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Protein

Pterin-4-alpha-carbinolamine dehydratase

Gene

Pcbd1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in tetrahydrobiopterin biosynthesis. Seems to both prevent the formation of 7-pterins and accelerate the formation of quinonoid-BH2. Coactivator for HNF1A-dependent transcription. Regulates the dimerization of homeodomain protein HNF1A and enhances its transcriptional activity.2 Publications

Catalytic activityi

(6R)-6-(L-erythro-1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-4a-hydroxypterin = (6R)-6-(L-erythro-1,2-dihydroxypropyl)-7,8-dihydro-6H-pterin + H2O.2 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, Lyase
Biological processTetrahydrobiopterin biosynthesis, Transcription, Transcription regulation

Enzyme and pathway databases

BRENDAi4.2.1.96 5301
ReactomeiR-RNO-71182 Phenylalanine and tyrosine catabolism

Protein family/group databases

MoonProtiP61459

Names & Taxonomyi

Protein namesi
Recommended name:
Pterin-4-alpha-carbinolamine dehydratase (EC:4.2.1.96)
Short name:
PHS
Alternative name(s):
4-alpha-hydroxy-tetrahydropterin dehydratase
Dimerization cofactor of hepatocyte nuclear factor 1-alpha
Short name:
DCoH
Short name:
Dimerization cofactor of HNF1
Phenylalanine hydroxylase-stimulating protein
Pterin carbinolamine dehydratase
Short name:
PCD
Gene namesi
Name:Pcbd1
Synonyms:Dcoh, Pcbd
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 20

Organism-specific databases

RGDi3263 Pcbd1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00000630542 – 104Pterin-4-alpha-carbinolamine dehydrataseAdd BLAST103

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanine1 Publication1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP61459
PRIDEiP61459

PTM databases

iPTMnetiP61459
PhosphoSitePlusiP61459

Expressioni

Gene expression databases

BgeeiENSRNOG00000000566
GenevisibleiP61459 RN

Interactioni

Subunit structurei

Homotetramer and homodimer. Heterotetramer with HNF1A; formed by a dimer of dimers.5 Publications

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000000687

Structurei

Secondary structure

1104
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi10 – 16Combined sources7
Helixi18 – 21Combined sources4
Turni22 – 24Combined sources3
Beta strandi29 – 32Combined sources4
Beta strandi34 – 39Combined sources6
Helixi43 – 60Combined sources18
Beta strandi65 – 69Combined sources5
Beta strandi72 – 77Combined sources6
Turni80 – 83Combined sources4
Helixi87 – 102Combined sources16

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1DCHX-ray3.00A/B/C/D/E/F/G/H1-104[»]
1DCOX-ray2.30A/B/C/D/E/F/G/H1-104[»]
1DCPX-ray2.30A/B/C/D/E/F/G/H1-104[»]
1F93X-ray2.60A/B/C/D1-104[»]
3HXAX-ray1.80A/B/C/D/E/F/G/H1-104[»]
ProteinModelPortaliP61459
SMRiP61459
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP61459

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni61 – 63Substrate binding3
Regioni78 – 81Substrate binding4

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG4073 Eukaryota
COG2154 LUCA
GeneTreeiENSGT00390000007221
HOGENOMiHOG000007680
HOVERGENiHBG000259
InParanoidiP61459
KOiK01724
OMAiAVGWNEV
OrthoDBiEOG091G120V
PhylomeDBiP61459
TreeFamiTF300188

Family and domain databases

Gene3Di3.30.1360.20, 1 hit
HAMAPiMF_00434 Pterin_4_alpha, 1 hit
InterProiView protein in InterPro
IPR036428 PCD_sf
IPR001533 Pterin_deHydtase
PfamiView protein in Pfam
PF01329 Pterin_4a, 1 hit
SUPFAMiSSF55248 SSF55248, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P61459-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGKAHRLSA EERDQLLPNL RAVGWNELEG RDAIFKQFHF KDFNRAFGFM
60 70 80 90 100
TRVALQAEKL DHHPEWFNVY NKVHITLSTH ECAGLSERDI NLASFIEQVA

VSMT
Length:104
Mass (Da):12,000
Last modified:January 23, 2007 - v2
Checksum:i997DF8C2417FE5F5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M83740 mRNA No translation available.
AJ005542 Genomic DNA Translation: CAA06587.1
L04537 mRNA Translation: AAA40609.1
PIRiA47189
RefSeqiNP_001007602.1, NM_001007601.2
XP_006256476.1, XM_006256414.1
UniGeneiRn.81180

Genome annotation databases

EnsembliENSRNOT00000000687; ENSRNOP00000000687; ENSRNOG00000000566
GeneIDi29700
KEGGirno:29700
UCSCiRGD:3263 rat

Similar proteinsi

Entry informationi

Entry nameiPHS_RAT
AccessioniPrimary (citable) accession number: P61459
Secondary accession number(s): P70519, P80095, Q9D930
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 116 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

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