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Protein

Superoxide dismutase [Mn]

Gene

sodA

Organism
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.

Catalytic activityi

2 superoxide + 2 H+ = O2 + H2O2.

Cofactori

Mn2+Note: Binds 1 Mn2+ ion per subunit.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi29Manganese1
Metal bindingi84Manganese1
Metal bindingi167Manganese1
Metal bindingi171Manganese1

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
LigandManganese, Metal-binding

Enzyme and pathway databases

BioCyciTTHE300852:G1GKC-574-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Superoxide dismutase [Mn] (EC:1.15.1.1)
Gene namesi
Name:sodA
Ordered Locus Names:TTHA0557
OrganismiThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Taxonomic identifieri300852 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
Proteomesi
  • UP000000532 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001601082 – 204Superoxide dismutase [Mn]Add BLAST203

Interactioni

Subunit structurei

Homotetramer.

Protein-protein interaction databases

STRINGi300852.TTHA0557

Structurei

Secondary structure

1204
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi14 – 17Combined sources4
Turni18 – 20Combined sources3
Helixi23 – 31Combined sources9
Helixi33 – 46Combined sources14
Helixi49 – 51Combined sources3
Helixi56 – 61Combined sources6
Helixi63 – 65Combined sources3
Helixi68 – 70Combined sources3
Helixi71 – 90Combined sources20
Helixi101 – 111Combined sources11
Helixi114 – 126Combined sources13
Beta strandi130 – 138Combined sources9
Beta strandi144 – 150Combined sources7
Helixi155 – 158Combined sources4
Beta strandi161 – 167Combined sources7
Helixi170 – 172Combined sources3
Helixi174 – 177Combined sources4
Helixi181 – 188Combined sources8
Turni189 – 191Combined sources3
Helixi194 – 202Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1MNGX-ray1.80A/B2-204[»]
3MDSX-ray1.80A/B2-204[»]
ProteinModelPortaliP61503
SMRiP61503
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP61503

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105CK4 Bacteria
COG0605 LUCA
HOGENOMiHOG000013583
KOiK04564
OMAiKWGSFDK
PhylomeDBiP61503

Family and domain databases

Gene3Di1.10.287.990, 1 hit
2.40.500.20, 1 hit
InterProiView protein in InterPro
IPR001189 Mn/Fe_SOD
IPR019833 Mn/Fe_SOD_BS
IPR019832 Mn/Fe_SOD_C
IPR019831 Mn/Fe_SOD_N
IPR036324 Mn/Fe_SOD_N_sf
IPR036314 SOD_C_sf
PfamiView protein in Pfam
PF02777 Sod_Fe_C, 1 hit
PF00081 Sod_Fe_N, 1 hit
PIRSFiPIRSF000349 SODismutase, 1 hit
PRINTSiPR01703 MNSODISMTASE
SUPFAMiSSF46609 SSF46609, 1 hit
SSF54719 SSF54719, 1 hit
PROSITEiView protein in PROSITE
PS00088 SOD_MN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P61503-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPYPFKLPDL GYPYEALEPH IDAKTMEIHH QKHHGAYVTN LNAALEKYPY
60 70 80 90 100
LHGVEVEVLL RHLAALPQDI QTAVRNNGGG HLNHSLFWRL LTPGGAKEPV
110 120 130 140 150
GELKKAIDEQ FGGFQALKEK LTQAAMGRFG SGWAWLVKDP FGKLHVLSTP
160 170 180 190 200
NQDNPVMEGF TPIVGIDVWE HAYYLKYQNR RADYLQAIWN VLNWDVAEEF

FKKA
Length:204
Mass (Da):23,230
Last modified:January 23, 2007 - v2
Checksum:i37B9C1956FD8D46B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008226 Genomic DNA Translation: BAD70380.1
RefSeqiWP_011172643.1, NC_006461.1
YP_143823.1, NC_006461.1

Genome annotation databases

EnsemblBacteriaiBAD70380; BAD70380; BAD70380
GeneIDi3169327
KEGGittj:TTHA0557
PATRICifig|300852.9.peg.556

Similar proteinsi

Entry informationi

Entry nameiSODM_THET8
AccessioniPrimary (citable) accession number: P61503
Secondary accession number(s): P09214, Q5SKT6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: January 23, 2007
Last modified: March 28, 2018
This is version 89 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome
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Main funding by: National Institutes of Health