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Protein

Superoxide dismutase [Mn]

Gene

sodA

Organism
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.

Catalytic activityi

2 superoxide + 2 H+ = O2 + H2O2.

Cofactori

Mn2+Note: Binds 1 Mn2+ ion per subunit.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi29Manganese1
Metal bindingi84Manganese1
Metal bindingi167Manganese1
Metal bindingi171Manganese1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Superoxide dismutase [Mn] (EC:1.15.1.1)
Gene namesi
Name:sodA
Ordered Locus Names:TTHA0557
OrganismiThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Taxonomic identifieri300852 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
Proteomesi
  • UP000000532 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001601082 – 204Superoxide dismutase [Mn]Add BLAST203

Interactioni

Subunit structurei

Homotetramer.

Protein-protein interaction databases

STRINGi300852.TTHA0557.

Structurei

Secondary structure

1204
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi14 – 17Combined sources4
Turni18 – 20Combined sources3
Helixi23 – 31Combined sources9
Helixi33 – 46Combined sources14
Helixi49 – 51Combined sources3
Helixi56 – 61Combined sources6
Helixi63 – 65Combined sources3
Helixi68 – 70Combined sources3
Helixi71 – 90Combined sources20
Helixi101 – 111Combined sources11
Helixi114 – 126Combined sources13
Beta strandi130 – 138Combined sources9
Beta strandi144 – 150Combined sources7
Helixi155 – 158Combined sources4
Beta strandi161 – 167Combined sources7
Helixi170 – 172Combined sources3
Helixi174 – 177Combined sources4
Helixi181 – 188Combined sources8
Turni189 – 191Combined sources3
Helixi194 – 202Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1MNGX-ray1.80A/B2-204[»]
3MDSX-ray1.80A/B2-204[»]
ProteinModelPortaliP61503.
SMRiP61503.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP61503.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105CK4. Bacteria.
COG0605. LUCA.
HOGENOMiHOG000013583.
KOiK04564.
OMAiINQGGGH.
PhylomeDBiP61503.

Family and domain databases

InterProiIPR001189. Mn/Fe_SOD.
IPR019833. Mn/Fe_SOD_BS.
IPR019832. Mn/Fe_SOD_C.
IPR019831. Mn/Fe_SOD_N.
[Graphical view]
PANTHERiPTHR11404. PTHR11404. 1 hit.
PfamiPF02777. Sod_Fe_C. 1 hit.
PF00081. Sod_Fe_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000349. SODismutase. 1 hit.
PRINTSiPR01703. MNSODISMTASE.
SUPFAMiSSF46609. SSF46609. 1 hit.
SSF54719. SSF54719. 1 hit.
PROSITEiPS00088. SOD_MN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P61503-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPYPFKLPDL GYPYEALEPH IDAKTMEIHH QKHHGAYVTN LNAALEKYPY
60 70 80 90 100
LHGVEVEVLL RHLAALPQDI QTAVRNNGGG HLNHSLFWRL LTPGGAKEPV
110 120 130 140 150
GELKKAIDEQ FGGFQALKEK LTQAAMGRFG SGWAWLVKDP FGKLHVLSTP
160 170 180 190 200
NQDNPVMEGF TPIVGIDVWE HAYYLKYQNR RADYLQAIWN VLNWDVAEEF

FKKA
Length:204
Mass (Da):23,230
Last modified:January 23, 2007 - v2
Checksum:i37B9C1956FD8D46B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008226 Genomic DNA. Translation: BAD70380.1.
RefSeqiWP_011172643.1. NC_006461.1.
YP_143823.1. NC_006461.1.

Genome annotation databases

EnsemblBacteriaiBAD70380; BAD70380; BAD70380.
GeneIDi3169327.
KEGGittj:TTHA0557.
PATRICi23956091. VBITheThe93045_0556.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008226 Genomic DNA. Translation: BAD70380.1.
RefSeqiWP_011172643.1. NC_006461.1.
YP_143823.1. NC_006461.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1MNGX-ray1.80A/B2-204[»]
3MDSX-ray1.80A/B2-204[»]
ProteinModelPortaliP61503.
SMRiP61503.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi300852.TTHA0557.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAD70380; BAD70380; BAD70380.
GeneIDi3169327.
KEGGittj:TTHA0557.
PATRICi23956091. VBITheThe93045_0556.

Phylogenomic databases

eggNOGiENOG4105CK4. Bacteria.
COG0605. LUCA.
HOGENOMiHOG000013583.
KOiK04564.
OMAiINQGGGH.
PhylomeDBiP61503.

Miscellaneous databases

EvolutionaryTraceiP61503.

Family and domain databases

InterProiIPR001189. Mn/Fe_SOD.
IPR019833. Mn/Fe_SOD_BS.
IPR019832. Mn/Fe_SOD_C.
IPR019831. Mn/Fe_SOD_N.
[Graphical view]
PANTHERiPTHR11404. PTHR11404. 1 hit.
PfamiPF02777. Sod_Fe_C. 1 hit.
PF00081. Sod_Fe_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000349. SODismutase. 1 hit.
PRINTSiPR01703. MNSODISMTASE.
SUPFAMiSSF46609. SSF46609. 1 hit.
SSF54719. SSF54719. 1 hit.
PROSITEiPS00088. SOD_MN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSODM_THET8
AccessioniPrimary (citable) accession number: P61503
Secondary accession number(s): P09214, Q5SKT6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 84 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.