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Protein

Pterin-4-alpha-carbinolamine dehydratase

Gene

Pcbd1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in tetrahydrobiopterin biosynthesis. Seems to both prevent the formation of 7-pterins and accelerate the formation of quinonoid-BH2. Coactivator for HNF1A-dependent transcription. Regulates the dimerization of homeodomain protein HNF1A and enhances its transcriptional activity (By similarity).By similarity

Catalytic activityi

(6R)-6-(L-erythro-1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-4a-hydroxypterin = (6R)-6-(L-erythro-1,2-dihydroxypropyl)-7,8-dihydro-6H-pterin + H2O.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator, Lyase

Keywords - Biological processi

Tetrahydrobiopterin biosynthesis, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-MMU-71182. Phenylalanine and tyrosine catabolism.

Names & Taxonomyi

Protein namesi
Recommended name:
Pterin-4-alpha-carbinolamine dehydratase (EC:4.2.1.96)
Short name:
PHS
Alternative name(s):
4-alpha-hydroxy-tetrahydropterin dehydratase
Dimerization cofactor of hepatocyte nuclear factor 1-alpha
Short name:
DCoH
Short name:
Dimerization cofactor of HNF1
Phenylalanine hydroxylase-stimulating protein
Pterin carbinolamine dehydratase
Short name:
PCD
Gene namesi
Name:Pcbd1
Synonyms:Dcoh, Pcbd
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:94873. Pcbd1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: MGI
  • extracellular exosome Source: MGI
  • nucleoplasm Source: MGI
  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 104103Pterin-4-alpha-carbinolamine dehydratasePRO_0000063053Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiP61458.
PaxDbiP61458.
PeptideAtlasiP61458.
PRIDEiP61458.

PTM databases

iPTMnetiP61458.
PhosphoSiteiP61458.

Expressioni

Gene expression databases

BgeeiENSMUSG00000020098.
GenevisibleiP61458. MM.

Interactioni

Subunit structurei

Homotetramer and homodimer. Heterotetramer with HNF1A; formed by a dimer of dimers (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi199068. 18 interactions.
IntActiP61458. 5 interactions.
MINTiMINT-4107515.
STRINGi10090.ENSMUSP00000020298.

Structurei

3D structure databases

ProteinModelPortaliP61458.
SMRiP61458. Positions 2-104.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni61 – 633Substrate bindingBy similarity
Regioni78 – 814Substrate bindingBy similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG4073. Eukaryota.
COG2154. LUCA.
GeneTreeiENSGT00390000007221.
HOGENOMiHOG000007680.
HOVERGENiHBG000259.
InParanoidiP61458.
KOiK01724.
OMAiIKAQEMD.
OrthoDBiEOG091G120V.
PhylomeDBiP61458.
TreeFamiTF300188.

Family and domain databases

Gene3Di3.30.1360.20. 1 hit.
HAMAPiMF_00434. Pterin_4_alpha. 1 hit.
InterProiIPR001533. Trans/pterin_deHydtase.
[Graphical view]
PANTHERiPTHR12599. PTHR12599. 1 hit.
PfamiPF01329. Pterin_4a. 1 hit.
[Graphical view]
SUPFAMiSSF55248. SSF55248. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P61458-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGKAHRLSA EERDQLLPNL RAVGWNEVEG RDAIFKQFHF KDFNRAFGFM
60 70 80 90 100
TRVALQAEKL DHHPEWFNVY NKVHITLSTH ECAGLSERDI NLASFIEQVA

VSMT
Length:104
Mass (Da):11,986
Last modified:January 23, 2007 - v2
Checksum:i13C798C25D9117E9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M83741 mRNA. No translation available.
AK007401 mRNA. Translation: BAB25014.1.
BC024354 mRNA. Translation: AAH24354.1.
CCDSiCCDS35913.1.
RefSeqiNP_079549.1. NM_025273.4.
UniGeneiMm.39473.

Genome annotation databases

EnsembliENSMUST00000020298; ENSMUSP00000020298; ENSMUSG00000020098.
GeneIDi13180.
KEGGimmu:13180.
UCSCiuc007ffj.3. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M83741 mRNA. No translation available.
AK007401 mRNA. Translation: BAB25014.1.
BC024354 mRNA. Translation: AAH24354.1.
CCDSiCCDS35913.1.
RefSeqiNP_079549.1. NM_025273.4.
UniGeneiMm.39473.

3D structure databases

ProteinModelPortaliP61458.
SMRiP61458. Positions 2-104.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi199068. 18 interactions.
IntActiP61458. 5 interactions.
MINTiMINT-4107515.
STRINGi10090.ENSMUSP00000020298.

PTM databases

iPTMnetiP61458.
PhosphoSiteiP61458.

Proteomic databases

MaxQBiP61458.
PaxDbiP61458.
PeptideAtlasiP61458.
PRIDEiP61458.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000020298; ENSMUSP00000020298; ENSMUSG00000020098.
GeneIDi13180.
KEGGimmu:13180.
UCSCiuc007ffj.3. mouse.

Organism-specific databases

CTDi5092.
MGIiMGI:94873. Pcbd1.

Phylogenomic databases

eggNOGiKOG4073. Eukaryota.
COG2154. LUCA.
GeneTreeiENSGT00390000007221.
HOGENOMiHOG000007680.
HOVERGENiHBG000259.
InParanoidiP61458.
KOiK01724.
OMAiIKAQEMD.
OrthoDBiEOG091G120V.
PhylomeDBiP61458.
TreeFamiTF300188.

Enzyme and pathway databases

ReactomeiR-MMU-71182. Phenylalanine and tyrosine catabolism.

Miscellaneous databases

PROiP61458.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000020098.
GenevisibleiP61458. MM.

Family and domain databases

Gene3Di3.30.1360.20. 1 hit.
HAMAPiMF_00434. Pterin_4_alpha. 1 hit.
InterProiIPR001533. Trans/pterin_deHydtase.
[Graphical view]
PANTHERiPTHR12599. PTHR12599. 1 hit.
PfamiPF01329. Pterin_4a. 1 hit.
[Graphical view]
SUPFAMiSSF55248. SSF55248. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPHS_MOUSE
AccessioniPrimary (citable) accession number: P61458
Secondary accession number(s): P70519, P80095, Q9D930
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.