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P61601

- NCALD_HUMAN

UniProt

P61601 - NCALD_HUMAN

Protein

Neurocalcin-delta

Gene

NCALD

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 2 (23 Jan 2007)
      Previous versions | rss
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    • Comment

    Functioni

    May be involved in the calcium-dependent regulation of rhodopsin phosphorylation. Binds three calcium ions.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Calcium bindingi73 – 84121PROSITE-ProRule annotationAdd
    BLAST
    Calcium bindingi109 – 120122PROSITE-ProRule annotationAdd
    BLAST
    Calcium bindingi157 – 168123PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. actin binding Source: UniProtKB
    2. calcium ion binding Source: InterPro
    3. clathrin binding Source: UniProtKB
    4. tubulin binding Source: UniProtKB

    GO - Biological processi

    1. calcium-mediated signaling Source: Ensembl
    2. regulation of systemic arterial blood pressure Source: Ensembl
    3. synaptic transmission Source: Reactome
    4. vesicle-mediated transport Source: UniProtKB

    Keywords - Ligandi

    Calcium, Metal-binding

    Enzyme and pathway databases

    ReactomeiREACT_21346. Activation of Ca-permeable Kainate Receptor.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Neurocalcin-delta
    Gene namesi
    Name:NCALD
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 8

    Organism-specific databases

    HGNCiHGNC:7655. NCALD.

    Subcellular locationi

    GO - Cellular componenti

    1. clathrin coat of trans-Golgi network vesicle Source: UniProtKB
    2. cytosol Source: UniProtKB
    3. extracellular vesicular exosome Source: UniProt
    4. intracellular Source: LIFEdb

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA31458.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 193192Neurocalcin-deltaPRO_0000073782Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Lipidationi2 – 21N-myristoyl glycineBy similarity

    Keywords - PTMi

    Lipoprotein, Myristate

    Proteomic databases

    MaxQBiP61601.
    PaxDbiP61601.
    PRIDEiP61601.

    PTM databases

    PhosphoSiteiP61601.

    Expressioni

    Tissue specificityi

    Retina, cerebrum, cerebellum, brain stem, spinal cord, testis, ovary and small intestine.

    Gene expression databases

    ArrayExpressiP61601.
    BgeeiP61601.
    CleanExiHS_NCALD.
    GenevestigatoriP61601.

    Organism-specific databases

    HPAiHPA043245.

    Interactioni

    Protein-protein interaction databases

    BioGridi123839. 4 interactions.
    IntActiP61601. 2 interactions.
    MINTiMINT-1436083.
    STRINGi9606.ENSP00000220931.

    Structurei

    3D structure databases

    ProteinModelPortaliP61601.
    SMRiP61601. Positions 5-185.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini23 – 5836EF-hand 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini60 – 9536EF-hand 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini96 – 13136EF-hand 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini144 – 17936EF-hand 4PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the recoverin family.Curated
    Contains 4 EF-hand domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG5126.
    HOGENOMiHOG000233019.
    HOVERGENiHBG108179.
    OMAiRQMDKNK.
    OrthoDBiEOG7GJ6F3.
    PhylomeDBiP61601.
    TreeFamiTF300009.

    Family and domain databases

    Gene3Di1.10.238.10. 3 hits.
    InterProiIPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    IPR028846. Recoverin.
    [Graphical view]
    PANTHERiPTHR23055. PTHR23055. 1 hit.
    PfamiPF00036. EF-hand_1. 1 hit.
    PF13499. EF-hand_7. 1 hit.
    [Graphical view]
    SMARTiSM00054. EFh. 3 hits.
    [Graphical view]
    PROSITEiPS00018. EF_HAND_1. 3 hits.
    PS50222. EF_HAND_2. 4 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P61601-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGKQNSKLRP EVMQDLLEST DFTEHEIQEW YKGFLRDCPS GHLSMEEFKK    50
    IYGNFFPYGD ASKFAEHVFR TFDANGDGTI DFREFIIALS VTSRGKLEQK 100
    LKWAFSMYDL DGNGYISKAE MLEIVQAIYK MVSSVMKMPE DESTPEKRTE 150
    KIFRQMDTNR DGKLSLEEFI RGAKSDPSIV RLLQCDPSSA GQF 193
    Length:193
    Mass (Da):22,245
    Last modified:January 23, 2007 - v2
    Checksum:i20DD8B6FF47C4CBF
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti123 – 1231E → V in CAB66547. (PubMed:11230166)Curated
    Sequence conflicti166 – 1661L → M in AAH36098. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF251061 mRNA. Translation: AAK34951.1.
    AL136612 mRNA. Translation: CAB66547.1.
    BC036098 mRNA. Translation: AAH36098.1.
    BC063428 mRNA. Translation: AAH63428.1.
    CCDSiCCDS6292.1.
    RefSeqiNP_001035714.1. NM_001040624.1.
    NP_001035715.1. NM_001040625.1.
    NP_001035716.1. NM_001040626.1.
    NP_001035717.1. NM_001040627.1.
    NP_001035718.1. NM_001040628.1.
    NP_001035719.1. NM_001040629.1.
    NP_001035720.1. NM_001040630.1.
    NP_114430.2. NM_032041.2.
    XP_006716735.1. XM_006716672.1.
    UniGeneiHs.492427.

    Genome annotation databases

    EnsembliENST00000220931; ENSP00000220931; ENSG00000104490.
    ENST00000311028; ENSP00000310587; ENSG00000104490.
    ENST00000395923; ENSP00000379256; ENSG00000104490.
    ENST00000519508; ENSP00000430476; ENSG00000104490.
    ENST00000521599; ENSP00000428105; ENSG00000104490.
    GeneIDi83988.
    KEGGihsa:83988.
    UCSCiuc003yke.3. human.

    Polymorphism databases

    DMDMi47606440.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF251061 mRNA. Translation: AAK34951.1 .
    AL136612 mRNA. Translation: CAB66547.1 .
    BC036098 mRNA. Translation: AAH36098.1 .
    BC063428 mRNA. Translation: AAH63428.1 .
    CCDSi CCDS6292.1.
    RefSeqi NP_001035714.1. NM_001040624.1.
    NP_001035715.1. NM_001040625.1.
    NP_001035716.1. NM_001040626.1.
    NP_001035717.1. NM_001040627.1.
    NP_001035718.1. NM_001040628.1.
    NP_001035719.1. NM_001040629.1.
    NP_001035720.1. NM_001040630.1.
    NP_114430.2. NM_032041.2.
    XP_006716735.1. XM_006716672.1.
    UniGenei Hs.492427.

    3D structure databases

    ProteinModelPortali P61601.
    SMRi P61601. Positions 5-185.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 123839. 4 interactions.
    IntActi P61601. 2 interactions.
    MINTi MINT-1436083.
    STRINGi 9606.ENSP00000220931.

    PTM databases

    PhosphoSitei P61601.

    Polymorphism databases

    DMDMi 47606440.

    Proteomic databases

    MaxQBi P61601.
    PaxDbi P61601.
    PRIDEi P61601.

    Protocols and materials databases

    DNASUi 83988.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000220931 ; ENSP00000220931 ; ENSG00000104490 .
    ENST00000311028 ; ENSP00000310587 ; ENSG00000104490 .
    ENST00000395923 ; ENSP00000379256 ; ENSG00000104490 .
    ENST00000519508 ; ENSP00000430476 ; ENSG00000104490 .
    ENST00000521599 ; ENSP00000428105 ; ENSG00000104490 .
    GeneIDi 83988.
    KEGGi hsa:83988.
    UCSCi uc003yke.3. human.

    Organism-specific databases

    CTDi 83988.
    GeneCardsi GC08M102767.
    HGNCi HGNC:7655. NCALD.
    HPAi HPA043245.
    MIMi 606722. gene.
    neXtProti NX_P61601.
    PharmGKBi PA31458.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5126.
    HOGENOMi HOG000233019.
    HOVERGENi HBG108179.
    OMAi RQMDKNK.
    OrthoDBi EOG7GJ6F3.
    PhylomeDBi P61601.
    TreeFami TF300009.

    Enzyme and pathway databases

    Reactomei REACT_21346. Activation of Ca-permeable Kainate Receptor.

    Miscellaneous databases

    ChiTaRSi NCALD. human.
    GenomeRNAii 83988.
    NextBioi 73126.
    PROi P61601.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P61601.
    Bgeei P61601.
    CleanExi HS_NCALD.
    Genevestigatori P61601.

    Family and domain databases

    Gene3Di 1.10.238.10. 3 hits.
    InterProi IPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    IPR028846. Recoverin.
    [Graphical view ]
    PANTHERi PTHR23055. PTHR23055. 1 hit.
    Pfami PF00036. EF-hand_1. 1 hit.
    PF13499. EF-hand_7. 1 hit.
    [Graphical view ]
    SMARTi SM00054. EFh. 3 hits.
    [Graphical view ]
    PROSITEi PS00018. EF_HAND_1. 3 hits.
    PS50222. EF_HAND_2. 4 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning, mapping and characterization of the human neurocalcin delta gene (NCALD)."
      Wang W., Zhou Z., Zhao W., Huang Y., Tang R., Ying K., Xie Y., Mao Y.
      Biochim. Biophys. Acta 1518:162-167(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Fetal brain.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiNCALD_HUMAN
    AccessioniPrimary (citable) accession number: P61601
    Secondary accession number(s): P29554, Q8IYC3, Q9H0W2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 24, 2004
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 103 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 8
      Human chromosome 8: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3