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P61587

- RND3_HUMAN

UniProt

P61587 - RND3_HUMAN

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Protein

Rho-related GTP-binding protein RhoE

Gene

RND3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Binds GTP but lacks intrinsic GTPase activity and is resistant to Rho-specific GTPase-activating proteins.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi30 – 378GTPBy similarity
Nucleotide bindingi77 – 815GTPBy similarity
Nucleotide bindingi135 – 1384GTPBy similarity

GO - Molecular functioni

  1. GTPase activity Source: ProtInc
  2. GTP binding Source: ProtInc

GO - Biological processi

  1. actin cytoskeleton organization Source: ProtInc
  2. cell adhesion Source: ProtInc
  3. GTP catabolic process Source: GOC
  4. small GTPase mediated signal transduction Source: InterPro
Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Rho-related GTP-binding protein RhoE
Alternative name(s):
Protein MemB
Rho family GTPase 3
Rho-related GTP-binding protein Rho8
Rnd3
Gene namesi
Name:RND3
Synonyms:ARHE, RHO8, RHOE
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:671. RND3.

Subcellular locationi

GO - Cellular componenti

  1. extracellular vesicular exosome Source: UniProt
  2. focal adhesion Source: UniProtKB
  3. Golgi apparatus Source: UniProtKB-KW
  4. membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA24953.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 241241Rho-related GTP-binding protein RhoEPRO_0000198878Add
BLAST
Propeptidei242 – 2443Removed in mature formBy similarityPRO_0000281230

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei241 – 2411Cysteine methyl esterBy similarity
Lipidationi241 – 2411S-farnesyl cysteine1 Publication

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

MaxQBiP61587.
PaxDbiP61587.
PRIDEiP61587.

PTM databases

PhosphoSiteiP61587.

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiP61587.
CleanExiHS_RND3.
ExpressionAtlasiP61587. baseline and differential.
GenevestigatoriP61587.

Interactioni

Subunit structurei

Binds ROCK1 (By similarity). Interacts with UBXD5.By similarity2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
YWHABP319462EBI-1111534,EBI-359815
YWHAZP6310411EBI-1111534,EBI-347088

Protein-protein interaction databases

BioGridi106883. 11 interactions.
IntActiP61587. 5 interactions.
MINTiMINT-3974781.
STRINGi9606.ENSP00000263895.

Structurei

Secondary structure

1
244
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi23 – 319Combined sources
Helixi36 – 4510Combined sources
Beta strandi56 – 6510Combined sources
Beta strandi70 – 789Combined sources
Helixi82 – 843Combined sources
Turni85 – 873Combined sources
Helixi88 – 914Combined sources
Beta strandi96 – 1038Combined sources
Helixi107 – 1159Combined sources
Helixi117 – 1248Combined sources
Beta strandi129 – 1357Combined sources
Helixi137 – 1415Combined sources
Helixi143 – 1508Combined sources
Turni151 – 1533Combined sources
Helixi159 – 16911Combined sources
Beta strandi172 – 1765Combined sources
Turni179 – 1813Combined sources
Helixi183 – 19816Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1M7BX-ray2.00A19-200[»]
2V55X-ray3.70B/D1-200[»]
4BG6X-ray2.30Q/R232-241[»]
ProteinModelPortaliP61587.
SMRiP61587. Positions 22-200.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP61587.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi52 – 609Effector regionSequence Analysis

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rho family.Curated

Phylogenomic databases

eggNOGiCOG1100.
GeneTreeiENSGT00760000119020.
HOGENOMiHOG000233974.
HOVERGENiHBG009351.
InParanoidiP61587.
KOiK07859.
OMAiLACINKS.
OrthoDBiEOG71P2BH.
PhylomeDBiP61587.
TreeFamiTF330887.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003578. Small_GTPase_Rho.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
PRINTSiPR00449. RASTRNSFRMNG.
SMARTiSM00174. RHO. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51420. RHO. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P61587-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKERRASQKL SSKSIMDPNQ NVKCKIVVVG DSQCGKTALL HVFAKDCFPE
60 70 80 90 100
NYVPTVFENY TASFEIDTQR IELSLWDTSG SPYYDNVRPL SYPDSDAVLI
110 120 130 140 150
CFDISRPETL DSVLKKWKGE IQEFCPNTKM LLVGCKSDLR TDVSTLVELS
160 170 180 190 200
NHRQTPVSYD QGANMAKQIG AATYIECSAL QSENSVRDIF HVATLACVNK
210 220 230 240
TNKNVKRNKS QRATKRISHM PSRPELSAVA TDLRKDKAKS CTVM
Length:244
Mass (Da):27,368
Last modified:May 24, 2004 - v1
Checksum:iDD2D4021CD42BACC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X95282 mRNA. Translation: CAA64603.1.
X97758 mRNA. Translation: CAA66352.1.
AF498969 mRNA. Translation: AAM21116.1.
BT006769 mRNA. Translation: AAP35415.1.
CH471058 Genomic DNA. Translation: EAX11524.1.
CH471058 Genomic DNA. Translation: EAX11526.1.
BC012513 mRNA. Translation: AAH12513.1.
S82240 mRNA. Translation: AAB47133.1.
CCDSiCCDS2190.1.
RefSeqiNP_001241667.1. NM_001254738.1.
NP_005159.1. NM_005168.4.
UniGeneiHs.6838.
Hs.713765.

Genome annotation databases

EnsembliENST00000263895; ENSP00000263895; ENSG00000115963.
ENST00000375734; ENSP00000364886; ENSG00000115963.
GeneIDi390.
KEGGihsa:390.
UCSCiuc002txe.3. human.

Polymorphism databases

DMDMi47606459.

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X95282 mRNA. Translation: CAA64603.1 .
X97758 mRNA. Translation: CAA66352.1 .
AF498969 mRNA. Translation: AAM21116.1 .
BT006769 mRNA. Translation: AAP35415.1 .
CH471058 Genomic DNA. Translation: EAX11524.1 .
CH471058 Genomic DNA. Translation: EAX11526.1 .
BC012513 mRNA. Translation: AAH12513.1 .
S82240 mRNA. Translation: AAB47133.1 .
CCDSi CCDS2190.1.
RefSeqi NP_001241667.1. NM_001254738.1.
NP_005159.1. NM_005168.4.
UniGenei Hs.6838.
Hs.713765.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1M7B X-ray 2.00 A 19-200 [» ]
2V55 X-ray 3.70 B/D 1-200 [» ]
4BG6 X-ray 2.30 Q/R 232-241 [» ]
ProteinModelPortali P61587.
SMRi P61587. Positions 22-200.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 106883. 11 interactions.
IntActi P61587. 5 interactions.
MINTi MINT-3974781.
STRINGi 9606.ENSP00000263895.

PTM databases

PhosphoSitei P61587.

Polymorphism databases

DMDMi 47606459.

Proteomic databases

MaxQBi P61587.
PaxDbi P61587.
PRIDEi P61587.

Protocols and materials databases

DNASUi 390.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000263895 ; ENSP00000263895 ; ENSG00000115963 .
ENST00000375734 ; ENSP00000364886 ; ENSG00000115963 .
GeneIDi 390.
KEGGi hsa:390.
UCSCi uc002txe.3. human.

Organism-specific databases

CTDi 390.
GeneCardsi GC02M151324.
HGNCi HGNC:671. RND3.
MIMi 602924. gene.
neXtProti NX_P61587.
PharmGKBi PA24953.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG1100.
GeneTreei ENSGT00760000119020.
HOGENOMi HOG000233974.
HOVERGENi HBG009351.
InParanoidi P61587.
KOi K07859.
OMAi LACINKS.
OrthoDBi EOG71P2BH.
PhylomeDBi P61587.
TreeFami TF330887.

Miscellaneous databases

ChiTaRSi RND3. human.
EvolutionaryTracei P61587.
GeneWikii Rnd3.
GenomeRNAii 390.
NextBioi 1627.
PROi P61587.
SOURCEi Search...

Gene expression databases

Bgeei P61587.
CleanExi HS_RND3.
ExpressionAtlasi P61587. baseline and differential.
Genevestigatori P61587.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003578. Small_GTPase_Rho.
[Graphical view ]
Pfami PF00071. Ras. 1 hit.
[Graphical view ]
PRINTSi PR00449. RASTRNSFRMNG.
SMARTi SM00174. RHO. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00231. small_GTP. 1 hit.
PROSITEi PS51420. RHO. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A new member of the Rho family, Rnd1, promotes disassembly of actin filament structures and loss of cell adhesion."
    Nobes C.D., Lauritzen I., Mattei M.-G., Paris S., Hall A., Chardin P.
    J. Cell Biol. 141:187-197(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Spleen.
  2. "memB, a progression marker of human melanoma cell lines, encodes a member of a rho-related family."
    van Groningen J.J.M., Van Rijk A.A.F., Bloemers H.P.J., Swart G.W.M.
    Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
    Puhl H.L. III, Ikeda S.R., Aronstam R.S.
    Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.
  4. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.
  7. "Identification of a novel human Rho protein with unusual properties: GTPase deficiency and in vivo farnesylation."
    Foster R., Hu K.-Q., Lu Y., Nolan K.M., Thissen J., Settleman J.
    Mol. Cell. Biol. 16:2689-2699(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 16-244, CHARACTERIZATION, ISOPRENYLATION AT CYS-241.
    Tissue: Fetal brain.
  8. "Socius is a novel Rnd GTPase-interacting protein involved in disassembly of actin stress fibers."
    Katoh H., Harada A., Mori K., Negishi M.
    Mol. Cell. Biol. 22:2952-2964(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH UBXD5.
  9. "Crystal structure of Rnd3/RhoE: functional implications."
    Fiegen D., Blumenstein L., Stege P., Vetter I.R., Ahmadian M.R.
    FEBS Lett. 525:100-104(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 21-200 IN COMPLEX WITH GTP.

Entry informationi

Entry nameiRND3_HUMAN
AccessioniPrimary (citable) accession number: P61587
Secondary accession number(s): D3DP95, P52199
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: May 24, 2004
Last modified: November 26, 2014
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3