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P61523

- ASSY_GEOSL

UniProt

P61523 - ASSY_GEOSL

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Protein

Argininosuccinate synthase

Gene
argG, GSU0153
Organism
Geobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei41 – 411ATP; via amide nitrogen and carbonyl oxygen By similarity
Binding sitei92 – 921Citrulline By similarity
Binding sitei97 – 971Citrulline By similarity
Binding sitei122 – 1221ATP; via amide nitrogen By similarity
Binding sitei124 – 1241Aspartate By similarity
Binding sitei128 – 1281Aspartate By similarity
Binding sitei128 – 1281Citrulline By similarity
Binding sitei129 – 1291Aspartate By similarity
Binding sitei132 – 1321Citrulline By similarity
Binding sitei181 – 1811Citrulline By similarity
Binding sitei190 – 1901Citrulline By similarity
Binding sitei266 – 2661Citrulline By similarity
Binding sitei278 – 2781Citrulline By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi14 – 229ATP By similarity

GO - Molecular functioni

  1. argininosuccinate synthase activity Source: UniProtKB-HAMAP
  2. ATP binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. arginine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Amino-acid biosynthesis, Arginine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciGSUL243231:GH27-159-MONOMER.
UniPathwayiUPA00068; UER00113.

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate synthase (EC:6.3.4.5)
Alternative name(s):
Citrulline--aspartate ligase
Gene namesi
Name:argG
Ordered Locus Names:GSU0153
OrganismiGeobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA)
Taxonomic identifieri243231 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfuromonadalesGeobacteraceaeGeobacter
ProteomesiUP000000577: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 406406Argininosuccinate synthaseUniRule annotationPRO_0000148595Add
BLAST

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi243231.GSU0153.

Structurei

3D structure databases

ProteinModelPortaliP61523.
SMRiP61523. Positions 10-403.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0137.
HOGENOMiHOG000230093.
KOiK01940.
OMAiVEEYIWR.
OrthoDBiEOG6K9QCV.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPiMF_00005. Arg_succ_synth_type1.
InterProiIPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF00764. Arginosuc_synth. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00032. argG. 1 hit.
PROSITEiPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P61523-1 [UniParc]FASTAAdd to Basket

« Hide

MAKAHKDVKK IVLAYSGGLD TSIILKWLKN EYGCEVIAFS ADLGQGDELA    50
PIRDKAIATG ADKVYIDDLK EEFVKDFVFP MFRANAIYEG HYLLGTSIAR 100
PLIAKRQMEI AKIEGADAVS HGATGKGNDQ VRFELAYYHF DPAITVVAPW 150
REWKLNSRQA LVNYARKNGI PIPVTKKRPW SSDRNLLHIS FEGGILEDTW 200
AEPPENMYVL TKAPEKAPNK PQFVEIEFKN GNAVAVDGEK MSPAQLLAHL 250
NYIGGEHGIG RVDLLENRSV GMKSRGVYET PGGTILREAH SAVEQITMDR 300
EVMRIRDSLI PEYARQVYAG YWFSPEREML QTLIDDSQKC VNGVARVKLY 350
KGHCRTVGRK SETNSLFNLD FATFEKDQVF NQADATGFIK INSLRLRIRS 400
LMQGKK 406
Length:406
Mass (Da):45,657
Last modified:May 24, 2004 - v1
Checksum:i16AD280BD3ADA902
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017180 Genomic DNA. Translation: AAR33488.1.
RefSeqiNP_951215.1. NC_002939.5.

Genome annotation databases

EnsemblBacteriaiAAR33488; AAR33488; GSU0153.
GeneIDi2687910.
KEGGigsu:GSU0153.
PATRICi22023054. VBIGeoSul17553_0154.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017180 Genomic DNA. Translation: AAR33488.1 .
RefSeqi NP_951215.1. NC_002939.5.

3D structure databases

ProteinModelPortali P61523.
SMRi P61523. Positions 10-403.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243231.GSU0153.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAR33488 ; AAR33488 ; GSU0153 .
GeneIDi 2687910.
KEGGi gsu:GSU0153.
PATRICi 22023054. VBIGeoSul17553_0154.

Phylogenomic databases

eggNOGi COG0137.
HOGENOMi HOG000230093.
KOi K01940.
OMAi VEEYIWR.
OrthoDBi EOG6K9QCV.

Enzyme and pathway databases

UniPathwayi UPA00068 ; UER00113 .
BioCyci GSUL243231:GH27-159-MONOMER.

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPi MF_00005. Arg_succ_synth_type1.
InterProi IPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
Pfami PF00764. Arginosuc_synth. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00032. argG. 1 hit.
PROSITEi PS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51573 / DSM 12127 / PCA.

Entry informationi

Entry nameiASSY_GEOSL
AccessioniPrimary (citable) accession number: P61523
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: May 24, 2004
Last modified: May 14, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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