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P61581

- NP24_HUMAN

UniProt

P61581 - NP24_HUMAN

Protein

Endogenous retrovirus group K member 24 Np9 protein

Gene

ERVK-24

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
  1. Functioni

    May possess a function in tumorigenesis.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Endogenous retrovirus group K member 24 Np9 protein
    Alternative name(s):
    HERV-K101 Np9 protein
    HERV-K_22q11.21 provirus Np9 protein
    Gene namesi
    Name:ERVK-24
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Unplaced

    Organism-specific databases

    HGNCiHGNC:39038. ERVK-24.

    Subcellular locationi

    Nucleus
    Note: When overexpressed.

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 7575Endogenous retrovirus group K member 24 Np9 proteinPRO_0000186785Add
    BLAST

    Expressioni

    Tissue specificityi

    Transcript detectable in many tumor cell lines and tumor tissues.

    Gene expression databases

    GenevestigatoriP61581.

    Family & Domainsi

    Phylogenomic databases

    HOVERGENiHBG052652.
    PhylomeDBiP61581.

    Sequencei

    Sequence statusi: Complete.

    P61581-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNPSEMQRKG PPRRWCLQVY PTAPKRQRPS RTGHDDDGGF VEKKRGKCGE   50
    KQERSDCYCV CVERSRHRRL HFVMC 75
    Length:75
    Mass (Da):8,893
    Last modified:May 24, 2004 - v1
    Checksum:i43D00FB321C07136
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF164609 Genomic DNA. No translation available.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF164609 Genomic DNA. No translation available.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    HGNCi HGNC:39038. ERVK-24.
    neXtProti NX_P61581.
    GenAtlasi Search...

    Phylogenomic databases

    HOVERGENi HBG052652.
    PhylomeDBi P61581.

    Miscellaneous databases

    NextBioi 35537772.

    Gene expression databases

    Genevestigatori P61581.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "Many human endogenous retrovirus K (HERV-K) proviruses are unique to humans."
      Barbulescu M., Turner G., Seaman M.I., Deinard A.S., Kidd K.K., Lenz J.
      Curr. Biol. 9:861-868(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "A novel gene from the human endogenous retrovirus K expressed in transformed cells."
      Armbruester V., Sauter M., Krautkraemer E., Meese E.U., Kleiman A., Best B., Roemer K., Mueller-Lantzsch N.
      Clin. Cancer Res. 8:1800-1807(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION.

    Entry informationi

    Entry nameiNP24_HUMAN
    AccessioniPrimary (citable) accession number: P61581
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 24, 2004
    Last sequence update: May 24, 2004
    Last modified: October 1, 2014
    This is version 44 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    Protein expressed at very low level.
    This Np9 protein is encoded by a human specific provirus.
    Has a type 1 genome. The HERV-K(HML-2) family contains type 1 and type 2 genomes depending on the absence or presence of 292 nucleotides at the 5'-end of the env gene. Np9 proteins are translated from a doubly spliced transcript expressed exclusively by HERV-K(HML-2) type 1 proviral genomes. Np9 proteins share 14 N-terminal amino acids with HERV-K(HML-2) type 2 envelope proteins. The rest of the protein is encoded by a small exon located at the 3' end of the envelope gene. This exon shares the same splice acceptor site and therefore overlaps HERV-K(HML-2) type 2 Rec protein second exon. It is yet translated from an alternate reading frame.
    Intergenic, closest flanking gene being PRODH.

    Keywords - Technical termi

    Complete proteome, ERV, Reference proteome, Transposable element

    Documents

    1. Human chromosome 22
      Human chromosome 22: entries, gene names and cross-references to MIM

    External Data

    Dasty 3