Neurocalcin-delta - Bos taurus (Bovine)

Contribute

Send feedback

Read comments (?) or add your own

P61602 (NCALD_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 70. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

text xml rdf/xml gff fasta

Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Neurocalcin-delta

Gene names

Name:

NCALD

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	193 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May be involved in the calcium-dependent regulation of rhodopsin phosphorylation. Binds three calcium ions.
Tissue specificity	Retina, cerebrum, cerebellum, brain stem, spinal cord, testis, ovary and small intestine.
Miscellaneous	Five isoprotein forms of neurocalcin are designated alpha, beta, gamma1, gamma2 and delta.
Sequence similarities	Belongs to the recoverin family. Contains 4 EF-hand domains.

Ontologies

Keywords
Domain	Repeat
Ligand	Calcium
PTM	Lipoprotein Myristate
Technical term	3D-structure Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Molecular function	actin binding Inferred from sequence or structural similarity. Source: UniProtKB calcium ion binding Non-traceable author statement Ref.2. Source: UniProtKB clathrin binding Inferred from sequence or structural similarity. Source: UniProtKB tubulin binding Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
PDE1A	P14100	2	EBI-908133,EBI-907809

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Initiator methionine

Removed

Chain

2 – 193

192

Neurocalcin-delta

PRO_0000073781

Regions

Domain

23 – 58

EF-hand 1

Domain

60 – 95

EF-hand 2

Domain

96 – 131

EF-hand 3

Domain

144 – 179

EF-hand 4

Calcium binding

73 – 84

1 Potential

Calcium binding

109 – 120

2 Potential

Calcium binding

157 – 168

3 Potential

Amino acid modifications

Lipidation

N-myristoyl glycine

Secondary structure

193

Helix Strand Turn

Details...

Sequences

Sequence

Length

Mass (Da)

Tools

P61602 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: 20DD8B6FF47C4CBF
Show »

FASTA

193

22,245

        10         20         30         40         50         60 
MGKQNSKLRP EVMQDLLEST DFTEHEIQEW YKGFLRDCPS GHLSMEEFKK IYGNFFPYGD 

        70         80         90        100        110        120 
ASKFAEHVFR TFDANGDGTI DFREFIIALS VTSRGKLEQK LKWAFSMYDL DGNGYISKAE 

       130        140        150        160        170        180 
MLEIVQAIYK MVSSVMKMPE DESTPEKRTE KIFRQMDTNR DGKLSLEEFI RGAKSDPSIV 

       190 
RLLQCDPSSA GQF

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Full sequence of neurocalcin, a novel calcium-binding protein abundant in central nervous system." Okazaki K., Watanabe M., Ando Y., Hagiwara M., Terasawa M., Hidaka H. Biochem. Biophys. Res. Commun. 185:147-153(1992) [PubMed: 1599450] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 107-112 AND 121-126. Tissue: Brain.
[2]	"Neurocalcin family: a novel calcium-binding protein abundant in bovine central nervous system." Hidaka H., Okazaki K. Neurosci. Res. 16:73-77(1993) [PubMed: 8387172] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain.
[3]	"Characterization of 954 bovine full-CDS cDNA sequences." Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L., Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L. BMC Genomics 6:166-166(2005) [PubMed: 16305752] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	NIH - Mammalian Gene Collection (MGC) project Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Hereford. Tissue: Thalamus.
[5]	"Calcium and membrane binding properties of bovine neurocalcin delta expressed in Escherichia coli." Ladant D. J. Biol. Chem. 270:3179-3185(1995) [PubMed: 7852401] [Abstract] Cited for: CALCIUM-BINDING.
[6]	"Crystallization and preliminary X-ray crystallographic studies of recombinant bovine neurocalcin delta." Kumar V.D., Hidaka H., Okazaki K., Vijay-Kumar S. Proteins 25:261-264(1996) [PubMed: 8811741] [Abstract] Cited for: CRYSTALLIZATION.
[7]	"Crystal structure of recombinant bovine neurocalcin." Vijay-Kumar S., Kumar V.D. Nat. Struct. Biol. 6:80-88(1999) [PubMed: 9886296] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS).
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

D10884 mRNA. Translation: BAA01706.1.
BT029820 mRNA. Translation: ABM06083.1.
BC122588 mRNA. Translation: AAI22589.1.

IPI

IPI00698069.

PIR

JH0616.

RefSeq

NP_776823.1. NM_174398.2.

UniGene

Bt.65801.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1BJF	X-ray	2.40	A/B	1-193	[»]

ProteinModelPortal

P61602.

SMR

P61602. Positions 5-185.

ModBase

Search...

Protein-protein interaction databases

IntAct

P61602. 2 interactions.

STRING

P61602.

Proteomic databases

PRIDE

P61602.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENSBTAT00000038591; ENSBTAP00000038404; ENSBTAG00000026963.

GeneID

281940.

KEGG

bta:281940.

Organism-specific databases

CTD

83988.

Phylogenomic databases

eggNOG

maNOG18738.

GeneTree

ENSGT00560000076803.

HOVERGEN

HBG108179.

InParanoid

P61602.

OrthoDB

EOG4MKNH8.

PhylomeDB

P61602.

Family and domain databases

InterPro

IPR018248. EF-hand.
IPR011992. EF-hand-like_dom.
IPR018247. EF_Hand_1_Ca_BS.
IPR018249. EF_HAND_2.
IPR002048. EF_hand_Ca-bd.
IPR001125. Recoverin.
[Graphical view]

Gene3D

G3DSA:1.10.238.10. EF-Hand_type. 1 hit.

Pfam

PF00036. efhand. 3 hits.
[Graphical view]

PRINTS

PR00450. RECOVERIN.

SMART

SM00054. EFh. 3 hits.
[Graphical view]

PROSITE

PS00018. EF_HAND_1. 3 hits.
PS50222. EF_HAND_2. 4 hits.
[Graphical view]

ProtoNet

Search...

Entry information

Entry name

NCALD_BOVIN

Accession

Primary (citable) accession number: P61602
Secondary accession number(s): A1L533

Q9H0W2

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 24, 2004
Last sequence update:	January 23, 2007
Last modified:	November 16, 2011
This is version 70 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Secondary structure

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Family and domain databases

Entry information

Relevant documents