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P61456 (SAHH_CORDI) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Adenosylhomocysteinase
EC=3.3.1.1
Alternative name(s):
S-adenosyl-L-homocysteine hydrolase
Short name=AdoHcyase
Gene names
Name:ahcY
Synonyms:sahH
Ordered Locus Names:DIP0692
OrganismCorynebacterium diphtheriae [Complete proteome] [HAMAP]
Taxonomic identifier1717 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Corynebacteriaceae › Corynebacterium

Protein attributes

Sequence length478 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine By similarity. HAMAP MF_00563

Catalytic activity

S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine. HAMAP MF_00563

Cofactor

Binds 1 NAD per subunit By similarity. HAMAP MF_00563

Pathway

Amino-acid biosynthesis; L-homocysteine biosynthesis; L-homocysteine from S-adenosyl-L-homocysteine: step 1/1. HAMAP MF_00563

Subcellular location

Cytoplasm By similarity HAMAP MF_00563.

Sequence similarities

Belongs to the adenosylhomocysteinase family.

Ontologies

Keywords
   Biological processOne-carbon metabolism
   Cellular componentCytoplasm
   LigandNAD
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processone-carbon metabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionadenosylhomocysteinase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 478478Adenosylhomocysteinase HAMAP MF_00563
PRO_0000116958

Regions

Nucleotide binding202 – 2043NAD By similarity
Nucleotide binding265 – 2706NAD By similarity
Nucleotide binding344 – 3463NAD By similarity

Sites

Binding site561Substrate By similarity
Binding site1391Substrate By similarity
Binding site2011Substrate By similarity
Binding site2311Substrate By similarity
Binding site2351Substrate By similarity
Binding site2361NAD By similarity
Binding site2881NAD By similarity
Binding site3231NAD By similarity
Binding site3921NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
P61456 [UniParc].

Last modified May 24, 2004. Version 1.
Checksum: 1A853BD46E1E8512

FASTA47852,208
        10         20         30         40         50         60 
MAAFDYNVKD LSLAEAGRHQ IRLAEYEMPG LMQLREEYQQ EQPLAGARIT GSIHMTVQTA 

        70         80         90        100        110        120 
VLIETLVALG AQVRWASCNI FSTQDEAAAA VVVGPHGTPE DPQGVPVFAW KGETLEEYWD 

       130        140        150        160        170        180 
CVDKIFSWGD ELPNMILDDG GDATMAVIRG KQFEEAGMVP PVEEGDSDEY QAFLGMLRKT 

       190        200        210        220        230        240 
LAEQPGKWTA IAESVKGVTE ETTTGVHRLY HFAEEGVLPF PAMNVNDAVT KSKFDNKYGT 

       250        260        270        280        290        300 
RHSLIDGINR ATDMLMGGKN VLICGYGDVG KGCAEAMAGQ GARVKVTEAD PINALQALMD 

       310        320        330        340        350        360 
GFPVVHVDQA IGDADIVITA TGNMGIISFE QMLAMKDHAV LGNIGHFDNE IDMASLLHRD 

       370        380        390        400        410        420 
DVSRVTIKPQ VDEFTLPNGK SIVVLSEGRL LNLGNATGHP SFVMSTSFAD QTIAQIELFQ 

       430        440        450        460        470 
NDGRYVNEVY RLPKILDEKV ARIHVEALGG TITELTKEQA EYIGVDVAGP YKPEHYRY

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BX248355 Genomic DNA. Translation: CAE49209.1.
RefSeqNP_939066.1. NC_002935.2.

3D structure databases

ProteinModelPortalP61456.
SMRP61456. Positions 5-478.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2650626.
GenomeReviewsGene locus DIP0692 in contig BX248353_GR.
KEGGcdi:DIP0692.
NMPDRfig|257309.1.peg.657.
PATRIC21482567. VBICorDip47633_0684.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG352029.
OMAGCAEAMA.
PhylomeDBP61456.
ProtClustDBPRK05476.

Enzyme and pathway databases

BioCycCDIP257309:DIP0692-MONOMER.

Family and domain databases

HAMAPMF_00563. AdoHcyase.
[Tree]
InterProIPR000043. Adenosylhomocysteinase.
IPR015878. Ado_hCys_hydrolase_NAD-bd.
IPR020082. S-Ado-L-homoCys_hydrolase_CS.
[Graphical view]
KOK01251.
PANTHERPTHR23420. Ad_hcy_hydrolase. 1 hit.
PfamPF05221. AdoHcyase. 1 hit.
PF00670. AdoHcyase_NAD. 1 hit.
[Graphical view]
PIRSFPIRSF001109. Ad_hcy_hydrolase. 1 hit.
SMARTSM00996. AdoHcyase. 1 hit.
SM00997. AdoHcyase_NAD. 1 hit.
[Graphical view]
TIGRFAMsTIGR00936. AhcY. 1 hit.
PROSITEPS00738. ADOHCYASE_1. 1 hit.
PS00739. ADOHCYASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSAHH_CORDI
AccessionPrimary (citable) accession number: P61456
Entry history
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: May 24, 2004
Last modified: January 25, 2012
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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