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P61601

- NCALD_HUMAN

UniProt

P61601 - NCALD_HUMAN

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Protein
Neurocalcin-delta
Gene
NCALD
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

May be involved in the calcium-dependent regulation of rhodopsin phosphorylation. Binds three calcium ions.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi73 – 84121 Reviewed prediction
Add
BLAST
Calcium bindingi109 – 120122 Reviewed prediction
Add
BLAST
Calcium bindingi157 – 168123 Reviewed prediction
Add
BLAST

GO - Molecular functioni

  1. actin binding Source: UniProtKB
  2. calcium ion binding Source: InterPro
  3. clathrin binding Source: UniProtKB
  4. tubulin binding Source: UniProtKB

GO - Biological processi

  1. calcium-mediated signaling Source: Ensembl
  2. regulation of systemic arterial blood pressure Source: Ensembl
  3. synaptic transmission Source: Reactome
  4. vesicle-mediated transport Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_21346. Activation of Ca-permeable Kainate Receptor.

Names & Taxonomyi

Protein namesi
Recommended name:
Neurocalcin-delta
Gene namesi
Name:NCALD
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 8

Organism-specific databases

HGNCiHGNC:7655. NCALD.

Subcellular locationi

GO - Cellular componenti

  1. clathrin coat of trans-Golgi network vesicle Source: UniProtKB
  2. cytosol Source: UniProtKB
  3. extracellular vesicular exosome Source: UniProt
  4. intracellular Source: LIFEdb
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31458.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 193192Neurocalcin-delta
PRO_0000073782Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi2 – 21N-myristoyl glycine By similarity

Keywords - PTMi

Lipoprotein, Myristate

Proteomic databases

MaxQBiP61601.
PaxDbiP61601.
PRIDEiP61601.

PTM databases

PhosphoSiteiP61601.

Expressioni

Tissue specificityi

Retina, cerebrum, cerebellum, brain stem, spinal cord, testis, ovary and small intestine.

Gene expression databases

ArrayExpressiP61601.
BgeeiP61601.
CleanExiHS_NCALD.
GenevestigatoriP61601.

Organism-specific databases

HPAiHPA043245.

Interactioni

Protein-protein interaction databases

BioGridi123839. 4 interactions.
IntActiP61601. 2 interactions.
MINTiMINT-1436083.
STRINGi9606.ENSP00000220931.

Structurei

3D structure databases

ProteinModelPortaliP61601.
SMRiP61601. Positions 5-185.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini23 – 5836EF-hand 1
Add
BLAST
Domaini60 – 9536EF-hand 2
Add
BLAST
Domaini96 – 13136EF-hand 3
Add
BLAST
Domaini144 – 17936EF-hand 4
Add
BLAST

Sequence similaritiesi

Belongs to the recoverin family.
Contains 4 EF-hand domains.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG5126.
HOGENOMiHOG000233019.
HOVERGENiHBG108179.
OMAiRQMDKNK.
OrthoDBiEOG7GJ6F3.
PhylomeDBiP61601.
TreeFamiTF300009.

Family and domain databases

Gene3Di1.10.238.10. 3 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR028846. Recoverin.
[Graphical view]
PANTHERiPTHR23055. PTHR23055. 1 hit.
PfamiPF00036. EF-hand_1. 1 hit.
PF13499. EF-hand_7. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 3 hits.
[Graphical view]
PROSITEiPS00018. EF_HAND_1. 3 hits.
PS50222. EF_HAND_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P61601-1 [UniParc]FASTAAdd to Basket

« Hide

MGKQNSKLRP EVMQDLLEST DFTEHEIQEW YKGFLRDCPS GHLSMEEFKK    50
IYGNFFPYGD ASKFAEHVFR TFDANGDGTI DFREFIIALS VTSRGKLEQK 100
LKWAFSMYDL DGNGYISKAE MLEIVQAIYK MVSSVMKMPE DESTPEKRTE 150
KIFRQMDTNR DGKLSLEEFI RGAKSDPSIV RLLQCDPSSA GQF 193
Length:193
Mass (Da):22,245
Last modified:January 23, 2007 - v2
Checksum:i20DD8B6FF47C4CBF
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti123 – 1231E → V in CAB66547. 1 Publication
Sequence conflicti166 – 1661L → M in AAH36098. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF251061 mRNA. Translation: AAK34951.1.
AL136612 mRNA. Translation: CAB66547.1.
BC036098 mRNA. Translation: AAH36098.1.
BC063428 mRNA. Translation: AAH63428.1.
CCDSiCCDS6292.1.
RefSeqiNP_001035714.1. NM_001040624.1.
NP_001035715.1. NM_001040625.1.
NP_001035716.1. NM_001040626.1.
NP_001035717.1. NM_001040627.1.
NP_001035718.1. NM_001040628.1.
NP_001035719.1. NM_001040629.1.
NP_001035720.1. NM_001040630.1.
NP_114430.2. NM_032041.2.
XP_006716735.1. XM_006716672.1.
UniGeneiHs.492427.

Genome annotation databases

EnsembliENST00000220931; ENSP00000220931; ENSG00000104490.
ENST00000311028; ENSP00000310587; ENSG00000104490.
ENST00000395923; ENSP00000379256; ENSG00000104490.
ENST00000519508; ENSP00000430476; ENSG00000104490.
ENST00000521599; ENSP00000428105; ENSG00000104490.
GeneIDi83988.
KEGGihsa:83988.
UCSCiuc003yke.3. human.

Polymorphism databases

DMDMi47606440.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF251061 mRNA. Translation: AAK34951.1 .
AL136612 mRNA. Translation: CAB66547.1 .
BC036098 mRNA. Translation: AAH36098.1 .
BC063428 mRNA. Translation: AAH63428.1 .
CCDSi CCDS6292.1.
RefSeqi NP_001035714.1. NM_001040624.1.
NP_001035715.1. NM_001040625.1.
NP_001035716.1. NM_001040626.1.
NP_001035717.1. NM_001040627.1.
NP_001035718.1. NM_001040628.1.
NP_001035719.1. NM_001040629.1.
NP_001035720.1. NM_001040630.1.
NP_114430.2. NM_032041.2.
XP_006716735.1. XM_006716672.1.
UniGenei Hs.492427.

3D structure databases

ProteinModelPortali P61601.
SMRi P61601. Positions 5-185.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 123839. 4 interactions.
IntActi P61601. 2 interactions.
MINTi MINT-1436083.
STRINGi 9606.ENSP00000220931.

PTM databases

PhosphoSitei P61601.

Polymorphism databases

DMDMi 47606440.

Proteomic databases

MaxQBi P61601.
PaxDbi P61601.
PRIDEi P61601.

Protocols and materials databases

DNASUi 83988.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000220931 ; ENSP00000220931 ; ENSG00000104490 .
ENST00000311028 ; ENSP00000310587 ; ENSG00000104490 .
ENST00000395923 ; ENSP00000379256 ; ENSG00000104490 .
ENST00000519508 ; ENSP00000430476 ; ENSG00000104490 .
ENST00000521599 ; ENSP00000428105 ; ENSG00000104490 .
GeneIDi 83988.
KEGGi hsa:83988.
UCSCi uc003yke.3. human.

Organism-specific databases

CTDi 83988.
GeneCardsi GC08M102767.
HGNCi HGNC:7655. NCALD.
HPAi HPA043245.
MIMi 606722. gene.
neXtProti NX_P61601.
PharmGKBi PA31458.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5126.
HOGENOMi HOG000233019.
HOVERGENi HBG108179.
OMAi RQMDKNK.
OrthoDBi EOG7GJ6F3.
PhylomeDBi P61601.
TreeFami TF300009.

Enzyme and pathway databases

Reactomei REACT_21346. Activation of Ca-permeable Kainate Receptor.

Miscellaneous databases

ChiTaRSi NCALD. human.
GenomeRNAii 83988.
NextBioi 73126.
PROi P61601.
SOURCEi Search...

Gene expression databases

ArrayExpressi P61601.
Bgeei P61601.
CleanExi HS_NCALD.
Genevestigatori P61601.

Family and domain databases

Gene3Di 1.10.238.10. 3 hits.
InterProi IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR028846. Recoverin.
[Graphical view ]
PANTHERi PTHR23055. PTHR23055. 1 hit.
Pfami PF00036. EF-hand_1. 1 hit.
PF13499. EF-hand_7. 1 hit.
[Graphical view ]
SMARTi SM00054. EFh. 3 hits.
[Graphical view ]
PROSITEi PS00018. EF_HAND_1. 3 hits.
PS50222. EF_HAND_2. 4 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning, mapping and characterization of the human neurocalcin delta gene (NCALD)."
    Wang W., Zhou Z., Zhao W., Huang Y., Tang R., Ying K., Xie Y., Mao Y.
    Biochim. Biophys. Acta 1518:162-167(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Fetal brain.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiNCALD_HUMAN
AccessioniPrimary (citable) accession number: P61601
Secondary accession number(s): P29554, Q8IYC3, Q9H0W2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: January 23, 2007
Last modified: September 3, 2014
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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