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P61588

- RND3_MOUSE

UniProt

P61588 - RND3_MOUSE

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Protein

Rho-related GTP-binding protein RhoE

Gene

Rnd3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Binds GTP but lacks intrinsic GTPase activity and is resistant to Rho-specific GTPase-activating proteins.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi30 – 378GTPBy similarity
Nucleotide bindingi77 – 815GTPBy similarity
Nucleotide bindingi135 – 1384GTPBy similarity

GO - Molecular functioni

  1. GTP binding Source: UniProtKB-KW

GO - Biological processi

  1. small GTPase mediated signal transduction Source: InterPro
Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Rho-related GTP-binding protein RhoE
Alternative name(s):
Rho family GTPase 3
Rnd3
Gene namesi
Name:Rnd3
Synonyms:Arhe, Rhoe
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:1921444. Rnd3.

Subcellular locationi

Golgi apparatus membrane 1 Publication; Peripheral membrane protein 1 Publication

GO - Cellular componenti

  1. extracellular vesicular exosome Source: Ensembl
  2. Golgi apparatus Source: UniProtKB-KW
  3. membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 241241Rho-related GTP-binding protein RhoEPRO_0000198879Add
BLAST
Propeptidei242 – 2443Removed in mature formBy similarityPRO_0000281231

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei241 – 2411Cysteine methyl esterBy similarity
Lipidationi241 – 2411S-farnesyl cysteineBy similarity

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

MaxQBiP61588.
PRIDEiP61588.

PTM databases

PhosphoSiteiP61588.

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiP61588.
CleanExiMM_RND3.
ExpressionAtlasiP61588. baseline and differential.
GenevestigatoriP61588.

Interactioni

Subunit structurei

Interacts with UBXD5 (By similarity). Binds ROCK1.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
ARHGAP5Q130172EBI-6930266,EBI-7237884From a different organism.
Rock1P703357EBI-6930266,EBI-989293
YWHABP319465EBI-6930266,EBI-359815From a different organism.
YWHAEP622582EBI-6930266,EBI-356498From a different organism.
YWHAGP619812EBI-6930266,EBI-359832From a different organism.
YWHAHQ049172EBI-6930266,EBI-306940From a different organism.
YWHAQP273482EBI-6930266,EBI-359854From a different organism.
YWHAZP631043EBI-6930266,EBI-347088From a different organism.

Protein-protein interaction databases

IntActiP61588. 9 interactions.

Structurei

Secondary structure

1
244
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi23 – 319Combined sources
Helixi36 – 4510Combined sources
Beta strandi56 – 7823Combined sources
Helixi82 – 843Combined sources
Turni85 – 873Combined sources
Helixi88 – 914Combined sources
Beta strandi96 – 1038Combined sources
Helixi107 – 1159Combined sources
Helixi117 – 1248Combined sources
Beta strandi129 – 1357Combined sources
Helixi137 – 1415Combined sources
Helixi143 – 1508Combined sources
Turni151 – 1533Combined sources
Helixi159 – 16911Combined sources
Beta strandi172 – 1765Combined sources
Turni179 – 1813Combined sources
Helixi183 – 19917Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1GWNX-ray2.10A/C16-200[»]
ProteinModelPortaliP61588.
SMRiP61588. Positions 22-200.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP61588.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi52 – 609Effector regionSequence Analysis

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rho family.Curated

Phylogenomic databases

eggNOGiCOG1100.
GeneTreeiENSGT00760000119020.
HOGENOMiHOG000233974.
HOVERGENiHBG009351.
InParanoidiP61588.
KOiK07859.
OMAiLACINKS.
OrthoDBiEOG71P2BH.
PhylomeDBiP61588.
TreeFamiTF330887.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003578. Small_GTPase_Rho.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
PRINTSiPR00449. RASTRNSFRMNG.
SMARTiSM00174. RHO. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51420. RHO. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P61588-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKERRASQKL SSKSIMDPNQ NVKCKIVVVG DSQCGKTALL HVFAKDCFPE
60 70 80 90 100
NYVPTVFENY TASFEIDTQR IELSLWDTSG SPYYDNVRPL SYPDSDAVLI
110 120 130 140 150
CFDISRPETL DSVLKKWKGE IQEFCPNTKM LLVGCKSDLR TDVSTLVELS
160 170 180 190 200
NHRQTPVSYD QGANMAKQIG AATYIECSAL QSENSVRDIF HVATLACVNK
210 220 230 240
TNKNVKRNKS QRATKRISHM PSRPELSAVA TDLRKDKAKS CTVM
Length:244
Mass (Da):27,368
Last modified:May 24, 2004 - v1
Checksum:iDD2D4021CD42BACC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK011442 mRNA. Translation: BAB27622.1.
AK035195 mRNA. Translation: BAC28975.1.
BC009002 mRNA. Translation: AAH09002.1.
CCDSiCCDS16028.1.
RefSeqiNP_083086.1. NM_028810.2.
UniGeneiMm.46497.

Genome annotation databases

EnsembliENSMUST00000017288; ENSMUSP00000017288; ENSMUSG00000017144.
GeneIDi74194.
KEGGimmu:74194.
UCSCiuc008jqf.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK011442 mRNA. Translation: BAB27622.1 .
AK035195 mRNA. Translation: BAC28975.1 .
BC009002 mRNA. Translation: AAH09002.1 .
CCDSi CCDS16028.1.
RefSeqi NP_083086.1. NM_028810.2.
UniGenei Mm.46497.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1GWN X-ray 2.10 A/C 16-200 [» ]
ProteinModelPortali P61588.
SMRi P61588. Positions 22-200.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P61588. 9 interactions.

PTM databases

PhosphoSitei P61588.

Proteomic databases

MaxQBi P61588.
PRIDEi P61588.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000017288 ; ENSMUSP00000017288 ; ENSMUSG00000017144 .
GeneIDi 74194.
KEGGi mmu:74194.
UCSCi uc008jqf.1. mouse.

Organism-specific databases

CTDi 390.
MGIi MGI:1921444. Rnd3.

Phylogenomic databases

eggNOGi COG1100.
GeneTreei ENSGT00760000119020.
HOGENOMi HOG000233974.
HOVERGENi HBG009351.
InParanoidi P61588.
KOi K07859.
OMAi LACINKS.
OrthoDBi EOG71P2BH.
PhylomeDBi P61588.
TreeFami TF330887.

Miscellaneous databases

ChiTaRSi Rnd3. mouse.
EvolutionaryTracei P61588.
NextBioi 1627.
PROi P61588.
SOURCEi Search...

Gene expression databases

Bgeei P61588.
CleanExi MM_RND3.
ExpressionAtlasi P61588. baseline and differential.
Genevestigatori P61588.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003578. Small_GTPase_Rho.
[Graphical view ]
Pfami PF00071. Ras. 1 hit.
[Graphical view ]
PRINTSi PR00449. RASTRNSFRMNG.
SMARTi SM00174. RHO. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00231. small_GTP. 1 hit.
PROSITEi PS51420. RHO. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryo.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "RhoE binds to ROCK I and inhibits downstream signaling."
    Riento K., Guasch R.M., Garg R., Jin B., Ridley A.J.
    Mol. Cell. Biol. 23:4219-4229(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ROCK1, SUBCELLULAR LOCATION.
  4. "Crystal structure of the core domain of RhoE/Rnd3: a constitutively activated small G protein."
    Garavini H., Riento K., Phelan J.P., McAlister M.S., Ridley A.J., Keep N.H.
    Biochemistry 41:6303-6310(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 14-200.

Entry informationi

Entry nameiRND3_MOUSE
AccessioniPrimary (citable) accession number: P61588
Secondary accession number(s): P52199, Q6ZWS2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: May 24, 2004
Last modified: November 26, 2014
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3