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Protein

Endogenous retrovirus group K member 16 Rec protein

Gene

ERVK-16

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Retroviral replication requires the nuclear export and translation of unspliced, singly-spliced and multiply-spliced derivatives of the initial genomic transcript. Rec interacts with a highly structured RNA element (RcRE) present in the viral 3'LTR and recruits the cellular nuclear export machinery. This permits export to the cytoplasm of unspliced genomic or incompletely spliced subgenomic viral transcripts (By similarity).By similarity

Miscellaneous

Despite functional similarity, Rec shares almost no sequence homology with HIV-1 Rev and HTLV-1 Rex.
Has a type 2 genome. The HERV-K(HML-2) family contains type 1 and type 2 genomes depending on the absence or presence of 292 nucleotides at the 5'-end of the env gene. Rec proteins are translated from a doubly spliced transcript expressed exclusively by HERV-K(HML-2) type 2 proviral genomes. The first exon comprises the 87 N-terminal amino acids of the HERV-K(HMLM-2) type 2 envelope protein. The second exon (18 amino acids) is positioned in the 3' part of the proviral genome.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRNA-binding
Biological processmRNA transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Endogenous retrovirus group K member 16 Rec protein
Alternative name(s):
HERV-K_10p14 provirus Rec protein
Gene namesi
Name:ERVK-16
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:39023. ERVK-16.

Subcellular locationi

  • Cytoplasm By similarity
  • Nucleusnucleolus By similarity

  • Note: Shuttles between the nucleus and the cytoplasm. When in the nucleus, resides in the nucleolus (By similarity).By similarity

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001867821 – 105Endogenous retrovirus group K member 16 Rec proteinAdd BLAST105

Proteomic databases

PRIDEiP61578.

Interactioni

Subunit structurei

Forms homodimers, homotrimers, and homotetramers via a C-terminal domain. Associates with XPO1 and with ZNF145 (By similarity).By similarity

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi13 – 20Nuclear localization signalSequence analysis8
Motifi50 – 59Nuclear export signalSequence analysis10

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi13 – 20Poly-Arg8

Phylogenomic databases

HOVERGENiHBG063444.
PhylomeDBiP61578.

Sequencei

Sequence statusi: Complete.

P61578-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNPSEMQRKA PPRRRRHRNR APSSHKMNKM MMSEEQMKLP STNKAEPLTW
60 70 80 90 100
AQLNKLTQLA TKCLENTKMT QTPESMLLAA LMIVSTVSAG VPNSSEETVT

IENGP
Length:105
Mass (Da):11,808
Last modified:May 24, 2004 - v1
Checksum:i3634F5D296303B81
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL392086 Genomic DNA. No translation available.

Similar proteinsi

Entry informationi

Entry nameiREC16_HUMAN
AccessioniPrimary (citable) accession number: P61578
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: May 24, 2004
Last modified: April 12, 2017
This is version 52 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, ERV, Reference proteome, Transposable element

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM