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Protein

10 kDa chaperonin

Gene

groS

Organism
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Enzyme and pathway databases

BioCyciTTHE300852:GH8R-286-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
10 kDa chaperonin
Alternative name(s):
GroES protein
Protein Cpn10
Gene namesi
Name:groS
Synonyms:chpS, groES, hsp10
Ordered Locus Names:TTHA0272
OrganismiThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Taxonomic identifieri300852 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
Proteomesi
  • UP000000532 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemoved1 Publication
Chaini2 – 10110010 kDa chaperoninPRO_0000174886Add
BLAST

Interactioni

Subunit structurei

Heptamer of 7 subunits arranged in a ring.By similarity

Protein-protein interaction databases

DIPiDIP-48332N.
STRINGi300852.TTHA0272.

Structurei

Secondary structure

1
101
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi9 – 113Combined sources
Beta strandi13 – 208Combined sources
Beta strandi28 – 303Combined sources
Helixi35 – 384Combined sources
Beta strandi42 – 498Combined sources
Beta strandi70 – 734Combined sources
Beta strandi78 – 836Combined sources
Beta strandi86 – 927Combined sources
Helixi93 – 953Combined sources
Beta strandi96 – 1005Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1WNRX-ray2.90A/B/C/D/E/F/G9-101[»]
ProteinModelPortaliP61493.
SMRiP61493. Positions 6-101.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP61493.

Family & Domainsi

Sequence similaritiesi

Belongs to the GroES chaperonin family.Curated

Phylogenomic databases

eggNOGiENOG4105K5Y. Bacteria.
COG0234. LUCA.
HOGENOMiHOG000133897.
KOiK04078.
OMAiDTGKEKP.
PhylomeDBiP61493.

Family and domain databases

CDDicd00320. cpn10. 1 hit.
Gene3Di2.30.33.40. 1 hit.
HAMAPiMF_00580. CH10. 1 hit.
InterProiIPR020818. Chaperonin_GroES.
IPR018369. Chaprnonin_Cpn10_CS.
IPR011032. GroES-like.
[Graphical view]
PANTHERiPTHR10772. PTHR10772. 1 hit.
PfamiPF00166. Cpn10. 1 hit.
[Graphical view]
PRINTSiPR00297. CHAPERONIN10.
SMARTiSM00883. Cpn10. 1 hit.
[Graphical view]
SUPFAMiSSF50129. SSF50129. 1 hit.
PROSITEiPS00681. CHAPERONINS_CPN10. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P61493-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAEVKTVIK PLGDRVVVKR IEEEPKTKGG IVLPDTAKEK PQKGKVIAVG
60 70 80 90 100
TGRVLENGQR VPLEVKEGDI VVFAKYGGTE IEIDGEEYVI LSERDLLAVL

Q
Length:101
Mass (Da):10,996
Last modified:January 23, 2007 - v2
Checksum:i49DCA870AC325063
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti20 – 201R → K AA sequence (PubMed:1682319).Curated
Sequence conflicti84 – 874DGEE → APRRT in AAA83440 (Ref. 2) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D45880 Genomic DNA. Translation: BAA08298.1.
U29483 Genomic DNA. Translation: AAA83440.1.
AP008226 Genomic DNA. Translation: BAD70095.1.
PIRiB39313.
RefSeqiWP_011174076.1. NC_006461.1.
YP_143538.1. NC_006461.1.

Genome annotation databases

EnsemblBacteriaiBAD70095; BAD70095; BAD70095.
GeneIDi3168828.
KEGGittj:TTHA0272.
PATRICi23955499. VBITheThe93045_0272.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D45880 Genomic DNA. Translation: BAA08298.1.
U29483 Genomic DNA. Translation: AAA83440.1.
AP008226 Genomic DNA. Translation: BAD70095.1.
PIRiB39313.
RefSeqiWP_011174076.1. NC_006461.1.
YP_143538.1. NC_006461.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1WNRX-ray2.90A/B/C/D/E/F/G9-101[»]
ProteinModelPortaliP61493.
SMRiP61493. Positions 6-101.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-48332N.
STRINGi300852.TTHA0272.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAD70095; BAD70095; BAD70095.
GeneIDi3168828.
KEGGittj:TTHA0272.
PATRICi23955499. VBITheThe93045_0272.

Phylogenomic databases

eggNOGiENOG4105K5Y. Bacteria.
COG0234. LUCA.
HOGENOMiHOG000133897.
KOiK04078.
OMAiDTGKEKP.
PhylomeDBiP61493.

Enzyme and pathway databases

BioCyciTTHE300852:GH8R-286-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP61493.

Family and domain databases

CDDicd00320. cpn10. 1 hit.
Gene3Di2.30.33.40. 1 hit.
HAMAPiMF_00580. CH10. 1 hit.
InterProiIPR020818. Chaperonin_GroES.
IPR018369. Chaprnonin_Cpn10_CS.
IPR011032. GroES-like.
[Graphical view]
PANTHERiPTHR10772. PTHR10772. 1 hit.
PfamiPF00166. Cpn10. 1 hit.
[Graphical view]
PRINTSiPR00297. CHAPERONIN10.
SMARTiSM00883. Cpn10. 1 hit.
[Graphical view]
SUPFAMiSSF50129. SSF50129. 1 hit.
PROSITEiPS00681. CHAPERONINS_CPN10. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCH10_THET8
AccessioniPrimary (citable) accession number: P61493
Secondary accession number(s): P45747, Q5SLM1, Q60017
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 84 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.