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Protein

Rho-related GTP-binding protein RhoE

Gene

RND3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds GTP but lacks intrinsic GTPase activity and is resistant to Rho-specific GTPase-activating proteins.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi30 – 37GTPBy similarity8
Nucleotide bindingi77 – 81GTPBy similarity5
Nucleotide bindingi135 – 138GTPBy similarity4

GO - Molecular functioni

  • GTPase activity Source: ProtInc
  • GTP binding Source: ProtInc

GO - Biological processi

  • actin cytoskeleton organization Source: ProtInc
  • cell adhesion Source: ProtInc
  • small GTPase mediated signal transduction Source: InterPro
Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000115963-MONOMER.
SIGNORiP61587.

Names & Taxonomyi

Protein namesi
Recommended name:
Rho-related GTP-binding protein RhoE
Alternative name(s):
Protein MemB
Rho family GTPase 3
Rho-related GTP-binding protein Rho8
Rnd3
Gene namesi
Name:RND3
Synonyms:ARHE, RHO8, RHOE
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:671. RND3.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • focal adhesion Source: UniProtKB
  • Golgi membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi390.
OpenTargetsiENSG00000115963.
PharmGKBiPA24953.

Polymorphism and mutation databases

BioMutaiRND3.
DMDMi47606459.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001988781 – 241Rho-related GTP-binding protein RhoEAdd BLAST241
PropeptideiPRO_0000281230242 – 244Removed in mature formBy similarity3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei241Cysteine methyl esterBy similarity1
Lipidationi241S-farnesyl cysteine1 Publication1

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

EPDiP61587.
MaxQBiP61587.
PaxDbiP61587.
PeptideAtlasiP61587.
PRIDEiP61587.

PTM databases

iPTMnetiP61587.
PhosphoSitePlusiP61587.

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiENSG00000115963.
CleanExiHS_RND3.
ExpressionAtlasiP61587. baseline and differential.
GenevisibleiP61587. HS.

Organism-specific databases

HPAiHPA060504.

Interactioni

Subunit structurei

Binds ROCK1 (By similarity). Interacts with UBXD5.By similarity2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
YWHABP319462EBI-1111534,EBI-359815
YWHAZP6310411EBI-1111534,EBI-347088

Protein-protein interaction databases

BioGridi106883. 14 interactors.
IntActiP61587. 5 interactors.
MINTiMINT-3974781.
STRINGi9606.ENSP00000263895.

Structurei

Secondary structure

1244
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi23 – 31Combined sources9
Helixi36 – 45Combined sources10
Beta strandi56 – 65Combined sources10
Beta strandi70 – 78Combined sources9
Helixi82 – 84Combined sources3
Turni85 – 87Combined sources3
Helixi88 – 91Combined sources4
Beta strandi96 – 103Combined sources8
Helixi107 – 115Combined sources9
Helixi117 – 124Combined sources8
Beta strandi129 – 135Combined sources7
Helixi137 – 141Combined sources5
Helixi143 – 150Combined sources8
Turni151 – 153Combined sources3
Helixi159 – 169Combined sources11
Beta strandi172 – 176Combined sources5
Turni179 – 181Combined sources3
Helixi183 – 198Combined sources16

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1M7BX-ray2.00A19-200[»]
2V55X-ray3.70B/D1-200[»]
4BG6X-ray2.30Q/R232-241[»]
ProteinModelPortaliP61587.
SMRiP61587.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP61587.

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi52 – 60Effector regionSequence analysis9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rho family.Curated

Phylogenomic databases

eggNOGiKOG0393. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00760000119020.
HOGENOMiHOG000233974.
HOVERGENiHBG009351.
InParanoidiP61587.
KOiK07859.
OMAiMKERRPC.
OrthoDBiEOG091G0M4M.
PhylomeDBiP61587.
TreeFamiTF330887.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51420. RHO. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P61587-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKERRASQKL SSKSIMDPNQ NVKCKIVVVG DSQCGKTALL HVFAKDCFPE
60 70 80 90 100
NYVPTVFENY TASFEIDTQR IELSLWDTSG SPYYDNVRPL SYPDSDAVLI
110 120 130 140 150
CFDISRPETL DSVLKKWKGE IQEFCPNTKM LLVGCKSDLR TDVSTLVELS
160 170 180 190 200
NHRQTPVSYD QGANMAKQIG AATYIECSAL QSENSVRDIF HVATLACVNK
210 220 230 240
TNKNVKRNKS QRATKRISHM PSRPELSAVA TDLRKDKAKS CTVM
Length:244
Mass (Da):27,368
Last modified:May 24, 2004 - v1
Checksum:iDD2D4021CD42BACC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X95282 mRNA. Translation: CAA64603.1.
X97758 mRNA. Translation: CAA66352.1.
AF498969 mRNA. Translation: AAM21116.1.
BT006769 mRNA. Translation: AAP35415.1.
CH471058 Genomic DNA. Translation: EAX11524.1.
CH471058 Genomic DNA. Translation: EAX11526.1.
BC012513 mRNA. Translation: AAH12513.1.
S82240 mRNA. Translation: AAB47133.1.
CCDSiCCDS2190.1.
RefSeqiNP_001241667.1. NM_001254738.1.
NP_005159.1. NM_005168.4.
UniGeneiHs.6838.
Hs.713765.

Genome annotation databases

EnsembliENST00000263895; ENSP00000263895; ENSG00000115963.
ENST00000375734; ENSP00000364886; ENSG00000115963.
GeneIDi390.
KEGGihsa:390.
UCSCiuc002txe.4. human.

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X95282 mRNA. Translation: CAA64603.1.
X97758 mRNA. Translation: CAA66352.1.
AF498969 mRNA. Translation: AAM21116.1.
BT006769 mRNA. Translation: AAP35415.1.
CH471058 Genomic DNA. Translation: EAX11524.1.
CH471058 Genomic DNA. Translation: EAX11526.1.
BC012513 mRNA. Translation: AAH12513.1.
S82240 mRNA. Translation: AAB47133.1.
CCDSiCCDS2190.1.
RefSeqiNP_001241667.1. NM_001254738.1.
NP_005159.1. NM_005168.4.
UniGeneiHs.6838.
Hs.713765.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1M7BX-ray2.00A19-200[»]
2V55X-ray3.70B/D1-200[»]
4BG6X-ray2.30Q/R232-241[»]
ProteinModelPortaliP61587.
SMRiP61587.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi106883. 14 interactors.
IntActiP61587. 5 interactors.
MINTiMINT-3974781.
STRINGi9606.ENSP00000263895.

PTM databases

iPTMnetiP61587.
PhosphoSitePlusiP61587.

Polymorphism and mutation databases

BioMutaiRND3.
DMDMi47606459.

Proteomic databases

EPDiP61587.
MaxQBiP61587.
PaxDbiP61587.
PeptideAtlasiP61587.
PRIDEiP61587.

Protocols and materials databases

DNASUi390.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000263895; ENSP00000263895; ENSG00000115963.
ENST00000375734; ENSP00000364886; ENSG00000115963.
GeneIDi390.
KEGGihsa:390.
UCSCiuc002txe.4. human.

Organism-specific databases

CTDi390.
DisGeNETi390.
GeneCardsiRND3.
HGNCiHGNC:671. RND3.
HPAiHPA060504.
MIMi602924. gene.
neXtProtiNX_P61587.
OpenTargetsiENSG00000115963.
PharmGKBiPA24953.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0393. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00760000119020.
HOGENOMiHOG000233974.
HOVERGENiHBG009351.
InParanoidiP61587.
KOiK07859.
OMAiMKERRPC.
OrthoDBiEOG091G0M4M.
PhylomeDBiP61587.
TreeFamiTF330887.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000115963-MONOMER.
SIGNORiP61587.

Miscellaneous databases

ChiTaRSiRND3. human.
EvolutionaryTraceiP61587.
GeneWikiiRnd3.
GenomeRNAii390.
PROiP61587.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000115963.
CleanExiHS_RND3.
ExpressionAtlasiP61587. baseline and differential.
GenevisibleiP61587. HS.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51420. RHO. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRND3_HUMAN
AccessioniPrimary (citable) accession number: P61587
Secondary accession number(s): D3DP95, P52199
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: May 24, 2004
Last modified: November 2, 2016
This is version 132 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.