Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Rho-related GTP-binding protein RhoE

Gene

Rnd3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds GTP but lacks intrinsic GTPase activity and is resistant to Rho-specific GTPase-activating proteins.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi30 – 37GTPBy similarity8
Nucleotide bindingi77 – 81GTPBy similarity5
Nucleotide bindingi135 – 138GTPBy similarity4

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Rho-related GTP-binding protein RhoE
Alternative name(s):
Rho family GTPase 3
Rnd3
Gene namesi
Name:Rnd3
Synonyms:Arhe, Rhoe
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1921444. Rnd3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001988791 – 241Rho-related GTP-binding protein RhoEAdd BLAST241
PropeptideiPRO_0000281231242 – 244Removed in mature formBy similarity3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei241Cysteine methyl esterBy similarity1
Lipidationi241S-farnesyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

MaxQBiP61588.
PaxDbiP61588.
PeptideAtlasiP61588.
PRIDEiP61588.

PTM databases

iPTMnetiP61588.
PhosphoSitePlusiP61588.

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiENSMUSG00000017144.
CleanExiMM_RND3.
ExpressionAtlasiP61588. baseline and differential.
GenevisibleiP61588. MM.

Interactioni

Subunit structurei

Interacts with UBXD5 (By similarity). Binds ROCK1.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
ARHGAP5Q130172EBI-6930266,EBI-7237884From a different organism.
Rock1P703357EBI-6930266,EBI-989293
YWHABP319465EBI-6930266,EBI-359815From a different organism.
YWHAEP622582EBI-6930266,EBI-356498From a different organism.
YWHAGP619812EBI-6930266,EBI-359832From a different organism.
YWHAHQ049172EBI-6930266,EBI-306940From a different organism.
YWHAQP273482EBI-6930266,EBI-359854From a different organism.
YWHAZP631043EBI-6930266,EBI-347088From a different organism.

Protein-protein interaction databases

IntActiP61588. 9 interactors.
STRINGi10090.ENSMUSP00000017288.

Structurei

Secondary structure

1244
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi23 – 31Combined sources9
Helixi36 – 45Combined sources10
Beta strandi56 – 78Combined sources23
Helixi82 – 84Combined sources3
Turni85 – 87Combined sources3
Helixi88 – 91Combined sources4
Beta strandi96 – 103Combined sources8
Helixi107 – 115Combined sources9
Helixi117 – 124Combined sources8
Beta strandi129 – 135Combined sources7
Helixi137 – 141Combined sources5
Helixi143 – 150Combined sources8
Turni151 – 153Combined sources3
Helixi159 – 169Combined sources11
Beta strandi172 – 176Combined sources5
Turni179 – 181Combined sources3
Helixi183 – 199Combined sources17

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1GWNX-ray2.10A/C16-200[»]
ProteinModelPortaliP61588.
SMRiP61588.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP61588.

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi52 – 60Effector regionSequence analysis9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rho family.Curated

Phylogenomic databases

eggNOGiKOG0393. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00760000119020.
HOGENOMiHOG000233974.
HOVERGENiHBG009351.
InParanoidiP61588.
KOiK07859.
OMAiMKERRPC.
OrthoDBiEOG091G0M4M.
PhylomeDBiP61588.
TreeFamiTF330887.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51420. RHO. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P61588-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKERRASQKL SSKSIMDPNQ NVKCKIVVVG DSQCGKTALL HVFAKDCFPE
60 70 80 90 100
NYVPTVFENY TASFEIDTQR IELSLWDTSG SPYYDNVRPL SYPDSDAVLI
110 120 130 140 150
CFDISRPETL DSVLKKWKGE IQEFCPNTKM LLVGCKSDLR TDVSTLVELS
160 170 180 190 200
NHRQTPVSYD QGANMAKQIG AATYIECSAL QSENSVRDIF HVATLACVNK
210 220 230 240
TNKNVKRNKS QRATKRISHM PSRPELSAVA TDLRKDKAKS CTVM
Length:244
Mass (Da):27,368
Last modified:May 24, 2004 - v1
Checksum:iDD2D4021CD42BACC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK011442 mRNA. Translation: BAB27622.1.
AK035195 mRNA. Translation: BAC28975.1.
BC009002 mRNA. Translation: AAH09002.1.
CCDSiCCDS16028.1.
RefSeqiNP_083086.1. NM_028810.2.
UniGeneiMm.46497.

Genome annotation databases

EnsembliENSMUST00000017288; ENSMUSP00000017288; ENSMUSG00000017144.
GeneIDi74194.
KEGGimmu:74194.
UCSCiuc008jqf.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK011442 mRNA. Translation: BAB27622.1.
AK035195 mRNA. Translation: BAC28975.1.
BC009002 mRNA. Translation: AAH09002.1.
CCDSiCCDS16028.1.
RefSeqiNP_083086.1. NM_028810.2.
UniGeneiMm.46497.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1GWNX-ray2.10A/C16-200[»]
ProteinModelPortaliP61588.
SMRiP61588.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP61588. 9 interactors.
STRINGi10090.ENSMUSP00000017288.

PTM databases

iPTMnetiP61588.
PhosphoSitePlusiP61588.

Proteomic databases

MaxQBiP61588.
PaxDbiP61588.
PeptideAtlasiP61588.
PRIDEiP61588.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000017288; ENSMUSP00000017288; ENSMUSG00000017144.
GeneIDi74194.
KEGGimmu:74194.
UCSCiuc008jqf.1. mouse.

Organism-specific databases

CTDi390.
MGIiMGI:1921444. Rnd3.

Phylogenomic databases

eggNOGiKOG0393. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00760000119020.
HOGENOMiHOG000233974.
HOVERGENiHBG009351.
InParanoidiP61588.
KOiK07859.
OMAiMKERRPC.
OrthoDBiEOG091G0M4M.
PhylomeDBiP61588.
TreeFamiTF330887.

Miscellaneous databases

ChiTaRSiRnd3. mouse.
EvolutionaryTraceiP61588.
PROiP61588.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000017144.
CleanExiMM_RND3.
ExpressionAtlasiP61588. baseline and differential.
GenevisibleiP61588. MM.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51420. RHO. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRND3_MOUSE
AccessioniPrimary (citable) accession number: P61588
Secondary accession number(s): P52199, Q6ZWS2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: May 24, 2004
Last modified: November 2, 2016
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.