Mass (Da):22,245
Last modified:January 23, 2007 - v2
Checksum:i20DD8B6FF47C4CBF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D10884 mRNA Translation: BAA01706.1
BT029820 mRNA Translation: ABM06083.1
BC122588 mRNA Translation: AAI22589.1
PIRiJH0616
RefSeqiNP_776823.1, NM_174398.2
XP_005215666.1, XM_005215609.3
XP_005215667.1, XM_005215610.3
XP_005215670.1, XM_005215613.3
XP_010810465.1, XM_010812163.2
XP_015329999.1, XM_015474513.1
UniGeneiBt.65801
Bt.90297

Genome annotation databases

EnsembliENSBTAT00000038591; ENSBTAP00000038404; ENSBTAG00000026963
GeneIDi281940
KEGGibta:281940

Similar proteinsi

Entry informationi

Entry nameiNCALD_BOVIN
AccessioniPrimary (citable) accession number: P61602
Secondary accession number(s): A1L533
, P29554, Q0IIL3, Q9H0W2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: January 23, 2007
Last modified: April 25, 2018
This is version 118 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome
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Main funding by: National Institutes of Health