P61581 (NP11_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: HERV-K_22q11.21 provirus Np9 protein Alternative name(s): HERV-K101 Np9 protein
Organism	Homo sapiens (Human) [Reference proteome]
Taxonomic identifier	9606 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	75 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May possess a function in tumorigenesis.
Subcellular location	Nucleus. Note: When overexpressed.
Tissue specificity	Transcript detectable in many tumor cell lines and tumor tissues.
Miscellaneous	Protein expressed at very low level. This Np9 protein is encoded by a human specific provirus. HERV-K_22q11.21 has a type 1 genome. The HERV-K(HML-2) family contains type 1 and type 2 genomes depending on the absence or presence of 292 nucleotides at the 5'-end of the env gene. Np9 proteins are translated from a doubly spliced transcript expressed exclusively by HERV-K(HML-2) type 1 proviral genomes. Np9 proteins share 14 N-terminal amino acids with HERV-K(HML-2) type 2 envelope proteins. The rest of the protein is encoded by a small exon located at the 3' end of the envelope gene. This exon shares the same splice acceptor site and therefore overlaps HERV-K(HML-2) type 2 Rec protein second exon. It is yet translated from an alternate reading frame. Intergenic, closest flanking gene being PRODH.

Ontologies

Keywords
Cellular component	Nucleus
Technical term	Complete proteome ERV Reference proteome Transposable element
Gene Ontology (GO)
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 75	75	HERV-K_22q11.21 provirus Np9 protein		PRO_0000186785

Sequences

	Sequence		Length	Mass (Da)
	P61581 [UniParc]. Last modified May 24, 2004. Version 1. Checksum: 43D00FB321C07136	FASTA	75	8,893
	10 20 30 40 50 60 MNPSEMQRKG PPRRWCLQVY PTAPKRQRPS RTGHDDDGGF VEKKRGKCGE KQERSDCYCV 70 CVERSRHRRL HFVMC

References

[1]	"Many human endogenous retrovirus K (HERV-K) proviruses are unique to humans." Barbulescu M., Turner G., Seaman M.I., Deinard A.S., Kidd K.K., Lenz J. Curr. Biol. 9:861-868(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"A novel gene from the human endogenous retrovirus K expressed in transformed cells." Armbruester V., Sauter M., Krautkraemer E., Meese E.U., Kleiman A., Best B., Roemer K., Mueller-Lantzsch N. Clin. Cancer Res. 8:1800-1807(2002) [PubMed] [Europe PMC] [Abstract] Cited for: CHARACTERIZATION.

Web resources

Human Endogenous Retrovirus Database (HERVd)

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF164609 Genomic DNA. No translation available.
IPI	IPI00414915.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
neXtProt	NX_P61581.
Phylogenomic databases
HOVERGEN	HBG052652.
Gene expression databases
Genevestigator	P61581.
Family and domain databases
ProtoNet	Search...
Other
NextBio	35537772.

Entry information

Entry name

NP11_HUMAN

Accession

Primary (citable) accession number: P61581

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 24, 2004
Last sequence update:	May 24, 2004
Last modified:	April 3, 2013
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.