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P61522

- ASSY_DESVH

UniProt

P61522 - ASSY_DESVH

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Protein

Argininosuccinate synthase

Gene

argG

Organism
Desulfovibrio vulgaris (strain Hildenborough / ATCC 29579 / NCIMB 8303)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei37 – 371ATP; via amide nitrogen and carbonyl oxygenUniRule annotation
Binding sitei88 – 881CitrullineUniRule annotation
Binding sitei93 – 931CitrullineUniRule annotation
Binding sitei118 – 1181ATP; via amide nitrogenUniRule annotation
Binding sitei120 – 1201AspartateUniRule annotation
Binding sitei124 – 1241AspartateUniRule annotation
Binding sitei124 – 1241CitrullineUniRule annotation
Binding sitei125 – 1251AspartateUniRule annotation
Binding sitei128 – 1281CitrullineUniRule annotation
Binding sitei176 – 1761CitrullineUniRule annotation
Binding sitei185 – 1851CitrullineUniRule annotation
Binding sitei261 – 2611CitrullineUniRule annotation
Binding sitei273 – 2731CitrullineUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi10 – 189ATPUniRule annotation

GO - Molecular functioni

  1. argininosuccinate synthase activity Source: UniProtKB-HAMAP
  2. ATP binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. arginine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Amino-acid biosynthesis, Arginine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciDVUL882:GJIL-1121-MONOMER.
UniPathwayiUPA00068; UER00113.

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate synthaseUniRule annotation (EC:6.3.4.5UniRule annotation)
Alternative name(s):
Citrulline--aspartate ligaseUniRule annotation
Gene namesi
Name:argGUniRule annotation
Ordered Locus Names:DVU_1095
OrganismiDesulfovibrio vulgaris (strain Hildenborough / ATCC 29579 / NCIMB 8303)
Taxonomic identifieri882 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfovibrionalesDesulfovibrionaceaeDesulfovibrio
ProteomesiUP000002194: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 396396Argininosuccinate synthasePRO_0000148593Add
BLAST

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi882.DVU1095.

Structurei

3D structure databases

ProteinModelPortaliP61522.
SMRiP61522. Positions 6-391.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the argininosuccinate synthase family. Type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0137.
KOiK01940.
OMAiAPPEEAY.
OrthoDBiEOG6K9QCV.
PhylomeDBiP61522.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPiMF_00005. Arg_succ_synth_type1.
InterProiIPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF00764. Arginosuc_synth. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00032. argG. 1 hit.
PROSITEiPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P61522-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSGIKKVVLA YSGGLDTSVI LKWLAVTYNC EVVTLTADLG QEEDLDGVDD
60 70 80 90 100
KAMRTGASRA YVEDLQEEFA RDFIFPMMRA GAVYEGRYLL GTSIARPLIA
110 120 130 140 150
KRLVEIARAE GAQAVAHGAT GKGNDQVRFE LAVNALAPDL RVIAPWREWD
160 170 180 190 200
LRSRTQLNAF AEEHGIPISS SAKQYSMDRN MLHCSFEGGE LEDPWNEPGP
210 220 230 240 250
NSYVMAVPME QAPDEAEYIS IDFEHGNPVA VNGERLSPAA LVKKLNSIGG
260 270 280 290 300
RHGIGRLDMV ENRFVGIKSR GVYETPGGTL IHIAHRDLEG ICIDRETMHL
310 320 330 340 350
RDAMLPRYAA AIYNGFWFAP EREAMQAMID VSQQRVTGTV RLKLYKGNAW
360 370 380 390
PVGRQSPNTL YCHDLATFED CATYDHKDAA GFIKLQGLRI RGYKKG
Length:396
Mass (Da):43,911
Last modified:May 24, 2004 - v1
Checksum:i1C53A441A6984BE3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017285 Genomic DNA. Translation: AAS95575.1.
RefSeqiWP_010938394.1. NC_002937.3.
YP_010316.1. NC_002937.3.

Genome annotation databases

EnsemblBacteriaiAAS95575; AAS95575; DVU_1095.
GeneIDi2794339.
KEGGidvu:DVU1095.
PATRICi32062096. VBIDesVul119526_1033.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017285 Genomic DNA. Translation: AAS95575.1 .
RefSeqi WP_010938394.1. NC_002937.3.
YP_010316.1. NC_002937.3.

3D structure databases

ProteinModelPortali P61522.
SMRi P61522. Positions 6-391.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 882.DVU1095.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAS95575 ; AAS95575 ; DVU_1095 .
GeneIDi 2794339.
KEGGi dvu:DVU1095.
PATRICi 32062096. VBIDesVul119526_1033.

Phylogenomic databases

eggNOGi COG0137.
KOi K01940.
OMAi APPEEAY.
OrthoDBi EOG6K9QCV.
PhylomeDBi P61522.

Enzyme and pathway databases

UniPathwayi UPA00068 ; UER00113 .
BioCyci DVUL882:GJIL-1121-MONOMER.

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPi MF_00005. Arg_succ_synth_type1.
InterProi IPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
Pfami PF00764. Arginosuc_synth. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00032. argG. 1 hit.
PROSITEi PS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Hildenborough / ATCC 29579 / NCIMB 8303.

Entry informationi

Entry nameiASSY_DESVH
AccessioniPrimary (citable) accession number: P61522
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: May 24, 2004
Last modified: November 26, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3