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Protein

Neurocalcin-delta

Gene

NCALD

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in the calcium-dependent regulation of rhodopsin phosphorylation. Binds three calcium ions.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi73 – 841PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi109 – 1202PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi157 – 1683PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

  • actin binding Source: UniProtKB
  • alpha-tubulin binding Source: Ensembl
  • calcium ion binding Source: InterPro
  • clathrin binding Source: UniProtKB
  • ligand-gated ion channel activity Source: Reactome
  • tubulin binding Source: UniProtKB

GO - Biological processi

Keywordsi

LigandCalcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-HSA-451308 Activation of Ca-permeable Kainate Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
Neurocalcin-delta
Gene namesi
Name:NCALD
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000104490.17
HGNCiHGNC:7655 NCALD
MIMi606722 gene
neXtProtiNX_P61601

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi83988
OpenTargetsiENSG00000104490
PharmGKBiPA31458

Polymorphism and mutation databases

BioMutaiNCALD
DMDMi47606440

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved
ChainiPRO_00000737822 – 193Neurocalcin-deltaAdd BLAST192

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycineBy similarity1

Keywords - PTMi

Lipoprotein, Myristate

Proteomic databases

EPDiP61601
MaxQBiP61601
PaxDbiP61601
PeptideAtlasiP61601
PRIDEiP61601

PTM databases

iPTMnetiP61601
PhosphoSitePlusiP61601

Expressioni

Tissue specificityi

Retina, cerebrum, cerebellum, brain stem, spinal cord, testis, ovary and small intestine.

Gene expression databases

BgeeiENSG00000104490
CleanExiHS_NCALD
ExpressionAtlasiP61601 baseline and differential
GenevisibleiP61601 HS

Organism-specific databases

HPAiHPA043245

Interactioni

Binary interactionsi

Show more details

GO - Molecular functioni

  • actin binding Source: UniProtKB
  • alpha-tubulin binding Source: Ensembl
  • clathrin binding Source: UniProtKB
  • tubulin binding Source: UniProtKB

Protein-protein interaction databases

BioGridi123839, 15 interactors
IntActiP61601, 15 interactors
MINTiP61601
STRINGi9606.ENSP00000220931

Structurei

3D structure databases

ProteinModelPortaliP61601
SMRiP61601
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 58EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini60 – 95EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini96 – 131EF-hand 3PROSITE-ProRule annotationAdd BLAST36
Domaini144 – 179EF-hand 4PROSITE-ProRule annotationAdd BLAST36

Sequence similaritiesi

Belongs to the recoverin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0044 Eukaryota
COG5126 LUCA
GeneTreeiENSGT00760000118820
HOGENOMiHOG000233019
HOVERGENiHBG108179
InParanoidiP61601
KOiK19695
OMAiCCNPIPS
PhylomeDBiP61601
TreeFamiTF300009

Family and domain databases

CDDicd00051 EFh, 2 hits
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
PfamiView protein in Pfam
PF13499 EF-hand_7, 1 hit
PF13833 EF-hand_8, 1 hit
SMARTiView protein in SMART
SM00054 EFh, 3 hits
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 3 hits
PS50222 EF_HAND_2, 4 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P61601-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKQNSKLRP EVMQDLLEST DFTEHEIQEW YKGFLRDCPS GHLSMEEFKK
60 70 80 90 100
IYGNFFPYGD ASKFAEHVFR TFDANGDGTI DFREFIIALS VTSRGKLEQK
110 120 130 140 150
LKWAFSMYDL DGNGYISKAE MLEIVQAIYK MVSSVMKMPE DESTPEKRTE
160 170 180 190
KIFRQMDTNR DGKLSLEEFI RGAKSDPSIV RLLQCDPSSA GQF
Length:193
Mass (Da):22,245
Last modified:January 23, 2007 - v2
Checksum:i20DD8B6FF47C4CBF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti123E → V in CAB66547 (PubMed:11230166).Curated1
Sequence conflicti166L → M in AAH36098 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF251061 mRNA Translation: AAK34951.1
AL136612 mRNA Translation: CAB66547.1
BC036098 mRNA Translation: AAH36098.1
BC063428 mRNA Translation: AAH63428.1
CCDSiCCDS6292.1
RefSeqiNP_001035714.1, NM_001040624.1
NP_001035715.1, NM_001040625.1
NP_001035716.1, NM_001040626.1
NP_001035717.1, NM_001040627.1
NP_001035718.1, NM_001040628.1
NP_001035719.1, NM_001040629.1
NP_001035720.1, NM_001040630.1
NP_114430.2, NM_032041.2
XP_011515634.1, XM_011517332.2
XP_011515635.1, XM_011517333.2
XP_011515636.1, XM_011517334.2
XP_011515637.1, XM_011517335.2
XP_016869390.1, XM_017013901.1
XP_016869391.1, XM_017013902.1
UniGeneiHs.492427

Genome annotation databases

EnsembliENST00000220931; ENSP00000220931; ENSG00000104490
ENST00000311028; ENSP00000310587; ENSG00000104490
ENST00000395923; ENSP00000379256; ENSG00000104490
ENST00000519508; ENSP00000430476; ENSG00000104490
ENST00000521599; ENSP00000428105; ENSG00000104490
GeneIDi83988
KEGGihsa:83988
UCSCiuc003yke.4 human

Similar proteinsi

Entry informationi

Entry nameiNCALD_HUMAN
AccessioniPrimary (citable) accession number: P61601
Secondary accession number(s): P29554, Q8IYC3, Q9H0W2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 134 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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