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Protein

60 kDa chaperonin

Gene

groL

Organism
Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
60 kDa chaperoninUniRule annotation
Alternative name(s):
GroEL proteinUniRule annotation
Heat shock protein 60
Protein Cpn60UniRule annotation
Gene namesi
Name:groLUniRule annotation
Synonyms:cpnL, groE, groELUniRule annotation, hsp60, mopA
Ordered Locus Names:TT_C1714
OrganismiThermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039)
Taxonomic identifieri262724 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
Proteomesi
  • UP000000592 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000635812 – 54360 kDa chaperoninAdd BLAST542

Proteomic databases

PRIDEiP61490.

Interactioni

Subunit structurei

Oligomer of 14 subunits composed of two stacked rings of 7 subunits.UniRule annotation1 Publication

Protein-protein interaction databases

STRINGi262724.TTC1714.

Structurei

Secondary structure

1543
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi3 – 7Combined sources5
Helixi8 – 26Combined sources19
Helixi27 – 29Combined sources3
Beta strandi36 – 39Combined sources4
Beta strandi42 – 45Combined sources4
Beta strandi47 – 49Combined sources3
Helixi52 – 58Combined sources7
Helixi64 – 84Combined sources21
Helixi88 – 107Combined sources20
Helixi112 – 132Combined sources21
Helixi140 – 151Combined sources12
Helixi154 – 165Combined sources12
Beta strandi171 – 177Combined sources7
Beta strandi179 – 182Combined sources4
Beta strandi184 – 188Combined sources5
Beta strandi190 – 194Combined sources5
Beta strandi197 – 199Combined sources3
Helixi200 – 202Combined sources3
Turni206 – 209Combined sources4
Beta strandi213 – 223Combined sources11
Helixi228 – 239Combined sources12
Beta strandi245 – 250Combined sources6
Helixi254 – 266Combined sources13
Beta strandi271 – 275Combined sources5
Beta strandi277 – 279Combined sources3
Helixi280 – 294Combined sources15
Turni301 – 303Combined sources3
Helixi307 – 309Combined sources3
Helixi312 – 314Combined sources3
Beta strandi316 – 323Combined sources8
Beta strandi328 – 333Combined sources6
Helixi337 – 351Combined sources15
Helixi357 – 370Combined sources14
Beta strandi374 – 379Combined sources6
Helixi384 – 407Combined sources24
Beta strandi409 – 411Combined sources3
Turni412 – 414Combined sources3
Helixi415 – 428Combined sources14
Helixi433 – 445Combined sources13
Helixi448 – 456Combined sources9
Helixi461 – 470Combined sources10
Beta strandi477 – 479Combined sources3
Turni481 – 483Combined sources3
Beta strandi486 – 488Combined sources3
Turni489 – 493Combined sources5
Beta strandi495 – 497Combined sources3
Helixi498 – 516Combined sources19
Beta strandi518 – 524Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4V4OX-ray2.80A/B/C/D/E/F/G/H/I/J/K/L/M/N/a/b/c/d/e/f/g/h/i/j/k/l/m/n1-543[»]
ProteinModelPortaliP61490.
SMRiP61490.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP61490.

Family & Domainsi

Sequence similaritiesi

Belongs to the chaperonin (HSP60) family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CJ9. Bacteria.
COG0459. LUCA.
KOiK04077.
OMAiTDTDKME.

Family and domain databases

Gene3Di1.10.560.10. 2 hits.
3.50.7.10. 1 hit.
HAMAPiMF_00600. CH60. 1 hit.
InterProiView protein in InterPro
IPR018370. Chaperonin_Cpn60_CS.
IPR001844. Chaprnin_Cpn60.
IPR002423. Cpn60/TCP-1.
IPR027409. GroEL-like_apical_dom.
IPR027413. GROEL-like_equatorial.
PfamiView protein in Pfam
PF00118. Cpn60_TCP1. 1 hit.
PRINTSiPR00298. CHAPERONIN60.
SUPFAMiSSF52029. SSF52029. 1 hit.
TIGRFAMsiTIGR02348. GroEL. 1 hit.
PROSITEiView protein in PROSITE
PS00296. CHAPERONINS_CPN60. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P61490-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKILVFDEA ARRALERGVN AVANAVKVTL GPRGRNVVLE KKFGSPTITK
60 70 80 90 100
DGVTVAKEVE LEDHLENIGA QLLKEVASKT NDVAGDGTTT ATVLAQAIVR
110 120 130 140 150
EGLKNVAAGA NPLALKRGIE KAVEAAVEKI KALAIPVEDR KAIEEVATIS
160 170 180 190 200
ANDPEVGKLI ADAMEKVGKE GIITVEESKS LETELKFVEG YQFDKGYISP
210 220 230 240 250
YFVTNPETME AVLEDAFILI VEKKVSNVRE LLPILEQVAQ TGKPLLIIAE
260 270 280 290 300
DVEGEALATL VVNKLRGTLS VAAVKAPGFG DRRKEMLKDI AAVTGGTVIS
310 320 330 340 350
EELGFKLENA TLSMLGRAER VRITKDETTI VGGKGKKEDI EARINGIKKE
360 370 380 390 400
LETTDSEYAR EKLQERLAKL AGGVAVIRVG AATETELKEK KHRFEDALNA
410 420 430 440 450
TRAAVEEGIV PGGGVTLLRA ISAVEELIKK LEGDEATGAK IVRRALEEPA
460 470 480 490 500
RQIAENAGYE GSVIVQQILA ETKNPRYGFN AATGEFVDMV EAGIVDPAKV
510 520 530 540
TRSALQNAAS IGALILTTEA VVAEKPEKKE STPASAGAGD MDF
Length:543
Mass (Da):57,889
Last modified:January 23, 2007 - v2
Checksum:i2F4E42EA89F3C3D3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti133L → P in CAB65482 (Ref. 1) Curated1
Sequence conflicti222E → K in CAB65482 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ250409 Genomic DNA. Translation: CAB65482.1.
AE017221 Genomic DNA. Translation: AAS82056.1.
RefSeqiWP_011174077.1. NC_005835.1.

Genome annotation databases

EnsemblBacteriaiAAS82056; AAS82056; TT_C1714.
KEGGitth:TT_C1714.

Similar proteinsi

Entry informationi

Entry nameiCH60_THET2
AccessioniPrimary (citable) accession number: P61490
Secondary accession number(s): P45746, Q60018, Q9RA44
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: January 23, 2007
Last modified: June 7, 2017
This is version 88 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families