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P61601 (NCALD_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 98. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Neurocalcin-delta
Gene names
Name:NCALD
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length193 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May be involved in the calcium-dependent regulation of rhodopsin phosphorylation. Binds three calcium ions.

Tissue specificity

Retina, cerebrum, cerebellum, brain stem, spinal cord, testis, ovary and small intestine.

Sequence similarities

Belongs to the recoverin family.

Contains 4 EF-hand domains.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 193192Neurocalcin-delta
PRO_0000073782

Regions

Domain23 – 5836EF-hand 1
Domain60 – 9536EF-hand 2
Domain96 – 13136EF-hand 3
Domain144 – 17936EF-hand 4
Calcium binding73 – 84121 Potential
Calcium binding109 – 120122 Potential
Calcium binding157 – 168123 Potential

Amino acid modifications

Lipidation21N-myristoyl glycine By similarity

Experimental info

Sequence conflict1231E → V in CAB66547. Ref.2
Sequence conflict1661L → M in AAH36098. Ref.3

Sequences

Sequence LengthMass (Da)Tools
P61601 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: 20DD8B6FF47C4CBF

FASTA19322,245
        10         20         30         40         50         60 
MGKQNSKLRP EVMQDLLEST DFTEHEIQEW YKGFLRDCPS GHLSMEEFKK IYGNFFPYGD 

        70         80         90        100        110        120 
ASKFAEHVFR TFDANGDGTI DFREFIIALS VTSRGKLEQK LKWAFSMYDL DGNGYISKAE 

       130        140        150        160        170        180 
MLEIVQAIYK MVSSVMKMPE DESTPEKRTE KIFRQMDTNR DGKLSLEEFI RGAKSDPSIV 

       190 
RLLQCDPSSA GQF 

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning, mapping and characterization of the human neurocalcin delta gene (NCALD)."
Wang W., Zhou Z., Zhao W., Huang Y., Tang R., Ying K., Xie Y., Mao Y.
Biochim. Biophys. Acta 1518:162-167(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Fetal brain.
[2]"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs."
Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S., Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W., Ottenwaelder B., Obermaier B. expand/collapse author list , Tampe J., Heubner D., Wambutt R., Korn B., Klein M., Poustka A.
Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF251061 mRNA. Translation: AAK34951.1.
AL136612 mRNA. Translation: CAB66547.1.
BC036098 mRNA. Translation: AAH36098.1.
BC063428 mRNA. Translation: AAH63428.1.
RefSeqNP_001035714.1. NM_001040624.1.
NP_001035715.1. NM_001040625.1.
NP_001035716.1. NM_001040626.1.
NP_001035717.1. NM_001040627.1.
NP_001035718.1. NM_001040628.1.
NP_001035719.1. NM_001040629.1.
NP_001035720.1. NM_001040630.1.
NP_114430.2. NM_032041.2.
UniGeneHs.492427.

3D structure databases

ProteinModelPortalP61601.
SMRP61601. Positions 5-185.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid123839. 4 interactions.
IntActP61601. 2 interactions.
MINTMINT-1436083.
STRING9606.ENSP00000220931.

PTM databases

PhosphoSiteP61601.

Polymorphism databases

DMDM47606440.

Proteomic databases

PaxDbP61601.
PRIDEP61601.

Protocols and materials databases

DNASU83988.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000220931; ENSP00000220931; ENSG00000104490.
ENST00000311028; ENSP00000310587; ENSG00000104490.
ENST00000395923; ENSP00000379256; ENSG00000104490.
ENST00000519508; ENSP00000430476; ENSG00000104490.
ENST00000521599; ENSP00000428105; ENSG00000104490.
GeneID83988.
KEGGhsa:83988.
UCSCuc003yke.3. human.

Organism-specific databases

CTD83988.
GeneCardsGC08M102767.
HGNCHGNC:7655. NCALD.
HPAHPA043245.
MIM606722. gene.
neXtProtNX_P61601.
PharmGKBPA31458.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5126.
HOGENOMHOG000233019.
HOVERGENHBG108179.
OMARQMDKNK.
OrthoDBEOG7GJ6F3.
PhylomeDBP61601.
TreeFamTF300009.

Enzyme and pathway databases

ReactomeREACT_13685. Neuronal System.

Gene expression databases

ArrayExpressP61601.
BgeeP61601.
CleanExHS_NCALD.
GenevestigatorP61601.

Family and domain databases

Gene3D1.10.238.10. 3 hits.
InterProIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR001125. Recoverin_like.
[Graphical view]
PfamPF00036. EF-hand_1. 1 hit.
PF13499. EF-hand_7. 1 hit.
[Graphical view]
PRINTSPR00450. RECOVERIN.
SMARTSM00054. EFh. 3 hits.
[Graphical view]
PROSITEPS00018. EF_HAND_1. 3 hits.
PS50222. EF_HAND_2. 4 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSNCALD. human.
GenomeRNAi83988.
NextBio73126.
PROP61601.
SOURCESearch...

Entry information

Entry nameNCALD_HUMAN
AccessionPrimary (citable) accession number: P61601
Secondary accession number(s): P29554, Q8IYC3, Q9H0W2
Entry history
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: January 23, 2007
Last modified: April 16, 2014
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 8

Human chromosome 8: entries, gene names and cross-references to MIM