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P61581 (NP11_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 43. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
HERV-K_22q11.21 provirus Np9 protein
Alternative name(s):
HERV-K101 Np9 protein
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length75 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May possess a function in tumorigenesis.

Subcellular location

Nucleus. Note: When overexpressed.

Tissue specificity

Transcript detectable in many tumor cell lines and tumor tissues.

Miscellaneous

Protein expressed at very low level.

This Np9 protein is encoded by a human specific provirus.

HERV-K_22q11.21 has a type 1 genome. The HERV-K(HML-2) family contains type 1 and type 2 genomes depending on the absence or presence of 292 nucleotides at the 5'-end of the env gene. Np9 proteins are translated from a doubly spliced transcript expressed exclusively by HERV-K(HML-2) type 1 proviral genomes. Np9 proteins share 14 N-terminal amino acids with HERV-K(HML-2) type 2 envelope proteins. The rest of the protein is encoded by a small exon located at the 3' end of the envelope gene. This exon shares the same splice acceptor site and therefore overlaps HERV-K(HML-2) type 2 Rec protein second exon. It is yet translated from an alternate reading frame.

Intergenic, closest flanking gene being PRODH.

Ontologies

Keywords
   Cellular componentNucleus
   Technical termComplete proteome
ERV
Reference proteome
Transposable element
Gene Ontology (GO)
   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 7575HERV-K_22q11.21 provirus Np9 protein
PRO_0000186785

Sequences

Sequence LengthMass (Da)Tools
P61581 [UniParc].

Last modified May 24, 2004. Version 1.
Checksum: 43D00FB321C07136

FASTA758,893
        10         20         30         40         50         60 
MNPSEMQRKG PPRRWCLQVY PTAPKRQRPS RTGHDDDGGF VEKKRGKCGE KQERSDCYCV 

        70 
CVERSRHRRL HFVMC 

« Hide

References

[1]"Many human endogenous retrovirus K (HERV-K) proviruses are unique to humans."
Barbulescu M., Turner G., Seaman M.I., Deinard A.S., Kidd K.K., Lenz J.
Curr. Biol. 9:861-868(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"A novel gene from the human endogenous retrovirus K expressed in transformed cells."
Armbruester V., Sauter M., Krautkraemer E., Meese E.U., Kleiman A., Best B., Roemer K., Mueller-Lantzsch N.
Clin. Cancer Res. 8:1800-1807(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: CHARACTERIZATION.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF164609 Genomic DNA. No translation available.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

neXtProtNX_P61581.

Phylogenomic databases

HOVERGENHBG052652.
PhylomeDBP61581.

Gene expression databases

GenevestigatorP61581.

Family and domain databases

ProtoNetSearch...

Other

NextBio35537772.

Entry information

Entry nameNP11_HUMAN
AccessionPrimary (citable) accession number: P61581
Entry history
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: May 24, 2004
Last modified: April 16, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 22

Human chromosome 22: entries, gene names and cross-references to MIM