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P61376 (LHX5_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
LIM/homeobox protein Lhx5
Short name=LIM homeobox protein 5
Alternative name(s):
Homeobox protein LIM-2
Gene names
Name:Lhx5
Synonyms:Lim-2, Lim2
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length402 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Plays an essential role in the regulation of neuronal differentiation and migration during development of the central nervous system.

Subcellular location

Nucleus Probable.

Sequence similarities

Contains 1 homeobox DNA-binding domain.

Contains 2 LIM zinc-binding domains.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 402402LIM/homeobox protein Lhx5
PRO_0000075791

Regions

Domain3 – 6159LIM zinc-binding 1
Domain62 – 12564LIM zinc-binding 2
DNA binding180 – 23960Homeobox

Sequences

Sequence LengthMass (Da)Tools
P61376 [UniParc].

Last modified May 24, 2004. Version 1.
Checksum: 8F2DBBF1C6237227

FASTA40244,388
        10         20         30         40         50         60 
MMVHCAGCER PILDRFLLNV LDRAWHIKCV QCCECKTNLS EKCFSREGKL YCKNDFFRRF 

        70         80         90        100        110        120 
GTKCAGCAQG ISPSDLVRKA RSKVFHLNCF TCMVCNKQLS TGEELYVIDE NKFVCKDDYL 

       130        140        150        160        170        180 
SSSSLKEGSL NSVSSCTDRS LSPDLQDPLQ DDPKETDNST SSDKETANNE NEEQNSGTKR 

       190        200        210        220        230        240 
RGPRTTIKAK QLETLKAAFA ATPKPTRHIR EQLAQETGLN MRVIQVWFQN RRSKERRMKQ 

       250        260        270        280        290        300 
LSALGARRHA FFRSPRRMRP LGGRLDESEM LGSTPYTYYG DYQSDYYAPG GNYDFFAHGP 

       310        320        330        340        350        360 
PSQAQSPADS SFLAASGPGS TPLGALEPPL AGPHGADNPR FTDMISHPDT PSPEPGLPGA 

       370        380        390        400 
LHPMPGEVFS GGPSPPFPMS GTSGYSGPLS HPNPELNEAA VW

« Hide

References

[1]"Topographic organization of embryonic motor neurons defined by expression of LIM homeobox genes."
Tsuchida T., Ensini M., Morton S.B., Baldassare M., Edlund T., Jessell T.M., Pfaff S.L.
Cell 79:957-970(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		L35572 mRNA. Translation: AAA62162.1.
IPIIPI00198471.
PIRI61573.
RefSeqNP_620605.1. NM_139036.1.
UniGeneRn.54653.

3D structure databases

ProteinModelPortalP61376.
SMRP61376. Positions 5-158, 186-236.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000001883; ENSRNOP00000001883; ENSRNOG00000001392.
GeneID124451.
KEGGrno:124451.
UCSCRGD:71079. rat.

Organism-specific databases

CTD64211.
RGD71079. Lhx5.

Phylogenomic databases

eggNOGNOG257130.
GeneTreeENSGT00700000104177.
HOGENOMHOG000231630.
HOVERGENHBG006263.
InParanoidP61376.
KOK09372.
OMASHQGQEM.
OrthoDBEOG405S1F.

Gene expression databases

GenevestigatorP61376.
GermOnlineENSRNOG00000001392. Rattus norvegicus.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
2.10.110.10. 2 hits.
InterProIPR017970. Homeobox_CS.
IPR001356. Homeodomain.
IPR009057. Homeodomain-like.
IPR001781. Znf_LIM.
[Graphical view]
PfamPF00046. Homeobox. 1 hit.
PF00412. LIM. 2 hits.
[Graphical view]
SMARTSM00389. HOX. 1 hit.
SM00132. LIM. 2 hits.
[Graphical view]
SUPFAMSSF46689. Homeodomain_like. 1 hit.
PROSITEPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00478. LIM_DOMAIN_1. 2 hits.
PS50023. LIM_DOMAIN_2. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio290846.

Entry information

Entry nameLHX5_RAT
AccessionPrimary (citable) accession number: P61376
Secondary accession number(s): P50459
Entry history
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: May 24, 2004
Last modified: May 1, 2013
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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