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Protein

Endogenous retrovirus group K member 24 Env polyprotein

Gene

ERVK-24

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution.
SU mediates receptor recognition.By similarity
TM anchors the envelope heterodimer to the viral membrane through one transmembrane domain. The other hydrophobic domain, called fusion peptide, mediates fusion of the viral membrane with the target cell membrane (By similarity).By similarity

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Recommended name:
Endogenous retrovirus group K member 24 Env polyprotein
Alternative name(s):
Envelope polyprotein
HERV-K101 envelope protein
HERV-K_22q11.21 provirus ancestral Env polyprotein
Cleaved into the following 2 chains:
Surface protein
Short name:
SU
Transmembrane protein
Short name:
TM
Gene namesi
Name:ERVK-24
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:39038. ERVK-24.

Subcellular locationi

Surface protein :
  • Cell membrane By similarity; Peripheral membrane protein By similarity

  • Note: The surface protein is not anchored to the membrane, but localizes to the extracellular surface through its binding to TM.By similarity

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei522 – 542HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane, Viral envelope protein, Virion

Pathology & Biotechi

Organism-specific databases

DisGeNETi100862684.

Polymorphism and mutation databases

DMDMi47605617.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000085231 – 588Endogenous retrovirus group K member 24 Env polyproteinAdd BLAST588
ChainiPRO_00000085241 – 354Surface proteinBy similarityAdd BLAST354
ChainiPRO_0000008525355 – 588Transmembrane proteinBy similarityAdd BLAST234

Post-translational modificationi

Specific enzymatic cleavages in vivo yield the mature SU and TM proteins.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei354 – 355CleavageBy similarity2

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PRIDEiP61566.

Expressioni

Tissue specificityi

Expressed in teratocarcinoma cell line.1 Publication

Interactioni

Subunit structurei

The surface (SU) and transmembrane (TM) proteins form a heterodimer. SU and TM are attached by noncovalent interactions or by a labile interchain disulfide bond (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliP61566.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni355 – 375Fusion peptideSequence analysisAdd BLAST21

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG051479.
PhylomeDBiP61566.

Family and domain databases

CDDicd09909. HIV-1-like_HR1-HR2. 1 hit.
InterProiView protein in InterPro
IPR000328. GP41-like.
IPR029104. HERV-K_env.
PfamiView protein in Pfam
PF00517. GP41. 1 hit.
PF13804. HERV-K_env_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P61566-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVTPVTWMDN PIEVYVNDSE WVPGPTDDRC PAKPEEEGMM INISIGYRYP
60 70 80 90 100
PICLGTAPGC LMPAVQNWLV EVPIVSPISR FTYHMVSGMS LRPRVNYLQD
110 120 130 140 150
FPYQRSLKFR PKGKPCPKEI PKESKNTEVL VWEECVANSA VILQNNEFGT
160 170 180 190 200
IIDWAPRGQF YHNCSGQTQS CPSAQVSPAV DSDLTESLDK HKHKKLQSFY
210 220 230 240 250
PWEWGEKGIS TPRPKIISPV SGPEHPELWR LTVASHHIRI WSGNQTLETR
260 270 280 290 300
DRKPFYTVDL NSSLTLPLQS CVKPPYMLVV GNIVIKPDSQ TITCENCRLL
310 320 330 340 350
TCIDSTFNWQ HRILLVRARE GVWILVSMDR PWEASPSVHI LTEVLKGVLN
360 370 380 390 400
RSKRFIFTLI AVIMGLIAVT ATGAVAGVAL HSSVQSVNFV NDWQKNSTRL
410 420 430 440 450
WNSQSSIDQK LANQINDLRQ TVIWMGDRLM SLEHRFQLQC DWNTSDFCIT
460 470 480 490 500
PQIYNESEHH WDMVRHHLQG REDNLTLDIS KLKEQIFEAS KAHLNLVPGT
510 520 530 540 550
EAIAGVADGL ANLNPVTWVK TIGSTTIINL ILILVCLFCL LLVCRCTQQL
560 570 580
RRDSDHRERA MMTMAVLSKR KGGNVGKSKR DQIVTVSV
Length:588
Mass (Da):66,585
Last modified:May 24, 2004 - v1
Checksum:i0C1ED9251CEB8656
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF164609 Genomic DNA. No translation available.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF164609 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortaliP61566.
ModBaseiSearch...
MobiDBiSearch...

Polymorphism and mutation databases

DMDMi47605617.

Proteomic databases

PRIDEiP61566.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

DisGeNETi100862684.
GeneCardsiERVK-24.
HGNCiHGNC:39038. ERVK-24.
neXtProtiNX_P61566.
GenAtlasiSearch...

Phylogenomic databases

HOVERGENiHBG051479.
PhylomeDBiP61566.

Family and domain databases

CDDicd09909. HIV-1-like_HR1-HR2. 1 hit.
InterProiView protein in InterPro
IPR000328. GP41-like.
IPR029104. HERV-K_env.
PfamiView protein in Pfam
PF00517. GP41. 1 hit.
PF13804. HERV-K_env_2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiENK24_HUMAN
AccessioniPrimary (citable) accession number: P61566
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: May 24, 2004
Last modified: November 2, 2016
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

This envelope protein is encoded by a human specific provirus.
Has a type 1 genome. The HERV-K(HML-2) family contains type 1 and type 2 genomes depending on the absence or presence of 292 nucleotides at the 5'-end of the env gene resulting in Env proteins of distinct sizes. Despite their overall retroviral envelope structure HERV-K(HML-2) type 1 envelope proteins lack a predictable signal sequence. Subgenomic RNA transcripts coding for full-length envelope proteins have been detected for both type of genomes.
Intergenic, closest flanking gene being PRODH.

Caution

No predictable signal peptide.Curated

Keywords - Technical termi

Complete proteome, ERV, Reference proteome, Transposable element

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.