##gff-version 3
P61457	UniProtKB	Initiator methionine	1	1	.	.	.	Note=Removed;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8444860;Dbxref=PMID:8444860	
P61457	UniProtKB	Chain	2	104	.	.	.	ID=PRO_0000063052;Note=Pterin-4-alpha-carbinolamine dehydratase	
P61457	UniProtKB	Binding site	61	63	.	.	.	Ontology_term=ECO:0000250;evidence=ECO:0000250	
P61457	UniProtKB	Binding site	78	81	.	.	.	Ontology_term=ECO:0000250;evidence=ECO:0000250	
P61457	UniProtKB	Modified residue	2	2	.	.	.	Note=N-acetylalanine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8444860;Dbxref=PMID:8444860	
P61457	UniProtKB	Natural variant	27	104	.	.	.	ID=VAR_084829;Note=In HPABH4D%3B reduced protein levels%3B loss of HNF1B interaction%3B loss of HNF1B-coactivator activity. Missing;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:24204001,ECO:0000269|PubMed:9760199;Dbxref=dbSNP:rs727505360,PMID:24204001,PMID:9760199	
P61457	UniProtKB	Natural variant	79	79	.	.	.	ID=VAR_005527;Note=In HPABH4D%3B increased proteolytic degradation%3B reduced interaction with HNF1B%3B loss of HNF1B-coactivator activity. T->I;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:24204001,ECO:0000269|PubMed:9585615;Dbxref=dbSNP:rs121913014,PMID:24204001,PMID:9585615	
P61457	UniProtKB	Natural variant	82	82	.	.	.	ID=VAR_005528;Note=In HPABH4D%3B increased proteolytic degradation%3B reduced dehydratase activity%3B no impact on hydroxytetrahydrobiopterin-binding%3B reduced interaction with HNF1B%3B partial impact on HNF1B-coactivator activity. C->R;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:24204001,ECO:0000269|PubMed:8352282,ECO:0000269|PubMed:8618906;Dbxref=dbSNP:rs104894177,PMID:24204001,PMID:8352282,PMID:8618906	
P61457	UniProtKB	Natural variant	87	104	.	.	.	ID=VAR_084830;Note=In HPABH4D%3B increased proteolytic degradation%3B loss of HNF1B interaction%3B loss of HNF1B-coactivator activity. Missing;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:24204001,ECO:0000269|PubMed:8352282,ECO:0000269|PubMed:9585615;Dbxref=dbSNP:rs104894172,PMID:24204001,PMID:8352282,PMID:9585615	
P61457	UniProtKB	Natural variant	88	88	.	.	.	ID=VAR_005529;Note=No impact on HNF1B interaction%3B no impact on HNF1B-coactivator activity. R->Q;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:24204001,ECO:0000269|PubMed:9760199;Dbxref=dbSNP:rs115117837,PMID:24204001,PMID:9760199	
P61457	UniProtKB	Natural variant	97	97	.	.	.	ID=VAR_005530;Note=In HPABH4D%3B increased proteolytic degradation%3B loss of HNF1B interaction%3B loss of HNF1B-coactivator activity. E->K;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:24204001,ECO:0000269|PubMed:9760199;Dbxref=dbSNP:rs397518416,PMID:24204001,PMID:9760199	
P61457	UniProtKB	Natural variant	98	104	.	.	.	ID=VAR_084831;Note=In HPABH4D%3B increased proteolytic degradation%3B loss of HNF1B interaction%3B loss of HNF1B-coactivator activity. Missing;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:24204001,ECO:0000269|PubMed:9585615;Dbxref=dbSNP:rs121913015,PMID:24204001,PMID:9585615