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Protein

LIM/homeobox protein Lhx5

Gene

Lhx5

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Plays an essential role in the regulation of neuronal differentiation and migration during development of the central nervous system.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi180 – 23960HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
LIM/homeobox protein Lhx5
Short name:
LIM homeobox protein 5
Alternative name(s):
Homeobox protein LIM-2
Gene namesi
Name:Lhx5
Synonyms:Lim-2, Lim2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 12

Organism-specific databases

RGDi71079. Lhx5.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 402402LIM/homeobox protein Lhx5PRO_0000075791Add
BLAST

Proteomic databases

PaxDbiP61376.
PRIDEiP61376.

Expressioni

Gene expression databases

GenevisibleiP61376. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000001883.

Structurei

3D structure databases

ProteinModelPortaliP61376.
SMRiP61376. Positions 5-158, 186-236.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini3 – 6159LIM zinc-binding 1PROSITE-ProRule annotationAdd
BLAST
Domaini62 – 12564LIM zinc-binding 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation
Contains 2 LIM zinc-binding domains.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox, LIM domain, Repeat

Phylogenomic databases

eggNOGiKOG0490. Eukaryota.
ENOG410YIJ3. LUCA.
GeneTreeiENSGT00760000118921.
HOGENOMiHOG000231630.
HOVERGENiHBG006263.
InParanoidiP61376.
KOiK18493.
OMAiQDPMQDD.
OrthoDBiEOG7PP56T.
PhylomeDBiP61376.
TreeFamiTF315442.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
2.10.110.10. 2 hits.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR001781. Znf_LIM.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF00412. LIM. 2 hits.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
SM00132. LIM. 2 hits.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00478. LIM_DOMAIN_1. 2 hits.
PS50023. LIM_DOMAIN_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P61376-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMVHCAGCER PILDRFLLNV LDRAWHIKCV QCCECKTNLS EKCFSREGKL
60 70 80 90 100
YCKNDFFRRF GTKCAGCAQG ISPSDLVRKA RSKVFHLNCF TCMVCNKQLS
110 120 130 140 150
TGEELYVIDE NKFVCKDDYL SSSSLKEGSL NSVSSCTDRS LSPDLQDPLQ
160 170 180 190 200
DDPKETDNST SSDKETANNE NEEQNSGTKR RGPRTTIKAK QLETLKAAFA
210 220 230 240 250
ATPKPTRHIR EQLAQETGLN MRVIQVWFQN RRSKERRMKQ LSALGARRHA
260 270 280 290 300
FFRSPRRMRP LGGRLDESEM LGSTPYTYYG DYQSDYYAPG GNYDFFAHGP
310 320 330 340 350
PSQAQSPADS SFLAASGPGS TPLGALEPPL AGPHGADNPR FTDMISHPDT
360 370 380 390 400
PSPEPGLPGA LHPMPGEVFS GGPSPPFPMS GTSGYSGPLS HPNPELNEAA

VW
Length:402
Mass (Da):44,388
Last modified:May 24, 2004 - v1
Checksum:i8F2DBBF1C6237227
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L35572 mRNA. Translation: AAA62162.1.
PIRiI61573.
RefSeqiNP_620605.1. NM_139036.1.
UniGeneiRn.54653.

Genome annotation databases

EnsembliENSRNOT00000001883; ENSRNOP00000001883; ENSRNOG00000001392.
GeneIDi124451.
KEGGirno:124451.
UCSCiRGD:71079. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L35572 mRNA. Translation: AAA62162.1.
PIRiI61573.
RefSeqiNP_620605.1. NM_139036.1.
UniGeneiRn.54653.

3D structure databases

ProteinModelPortaliP61376.
SMRiP61376. Positions 5-158, 186-236.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000001883.

Proteomic databases

PaxDbiP61376.
PRIDEiP61376.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000001883; ENSRNOP00000001883; ENSRNOG00000001392.
GeneIDi124451.
KEGGirno:124451.
UCSCiRGD:71079. rat.

Organism-specific databases

CTDi64211.
RGDi71079. Lhx5.

Phylogenomic databases

eggNOGiKOG0490. Eukaryota.
ENOG410YIJ3. LUCA.
GeneTreeiENSGT00760000118921.
HOGENOMiHOG000231630.
HOVERGENiHBG006263.
InParanoidiP61376.
KOiK18493.
OMAiQDPMQDD.
OrthoDBiEOG7PP56T.
PhylomeDBiP61376.
TreeFamiTF315442.

Miscellaneous databases

NextBioi620463.
PROiP61376.

Gene expression databases

GenevisibleiP61376. RN.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
2.10.110.10. 2 hits.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR001781. Znf_LIM.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF00412. LIM. 2 hits.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
SM00132. LIM. 2 hits.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00478. LIM_DOMAIN_1. 2 hits.
PS50023. LIM_DOMAIN_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Topographic organization of embryonic motor neurons defined by expression of LIM homeobox genes."
    Tsuchida T., Ensini M., Morton S.B., Baldassare M., Edlund T., Jessell T.M., Pfaff S.L.
    Cell 79:957-970(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiLHX5_RAT
AccessioniPrimary (citable) accession number: P61376
Secondary accession number(s): P50459
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: May 24, 2004
Last modified: February 17, 2016
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.