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Protein

60 kDa chaperonin

Gene

groL

Organism
Thermus thermophilus
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.By similarity

Caution

The sequence shown here has been extracted from PDB entry 1SRV.Curated

GO - Molecular functioni

Keywordsi

Molecular functionChaperone
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
60 kDa chaperonin
Alternative name(s):
GroEL protein
Heat shock protein 60
Protein Cpn60
Gene namesi
Name:groL
Synonyms:cpnL, groEL, hsp60, mopA
OrganismiThermus thermophilus
Taxonomic identifieri274 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000063583‹1 – ›14560 kDa chaperoninAdd BLAST›145

Interactioni

Subunit structurei

Oligomer of 14 subunits composed of two stacked rings of 7 subunits.By similarity

Structurei

Secondary structure

1145
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi2 – 5Combined sources4
Helixi11 – 13Combined sources3
Turni17 – 20Combined sources4
Beta strandi21 – 36Combined sources16
Helixi39 – 50Combined sources12
Beta strandi56 – 63Combined sources8
Helixi65 – 76Combined sources12
Beta strandi82 – 86Combined sources5
Helixi91 – 105Combined sources15
Turni112 – 115Combined sources4
Helixi118 – 120Combined sources3
Helixi123 – 125Combined sources3
Beta strandi127 – 134Combined sources8
Beta strandi139 – 144Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1SRVX-ray1.70A1-145[»]
ProteinModelPortaliP61491
SMRiP61491
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP61491

Family & Domainsi

Sequence similaritiesi

Belongs to the chaperonin (HSP60) family.Curated

Phylogenomic databases

eggNOGiENOG4105CJ9 Bacteria
COG0459 LUCA

Family and domain databases

Gene3Di3.50.7.10, 1 hit
InterProiView protein in InterPro
IPR002423 Cpn60/TCP-1
IPR027409 GroEL-like_apical_dom_sf
PfamiView protein in Pfam
PF00118 Cpn60_TCP1, 1 hit
SUPFAMiSSF52029 SSF52029, 1 hit

Sequencei

Sequence statusi: Fragment.

P61491-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
GYQFDKGYIS PYFVTNPETM EAVLEDAFIL IVEKKVSNVR ELLPILEQVA
60 70 80 90 100
QTGKPLLIIA EDVEGEALAT LVVNKLRGTL SVAAVKAPGF GDRRKEMLKD
110 120 130 140
IAAVTGGTVI SEELGFKLEN ATLSMLGRAE RVRITKDETT IVGGK
Length:145
Mass (Da):15,736
Last modified:May 24, 2005 - v2
Checksum:i7E02F2AE0DF7C024
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11
Non-terminal residuei1451

Similar proteinsi

Entry informationi

Entry nameiCH60_THETH
AccessioniPrimary (citable) accession number: P61491
Secondary accession number(s): P45746, Q60018, Q9RA44
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: May 24, 2005
Last modified: May 23, 2018
This is version 63 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure
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Main funding by: National Institutes of Health