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P61521

- ASSY_CORDI

UniProt

P61521 - ASSY_CORDI

Protein

Argininosuccinate synthase

Gene

argG

Organism
Corynebacterium diphtheriae (strain ATCC 700971 / NCTC 13129 / Biotype gravis)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 75 (01 Oct 2014)
      Sequence version 1 (24 May 2004)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei87 – 871CitrullineUniRule annotation
    Binding sitei117 – 1171ATP; via amide nitrogenUniRule annotation
    Binding sitei119 – 1191AspartateUniRule annotation
    Binding sitei123 – 1231AspartateUniRule annotation
    Binding sitei123 – 1231CitrullineUniRule annotation
    Binding sitei124 – 1241AspartateUniRule annotation
    Binding sitei127 – 1271CitrullineUniRule annotation
    Binding sitei175 – 1751CitrullineUniRule annotation
    Binding sitei259 – 2591CitrullineUniRule annotation
    Binding sitei271 – 2711CitrullineUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi8 – 169ATPUniRule annotation

    GO - Molecular functioni

    1. argininosuccinate synthase activity Source: UniProtKB-HAMAP
    2. ATP binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. arginine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Amino-acid biosynthesis, Arginine biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    UniPathwayiUPA00068; UER00113.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Argininosuccinate synthaseUniRule annotation (EC:6.3.4.5UniRule annotation)
    Alternative name(s):
    Citrulline--aspartate ligaseUniRule annotation
    Gene namesi
    Name:argGUniRule annotation
    Ordered Locus Names:DIP1173
    OrganismiCorynebacterium diphtheriae (strain ATCC 700971 / NCTC 13129 / Biotype gravis)
    Taxonomic identifieri257309 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium
    ProteomesiUP000002198: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 399399Argininosuccinate synthasePRO_0000148588Add
    BLAST

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotation

    Protein-protein interaction databases

    STRINGi257309.DIP1173.

    Structurei

    3D structure databases

    ProteinModelPortaliP61521.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the argininosuccinate synthase family. Type 1 subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0137.
    HOGENOMiHOG000230093.
    KOiK01940.
    OMAiKANALYM.
    OrthoDBiEOG6K9QCV.

    Family and domain databases

    Gene3Di3.40.50.620. 1 hit.
    3.90.1260.10. 1 hit.
    HAMAPiMF_00005. Arg_succ_synth_type1.
    InterProiIPR001518. Arginosuc_synth.
    IPR018223. Arginosuc_synth_CS.
    IPR023434. Arginosuc_synth_type_1_subfam.
    IPR024074. AS_cat/multimer_dom_body.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view]
    PfamiPF00764. Arginosuc_synth. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00032. argG. 1 hit.
    PROSITEiPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
    PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P61521-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTNRVVLAYS GGLDTSVAIP YLAKMTGGEV VAVSLDLGQG GEDMESVRQR    50
    ALDCGAVESI VIDAKDEFAN DYCLPTIKAN GMYMKQYPLV SAISRPLIVK 100
    HLVEAAKKHG GTHVSHGCTG KGNDQVRFEV GFRNLAPELQ IIAPARDYAW 150
    TRDKAIAFAE EINLPIEQSK KSPFSIDQNV WGRAVETGFL EDLWNPPTKD 200
    LYSYTEDPAL GNAPDEIIIS FKAGVPVAID GRPVTVLEAI EEMNRRAGAQ 250
    GIGRLDMVED RLVGIKSREV YEAPGAIALI TAHQAMEDVT IERELARYKR 300
    GIDARWSEEV YDGLWYAPLK RSLDAFIENT QEHVTGDIRM VMHAGKCTVN 350
    GRRSEHSLYD FDLATYDTGD TFDQTLAKGF VELHGLSSKI SNKRDREAQ 399
    Length:399
    Mass (Da):44,082
    Last modified:May 24, 2004 - v1
    Checksum:iB83FD37285891D64
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX248357 Genomic DNA. Translation: CAE49693.1.
    RefSeqiNP_939530.1. NC_002935.2.
    WP_003851325.1. NC_002935.2.

    Genome annotation databases

    EnsemblBacteriaiCAE49693; CAE49693; DIP1173.
    GeneIDi2649725.
    KEGGicdi:DIP1173.
    PATRICi21483535. VBICorDip47633_1156.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX248357 Genomic DNA. Translation: CAE49693.1 .
    RefSeqi NP_939530.1. NC_002935.2.
    WP_003851325.1. NC_002935.2.

    3D structure databases

    ProteinModelPortali P61521.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 257309.DIP1173.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAE49693 ; CAE49693 ; DIP1173 .
    GeneIDi 2649725.
    KEGGi cdi:DIP1173.
    PATRICi 21483535. VBICorDip47633_1156.

    Phylogenomic databases

    eggNOGi COG0137.
    HOGENOMi HOG000230093.
    KOi K01940.
    OMAi KANALYM.
    OrthoDBi EOG6K9QCV.

    Enzyme and pathway databases

    UniPathwayi UPA00068 ; UER00113 .

    Family and domain databases

    Gene3Di 3.40.50.620. 1 hit.
    3.90.1260.10. 1 hit.
    HAMAPi MF_00005. Arg_succ_synth_type1.
    InterProi IPR001518. Arginosuc_synth.
    IPR018223. Arginosuc_synth_CS.
    IPR023434. Arginosuc_synth_type_1_subfam.
    IPR024074. AS_cat/multimer_dom_body.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view ]
    Pfami PF00764. Arginosuc_synth. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00032. argG. 1 hit.
    PROSITEi PS00564. ARGININOSUCCIN_SYN_1. 1 hit.
    PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700971 / NCTC 13129 / Biotype gravis.

    Entry informationi

    Entry nameiASSY_CORDI
    AccessioniPrimary (citable) accession number: P61521
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 24, 2004
    Last sequence update: May 24, 2004
    Last modified: October 1, 2014
    This is version 75 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3