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P61581

- NP11_HUMAN

UniProt

P61581 - NP11_HUMAN

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Protein
HERV-K_22q11.21 provirus Np9 protein
Gene
N/A
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

May possess a function in tumorigenesis.

Names & Taxonomyi

Protein namesi
Recommended name:
HERV-K_22q11.21 provirus Np9 protein
Alternative name(s):
HERV-K101 Np9 protein
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Unplaced

Subcellular locationi

Nucleus
Note: When overexpressed.

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 7575HERV-K_22q11.21 provirus Np9 protein
PRO_0000186785Add
BLAST

Expressioni

Tissue specificityi

Transcript detectable in many tumor cell lines and tumor tissues.

Gene expression databases

GenevestigatoriP61581.

Family & Domainsi

Phylogenomic databases

HOVERGENiHBG052652.
PhylomeDBiP61581.

Sequencei

Sequence statusi: Complete.

P61581-1 [UniParc]FASTAAdd to Basket

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MNPSEMQRKG PPRRWCLQVY PTAPKRQRPS RTGHDDDGGF VEKKRGKCGE   50
KQERSDCYCV CVERSRHRRL HFVMC 75
Length:75
Mass (Da):8,893
Last modified:May 24, 2004 - v1
Checksum:i43D00FB321C07136
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF164609 Genomic DNA. No translation available.

Cross-referencesi

Web resourcesi

Human Endogenous Retrovirus Database (HERVd)

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF164609 Genomic DNA. No translation available.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

neXtProti NX_P61581.

Phylogenomic databases

HOVERGENi HBG052652.
PhylomeDBi P61581.

Miscellaneous databases

NextBioi 35537772.

Gene expression databases

Genevestigatori P61581.

Family and domain databases

ProtoNeti Search...

Publicationsi

  1. "Many human endogenous retrovirus K (HERV-K) proviruses are unique to humans."
    Barbulescu M., Turner G., Seaman M.I., Deinard A.S., Kidd K.K., Lenz J.
    Curr. Biol. 9:861-868(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "A novel gene from the human endogenous retrovirus K expressed in transformed cells."
    Armbruester V., Sauter M., Krautkraemer E., Meese E.U., Kleiman A., Best B., Roemer K., Mueller-Lantzsch N.
    Clin. Cancer Res. 8:1800-1807(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.

Entry informationi

Entry nameiNP11_HUMAN
AccessioniPrimary (citable) accession number: P61581
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: May 24, 2004
Last modified: April 16, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Protein expressed at very low level.
This Np9 protein is encoded by a human specific provirus.
HERV-K_22q11.21 has a type 1 genome. The HERV-K(HML-2) family contains type 1 and type 2 genomes depending on the absence or presence of 292 nucleotides at the 5'-end of the env gene. Np9 proteins are translated from a doubly spliced transcript expressed exclusively by HERV-K(HML-2) type 1 proviral genomes. Np9 proteins share 14 N-terminal amino acids with HERV-K(HML-2) type 2 envelope proteins. The rest of the protein is encoded by a small exon located at the 3' end of the envelope gene. This exon shares the same splice acceptor site and therefore overlaps HERV-K(HML-2) type 2 Rec protein second exon. It is yet translated from an alternate reading frame.
Intergenic, closest flanking gene being PRODH.

Keywords - Technical termi

Complete proteome, ERV, Reference proteome, Transposable element

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM

External Data

Dasty 3

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