P61601 (NCALD_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Neurocalcin-delta

Gene names

Name:

NCALD

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	193 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May be involved in the calcium-dependent regulation of rhodopsin phosphorylation. Binds three calcium ions.
Tissue specificity	Retina, cerebrum, cerebellum, brain stem, spinal cord, testis, ovary and small intestine.
Sequence similarities	Belongs to the recoverin family. Contains 4 EF-hand domains.

Ontologies

Keywords
Domain	Repeat
Ligand	Calcium Metal-binding
PTM	Lipoprotein Myristate
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	synaptic transmission Traceable author statement. Source: Reactome vesicle-mediated transport Non-traceable author statement PubMed 11964161. Source: UniProtKB
Cellular_component	clathrin coat of trans-Golgi network vesicle Non-traceable author statement PubMed 11964161. Source: UniProtKB cytosol Non-traceable author statement PubMed 11964161. Source: UniProtKB
Molecular_function	actin binding Inferred from direct assay PubMed 11964161. Source: UniProtKB calcium ion binding Inferred from electronic annotation. Source: InterPro clathrin binding Inferred from direct assay PubMed 11964161. Source: UniProtKB tubulin binding Inferred from direct assay PubMed 11964161. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 193	192	Neurocalcin-delta		PRO_0000073782
Regions
	Domain	23 – 58	36	EF-hand 1
	Domain	60 – 95	36	EF-hand 2
	Domain	96 – 131	36	EF-hand 3
	Domain	144 – 179	36	EF-hand 4
	Calcium binding	73 – 84	12	1 Potential
	Calcium binding	109 – 120	12	2 Potential
	Calcium binding	157 – 168	12	3 Potential
Amino acid modifications
	Lipidation	2	1	N-myristoyl glycine By similarity
Experimental info
	Sequence conflict	123	1	E → V in CAB66547. Ref.2
	Sequence conflict	166	1	L → M in AAH36098. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	P61601 [UniParc]. Last modified January 23, 2007. Version 2. Checksum: 20DD8B6FF47C4CBF	FASTA	193	22,245
	10 20 30 40 50 60 MGKQNSKLRP EVMQDLLEST DFTEHEIQEW YKGFLRDCPS GHLSMEEFKK IYGNFFPYGD 70 80 90 100 110 120 ASKFAEHVFR TFDANGDGTI DFREFIIALS VTSRGKLEQK LKWAFSMYDL DGNGYISKAE 130 140 150 160 170 180 MLEIVQAIYK MVSSVMKMPE DESTPEKRTE KIFRQMDTNR DGKLSLEEFI RGAKSDPSIV 190 RLLQCDPSSA GQF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning, mapping and characterization of the human neurocalcin delta gene (NCALD)." Wang W., Zhou Z., Zhao W., Huang Y., Tang R., Ying K., Xie Y., Mao Y. Biochim. Biophys. Acta 1518:162-167(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Fetal brain.
[2]	"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs." Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S., Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W., Ottenwaelder B., Obermaier B. , Tampe J., Heubner D., Wambutt R., Korn B., Klein M., Poustka A. Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF251061 mRNA. Translation: AAK34951.1. AL136612 mRNA. Translation: CAB66547.1. BC036098 mRNA. Translation: AAH36098.1. BC063428 mRNA. Translation: AAH63428.1.
IPI	IPI00395510.
RefSeq	NP_001035714.1. NM_001040624.1. NP_001035715.1. NM_001040625.1. NP_001035716.1. NM_001040626.1. NP_001035717.1. NM_001040627.1. NP_001035718.1. NM_001040628.1. NP_001035719.1. NM_001040629.1. NP_001035720.1. NM_001040630.1. NP_114430.2. NM_032041.2.
UniGene	Hs.492427.
3D structure databases
ProteinModelPortal	P61601.
ModBase	Search...
Protein-protein interaction databases
IntAct	P61601. 1 interaction.
MINT	MINT-1436083.
STRING	9606.ENSP00000220931.
PTM databases
PhosphoSite	P61601.
Polymorphism databases
DMDM	47606440.
Proteomic databases
PaxDb	P61601.
PRIDE	P61601.
Protocols and materials databases
DNASU	83988.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000220931; ENSP00000220931; ENSG00000104490. ENST00000311028; ENSP00000310587; ENSG00000104490. ENST00000395923; ENSP00000379256; ENSG00000104490. ENST00000519508; ENSP00000430476; ENSG00000104490. ENST00000521599; ENSP00000428105; ENSG00000104490.
GeneID	83988.
KEGG	hsa:83988.
UCSC	uc003yke.3. human.
Organism-specific databases
CTD	83988.
GeneCards	GC08M102767.
HGNC	HGNC:7655. NCALD.
HPA	HPA043245.
MIM	606722. gene.
neXtProt	NX_P61601.
PharmGKB	PA31458.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5126.
HOGENOM	HOG000233019.
HOVERGEN	HBG108179.
OMA	RQMDKNK.
OrthoDB	EOG4MKNH8.
PhylomeDB	P61601.
Enzyme and pathway databases
Reactome	REACT_13685. Neuronal System.
Gene expression databases
ArrayExpress	P61601.
Bgee	P61601.
CleanEx	HS_NCALD.
Genevestigator	P61601.
GermOnline	ENSG00000104490. Homo sapiens.
Family and domain databases
Gene3D	1.10.238.10. 3 hits.
InterPro	IPR011992. EF-hand-like_dom. IPR018247. EF_Hand_1_Ca_BS. IPR002048. EF_hand_dom. IPR001125. Recoverin. [Graphical view]
Pfam	PF13499. EF_hand_5. 1 hit. PF00036. efhand. 1 hit. [Graphical view]
PRINTS	PR00450. RECOVERIN.
SMART	SM00054. EFh. 3 hits. [Graphical view]
PROSITE	PS00018. EF_HAND_1. 3 hits. PS50222. EF_HAND_2. 4 hits. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	NCALD. human.
GenomeRNAi	83988.
NextBio	73126.
SOURCE	Search...

Entry information

Entry name

NCALD_HUMAN

Accession

Primary (citable) accession number: P61601
Secondary accession number(s): P29554, Q8IYC3, Q9H0W2

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 24, 2004
Last sequence update:	January 23, 2007
Last modified:	May 1, 2013
This is version 90 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.