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P61421

- VA0D1_HUMAN

UniProt

P61421 - VA0D1_HUMAN

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Protein

V-type proton ATPase subunit d 1

Gene

ATP6V0D1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. May play a role in coupling of proton transport and ATP hydrolysis (By similarity). May play a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium (By similarity).By similarity

GO - Molecular functioni

  1. hydrogen-exporting ATPase activity, phosphorylative mechanism Source: Ensembl

GO - Biological processi

  1. activation of signaling protein activity involved in unfolded protein response Source: Reactome
  2. ATP hydrolysis coupled proton transport Source: InterPro
  3. brain development Source: Ensembl
  4. cellular iron ion homeostasis Source: Reactome
  5. cellular protein metabolic process Source: Reactome
  6. cilium assembly Source: UniProtKB
  7. endoplasmic reticulum unfolded protein response Source: Reactome
  8. insulin receptor signaling pathway Source: Reactome
  9. interaction with host Source: Reactome
  10. phagosome maturation Source: Reactome
  11. proton transport Source: UniProtKB
  12. transferrin transport Source: Reactome
  13. transmembrane transport Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Cilium biogenesis/degradation, Hydrogen ion transport, Ion transport, Transport

Enzyme and pathway databases

BioCyciMetaCyc:HS08417-MONOMER.
ReactomeiREACT_1109. Insulin receptor recycling.
REACT_121256. Phagosomal maturation (early endosomal stage).
REACT_18273. XBP1(S) activates chaperone genes.
REACT_25283. Transferrin endocytosis and recycling.

Protein family/group databases

TCDBi3.A.2.2.4. the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
V-type proton ATPase subunit d 1
Short name:
V-ATPase subunit d 1
Alternative name(s):
32 kDa accessory protein
V-ATPase 40 kDa accessory protein
V-ATPase AC39 subunit
Short name:
p39
Vacuolar proton pump subunit d 1
Gene namesi
Name:ATP6V0D1
Synonyms:ATP6D, VPATPD
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 16

Organism-specific databases

HGNCiHGNC:13724. ATP6V0D1.

Subcellular locationi

Membrane 1 Publication; Peripheral membrane protein 1 Publication; Cytoplasmic side 1 Publication
Note: Localizes to centrosome and the base of the cilium.

GO - Cellular componenti

  1. apical plasma membrane Source: Ensembl
  2. axon terminus Source: Ensembl
  3. early endosome Source: Ensembl
  4. endosome membrane Source: Reactome
  5. extracellular vesicular exosome Source: UniProtKB
  6. lysosomal membrane Source: UniProtKB
  7. membrane Source: UniProtKB
  8. phagocytic vesicle membrane Source: Reactome
  9. proton-transporting V-type ATPase, V0 domain Source: InterPro
  10. synaptic vesicle Source: Ensembl
  11. vacuolar proton-transporting V-type ATPase complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25150.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 351351V-type proton ATPase subunit d 1PRO_0000119350Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei270 – 2701PhosphotyrosineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP61421.
PaxDbiP61421.
PeptideAtlasiP61421.
PRIDEiP61421.

PTM databases

PhosphoSiteiP61421.

Expressioni

Tissue specificityi

Ubiquitous.2 Publications

Gene expression databases

BgeeiP61421.
CleanExiHS_ATP6V0D1.
ExpressionAtlasiP61421. baseline and differential.
GenevestigatoriP61421.

Organism-specific databases

HPAiHPA016938.

Interactioni

Subunit structurei

V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'' and d).

Protein-protein interaction databases

BioGridi114564. 14 interactions.
IntActiP61421. 2 interactions.
MINTiMINT-5006032.
STRINGi9606.ENSP00000290949.

Structurei

3D structure databases

ProteinModelPortaliP61421.
SMRiP61421. Positions 28-55.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the V-ATPase V0D/AC39 subunit family.Curated

Phylogenomic databases

eggNOGiCOG1527.
GeneTreeiENSGT00390000002200.
HOGENOMiHOG000199065.
HOVERGENiHBG018065.
InParanoidiP61421.
KOiK02146.
OrthoDBiEOG7KH9JT.
PhylomeDBiP61421.
TreeFamiTF300857.

Family and domain databases

InterProiIPR002843. ATPase_V0-cplx_csu/dsu.
IPR016727. ATPase_V0-cplx_dsu.
[Graphical view]
PANTHERiPTHR11028. PTHR11028. 1 hit.
PfamiPF01992. vATP-synt_AC39. 1 hit.
[Graphical view]
PIRSFiPIRSF018497. V-ATP_synth_D. 1 hit.
SUPFAMiSSF103486. SSF103486. 1 hit.

Sequencei

Sequence statusi: Complete.

P61421 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSFFPELYFN VDNGYLEGLV RGLKAGVLSQ ADYLNLVQCE TLEDLKLHLQ
60 70 80 90 100
STDYGNFLAN EASPLTVSVI DDRLKEKMVV EFRHMRNHAY EPLASFLDFI
110 120 130 140 150
TYSYMIDNVI LLITGTLHQR SIAELVPKCH PLGSFEQMEA VNIAQTPAEL
160 170 180 190 200
YNAILVDTPL AAFFQDCISE QDLDEMNIEI IRNTLYKAYL ESFYKFCTLL
210 220 230 240 250
GGTTADAMCP ILEFEADRRA FIITINSFGT ELSKEDRAKL FPHCGRLYPE
260 270 280 290 300
GLAQLARADD YEQVKNVADY YPEYKLLFEG AGSNPGDKTL EDRFFEHEVK
310 320 330 340 350
LNKLAFLNQF HFGVFYAFVK LKEQECRNIV WIAECIAQRH RAKIDNYIPI

F
Length:351
Mass (Da):40,329
Last modified:May 24, 2004 - v1
Checksum:iA720F8A87511203C
GO

Sequence cautioni

The sequence CAA50591.1 differs from that shown. Reason: Frameshift at positions 22, 25, 64 and 66.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti27 – 271V → E in CAA50591. (PubMed:8250920)Curated
Sequence conflicti266 – 2672NV → KL in CAA50591. (PubMed:8250920)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X71490 mRNA. Translation: CAA50591.1. Frameshift.
BC008861 mRNA. Translation: AAH08861.1.
L05087 mRNA. Translation: AAC15852.1.
CCDSiCCDS10838.1.
RefSeqiNP_004682.2. NM_004691.4.
UniGeneiHs.106876.

Genome annotation databases

EnsembliENST00000290949; ENSP00000290949; ENSG00000159720.
GeneIDi9114.
KEGGihsa:9114.
UCSCiuc002ete.1. human.

Polymorphism databases

DMDMi47606646.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X71490 mRNA. Translation: CAA50591.1 . Frameshift.
BC008861 mRNA. Translation: AAH08861.1 .
L05087 mRNA. Translation: AAC15852.1 .
CCDSi CCDS10838.1.
RefSeqi NP_004682.2. NM_004691.4.
UniGenei Hs.106876.

3D structure databases

ProteinModelPortali P61421.
SMRi P61421. Positions 28-55.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 114564. 14 interactions.
IntActi P61421. 2 interactions.
MINTi MINT-5006032.
STRINGi 9606.ENSP00000290949.

Protein family/group databases

TCDBi 3.A.2.2.4. the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily.

PTM databases

PhosphoSitei P61421.

Polymorphism databases

DMDMi 47606646.

Proteomic databases

MaxQBi P61421.
PaxDbi P61421.
PeptideAtlasi P61421.
PRIDEi P61421.

Protocols and materials databases

DNASUi 9114.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000290949 ; ENSP00000290949 ; ENSG00000159720 .
GeneIDi 9114.
KEGGi hsa:9114.
UCSCi uc002ete.1. human.

Organism-specific databases

CTDi 9114.
GeneCardsi GC16M067471.
HGNCi HGNC:13724. ATP6V0D1.
HPAi HPA016938.
MIMi 607028. gene.
neXtProti NX_P61421.
PharmGKBi PA25150.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG1527.
GeneTreei ENSGT00390000002200.
HOGENOMi HOG000199065.
HOVERGENi HBG018065.
InParanoidi P61421.
KOi K02146.
OrthoDBi EOG7KH9JT.
PhylomeDBi P61421.
TreeFami TF300857.

Enzyme and pathway databases

BioCyci MetaCyc:HS08417-MONOMER.
Reactomei REACT_1109. Insulin receptor recycling.
REACT_121256. Phagosomal maturation (early endosomal stage).
REACT_18273. XBP1(S) activates chaperone genes.
REACT_25283. Transferrin endocytosis and recycling.

Miscellaneous databases

ChiTaRSi ATP6V0D1. human.
GeneWikii ATP6V0D1.
GenomeRNAii 9114.
NextBioi 34161.
PROi P61421.
SOURCEi Search...

Gene expression databases

Bgeei P61421.
CleanExi HS_ATP6V0D1.
ExpressionAtlasi P61421. baseline and differential.
Genevestigatori P61421.

Family and domain databases

InterProi IPR002843. ATPase_V0-cplx_csu/dsu.
IPR016727. ATPase_V0-cplx_dsu.
[Graphical view ]
PANTHERi PTHR11028. PTHR11028. 1 hit.
Pfami PF01992. vATP-synt_AC39. 1 hit.
[Graphical view ]
PIRSFi PIRSF018497. V-ATP_synth_D. 1 hit.
SUPFAMi SSF103486. SSF103486. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and tissue distribution of subunits C, D, and E of the human vacuolar H(+)-ATPase."
    van Hille B., Vanek M., Richener H., Green J.R., Bilbe G.
    Biochem. Biophys. Res. Commun. 197:15-21(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Osteoclastoma.
  2. "Structure of the VPATPD gene encoding subunit D of the human vacuolar proton ATPase."
    Agarwal A.K., White P.C.
    Biochem. Biophys. Res. Commun. 279:543-547(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  4. "Expressed sequence tags from a human cell line."
    Bhat K.S.
    Submitted (NOV-1992) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 264-351.
  5. "Molecular cloning and characterization of novel tissue-specific isoforms of the human vacuolar H(+)-ATPase C, G and d subunits, and their evaluation in autosomal recessive distal renal tubular acidosis."
    Smith A.N., Borthwick K.J., Karet F.E.
    Gene 297:169-177(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. "A SNX10/V-ATPase pathway regulates ciliogenesis in vitro and in vivo."
    Chen Y., Wu B., Xu L., Li H., Xia J., Yin W., Li Z., Shi D., Li S., Lin S., Shu X., Pei D.
    Cell Res. 22:333-345(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.

Entry informationi

Entry nameiVA0D1_HUMAN
AccessioniPrimary (citable) accession number: P61421
Secondary accession number(s): P12953, Q02547
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: May 24, 2004
Last modified: October 29, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3