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Protein

Neurocalcin-delta

Gene

NCALD

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in the calcium-dependent regulation of rhodopsin phosphorylation. Binds three calcium ions.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi73 – 841PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi109 – 1202PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi157 – 1683PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

  • actin binding Source: UniProtKB
  • calcium ion binding Source: UniProtKB
  • clathrin binding Source: UniProtKB
  • tubulin binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-BTA-451308. Activation of Ca-permeable Kainate Receptor.

Names & Taxonomyi

Protein namesi
Recommended name:
Neurocalcin-delta
Gene namesi
Name:NCALD
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 14

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved
ChainiPRO_00000737812 – 193Neurocalcin-deltaAdd BLAST192

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycine1 Publication1

Keywords - PTMi

Lipoprotein, Myristate

Proteomic databases

PaxDbiP61602.
PRIDEiP61602.

Expressioni

Tissue specificityi

Retina, cerebrum, cerebellum, brain stem, spinal cord, testis, ovary and small intestine.

Gene expression databases

BgeeiENSBTAG00000026963.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
PDE1AP141002EBI-908133,EBI-907809

GO - Molecular functioni

Protein-protein interaction databases

IntActiP61602. 2 interactors.
MINTiMINT-235958.
STRINGi9913.ENSBTAP00000038404.

Structurei

Secondary structure

1193
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi10 – 19Combined sources10
Helixi24 – 37Combined sources14
Beta strandi41 – 44Combined sources4
Helixi45 – 52Combined sources8
Turni53 – 55Combined sources3
Beta strandi56 – 59Combined sources4
Helixi62 – 72Combined sources11
Beta strandi77 – 81Combined sources5
Helixi82 – 92Combined sources11
Helixi97 – 108Combined sources12
Helixi118 – 129Combined sources12
Turni135 – 137Combined sources3
Helixi140 – 142Combined sources3
Helixi145 – 155Combined sources11
Beta strandi161 – 164Combined sources4
Helixi166 – 175Combined sources10
Helixi178 – 181Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BJFX-ray2.40A/B1-193[»]
ProteinModelPortaliP61602.
SMRiP61602.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP61602.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 58EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini60 – 95EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini96 – 131EF-hand 3PROSITE-ProRule annotationAdd BLAST36
Domaini144 – 179EF-hand 4PROSITE-ProRule annotationAdd BLAST36

Sequence similaritiesi

Belongs to the recoverin family.Curated
Contains 4 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0044. Eukaryota.
COG5126. LUCA.
GeneTreeiENSGT00760000118820.
HOVERGENiHBG108179.
InParanoidiP61602.
KOiK19695.
OMAiQCDPSAQ.
OrthoDBiEOG091G11T4.
TreeFamiTF300009.

Family and domain databases

CDDicd00051. EFh. 2 hits.
Gene3Di1.10.238.10. 3 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR028846. Recoverin.
[Graphical view]
PANTHERiPTHR23055. PTHR23055. 1 hit.
PfamiPF13499. EF-hand_7. 1 hit.
PF13833. EF-hand_8. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 3 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 3 hits.
PS50222. EF_HAND_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P61602-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKQNSKLRP EVMQDLLEST DFTEHEIQEW YKGFLRDCPS GHLSMEEFKK
60 70 80 90 100
IYGNFFPYGD ASKFAEHVFR TFDANGDGTI DFREFIIALS VTSRGKLEQK
110 120 130 140 150
LKWAFSMYDL DGNGYISKAE MLEIVQAIYK MVSSVMKMPE DESTPEKRTE
160 170 180 190
KIFRQMDTNR DGKLSLEEFI RGAKSDPSIV RLLQCDPSSA GQF
Length:193
Mass (Da):22,245
Last modified:January 23, 2007 - v2
Checksum:i20DD8B6FF47C4CBF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D10884 mRNA. Translation: BAA01706.1.
BT029820 mRNA. Translation: ABM06083.1.
BC122588 mRNA. Translation: AAI22589.1.
PIRiJH0616.
RefSeqiNP_776823.1. NM_174398.2.
XP_005215666.1. XM_005215609.3.
XP_005215667.1. XM_005215610.3.
XP_005215670.1. XM_005215613.3.
XP_010810465.1. XM_010812163.2.
XP_015329999.1. XM_015474513.1.
UniGeneiBt.65801.

Genome annotation databases

EnsembliENSBTAT00000038591; ENSBTAP00000038404; ENSBTAG00000026963.
GeneIDi281940.
KEGGibta:281940.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D10884 mRNA. Translation: BAA01706.1.
BT029820 mRNA. Translation: ABM06083.1.
BC122588 mRNA. Translation: AAI22589.1.
PIRiJH0616.
RefSeqiNP_776823.1. NM_174398.2.
XP_005215666.1. XM_005215609.3.
XP_005215667.1. XM_005215610.3.
XP_005215670.1. XM_005215613.3.
XP_010810465.1. XM_010812163.2.
XP_015329999.1. XM_015474513.1.
UniGeneiBt.65801.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BJFX-ray2.40A/B1-193[»]
ProteinModelPortaliP61602.
SMRiP61602.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP61602. 2 interactors.
MINTiMINT-235958.
STRINGi9913.ENSBTAP00000038404.

Proteomic databases

PaxDbiP61602.
PRIDEiP61602.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000038591; ENSBTAP00000038404; ENSBTAG00000026963.
GeneIDi281940.
KEGGibta:281940.

Organism-specific databases

CTDi83988.

Phylogenomic databases

eggNOGiKOG0044. Eukaryota.
COG5126. LUCA.
GeneTreeiENSGT00760000118820.
HOVERGENiHBG108179.
InParanoidiP61602.
KOiK19695.
OMAiQCDPSAQ.
OrthoDBiEOG091G11T4.
TreeFamiTF300009.

Enzyme and pathway databases

ReactomeiR-BTA-451308. Activation of Ca-permeable Kainate Receptor.

Miscellaneous databases

EvolutionaryTraceiP61602.

Gene expression databases

BgeeiENSBTAG00000026963.

Family and domain databases

CDDicd00051. EFh. 2 hits.
Gene3Di1.10.238.10. 3 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR028846. Recoverin.
[Graphical view]
PANTHERiPTHR23055. PTHR23055. 1 hit.
PfamiPF13499. EF-hand_7. 1 hit.
PF13833. EF-hand_8. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 3 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 3 hits.
PS50222. EF_HAND_2. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNCALD_BOVIN
AccessioniPrimary (citable) accession number: P61602
Secondary accession number(s): A1L533
, P29554, Q0IIL3, Q9H0W2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Five isoprotein forms of neurocalcin are designated alpha, beta, gamma1, gamma2 and delta.

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.