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Protein

Superoxide dismutase [Mn]

Gene

sodA

Organism
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.

Catalytic activityi

2 superoxide + 2 H+ = O2 + H2O2.

Cofactori

Mn2+Note: Binds 1 Mn2+ ion per subunit.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi29 – 291Manganese
Metal bindingi84 – 841Manganese
Metal bindingi167 – 1671Manganese
Metal bindingi171 – 1711Manganese

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Manganese, Metal-binding

Enzyme and pathway databases

BioCyciTTHE300852:GH8R-582-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Superoxide dismutase [Mn] (EC:1.15.1.1)
Gene namesi
Name:sodA
Ordered Locus Names:TTHA0557
OrganismiThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Taxonomic identifieri300852 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
Proteomesi
  • UP000000532 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemoved1 Publication
Chaini2 – 204203Superoxide dismutase [Mn]PRO_0000160108Add
BLAST

Interactioni

Subunit structurei

Homotetramer.

Protein-protein interaction databases

STRINGi300852.TTHA0557.

Structurei

Secondary structure

1
204
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi14 – 174Combined sources
Turni18 – 203Combined sources
Helixi23 – 319Combined sources
Helixi33 – 4614Combined sources
Helixi49 – 513Combined sources
Helixi56 – 616Combined sources
Helixi63 – 653Combined sources
Helixi68 – 703Combined sources
Helixi71 – 9020Combined sources
Helixi101 – 11111Combined sources
Helixi114 – 12613Combined sources
Beta strandi130 – 1389Combined sources
Beta strandi144 – 1507Combined sources
Helixi155 – 1584Combined sources
Beta strandi161 – 1677Combined sources
Helixi170 – 1723Combined sources
Helixi174 – 1774Combined sources
Helixi181 – 1888Combined sources
Turni189 – 1913Combined sources
Helixi194 – 2029Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1MNGX-ray1.80A/B2-204[»]
3MDSX-ray1.80A/B2-204[»]
ProteinModelPortaliP61503.
SMRiP61503. Positions 2-204.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP61503.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105CK4. Bacteria.
COG0605. LUCA.
HOGENOMiHOG000013583.
KOiK04564.
OMAiEPIMAHT.
OrthoDBiEOG63NMNT.
PhylomeDBiP61503.

Family and domain databases

InterProiIPR001189. Mn/Fe_SOD.
IPR019833. Mn/Fe_SOD_BS.
IPR019832. Mn/Fe_SOD_C.
IPR019831. Mn/Fe_SOD_N.
[Graphical view]
PANTHERiPTHR11404. PTHR11404. 1 hit.
PfamiPF02777. Sod_Fe_C. 1 hit.
PF00081. Sod_Fe_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000349. SODismutase. 1 hit.
PRINTSiPR01703. MNSODISMTASE.
SUPFAMiSSF46609. SSF46609. 1 hit.
SSF54719. SSF54719. 1 hit.
PROSITEiPS00088. SOD_MN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P61503-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPYPFKLPDL GYPYEALEPH IDAKTMEIHH QKHHGAYVTN LNAALEKYPY
60 70 80 90 100
LHGVEVEVLL RHLAALPQDI QTAVRNNGGG HLNHSLFWRL LTPGGAKEPV
110 120 130 140 150
GELKKAIDEQ FGGFQALKEK LTQAAMGRFG SGWAWLVKDP FGKLHVLSTP
160 170 180 190 200
NQDNPVMEGF TPIVGIDVWE HAYYLKYQNR RADYLQAIWN VLNWDVAEEF

FKKA
Length:204
Mass (Da):23,230
Last modified:January 23, 2007 - v2
Checksum:i37B9C1956FD8D46B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008226 Genomic DNA. Translation: BAD70380.1.
RefSeqiWP_011172643.1. NC_006461.1.
YP_143823.1. NC_006461.1.

Genome annotation databases

EnsemblBacteriaiBAD70380; BAD70380; BAD70380.
GeneIDi3169327.
KEGGittj:TTHA0557.
PATRICi23956091. VBITheThe93045_0556.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008226 Genomic DNA. Translation: BAD70380.1.
RefSeqiWP_011172643.1. NC_006461.1.
YP_143823.1. NC_006461.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1MNGX-ray1.80A/B2-204[»]
3MDSX-ray1.80A/B2-204[»]
ProteinModelPortaliP61503.
SMRiP61503. Positions 2-204.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi300852.TTHA0557.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAD70380; BAD70380; BAD70380.
GeneIDi3169327.
KEGGittj:TTHA0557.
PATRICi23956091. VBITheThe93045_0556.

Phylogenomic databases

eggNOGiENOG4105CK4. Bacteria.
COG0605. LUCA.
HOGENOMiHOG000013583.
KOiK04564.
OMAiEPIMAHT.
OrthoDBiEOG63NMNT.
PhylomeDBiP61503.

Enzyme and pathway databases

BioCyciTTHE300852:GH8R-582-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP61503.

Family and domain databases

InterProiIPR001189. Mn/Fe_SOD.
IPR019833. Mn/Fe_SOD_BS.
IPR019832. Mn/Fe_SOD_C.
IPR019831. Mn/Fe_SOD_N.
[Graphical view]
PANTHERiPTHR11404. PTHR11404. 1 hit.
PfamiPF02777. Sod_Fe_C. 1 hit.
PF00081. Sod_Fe_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000349. SODismutase. 1 hit.
PRINTSiPR01703. MNSODISMTASE.
SUPFAMiSSF46609. SSF46609. 1 hit.
SSF54719. SSF54719. 1 hit.
PROSITEiPS00088. SOD_MN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete genome sequence of Thermus thermophilus HB8."
    Masui R., Kurokawa K., Nakagawa N., Tokunaga F., Koyama Y., Shibata T., Oshima T., Yokoyama S., Yasunaga T., Kuramitsu S.
    Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HB8 / ATCC 27634 / DSM 579.
  2. "Amino-acid sequence of a tetrameric, manganese superoxide dismutase from Thermus thermophilus HB8."
    Sato S., Nakada Y., Nakazawa-Tomizawa K.
    Biochim. Biophys. Acta 912:178-184(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-204.
  3. "The structure of manganese superoxide dismutase from Thermus thermophilus HB8 at 2.4-A resolution."
    Stallings W.C., Pattridge K.A., Strong R.K., Ludwig M.L.
    J. Biol. Chem. 260:16424-16432(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS).
  4. "Manganese superoxide dismutase from Thermus thermophilus. A structural model refined at 1.8-A resolution."
    Ludwig M.L., Metzger A.L., Pattridge K.A., Stallings W.C.
    J. Mol. Biol. 219:335-358(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS).

Entry informationi

Entry nameiSODM_THET8
AccessioniPrimary (citable) accession number: P61503
Secondary accession number(s): P09214, Q5SKT6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: January 23, 2007
Last modified: November 11, 2015
This is version 81 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.