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P61587 (RND3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 111. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Rho-related GTP-binding protein RhoE
Alternative name(s):
Protein MemB
Rho family GTPase 3
Rho-related GTP-binding protein Rho8
Rnd3
Gene names
Name:RND3
Synonyms:ARHE, RHO8, RHOE
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length244 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Binds GTP but lacks intrinsic GTPase activity and is resistant to Rho-specific GTPase-activating proteins.

Subunit structure

Binds ROCK1 By similarity. Interacts with UBXD5. Ref.8

Subcellular location

Golgi apparatus membrane; Peripheral membrane protein.

Tissue specificity

Ubiquitous.

Sequence similarities

Belongs to the small GTPase superfamily. Rho family.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

YWHABP319462EBI-1111534,EBI-359815
YWHAZP6310411EBI-1111534,EBI-347088

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 241241Rho-related GTP-binding protein RhoE
PRO_0000198878
Propeptide242 – 2443Removed in mature form By similarity
PRO_0000281230

Regions

Nucleotide binding30 – 378GTP By similarity
Nucleotide binding77 – 815GTP By similarity
Nucleotide binding135 – 1384GTP By similarity
Motif52 – 609Effector region Potential

Amino acid modifications

Modified residue2411Cysteine methyl ester By similarity
Lipidation2411S-farnesyl cysteine Ref.7

Secondary structure

.................................. 244
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P61587 [UniParc].

Last modified May 24, 2004. Version 1.
Checksum: DD2D4021CD42BACC

FASTA24427,368
        10         20         30         40         50         60 
MKERRASQKL SSKSIMDPNQ NVKCKIVVVG DSQCGKTALL HVFAKDCFPE NYVPTVFENY 

        70         80         90        100        110        120 
TASFEIDTQR IELSLWDTSG SPYYDNVRPL SYPDSDAVLI CFDISRPETL DSVLKKWKGE 

       130        140        150        160        170        180 
IQEFCPNTKM LLVGCKSDLR TDVSTLVELS NHRQTPVSYD QGANMAKQIG AATYIECSAL 

       190        200        210        220        230        240 
QSENSVRDIF HVATLACVNK TNKNVKRNKS QRATKRISHM PSRPELSAVA TDLRKDKAKS 


CTVM 

« Hide

References

« Hide 'large scale' references
[1]"A new member of the Rho family, Rnd1, promotes disassembly of actin filament structures and loss of cell adhesion."
Nobes C.D., Lauritzen I., Mattei M.-G., Paris S., Hall A., Chardin P.
J. Cell Biol. 141:187-197(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Spleen.
[2]"memB, a progression marker of human melanoma cell lines, encodes a member of a rho-related family."
van Groningen J.J.M., Van Rijk A.A.F., Bloemers H.P.J., Swart G.W.M.
Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
Puhl H.L. III, Ikeda S.R., Aronstam R.S.
Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Placenta.
[4]"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Kidney.
[7]"Identification of a novel human Rho protein with unusual properties: GTPase deficiency and in vivo farnesylation."
Foster R., Hu K.-Q., Lu Y., Nolan K.M., Thissen J., Settleman J.
Mol. Cell. Biol. 16:2689-2699(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 16-244, CHARACTERIZATION, ISOPRENYLATION AT CYS-241.
Tissue: Fetal brain.
[8]"Socius is a novel Rnd GTPase-interacting protein involved in disassembly of actin stress fibers."
Katoh H., Harada A., Mori K., Negishi M.
Mol. Cell. Biol. 22:2952-2964(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH UBXD5.
[9]"Crystal structure of Rnd3/RhoE: functional implications."
Fiegen D., Blumenstein L., Stege P., Vetter I.R., Ahmadian M.R.
FEBS Lett. 525:100-104(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 21-200 IN COMPLEX WITH GTP.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X95282 mRNA. Translation: CAA64603.1.
X97758 mRNA. Translation: CAA66352.1.
AF498969 mRNA. Translation: AAM21116.1.
BT006769 mRNA. Translation: AAP35415.1.
CH471058 Genomic DNA. Translation: EAX11524.1.
CH471058 Genomic DNA. Translation: EAX11526.1.
BC012513 mRNA. Translation: AAH12513.1.
S82240 mRNA. Translation: AAB47133.1.
CCDSCCDS2190.1.
RefSeqNP_001241667.1. NM_001254738.1.
NP_005159.1. NM_005168.4.
UniGeneHs.6838.
Hs.713765.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1M7BX-ray2.00A19-200[»]
2V55X-ray3.70B/D1-200[»]
4BG6X-ray2.30Q/R232-241[»]
ProteinModelPortalP61587.
SMRP61587. Positions 22-200.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid106883. 11 interactions.
IntActP61587. 5 interactions.
MINTMINT-3974781.
STRING9606.ENSP00000263895.

PTM databases

PhosphoSiteP61587.

Polymorphism databases

DMDM47606459.

Proteomic databases

MaxQBP61587.
PaxDbP61587.
PRIDEP61587.

Protocols and materials databases

DNASU390.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000263895; ENSP00000263895; ENSG00000115963.
ENST00000375734; ENSP00000364886; ENSG00000115963.
GeneID390.
KEGGhsa:390.
UCSCuc002txe.3. human.

Organism-specific databases

CTD390.
GeneCardsGC02M151324.
HGNCHGNC:671. RND3.
MIM602924. gene.
neXtProtNX_P61587.
PharmGKBPA24953.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG1100.
HOGENOMHOG000233974.
HOVERGENHBG009351.
InParanoidP61587.
KOK07859.
OMALACINKS.
OrthoDBEOG71P2BH.
PhylomeDBP61587.
TreeFamTF330887.

Gene expression databases

ArrayExpressP61587.
BgeeP61587.
CleanExHS_RND3.
GenevestigatorP61587.

Family and domain databases

Gene3D3.40.50.300. 1 hit.
InterProIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003578. Small_GTPase_Rho.
[Graphical view]
PfamPF00071. Ras. 1 hit.
[Graphical view]
PRINTSPR00449. RASTRNSFRMNG.
SMARTSM00174. RHO. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR00231. small_GTP. 1 hit.
PROSITEPS51420. RHO. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP61587.
GeneWikiRnd3.
GenomeRNAi390.
NextBio1627.
PROP61587.
SOURCESearch...

Entry information

Entry nameRND3_HUMAN
AccessionPrimary (citable) accession number: P61587
Secondary accession number(s): D3DP95, P52199
Entry history
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: May 24, 2004
Last modified: July 9, 2014
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 2

Human chromosome 2: entries, gene names and cross-references to MIM