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Protein

Neurocalcin-delta

Gene

NCALD

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in the calcium-dependent regulation of rhodopsin phosphorylation. Binds three calcium ions.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi73 – 84121PROSITE-ProRule annotationAdd
BLAST
Calcium bindingi109 – 120122PROSITE-ProRule annotationAdd
BLAST
Calcium bindingi157 – 168123PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. actin binding Source: UniProtKB
  2. calcium ion binding Source: InterPro
  3. clathrin binding Source: UniProtKB
  4. tubulin binding Source: UniProtKB

GO - Biological processi

  1. calcium-mediated signaling Source: Ensembl
  2. regulation of systemic arterial blood pressure Source: Ensembl
  3. synaptic transmission Source: Reactome
  4. vesicle-mediated transport Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_21346. Activation of Ca-permeable Kainate Receptor.

Names & Taxonomyi

Protein namesi
Recommended name:
Neurocalcin-delta
Gene namesi
Name:NCALD
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:7655. NCALD.

Subcellular locationi

GO - Cellular componenti

  1. clathrin coat of trans-Golgi network vesicle Source: UniProtKB
  2. cytosol Source: UniProtKB
  3. extracellular vesicular exosome Source: UniProtKB
  4. intracellular Source: LIFEdb
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31458.

Polymorphism and mutation databases

BioMutaiNCALD.
DMDMi47606440.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed
Chaini2 – 193192Neurocalcin-deltaPRO_0000073782Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi2 – 21N-myristoyl glycineBy similarity

Keywords - PTMi

Lipoprotein, Myristate

Proteomic databases

MaxQBiP61601.
PaxDbiP61601.
PRIDEiP61601.

PTM databases

PhosphoSiteiP61601.

Expressioni

Tissue specificityi

Retina, cerebrum, cerebellum, brain stem, spinal cord, testis, ovary and small intestine.

Gene expression databases

BgeeiP61601.
CleanExiHS_NCALD.
ExpressionAtlasiP61601. baseline and differential.
GenevestigatoriP61601.

Organism-specific databases

HPAiHPA043245.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
C1QTNF2Q9BXJ56EBI-749635,EBI-2817707
DTX2Q4ZH495EBI-749635,EBI-10192429
DTX2Q86UW97EBI-749635,EBI-740376
MEOX2A4D1273EBI-749635,EBI-10172134
tirQ7DB773EBI-749635,EBI-6480811From a different organism.

Protein-protein interaction databases

BioGridi123839. 11 interactions.
IntActiP61601. 7 interactions.
MINTiMINT-1436083.
STRINGi9606.ENSP00000220931.

Structurei

3D structure databases

ProteinModelPortaliP61601.
SMRiP61601. Positions 5-185.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini23 – 5836EF-hand 1PROSITE-ProRule annotationAdd
BLAST
Domaini60 – 9536EF-hand 2PROSITE-ProRule annotationAdd
BLAST
Domaini96 – 13136EF-hand 3PROSITE-ProRule annotationAdd
BLAST
Domaini144 – 17936EF-hand 4PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the recoverin family.Curated
Contains 4 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG5126.
GeneTreeiENSGT00760000118820.
HOGENOMiHOG000233019.
HOVERGENiHBG108179.
InParanoidiP61601.
OMAiQCDPSAQ.
OrthoDBiEOG7GJ6F3.
PhylomeDBiP61601.
TreeFamiTF300009.

Family and domain databases

Gene3Di1.10.238.10. 3 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR028846. Recoverin.
[Graphical view]
PANTHERiPTHR23055. PTHR23055. 1 hit.
PfamiPF00036. EF-hand_1. 1 hit.
PF13499. EF-hand_7. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 3 hits.
[Graphical view]
PROSITEiPS00018. EF_HAND_1. 3 hits.
PS50222. EF_HAND_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P61601-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKQNSKLRP EVMQDLLEST DFTEHEIQEW YKGFLRDCPS GHLSMEEFKK
60 70 80 90 100
IYGNFFPYGD ASKFAEHVFR TFDANGDGTI DFREFIIALS VTSRGKLEQK
110 120 130 140 150
LKWAFSMYDL DGNGYISKAE MLEIVQAIYK MVSSVMKMPE DESTPEKRTE
160 170 180 190
KIFRQMDTNR DGKLSLEEFI RGAKSDPSIV RLLQCDPSSA GQF
Length:193
Mass (Da):22,245
Last modified:January 23, 2007 - v2
Checksum:i20DD8B6FF47C4CBF
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti123 – 1231E → V in CAB66547 (PubMed:11230166).Curated
Sequence conflicti166 – 1661L → M in AAH36098 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF251061 mRNA. Translation: AAK34951.1.
AL136612 mRNA. Translation: CAB66547.1.
BC036098 mRNA. Translation: AAH36098.1.
BC063428 mRNA. Translation: AAH63428.1.
CCDSiCCDS6292.1.
RefSeqiNP_001035714.1. NM_001040624.1.
NP_001035715.1. NM_001040625.1.
NP_001035716.1. NM_001040626.1.
NP_001035717.1. NM_001040627.1.
NP_001035718.1. NM_001040628.1.
NP_001035719.1. NM_001040629.1.
NP_001035720.1. NM_001040630.1.
NP_114430.2. NM_032041.2.
UniGeneiHs.492427.

Genome annotation databases

EnsembliENST00000220931; ENSP00000220931; ENSG00000104490.
ENST00000311028; ENSP00000310587; ENSG00000104490.
ENST00000395923; ENSP00000379256; ENSG00000104490.
ENST00000519508; ENSP00000430476; ENSG00000104490.
ENST00000521599; ENSP00000428105; ENSG00000104490.
GeneIDi83988.
KEGGihsa:83988.
UCSCiuc003yke.3. human.

Polymorphism and mutation databases

BioMutaiNCALD.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF251061 mRNA. Translation: AAK34951.1.
AL136612 mRNA. Translation: CAB66547.1.
BC036098 mRNA. Translation: AAH36098.1.
BC063428 mRNA. Translation: AAH63428.1.
CCDSiCCDS6292.1.
RefSeqiNP_001035714.1. NM_001040624.1.
NP_001035715.1. NM_001040625.1.
NP_001035716.1. NM_001040626.1.
NP_001035717.1. NM_001040627.1.
NP_001035718.1. NM_001040628.1.
NP_001035719.1. NM_001040629.1.
NP_001035720.1. NM_001040630.1.
NP_114430.2. NM_032041.2.
UniGeneiHs.492427.

3D structure databases

ProteinModelPortaliP61601.
SMRiP61601. Positions 5-185.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123839. 11 interactions.
IntActiP61601. 7 interactions.
MINTiMINT-1436083.
STRINGi9606.ENSP00000220931.

PTM databases

PhosphoSiteiP61601.

Polymorphism and mutation databases

BioMutaiNCALD.
DMDMi47606440.

Proteomic databases

MaxQBiP61601.
PaxDbiP61601.
PRIDEiP61601.

Protocols and materials databases

DNASUi83988.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000220931; ENSP00000220931; ENSG00000104490.
ENST00000311028; ENSP00000310587; ENSG00000104490.
ENST00000395923; ENSP00000379256; ENSG00000104490.
ENST00000519508; ENSP00000430476; ENSG00000104490.
ENST00000521599; ENSP00000428105; ENSG00000104490.
GeneIDi83988.
KEGGihsa:83988.
UCSCiuc003yke.3. human.

Organism-specific databases

CTDi83988.
GeneCardsiGC08M102698.
HGNCiHGNC:7655. NCALD.
HPAiHPA043245.
MIMi606722. gene.
neXtProtiNX_P61601.
PharmGKBiPA31458.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG5126.
GeneTreeiENSGT00760000118820.
HOGENOMiHOG000233019.
HOVERGENiHBG108179.
InParanoidiP61601.
OMAiQCDPSAQ.
OrthoDBiEOG7GJ6F3.
PhylomeDBiP61601.
TreeFamiTF300009.

Enzyme and pathway databases

ReactomeiREACT_21346. Activation of Ca-permeable Kainate Receptor.

Miscellaneous databases

ChiTaRSiNCALD. human.
GenomeRNAii83988.
NextBioi73126.
PROiP61601.
SOURCEiSearch...

Gene expression databases

BgeeiP61601.
CleanExiHS_NCALD.
ExpressionAtlasiP61601. baseline and differential.
GenevestigatoriP61601.

Family and domain databases

Gene3Di1.10.238.10. 3 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR028846. Recoverin.
[Graphical view]
PANTHERiPTHR23055. PTHR23055. 1 hit.
PfamiPF00036. EF-hand_1. 1 hit.
PF13499. EF-hand_7. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 3 hits.
[Graphical view]
PROSITEiPS00018. EF_HAND_1. 3 hits.
PS50222. EF_HAND_2. 4 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning, mapping and characterization of the human neurocalcin delta gene (NCALD)."
    Wang W., Zhou Z., Zhao W., Huang Y., Tang R., Ying K., Xie Y., Mao Y.
    Biochim. Biophys. Acta 1518:162-167(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Fetal brain.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiNCALD_HUMAN
AccessioniPrimary (citable) accession number: P61601
Secondary accession number(s): P29554, Q8IYC3, Q9H0W2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: January 23, 2007
Last modified: April 29, 2015
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.