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P61599

- NAA20_HUMAN

UniProt

P61599 - NAA20_HUMAN

Protein

N-alpha-acetyltransferase 20

Gene

NAA20

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 1 (24 May 2004)
      Previous versions | rss
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    Functioni

    Catalytic subunit of the NatB complex which catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Asp, Met-Glu, Met-Asn and Met-Gln. Proteins with cell cycle functions are overrepresented in the pool of NatB substrates. Required for maintaining the structure and function of actomyosin fibers and for proper cellular migration.1 Publication

    Catalytic activityi

    Acetyl-CoA + peptide = N(alpha)-acetylpeptide + CoA.

    GO - Molecular functioni

    1. peptide alpha-N-acetyltransferase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Acyltransferase, Transferase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    N-alpha-acetyltransferase 20 (EC:2.3.1.88)
    Alternative name(s):
    Methionine N-acetyltransferase
    N-acetyltransferase 5
    N-terminal acetyltransferase B complex catalytic subunit NAA20
    N-terminal acetyltransferase B complex catalytic subunit NAT5
    Short name:
    NatB complex subunit NAT5
    NatB catalytic subunit
    Gene namesi
    Name:NAA20
    Synonyms:NAT5
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 20

    Organism-specific databases

    HGNCiHGNC:15908. NAA20.

    Subcellular locationi

    Cytoplasm 1 Publication. Nucleus 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. intracellular Source: LIFEdb
    3. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA31449.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 178178N-alpha-acetyltransferase 20PRO_0000074534Add
    BLAST

    Proteomic databases

    MaxQBiP61599.
    PaxDbiP61599.
    PRIDEiP61599.

    PTM databases

    PhosphoSiteiP61599.

    Expressioni

    Gene expression databases

    ArrayExpressiP61599.
    BgeeiP61599.
    CleanExiHS_NAT5.
    GenevestigatoriP61599.

    Organism-specific databases

    HPAiHPA053117.

    Interactioni

    Subunit structurei

    Component of the N-terminal acetyltransferase B (NatB) complex which is composed of NAA20 and NAA25.

    Protein-protein interaction databases

    BioGridi119313. 8 interactions.
    IntActiP61599. 1 interaction.
    MINTiMINT-3022686.
    STRINGi9606.ENSP00000335636.

    Structurei

    3D structure databases

    ProteinModelPortaliP61599.
    SMRiP61599. Positions 4-157.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini2 – 157156N-acetyltransferasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 N-acetyltransferase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0456.
    HOVERGENiHBG107217.
    InParanoidiP61599.
    KOiK17972.
    OMAiPWHAHIT.
    OrthoDBiEOG7PP57X.
    PhylomeDBiP61599.
    TreeFamiTF105829.

    Family and domain databases

    Gene3Di3.40.630.30. 1 hit.
    InterProiIPR016181. Acyl_CoA_acyltransferase.
    IPR000182. GNAT_dom.
    [Graphical view]
    PfamiPF00583. Acetyltransf_1. 1 hit.
    [Graphical view]
    SUPFAMiSSF55729. SSF55729. 1 hit.
    PROSITEiPS51186. GNAT. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P61599-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MTTLRAFTCD DLFRFNNINL DPLTETYGIP FYLQYLAHWP EYFIVAEAPG    50
    GELMGYIMGK AEGSVAREEW HGHVTALSVA PEFRRLGLAA KLMELLEEIS 100
    ERKGGFFVDL FVRVSNQVAV NMYKQLGYSV YRTVIEYYSA SNGEPDEDAY 150
    DMRKALSRDT EKKSIIPLPH PVRPEDIE 178
    Length:178
    Mass (Da):20,368
    Last modified:May 24, 2004 - v1
    Checksum:iC5CCEA50CD60E097
    GO
    Isoform 2 (identifier: P61599-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         103-178: KGGFFVDLFV...PHPVRPEDIE → YEESTFQGY

    Note: No experimental confirmation available.

    Show »
    Length:111
    Mass (Da):12,746
    Checksum:i55D80084800FB8E3
    GO

    Sequence cautioni

    The sequence BG548527 differs from that shown. Reason: Frameshift at position 111.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti47 – 471E → V in CAB66576. (PubMed:11230166)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei103 – 17876KGGFF…PEDIE → YEESTFQGY in isoform 2. 1 PublicationVSP_045644Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF085355 mRNA. Translation: AAD40190.1.
    AL136641 mRNA. Translation: CAB66576.1.
    AK311819 mRNA. Translation: BAG34761.1.
    AL049538, AL035454 Genomic DNA. Translation: CAI19341.1.
    AL035454, AL049538 Genomic DNA. Translation: CAI42118.1.
    AL035454, AL049538 Genomic DNA. Translation: CAX15127.1.
    AL049538, AL035454 Genomic DNA. Translation: CAX15212.1.
    CH471133 Genomic DNA. Translation: EAX10214.1.
    CH471133 Genomic DNA. Translation: EAX10215.1.
    BC005181 mRNA. Translation: AAH05181.1.
    BC008446 mRNA. Translation: AAH08446.1.
    BG548527 mRNA. No translation available.
    CCDSiCCDS13141.1. [P61599-1]
    CCDS13142.1. [P61599-2]
    RefSeqiNP_057184.1. NM_016100.4. [P61599-1]
    NP_852669.1. NM_181528.3. [P61599-2]
    UniGeneiHs.368783.
    Hs.708298.

    Genome annotation databases

    EnsembliENST00000310450; ENSP00000311027; ENSG00000173418. [P61599-2]
    ENST00000334982; ENSP00000335636; ENSG00000173418. [P61599-1]
    GeneIDi51126.
    KEGGihsa:51126.
    UCSCiuc002wrp.3. human. [P61599-1]
    uc002wrq.3. human.

    Polymorphism databases

    DMDMi47606438.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF085355 mRNA. Translation: AAD40190.1 .
    AL136641 mRNA. Translation: CAB66576.1 .
    AK311819 mRNA. Translation: BAG34761.1 .
    AL049538 , AL035454 Genomic DNA. Translation: CAI19341.1 .
    AL035454 , AL049538 Genomic DNA. Translation: CAI42118.1 .
    AL035454 , AL049538 Genomic DNA. Translation: CAX15127.1 .
    AL049538 , AL035454 Genomic DNA. Translation: CAX15212.1 .
    CH471133 Genomic DNA. Translation: EAX10214.1 .
    CH471133 Genomic DNA. Translation: EAX10215.1 .
    BC005181 mRNA. Translation: AAH05181.1 .
    BC008446 mRNA. Translation: AAH08446.1 .
    BG548527 mRNA. No translation available.
    CCDSi CCDS13141.1. [P61599-1 ]
    CCDS13142.1. [P61599-2 ]
    RefSeqi NP_057184.1. NM_016100.4. [P61599-1 ]
    NP_852669.1. NM_181528.3. [P61599-2 ]
    UniGenei Hs.368783.
    Hs.708298.

    3D structure databases

    ProteinModelPortali P61599.
    SMRi P61599. Positions 4-157.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 119313. 8 interactions.
    IntActi P61599. 1 interaction.
    MINTi MINT-3022686.
    STRINGi 9606.ENSP00000335636.

    PTM databases

    PhosphoSitei P61599.

    Polymorphism databases

    DMDMi 47606438.

    Proteomic databases

    MaxQBi P61599.
    PaxDbi P61599.
    PRIDEi P61599.

    Protocols and materials databases

    DNASUi 51126.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000310450 ; ENSP00000311027 ; ENSG00000173418 . [P61599-2 ]
    ENST00000334982 ; ENSP00000335636 ; ENSG00000173418 . [P61599-1 ]
    GeneIDi 51126.
    KEGGi hsa:51126.
    UCSCi uc002wrp.3. human. [P61599-1 ]
    uc002wrq.3. human.

    Organism-specific databases

    CTDi 51126.
    GeneCardsi GC20P019997.
    HGNCi HGNC:15908. NAA20.
    HPAi HPA053117.
    MIMi 610833. gene.
    neXtProti NX_P61599.
    PharmGKBi PA31449.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0456.
    HOVERGENi HBG107217.
    InParanoidi P61599.
    KOi K17972.
    OMAi PWHAHIT.
    OrthoDBi EOG7PP57X.
    PhylomeDBi P61599.
    TreeFami TF105829.

    Miscellaneous databases

    ChiTaRSi NAA20. human.
    GeneWikii NAT5.
    GenomeRNAii 51126.
    NextBioi 53927.
    PROi P61599.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P61599.
    Bgeei P61599.
    CleanExi HS_NAT5.
    Genevestigatori P61599.

    Family and domain databases

    Gene3Di 3.40.630.30. 1 hit.
    InterProi IPR016181. Acyl_CoA_acyltransferase.
    IPR000182. GNAT_dom.
    [Graphical view ]
    Pfami PF00583. Acetyltransf_1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55729. SSF55729. 1 hit.
    PROSITEi PS51186. GNAT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Human N-terminal acetyltransferase complex ard1 subunit homologue, complete CDS."
      Liu T., Tao J., Zhang J., Li W., Ye M., Zhou J., Wu J., Shen Y., Yu M., Chen S., Mao M., Chen Z.
      Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    4. "The DNA sequence and comparative analysis of human chromosome 20."
      Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
      , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
      Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Brain, Lung and Pancreas.
    7. "Identification of the human N(alpha)-acetyltransferase complex B (hNatB): a complex important for cell-cycle progression."
      Starheim K.K., Arnesen T., Gromyko D., Ryningen A., Varhaug J.E., Lillehaug J.R.
      Biochem. J. 415:325-331(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH NAA25, SUBCELLULAR LOCATION.
    8. "A synopsis of eukaryotic Nalpha-terminal acetyltransferases: nomenclature, subunits and substrates."
      Polevoda B., Arnesen T., Sherman F.
      BMC Proc. 3:S2-S2(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NOMENCLATURE.
    9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiNAA20_HUMAN
    AccessioniPrimary (citable) accession number: P61599
    Secondary accession number(s): A6NHA3
    , B2R4G4, Q5TFT7, Q9D7H8, Q9H0Y4, Q9NQH6, Q9Y6D2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 24, 2004
    Last sequence update: May 24, 2004
    Last modified: October 1, 2014
    This is version 99 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 20
      Human chromosome 20: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3