ID   NP24_HUMAN              Reviewed;          75 AA.
AC   P61581;
DT   24-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2004, sequence version 1.
DT   08-NOV-2023, entry version 67.
DE   RecName: Full=Endogenous retrovirus group K member 24 Np9 protein;
DE   AltName: Full=HERV-K101 Np9 protein;
DE   AltName: Full=HERV-K_22q11.21 provirus Np9 protein;
GN   Name=ERVK-24;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=10469592; DOI=10.1016/s0960-9822(99)80390-x;
RA   Barbulescu M., Turner G., Seaman M.I., Deinard A.S., Kidd K.K., Lenz J.;
RT   "Many human endogenous retrovirus K (HERV-K) proviruses are unique to
RT   humans.";
RL   Curr. Biol. 9:861-868(1999).
RN   [2]
RP   CHARACTERIZATION.
RX   PubMed=12060620;
RA   Armbruester V., Sauter M., Krautkraemer E., Meese E.U., Kleiman A.,
RA   Best B., Roemer K., Mueller-Lantzsch N.;
RT   "A novel gene from the human endogenous retrovirus K expressed in
RT   transformed cells.";
RL   Clin. Cancer Res. 8:1800-1807(2002).
CC   -!- FUNCTION: May possess a function in tumorigenesis.
CC   -!- SUBCELLULAR LOCATION: Nucleus. Note=When overexpressed.
CC   -!- TISSUE SPECIFICITY: Transcript detectable in many tumor cell lines and
CC       tumor tissues.
CC   -!- MISCELLANEOUS: Protein expressed at very low level.
CC   -!- MISCELLANEOUS: This Np9 protein is encoded by a human specific
CC       provirus.
CC   -!- MISCELLANEOUS: Has a type 1 genome. The HERV-K(HML-2) family contains
CC       type 1 and type 2 genomes depending on the absence or presence of 292
CC       nucleotides at the 5'-end of the env gene. Np9 proteins are translated
CC       from a doubly spliced transcript expressed exclusively by HERV-K(HML-2)
CC       type 1 proviral genomes. Np9 proteins share 14 N-terminal amino acids
CC       with HERV-K(HML-2) type 2 envelope proteins. The rest of the protein is
CC       encoded by a small exon located at the 3' end of the envelope gene.
CC       This exon shares the same splice acceptor site and therefore overlaps
CC       HERV-K(HML-2) type 2 Rec protein second exon. It is yet translated from
CC       an alternate reading frame.
CC   -!- MISCELLANEOUS: Intergenic, closest flanking gene being PRODH.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AF164609; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; P61581; -.
DR   BioMuta; HGNC:39038; -.
DR   MassIVE; P61581; -.
DR   PaxDb; 9606-ENSP00000485226; -.
DR   GeneCards; ERVK-24; -.
DR   HGNC; HGNC:39038; ERVK-24.
DR   neXtProt; NX_P61581; -.
DR   eggNOG; ENOG502TK7B; Eukaryota.
DR   PhylomeDB; P61581; -.
DR   Pharos; P61581; Tdark.
DR   Proteomes; UP000005640; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
PE   1: Evidence at protein level;
KW   ERV; Nucleus; Reference proteome; Transposable element.
FT   CHAIN           1..75
FT                   /note="Endogenous retrovirus group K member 24 Np9 protein"
FT                   /id="PRO_0000186785"
FT   REGION          22..43
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        28..43
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   75 AA;  8893 MW;  43D00FB321C07136 CRC64;
     MNPSEMQRKG PPRRWCLQVY PTAPKRQRPS RTGHDDDGGF VEKKRGKCGE KQERSDCYCV
     CVERSRHRRL HFVMC
//